Immunology

Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies against Delta and Omicron in Mice

1. Petrus Jansen van Vuren
2. Alexander J. McAuley
3. Michael J. Kuiper
4. Nagendrakumar Balasubramanian Singanallur
5. Matthew P. Bruce
6. Shane Riddell
7. Sarah Goldie
8. Shruthi Mangalaganesh
9. Simran Chahal
10. Trevor W. Drew
11. Kim R. Blasdell
12. Mary Tachedjian
13. Leon Caly
14. Julian D. Druce
15. Shahbaz Ahmed
16. Mohammad Suhail Khan
17. Sameer Kumar Malladi
18. Randhir Singh
19. Suman Pandey
20. Raghavan Varadarajan
21. Seshadri S. Vasan

Reviewed by ScreenIT

Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

1. Michael S. Piepenbrink
2. Jun-Gyu Park
3. Ashlesha Desphande
4. Andreas Loos
5. Chengjin Ye
6. Madhubanti Basu
7. Sanghita Sarkar
8. David Chauvin
9. Jennifer Woo
10. Philip Lovalenti
11. Nathaniel B. Erdmann
12. Paul A. Goepfert
13. Vu L. Truong
14. Richard A. Bowen
15. Mark R. Walter
16. Luis Martinez-Sobrido
17. James J. Kobie

Reviewed by ScreenIT

Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

1. Julio García-Villalba
2. Laura Hurtado-Navarro
3. Alejandro Peñín-Franch
4. Cristina Molina-López
5. Laura Martínez-Alarcón
6. Diego Angosto-Bazarra
7. Alberto Baroja-Mazo
8. Pablo Pelegrín

Reviewed by ScreenIT

Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

1. Helen J. von Richthofen
2. Geertje H.A. Westerlaken
3. Doron Gollnast
4. Sjanna Besteman
5. Eveline M. Delemarre
6. Karlijn Rodenburg
7. Petra Moerer
8. Daphne A.C. Stapels
9. Anand K. Andiappan
10. Olaf Rötzschke
11. Stefan Nierkens
12. Helen L. Leavis
13. Louis J. Bont
14. Suzan H.M. Rooijakkers
15. Linde Meyaard

Reviewed by ScreenIT

Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune Hamsters

1. Maarten Swart
2. Adriaan de Wilde
3. Sonja Schmit-Tillemans
4. Johan Verspuij
5. Chenandly Daal
6. Ying Choi
7. Aditya Perkasa
8. Eleni Kourkouta
9. Issam Tahiri
10. Michel Mulders
11. Ana Izquierdo Gil
12. Leacky Muchene
13. Jarek Juraszek
14. Jort Vellinga
15. Jerome Custers
16. Rinke Bos
17. Hanneke Schuitemaker
18. Frank Wegmann
19. Ramon Roozendaal
20. Harmjan Kuipers
21. Roland Zahn

Reviewed by ScreenIT

Antigen experience relaxes the organisational structure of the T cell receptor repertoire

1. Michal Mark
2. Shlomit Reich-Zeliger
3. Erez Greenstein
4. Dan Reshef
5. Asaf Madi
6. Benny Chain
7. Nir Friedman

• Curated by eLife

  Evaluation Summary:

  This study will be of interest for the fields of T cell immunology and computational biology. It represents a careful descriptive study of the T cell repertoires of young and old mice, quantifying the relationships between naive, regulatory, effector and memory subsets. It represents a first step and would benefit from additional analyses and interpretations.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Immunological memory to Common Cold Coronaviruses assessed longitudinally over a three-year period

1. Esther Dawen Yu
2. Tara M. Narowski
3. Eric Wang
4. Emily Garrigan
5. Jose Mateus
6. April Frazier
7. Daniela Weiskopf
8. Alba Grifoni
9. Lakshmanane Premkumar
10. Ricardo da Silva Antunes
11. Alessandro Sette

Reviewed by ScreenIT

Intranasal Immunization with a Proteosome-Adjuvanted SARS-CoV2 Spike Protein-Based Vaccine is Immunogenic and Efficacious in Mice & Hamsters

1. Felicity C. Stark
2. Bassel Akache
3. Lise Deschatelets
4. Anh Tran
5. Matthew Stuible
6. Yves Durocher
7. Michael J. McCluskie
8. Gerard Agbayani
9. Renu Dudani
10. Blair A. Harrison
11. Tyler M. Renner
12. Shawn R. Makinen
13. Jegarubee Bavananthasivam
14. Diana Duque
15. Martin Gagne
16. Joseph Zimmermann
17. C. David Zarley
18. Terrence R. Cochrane
19. Martin Handfield

Reviewed by ScreenIT

Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination

1. Lisa Paschold
2. Bianca Klee
3. Cornelia Gottschick
4. Edith Willscher
5. Sophie Diexer
6. Christoph Schultheiß
7. Donjete Simnica
8. Daniel Sedding
9. Matthias Girndt
10. Michael Gekle
11. Rafael Mikolajczyk
12. Mascha Binder

Reviewed by ScreenIT

Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccine

1. Yi-Jiun Lin
2. Meei-Yun Lin
3. Ya-Shan Chuang
4. Luke Tzu-Chi Liu
5. Tsun-Yung Kuo
6. Charles Chen
7. Shyamala Ganesan
8. Ali Fattom
9. Vira Bitko
10. Chia-En Lien

Reviewed by ScreenIT