Immunology

BCG vaccination of Diversity Outbred mice induces cross-reactive antibodies to SARS-CoV-2 spike protein

1. Aubrey G. Specht
2. Sherry L. Kurtz
3. Karen L. Elkins
4. Harrison Specht
5. Gillian Beamer

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An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models

1. Ankita Leekha
2. Arash Saeedi
3. Monish Kumar
4. K. M. Samiur Rahman Sefat
5. Melisa Martinez-Paniagua
6. Hui Meng
7. Mohsen Fathi
8. Rohan Kulkarni
9. Kate Reichel
10. Sujit Biswas
11. Daphne Tsitoura
12. Xinli Liu
13. Laurence J. N. Cooper
14. Courtney M. Sands
15. Vallabh E. Das
16. Manu Sebastian
17. Brett L. Hurst
18. Navin Varadarajan

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Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein

1. Kamyab Javanmardi
2. Thomas H. Segall-Shapiro
3. Chia-Wei Chou
4. Daniel R. Boutz
5. Randall J. Olsen
6. Xuping Xie
7. Hongjie Xia
8. Pei-Yong Shi
9. Charlie D. Johnson
10. Ankur Annapareddy
11. Scott Weaver
12. James M. Musser
13. Andrew D. Ellington
14. Ilya J. Finkelstein
15. Jimmy D. Gollihar

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The SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity

1. Chihiro Motozono
2. Mako Toyoda
3. Toong Seng Tan
4. Hiroshi Hamana
5. Yoshiki Aritsu
6. Yusuke Miyashita
7. Hiroyuki Oshiumi
8. Kimitoshi Nakamura
9. Seiji Okada
10. Keiko Udaka
11. Mizuki Kitamatsu
12. Hiroyuki Kishi
13. Takamasa Ueno

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Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response

1. Antonio Astorga-Gamaza
2. Judith Grau-Expósito
3. Joaquín Burgos
4. Jordi Navarro
5. Adrià Curran
6. Bibiana Planas
7. Paula Suanzes
8. Vicenç Falcó
9. Meritxell Genescà
10. Maria J Buzon

• Curated by eLife

  Evaluation Summary:

  Persistence of the viral reservoir is hampering HIV cure and thus understanding how these cells persist is important. This study describes a possible way that HIV-infected cells in the reservoir may escape antibody killing. The reservoir cells tend to have less availability of a receptor that binds HIV antibodies that would ordinarily help in killing. These cells are not only less susceptible to antibody killing but also seem to be susceptible to proliferation, which helps maintain the reservoir.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

Reviewed by eLife

Epitope Mapping of SARS-CoV-2 Spike Protein Reveals Distinct Antibody Binding Activity of Vaccinated and Infected Individuals

1. Nathaniel Felbinger
2. David Trudil
3. Lawrence Loomis
4. Richard Ascione
5. Gregory Siragusa
6. Seiji Haba
7. Shruti Rastogi
8. Aidan Mucci
9. Mark Claycomb
10. Sebastian Snowberger
11. Brian Luke
12. Stephen Francesconi
13. Shirley Tsang

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Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

1. Mingxi Li
2. Yifei Ren
3. Zhen Qin Aw
4. Bo Chen
5. Ziqing Yang
6. Yuqing Lei
7. Lin Cheng
8. Qingtai Liang
9. Junxian Hong
10. Yiling Yang
11. Jing Chen
12. Yi Hao Wong
13. Sisi Shan
14. Senyan Zhang
15. Jiwan Ge
16. Ruoke Wang
17. Xuanling Shi
18. Qi Zhang
19. Zheng Zhang
20. Justin Jang Hann Chu
21. Xinquan Wang
22. Linqi Zhang

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The SARS-CoV-2 receptor-binding domain facilitates neutrophil transepithelial migration and nanoparticle uptake in the mice airways

1. Elena L. Bolkhovitina
2. Julia D. Vavilova
3. Andrey O. Bogorodskiy
4. Yuliya A. Zagryadskaya
5. Ivan S. Okhrimenko
6. Alexander M. Sapozhnikov
7. Valentin I. Borshchevskiy
8. Marina A. Shevchenko

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An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

1. Nathalie M Schmidt
2. Peter AC Wing
3. Rory Peters
4. Rachel Brown
5. Hao Wang
6. Leo Swadling
7. COVIDsortium Investigators
8. Joseph Newman
9. Nazia Thakur
10. Kaho Shionoya
11. Sophie B Morgan
12. Timothy SC Hinks
13. Koichi Watashi
14. Dalan Bailey
15. Scott B Hansen
16. Mala K Maini
17. Jane A McKeating

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Broadly neutralizing antibodies target the coronavirus fusion peptide

1. Cherrelle Dacon
2. Courtney Tucker
3. Linghang Peng
4. Chang-Chun D. Lee
5. Ting-Hui Lin
6. Meng Yuan
7. Yu Cong
8. Lingshu Wang
9. Lauren Purser
10. Jazmean K. Williams
11. Chul-Woo Pyo
12. Ivan Kosik
13. Zhe Hu
14. Ming Zhao
15. Divya Mohan
16. Andrew J. R. Cooper
17. Mary Peterson
18. Jeff Skinner
19. Saurabh Dixit
20. Erin Kollins
21. Louis Huzella
22. Donna Perry
23. Russell Byrum
24. Sanae Lembirik
25. David Drawbaugh
26. Brett Eaton
27. Yi Zhang
28. Eun Sung Yang
29. Man Chen
30. Kwanyee Leung
31. Rona S. Weinberg
32. Amarendra Pegu
33. Daniel E. Geraghty
34. Edgar Davidson
35. Iyadh Douagi
36. Susan Moir
37. Jonathan W. Yewdell
38. Connie Schmaljohn
39. Peter D. Crompton
40. Michael R. Holbrook
41. David Nemazee
42. John R. Mascola
43. Ian A. Wilson
44. Joshua Tan

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