Impact of Prior Infection on SARS-CoV-2 Antibody Responses in Vaccinated Long-Term Care Facility Staff
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Abstract
Long-term care facilities (LTCFs) have been disproportionately impacted by COVID-19, due to their communal nature, the high-risk profile of residents, and the vulnerability of residents to respiratory pathogens. In this study, we analyzed the role of prior natural immunity to SARS-CoV-2 in postvaccination antibody responses.
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SciScore for 10.1101/2022.04.04.487083: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Human specimens: This study was approved by the Colorado State University Institutional Review Board under protocol number 20-10057H. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Plates were washed and a secondary anti-human IgG-horseradish peroxidase conjugated secondary antibody was added. anti-human IgG-horseradishsuggested: NoneExperimental Models: Cell Lines Sentences Resources Briefly, diluted sera were mixed with virus, incubated for one hour at 37°C, added to a Vero cell monolayer, incubated an additional hour at 37°C, then overlaid … SciScore for 10.1101/2022.04.04.487083: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Human specimens: This study was approved by the Colorado State University Institutional Review Board under protocol number 20-10057H. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources Plates were washed and a secondary anti-human IgG-horseradish peroxidase conjugated secondary antibody was added. anti-human IgG-horseradishsuggested: NoneExperimental Models: Cell Lines Sentences Resources Briefly, diluted sera were mixed with virus, incubated for one hour at 37°C, added to a Vero cell monolayer, incubated an additional hour at 37°C, then overlaid with tragacanth media and incubated for two days. Verosuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- No conflict of interest statement was detected. If there are no conflicts, we encourage authors to explicit state so.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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