Immunology

  1. Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

    1. Sara E Vazquez
    2. Sabrina A Mann
    3. Aaron Bodansky
    4. Andrew F Kung
    5. Zoe Quandt
    6. Elise MN Ferré
    7. Nils Landegren
    8. Daniel Eriksson
    9. Paul Bastard
    10. Shen-Ying Zhang
    11. Jamin Liu
    12. Anthea Mitchell
    13. Irina Proekt
    14. David Yu
    15. Caleigh Mandel-Brehm
    16. Chung-Yu Wang
    17. Brenda Miao
    18. Gavin Sowa
    19. Kelsey Zorn
    20. Alice Y Chan
    21. Veronica M Tagi
    22. Chisato Shimizu
    23. Adriana Tremoulet
    24. Kara Lynch
    25. Michael R Wilson
    26. Olle Kämpe
    27. Kerry Dobbs
    28. Ottavia M Delmonte
    29. Rosa Bacchetta
    30. Luigi D Notarangelo
    31. Jane C Burns
    32. Jean-Laurent Casanova
    33. Michail S Lionakis
    34. Troy R Torgerson
    35. Mark S Anderson
    36. Joseph L DeRisi

    • Curated by eLife

      Evaluation Summary:

      This work presents a series of enhancements to the PhIP-seq method of autoantibody discovery, with the goal of improving scaling to larger cohorts and increasing disease specificity. The strength of the paper is the validation of the high throughput format, although results from screening patient samples confirm or only modestly extend previous data.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    6 evaluationsAppears in 2 listsLatest version Latest activity

  2. Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice

    1. Irene González-Domínguez
    2. Jose Luis Martínez
    3. Stefan Slamanig
    4. Nicholas Lemus
    5. Yonghong Liu
    6. Tsoi Ying Lai
    7. Juan Manuel Carreño
    8. Gagandeep Singh
    9. Gagandeep Singh
    10. Michael Schotsaert
    11. Ignacio Mena
    12. Stephen McCroskery
    13. Lynda Coughlan
    14. Florian Krammer
    15. Adolfo García-Sastre
    16. Peter Palese
    17. Weina Sun

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

    1. Anja Schlör
    2. Stefan Hirschberg
    3. Ghada Ben Amor
    4. Toni Luise Meister
    5. Prerna Arora
    6. Stefan Pöhlmann
    7. Markus Hoffmann
    8. Stephanie Pfaender
    9. Omar Kamal Eddin
    10. Julian Kamhieh-Milz
    11. Katja Hanack

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

    1. Emily A. Voigt
    2. Alana Gerhardt
    3. Derek Hanson
    4. Madeleine F. Jennewein
    5. Peter Battisti
    6. Sierra Reed
    7. Jasneet Singh
    8. Raodoh Mohamath
    9. Julie Bakken
    10. Samuel Beaver
    11. Christopher Press
    12. Patrick Soon-Shiong
    13. Christopher J. Paddon
    14. Christopher B. Fox
    15. Corey Casper

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    6 evaluationsAppears in 2 listsLatest version Latest activity

  5. Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice

    1. Shyamala Ganesan
    2. Hugo Acosta
    3. Chris Brigolin
    4. Kallista Orange
    5. Kevin Trabbic
    6. Charles Chen
    7. Chia-En Lien
    8. Yi-Jiun Lin
    9. Meei-Yun Lin
    10. Ya-Shan Chuang
    11. Ali Fattom
    12. Vira Bitko

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. In silico analysis predicts a limited impact of SARS-CoV-2 variants on CD8 T cell recognition

    1. Olga I. Isaeva
    2. Steven L.C. Ketelaars
    3. Pia Kvistborg

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

    1. Zhenhao Fang
    2. Lei Peng
    3. Carolina Lucas
    4. Qianqian Lin
    5. Liqun Zhou
    6. Luojia Yang
    7. Yanzhi Feng
    8. Ping Ren
    9. Paul A. Renauer
    10. Valter S. Monteiro
    11. Anne M. Hahn
    12. Jonathan J. Park
    13. Xiaoyu Zhou
    14. Yale SARS-CoV-2 Genomic Surveillance Initiative
    15. Kendall Billig
    16. Mallery I. Breban
    17. Christopher Castaldi
    18. Chrispin Chaguza
    19. Nicholas Chen
    20. David Ferguson
    21. Nicholas Kerantzas
    22. Tobias R. Koch
    23. Bony De Kumar
    24. Marie L. Landry
    25. David Peaper
    26. Kien Pham
    27. Wade Schulz
    28. Irina R. Tikhonova
    29. Chantal B. F. Vogels
    30. Nathan D. Grubaugh
    31. Craig B. Wilen
    32. Sidi Chen

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice

    1. Pascal Brandys
    2. Xavier Montagutelli
    3. Irena Merenkova
    4. Güliz T Barut
    5. Volker Thiel
    6. Nicholas J Schork
    7. Bettina Trüeb
    8. Laurine Conquet
    9. Aihua Deng
    10. Aleksandar Antanasijevic
    11. Hyun-Ku Lee
    12. Martine Valière
    13. Anoop Sindhu
    14. Gita Singh
    15. Jens Herold

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication

    1. Larisa I Labzin
    2. Keng Yih Chew
    3. Kathrin Eschke
    4. Xiaohui Wang
    5. Tyron Esposito
    6. Claudia J Stocks
    7. James Rae
    8. Ralph Patrick
    9. Helen Mostafavi
    10. Brittany Hill
    11. Teodor E. Yordanov
    12. Caroline L Holley
    13. Stefan Emming
    14. Svenja Fritzlar
    15. Francesca L. Mordant
    16. Daniel P. Steinfort
    17. Kanta Subbarao
    18. Christian M. Nefzger
    19. Anne K Lagendijk
    20. Emma Gordon
    21. Robert Parton
    22. Kirsty R. Short
    23. Sarah L. Londrigan
    24. Kate Schroder

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Humoral and cellular immune memory to four COVID-19 vaccines

    1. Zeli Zhang
    2. Jose Mateus
    3. Camila H. Coelho
    4. Jennifer M. Dan
    5. Carolyn Rydyznski Moderbacher
    6. Rosa Isela Gálvez
    7. Fernanda H. Cortes
    8. Alba Grifoni
    9. Alison Tarke
    10. James Chang
    11. E. Alexandar Escarrega
    12. Christina Kim
    13. Benjamin Goodwin
    14. Nathaniel I. Bloom
    15. April Frazier
    16. Daniela Weiskopf
    17. Alessandro Sette
    18. Shane Crotty

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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