Immunology

An intranasal lentiviral booster broadens immune recognition of SARS-CoV-2 variants and reinforces the waning mRNA vaccine-induced immunity that it targets to lung mucosa

1. Benjamin Vesin
2. Jodie Lopez
3. Amandine Noirat
4. Pierre Authié
5. Ingrid Fert
6. Fabien Le Chevalier
7. Fanny Moncoq
8. Kirill Nemirov
9. Catherine Blanc
10. Cyril Planchais
11. Hugo Mouquet
12. Françoise Guinet
13. David Hardy
14. Christiane Gerke
15. François Anna
16. Maryline Bourgine
17. Laleh Majiessi
18. Pierre Charneau

Reviewed by ScreenIT

T cells discriminate between groups C1 and C2 HLA-C

1. Malcolm J W Sim
2. Zachary Stotz
3. Jinghua Lu
4. Paul Brennan
5. Eric O Long
6. Peter D Sun

• Curated by eLife

  Evaluation Summary:

  In this study, the authors use structural, functional and immunopeptidomics analysis to provide insights into how HLA-C C1/C2 dimorphism impacts T cell recognition. This knowledge is important in immunotherapies targeting HLA-C-specific T cells. Overall, the experiments are well-performed, and the conclusions are largely supported by the presented data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Mapping SARS-CoV-2 antigenic relationships and serological responses

1. Samuel H. Wilks
2. Barbara Mühlemann
3. Xiaoying Shen
4. Sina Türeli
5. Eric B. LeGresley
6. Antonia Netzl
7. Miguela A. Caniza
8. Jesus N. Chacaltana-Huarcaya
9. Victor M. Corman
10. Xiaoju Daniell
11. Michael B. Datto
12. Fatimah S. Dawood
13. Thomas N. Denny
14. Christian Drosten
15. Ron A. M. Fouchier
16. Patricia J. Garcia
17. Peter J. Halfmann
18. Agatha Jassem
19. Lara M. Jeworowski
20. Terry C. Jones
21. Yoshihiro Kawaoka
22. Florian Krammer
23. Charlene McDanal
24. Rolando Pajon
25. Viviana Simon
26. Melissa S. Stockwell
27. Haili Tang
28. Harm van Bakel
29. Vic Veguilla
30. Richard Webby
31. David C. Montefiori
32. Derek J. Smith

Reviewed by ScreenIT

Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine

1. Dapeng Li
2. David R. Martinez
3. Alexandra Schäfer
4. Haiyan Chen
5. Maggie Barr
6. Laura L. Sutherland
7. Esther Lee
8. Robert Parks
9. Dieter Mielke
10. Whitney Edwards
11. Amanda Newman
12. Kevin W. Bock
13. Mahnaz Minai
14. Bianca M. Nagata
15. Matthew Gagne
16. Daniel C. Douek
17. C. Todd DeMarco
18. Thomas N. Denny
19. Thomas H. Oguin
20. Alecia Brown
21. Wes Rountree
22. Yunfei Wang
23. Katayoun Mansouri
24. Robert J. Edwards
25. Guido Ferrari
26. Gregory D. Sempowski
27. Amanda Eaton
28. Juanjie Tang
29. Derek W. Cain
30. Sampa Santra
31. Norbert Pardi
32. Drew Weissman
33. Mark A. Tomai
34. Christopher B. Fox
35. Ian N. Moore
36. Hanne Andersen
37. Mark G. Lewis
38. Hana Golding
39. Robert Seder
40. Surender Khurana
41. Ralph S. Baric
42. David C. Montefiori
43. Kevin O. Saunders
44. Barton F. Haynes

Reviewed by ScreenIT

Impact of various vaccine boosters on neutralization against omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

1. Qingrui Huang
2. Jiawei Zeng
3. Qingyun Lang
4. Feng Gao
5. Dejun Liu
6. Siyu Tian
7. Rui Shi
8. Ling Luo
9. Hao Wang
10. Liping Hu
11. Linrui Jiang
12. Yawei Liu
13. Kailiang Li
14. Yunbo Wu
15. Junjie Xu
16. Wenxi Jiang
17. Ning Guo
18. Zhihai Chen
19. Xiaohua Hao
20. Ronghua Jin
21. Jinghua Yan
22. Yufa Sun

Reviewed by ScreenIT

Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

1. Kiyomi Shitaoka
2. Yohei Kawano
3. Akifumi Higashiura
4. Yoko Mizoguchi
5. Takao Hashiguchi
6. Norihisa Nishimichi
7. Shiyu Huang
8. Ayano Ito
9. Akima Yamamoto
10. Shun Ohki
11. Miyuki Kanda
12. Tomohiro Taniguchi
13. Yasuyuki Yokosaki
14. Satoshi Okada
15. Takemasa Sakaguchi
16. Tomoharu Yasuda

Reviewed by ScreenIT

Antibodies targeting conserved non-canonical antigens and endemic coronaviruses associate with favorable outcomes in severe COVID-19

1. Sai Preetham Peddireddy
2. Syed A. Rahman
3. Anthony R. Cillo
4. Godhev Manakkat Vijay
5. Ashwin Somasundaram
6. Creg J. Workman
7. William Bain
8. Bryan J. McVerry
9. Barbara Methe
10. Janet S. Lee
11. Prabir Ray
12. Anuradha Ray
13. Tullia C. Bruno
14. Dario A.A. Vignali
15. Georgios D. Kitsios
16. Alison Morris
17. Harinder Singh
18. Aniruddh Sarkar
19. Jishnu Das

Reviewed by ScreenIT

Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability

1. Wei Shi
2. Lingshu Wang
3. Tongqing Zhou
4. Mallika Sastry
5. Eun Sung Yang
6. Yi Zhang
7. Man Chen
8. Xuejun Chen
9. Misook Choe
10. Adrian Creanga
11. Kwan Leung
12. Adam S. Olia
13. Amarendra Pegu
14. Reda Rawi
15. Arne Schön
16. Chen-Hsiang Shen
17. Erik-Stephane D. Stancofski
18. Chloe Adrienna Talana
19. I-Ting Teng
20. Shuishu Wang
21. Kizzmekia S. Corbett
22. Yaroslav Tsybovsky
23. John R. Mascola
24. Peter D. Kwong

Reviewed by ScreenIT

Unadjuvanted intranasal spike vaccine booster elicits robust protective mucosal immunity against sarbecoviruses

1. Tianyang Mao
2. Benjamin Israelow
3. Alexandra Suberi
4. Liqun Zhou
5. Melanie Reschke
6. Mario A Peña-Hernández
7. Huiping Dong
8. Robert J. Homer
9. W. Mark Saltzman
10. Akiko Iwasaki

Reviewed by ScreenIT

Cytotoxic T Lymphocytes Targeting a Conserved SARS-CoV-2 Spike Epitope are Efficient Serial Killers

1. Mohsen Fathi
2. Lindsey Charley
3. Laurence JN Cooper
4. Navin Varadarajan
5. Daniel D Meyer

Reviewed by ScreenIT