Immunology

Edible formulations of chicken egg derived IgY antibodies neutralize SarsCoV2 Omicron RBD binding to human ACE2

1. Kranti Meher
2. S. Sivakumar
3. Gopi Kadiyala
4. Subramanian Iyer
5. Subhramanyam Vangala
6. Satish Chandran
7. Uday Saxena

Reviewed by ScreenIT

Pyruvate Supports RET-Dependent Mitochondrial ROS Production to Control Mycobacterium avium Infection in Human Primary Macrophages

1. Lisa Marie Røst
2. Claire Louet
3. Per Bruheim
4. Trude Helen Flo
5. Alexandre Gidon

Reviewed by Review Commons

A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

1. Massimo Andreatta
2. Ariel Tjitropranoto
3. Zachary Sherman
4. Michael C Kelly
5. Thomas Ciucci
6. Santiago J Carmona

• Curated by eLife

  Evaluation Summary:

  This paper uses single-cell genomics to examine the heterogeneity of virus-specific CD4 T cells over time in both acute and chronic viral infection. Further, the authors build a comprehensive atlas of the transcriptional evolution of virus-specific CD4 T cell responses that could be used as a reference tool to interpret other datasets. This work characterizes how the antiviral CD4 T cell transcriptional landscape changes with time and will be of broad interest to those that study acute and chronic CD4 T cell responses.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

1. Riccardo Biavasco
2. Marco De Giovanni

Reviewed by ScreenIT

Preparing for the next COVID: Deep Reinforcement Learning trained Artificial Intelligence discovery of multi-modal immunomodulatory control of systemic inflammation in the absence of effective anti-microbials

1. Dale Larie
2. Gary An
3. Chase Cockrell

Reviewed by ScreenIT

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

1. Chuan Chen
2. James W. Saville
3. Michelle M. Marti
4. Alexandra Schäfer
5. Mary Hongying Cheng
6. Dhiraj Mannar
7. Xing Zhu
8. Alison M. Berezuk
9. Anupam Banerjee
10. Michele D. Sobolewski
11. Andrew Kim
12. Benjamin R. Treat
13. Priscila Mayrelle Da Silva Castanha
14. Nathan Enick
15. Kevin D McCormick
16. Xianglei Liu
17. Cynthia Adams
18. Margaret Grace Hines
19. Zehua Sun
20. Weizao Chen
21. Jana L. Jacobs
22. Simon M. Barratt-Boyes
23. John W. Mellors
24. Ralph S. Baric
25. Ivet Bahar
26. Dimiter S. Dimitrov
27. Sriram Subramaniam
28. David R. Martinez
29. Wei Li

Reviewed by ScreenIT

Resistance of SARS-CoV-2 Omicron BA.1 and BA.2 Variants to Vaccine-Elicited Sera and Therapeutic Monoclonal Antibodies

1. Hao Zhou
2. Belinda M. Dcosta
3. Nathaniel R. Landau
4. Takuya Tada

Reviewed by ScreenIT

Mathematical model of a cytokine storm

1. Irina Kareva
2. Faina Berezovskaya
3. Georgy Karev

Reviewed by ScreenIT

Non-productive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immunity responses

1. Julia Kazmierski
2. Kirstin Friedmann
3. Dylan Postmus
4. Cornelius Fischer
5. Jenny Jansen
6. Anja Richter
7. Laure Bosquillon de Jarcy
8. Christiane Schüler
9. Madlen Sohn
10. Sascha Sauer
11. Christian Drosten
12. Antoine-Emmanuel Saliba
13. Leif Erik Sander
14. Daniela Niemeyer
15. Christine Goffinet

Reviewed by ScreenIT

Reduced antigenicity of Omicron lowers host serologic response

1. Jérôme Tubiana
2. Yufei Xiang
3. Li Fan
4. Haim J. Wolfson
5. Kong Chen
6. Dina Schneidman-Duhovny
7. Yi Shi

Reviewed by ScreenIT