Immunology

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

1. Yunlong Cao
2. Ayijiang Yisimayi
3. Fanchong Jian
4. Weiliang Song
5. Tianhe Xiao
6. Lei Wang
7. Shuo Du
8. Jing Wang
9. Qianqian Li
10. Xiaosu Chen
11. Yuanling Yu
12. Peng Wang
13. Zhiying Zhang
14. Pulan Liu
15. Ran An
16. Xiaohua Hao
17. Yao Wang
18. Jing Wang
19. Rui Feng
20. Haiyan Sun
21. Lijuan Zhao
22. Wen Zhang
23. Dong Zhao
24. Jiang Zheng
25. Lingling Yu
26. Can Li
27. Na Zhang
28. Rui Wang
29. Xiao Niu
30. Sijie Yang
31. Xuetao Song
32. Yangyang Chai
33. Ye Hu
34. Yansong Shi
35. Linlin Zheng
36. Zhiqiang Li
37. Qingqing Gu
38. Fei Shao
39. Weijin Huang
40. Ronghua Jin
41. Zhongyang Shen
42. Youchun Wang
43. Xiangxi Wang
44. Junyu Xiao
45. Xiaoliang Sunney Xie

Reviewed by ScreenIT

The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency

1. Sigrid Wahlen
2. Filip Matthijssens
3. Wouter Van Loocke
4. Sylvie Taveirne
5. Laura Kiekens
6. Eva Persyn
7. Els Van Ammel
8. Zenzi De Vos
9. Stijn De Munter
10. Patrick Matthys
11. Filip Van Nieuwerburgh
12. Tom Taghon
13. Bart Vandekerckhove
14. Pieter Van Vlierberghe
15. Georges Leclercq

Reviewed by Review Commons

Immediate myeloid depot for SARS-CoV-2 in the human lung

1. Mélia Magnen
2. Ran You
3. Arjun A. Rao
4. Ryan T. Davis
5. Lauren Rodriguez
6. Olivier Bernard
7. Camille R. Simoneau
8. Lisiena Hysenaj
9. Kenneth H. Hu
10. Mazharul Maishan
11. Catharina Conrad
12. Oghenekevwe M. Gbenedio
13. Bushra Samad
14. The UCSF COMET Consortium
15. Christina Love
16. Prescott G. Woodruff
17. David J. Erle
18. Carolyn M. Hendrickson
19. Carolyn S. Calfee
20. Michael A. Matthay
21. Jeroen P. Roose
22. Anita Sil
23. Melanie Ott
24. Charles R. Langelier
25. Matthew F. Krummel
26. Mark R. Looney

Reviewed by ScreenIT

Diet induced obesity and type 2 diabetes drives exacerbated sex-associated disease profiles in K18-hACE2-mice challenged with SARS-CoV-2

1. Katherine S. Lee
2. Brynnan P. Russ
3. Ting Y. Wong
4. Alexander M. Horspool
5. Michael T. Winters
6. Mariette Barbier
7. Justin R. Bevere
8. Ivan Martinez
9. F. Heath Damron
10. Holly A. Cyphert

Reviewed by ScreenIT

GM-CSF-activated human dendritic cells promote type1 T follicular helper cells (Tfh1) polarization in a CD40-dependent manner

1. Sarantis Korniotis
2. Melissa Saichi
3. Coline Trichot
4. Caroline Hoffmann
5. Elise Amblard
6. Annick Viguier
7. Sophie Grondin
8. Floriane Noel
9. Hamid Mattoo
10. Vassili Soumelis

Reviewed by ScreenIT

Two types of human TCR differentially regulate reactivity to self and non-self antigens

1. Assya Trofimov
2. Philippe Brouillard
3. Jean-David Larouche
4. Jonathan Séguin
5. Jean-Philippe Laverdure
6. Ann Brasey
7. Gregory Ehx
8. Denis-Claude Roy
9. Lambert Busque
10. Silvy Lachance
11. Sébastien Lemieux
12. Claude Perreault

Reviewed by ScreenIT

Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains in mice

1. Qiong Zhang
2. Shashi Tiwari
3. Jing Wen
4. Shaobo Wang
5. Lingling Wang
6. Wanyu Li
7. Lingzhi Zhang
8. Stephen Rawling
9. Yong Cheng
10. Jesse Jokerst
11. Tariq M. Rana

Reviewed by ScreenIT

Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement

1. Anas H. A. Abu-Humaidan
2. Fatima M. Ahmad
3. Dima Awajan
4. Raba’a F. Jarrar
5. Nader Alaridah

Reviewed by ScreenIT

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

1. Xinghai Zhang
2. Feiyang Luo
3. huajun Zhang
4. Hangtian Guo
5. Junhui Zhou
6. Tingting Li
7. Shaohong Chen
8. Shuyi Song
9. Meiying Shen
10. Yan Wu
11. Yan Gao
12. Xiaojian Han
13. Yingming Wang
14. Chao Hu
15. Yuchi Lu
16. Wei Wang
17. Kai Wang
18. Ni Tang
19. Tengchuan Jin
20. Chengyong Yang
21. Guofeng Cheng
22. Haitao Yang
23. Aishun Jin
24. Xiaoyun Ji
25. Rui Gong
26. Sandra Chiu
27. Ailong Huang

Reviewed by ScreenIT

Macrophages regulate gastrointestinal motility through complement component 1q

1. Mihir Pendse
2. Haley De Selle
3. Nguyen Vo
4. Gabriella Quinn
5. Chaitanya Dende
6. Yun Li
7. Cristine N Salinas
8. Tarun Srinivasan
9. Daniel C Propheter
10. Alexander A Crofts
11. Eugene Koo
12. Brian Hassell
13. Kelly A Ruhn
14. Prithvi Raj
15. Yuuki Obata
16. Lora V Hooper

• Curated by eLife

  Evaluation Summary:

  This study will be of broad interest to neuroscientists, immunologists, and gastroenterologists, revealing a novel role of complement C1q in intestinal macrophages and the regulation of gut motility. The manuscript is well written and key datasets are convincing, but the lack of mechanistic details that lead to dysmotility require additional supportive datasets at this time.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife