Immunology

  1. Tongue immune compartment analysis reveals spatial macrophage heterogeneity

    1. Ekaterini Maria Lyras
    2. Karin Zimmermann
    3. Lisa Katharina Wagner
    4. Dorothea Dörr
    5. Christoph SN Klose
    6. Cornelius Fischer
    7. Steffen Jung
    8. Simon Yona
    9. Avi-Hai Hovav
    10. Werner Stenzel
    11. Steffen Dommerich
    12. Thomas Conrad
    13. Achim Leutz
    14. Alexander Mildner

    • Curated by eLife

      Evaluation Summary:

      In this manuscript, the authors map the cellular landscape in the tongue, which is an underrated immunological organ, with a main focus on tissue-resident myeloid cells under homeostatic and inflammatory conditions. They identify two major subsets of macrophages, which occupy distinct anatomical niches and develop from local precursors, while under immune compromised conditions they can also be replenished from circulating hematopoietic precursors. These findings provide an important basis for future investigations of the tongue immune function in the context of infection, inflammation, and neoplastic diseases.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. SARS-CoV-2 mutations affect proteasome processing to alter CD8 + T cell responses

    1. Dannielle Wellington
    2. Zixi Yin
    3. Zhanru Yu
    4. Raphael Heilig
    5. Simon Davis
    6. Roman Fischer
    7. Suet Ling Felce
    8. Philip Hublitz
    9. Ryan Beveridge
    10. Danning Dong
    11. Guihai Liu
    12. Xuan Yao
    13. Yanchun Peng
    14. Benedikt M Kessler
    15. Tao Dong

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

    1. Zaigham Abbas Rizvi
    2. Srikanth Sadhu
    3. Jyotsna Dandotiya
    4. Akshay Binyka
    5. Puja Sharma
    6. Virendra Singh
    7. Vinayaka Das
    8. Ritika Khatri
    9. Rajesh Kumar
    10. Sweety Samal
    11. Manjula Kalia
    12. Amit Awasthi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4 + and CD8 + T cell responses

    1. Carolyn Rydyznski Moderbacher
    2. Christina Kim
    3. Jose Mateus
    4. Joyce Plested
    5. Mingzhu Zhu
    6. Shane Cloney-Clark
    7. Daniela Weiskopf
    8. Alessandro Sette
    9. Louis Fries
    10. Gregory Glenn
    11. Shane Crotty

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Plant-produced RBD and cocktail-based vaccine candidates are highly effective against SARS-CoV-2, independently of its emerging variants

    1. Tarlan Mamedov
    2. Damla Yuksel
    3. Irem Gurbuzaslan
    4. Merve Ilgin
    5. Burcu Gulec
    6. Gulshan Mammadova
    7. Aykut Ozdarendeli
    8. Shaikh Terkis Islam Pavel
    9. Hazel Yetiskin
    10. Busra Kaplan
    11. Muhammet Ali Uygut
    12. Gulnara Hasanova

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

    1. Mohamed M. Shamseldin
    2. Ashley Zani
    3. Adam Kenney
    4. Jack Evans
    5. Cong Zeng
    6. Kaitlin A. Read
    7. Kyle Caution
    8. Jesse M. Hall
    9. Jessica M. Brown
    10. Gilian Gunsch
    11. Kara N. Corps
    12. Supranee Chaiwatpongsakorn
    13. KC Mahesh
    14. Mijia Lu
    15. Rajendar Deora
    16. Mark E. Peeples
    17. Jianrong Li
    18. Kenneth J. Oestreich
    19. Shan-Lu Liu
    20. Jacob S. Yount
    21. Purnima Dubey

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Delineating antibody escape from Omicron sublineages

    1. Henning Gruell
    2. Kanika Vanshylla
    3. Michael Korenkov
    4. Pinkus Tober-Lau
    5. Matthias Zehner
    6. Friederike Münn
    7. Hanna Janicki
    8. Max Augustin
    9. Philipp Schommers
    10. Leif Erik Sander
    11. Florian Kurth
    12. Christoph Kreer
    13. Florian Klein

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

    1. Simone Parn
    2. Kush Savsani
    3. Sivanesan Dakshanamurthy

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Immunopharmacological evaluation of adjuvant efficacy of Monophosphoryl lipid-A and CpG ODN with SARS-CoV-2 RBD antigen

    1. Shainy Sambyal
    2. Vemireddy Sravanthi
    3. Ritika Khatri
    4. Gazala Siddqui
    5. Shubbir Ahmed
    6. Sweety Samal
    7. Halmuthur M Sampath Kumar

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Impact of Prior Infection on SARS-CoV-2 Antibody Responses in Vaccinated Long-Term Care Facility Staff

    1. Emily N. Gallichotte
    2. Mary Nehring
    3. Sophia Stromberg
    4. Michael C. Young
    5. Ashley Snell
    6. Josh Daniels
    7. Kristy L. Pabilonia
    8. Sue VandeWoude
    9. Nicole Ehrhart
    10. Gregory D. Ebel

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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