Immunology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

1. Lyra O Randzavola
2. Paige M Mortimer
3. Emma Garside
4. Elizabeth R Dufficy
5. Andrea Schejtman
6. Georgia Roumelioti
7. Lu Yu
8. Mercedes Pardo
9. Kerstin Spirohn
10. Charlotte Tolley
11. Cordelia Brandt
12. Katherine Harcourt
13. Esme Nichols
14. Mike Nahorski
15. Geoff Woods
16. James C Williamson
17. Shreehari Suresh
18. John M Sowerby
19. Misaki Matsumoto
20. Celio XC Santos
21. Cher Shen Kiar
22. Subhankar Mukhopadhyay
23. William M Rae
24. Gordon J Dougan
25. John Grainger
26. Paul J Lehner
27. Michael A Calderwood
28. Jyoti Choudhary
29. Simon Clare
30. Anneliese Speak
31. Giorgia Santilli
32. Alex Bateman
33. Kenneth GC Smith
34. Francesca Magnani
35. David C Thomas

• Curated by eLife

  Evaluation Summary:

  This study focus follows this group's previous work on EROS and NOX2. In this current study the authors examine neutrophil EROS in the generation of superoxide by the NADPH oxidase. They demonstrate how EROS is involved in the maturation of gp91phox and expand our knowledge on the role of EROS in regulating expression of the P2x7 ion channel.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

1. Shasha Li
2. Michael D Bern
3. Benpeng Miao
4. Changxu Fan
5. Xiaoyun Xing
6. Takeshi Inoue
7. Sytse J Piersma
8. Ting Wang
9. Marco Colonna
10. Tomohiro Kurosaki
11. Wayne M Yokoyama

• Curated by eLife

  Evaluation Summary:

  The strength of this paper is identifying a novel factor Bach2 that might be involved in the generation and/or maintenance of NK cells. To date, the full molecular network guiding the development, maturation and maintenance of NK cells has not been fully defined and Bach2 has not yet been investigated.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by PREreview, eLife

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

1. Ruofan Li
2. Michael Mor
3. Bingting Ma
4. Alex E. Clark
5. Joel Alter
6. Michal Werbner
7. Jamie Casey Lee
8. Sandra L. Leibel
9. Aaron F. Carlin
10. Moshe Dessau
11. Meital Gal-Tanamy
12. Ben A. Croker
13. Ye Xiang
14. Natalia T. Freund

Reviewed by ScreenIT

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19

1. Allison K. Maher
2. Katie L. Burnham
3. Emma Jones
4. Laury Baillon
5. Claudia Selck
6. Nicolas Giang
7. Rafael Argüello
8. Charlotte-Eve Short
9. Rachael Quinlan
10. Wendy S. Barclay
11. Nichola Cooper
12. Graham P. Taylor
13. Emma E. Davenport
14. Margarita Dominguez-Villar

Reviewed by ScreenIT

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

1. Boyang Ren
2. Huan Xia
3. Yijun Liao
4. Hang Zhou
5. Zhongnan Wang
6. Yaoyao Shi
7. Mingzhao Zhu

• Curated by eLife

  Evaluation Summary:

  The primary audience that will be keenly interested in these findings will be those with an interest in T cell development and thymic function, however given the broad applicability of transendothelial migration, there will also likely be broader interest in these findings. The manuscript provides key new insight into the importation of hematopoietic progenitors into the thymus to initiate T cell development. Overall, the main claims of the paper are well supported by the studies presented, although some clarification is needed regarding some experimental details, in particular the thymus reconstitution model used to test the effects of CD47-SIRPa inhibition in immunotherapy.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife

Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infection

1. Chengzi I. Kaku
2. Alan J. Bergeron
3. Clas Ahlm
4. Johan Normark
5. Mrunal Sakharkar
6. Mattias N. E. Forsell
7. Laura M. Walker

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

1. Cyril Planchais
2. Ignacio Fernández
3. Timothée Bruel
4. Guilherme Dias de Melo
5. Matthieu Prot
6. Maxime Beretta
7. Pablo Guardado-Calvo
8. Jérémy Dufloo
9. Luis M. Molinos-Albert
10. Marija Backovic
11. Jeanne Chiaravalli
12. Emilie Giraud
13. Benjamin Vesin
14. Laurine Conquet
15. Ludivine Grzelak
16. Delphine Planas
17. Isabelle Staropoli
18. Florence Guivel-Benhassine
19. Thierry Hieu
20. Mikaël Boullé
21. Minerva Cervantes-Gonzalez
22. Marie-Noëlle Ungeheuer
23. Pierre Charneau
24. Sylvie van der Werf
25. Fabrice Agou
26. French COVID Cohort Study Group
27. Marie Bartoli
28. Alpha Diallo
29. Soizic Le Mestre
30. Christelle Paul
31. Ventzislava Petrov-Sanchez
32. Yazdan Yazdanpanah
33. Cécile Ficko
34. Catherine Chirouze
35. Claire Andrejak
36. Denis Malvy
37. François Goehringer
38. Patrick Rossignol
39. Tristan Gigante
40. Morgane Gilg
41. Bénédicte Rossignol
42. Manuel Etienne
43. Marine Beluze
44. Delphine Bachelet
45. Krishna Bhavsar
46. Lila Bouadma
47. Minerva Cervantes-Gonzalez
48. Anissa Chair
49. Charlotte Charpentier
50. Léo Chenard
51. Camille Couffignal
52. Marie-Pierre Debray
53. Diane Descamps
54. Xavier Duval
55. Philippine Eloy
56. Marina Esposito-Farese
57. Aline-Marie Florence
58. Jade Ghosn
59. Isabelle Hoffmann
60. Ouifiya Kafif
61. Antoine Khalil
62. Nadhem Lafhej
63. Cédric Laouénan
64. Samira Laribi
65. Minh Le
66. Quentin Le Hingrat
67. Sophie Letrou
68. France Mentré
69. Gilles Peytavin
70. Valentine Piquard
71. Carine Roy
72. Marion Schneider
73. Richa Su
74. Coralie Tardivon
75. Jean-François Timsit
76. Sarah Tubiana
77. Benoît Visseaux
78. Dominique Deplanque
79. Jean-Sébastien Hulot
80. Jean-Luc Diehl
81. Olivier Picone
82. François Angoulvant
83. Amal Abrous
84. Sandrine Couffin-Cadiergues
85. Fernanda Dias Da Silva
86. Hélène Esperou
87. Ikram Houas
88. Salma Jaafoura
89. Aurélie Papadopoulos
90. Alexandre Gaymard
91. Bruno Lina
92. Manuel Rosa-Calatrava
93. Céline Dorival
94. Jérémie Guedj
95. Guillaume Lingas
96. Nadège Neant
97. Laurent Abel
98. Victoria Manda
99. Sylvie Behillil
100. Vincent Enouf
101. Yves Levy
102. Aurélie Wiedemann
103. CORSER Study Group
104. Laurence Arowas
105. Blanca Liliana Perlaza
106. Louise Perrin de Facci
107. Sophie Chaouche
108. Linda Sangari
109. Charlotte Renaudat
110. Sandrine Fernandes Pellerin
111. Cassandre van Platen
112. Nathalie Jolly
113. Lucie Kuhmel
114. Valentine Garaud
115. Hantaniaina Rafanoson
116. Soazic Gardais
117. Nathalie de Parseval
118. Claire Dugast
119. Caroline Jannet
120. Sandrine Ropars
121. Fanny Momboisse
122. Isabelle Porteret
123. Isabelle Cailleau
124. Bruno Hoen
125. Laura Tondeur
126. Camille Besombes
127. Arnaud Fontanet
128. Jordan D. Dimitrov
129. Etienne Simon-Lorière
130. Hervé Bourhy
131. Xavier Montagutelli
132. Félix A. Rey
133. Olivier Schwartz
134. Hugo Mouquet

Reviewed by ScreenIT

Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans

1. Alice Cho
2. Frauke Muecksch
3. Zijun Wang
4. Tarek Ben Tanfous
5. Justin DaSilva
6. Raphael Raspe
7. Brianna Johnson
8. Eva Bednarski
9. Victor Ramos
10. Dennis Schaefer-Babajew
11. Irina Shimeliovich
12. Juan P. Dizon
13. Kai-Hui Yao
14. Fabian Schmidt
15. Katrina G. Millard
16. Martina Turroja
17. Mila Jankovic
18. Thiago Y. Oliveira
19. Anna Gazumyan
20. Christian Gaebler
21. Marina Caskey
22. Theodora Hatziioannou
23. Paul D. Bieniasz
24. Michel C. Nussenzweig

Reviewed by ScreenIT

Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

1. Jasmin Quandt
2. Alexander Muik
3. Nadine Salisch
4. Bonny Gaby Lui
5. Sebastian Lutz
6. Kimberly Krüger
7. Ann-Kathrin Wallisch
8. Petra Adams-Quack
9. Maren Bacher
10. Andrew Finlayson
11. Orkun Ozhelvaci
12. Isabel Vogler
13. Katharina Grikscheit
14. Sebastian Hoehl
15. Udo Goetsch
16. Sandra Ciesek
17. Özlem Türeci
18. Ugur Sahin

Reviewed by ScreenIT

SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity

1. Guillaume Beaudoin-Bussières
2. Ariana Arduini
3. Catherine Bourassa
4. Halima Medjahed
5. Gabrielle Gendron-Lepage
6. Jonathan Richard
7. Qinghua Pan
8. Zhen Wang
9. Chen Liang
10. Andrés Finzi

Reviewed by ScreenIT