Immunology

  1. Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infection

    1. Chengzi I. Kaku
    2. Alan J. Bergeron
    3. Clas Ahlm
    4. Johan Normark
    5. Mrunal Sakharkar
    6. Mattias N. E. Forsell
    7. Laura M. Walker

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    3 evaluationsAppears in 2 listsLatest version Latest activity

  2. Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2

    1. Cyril Planchais
    2. Ignacio Fernández
    3. Timothée Bruel
    4. Guilherme Dias de Melo
    5. Matthieu Prot
    6. Maxime Beretta
    7. Pablo Guardado-Calvo
    8. Jérémy Dufloo
    9. Luis M. Molinos-Albert
    10. Marija Backovic
    11. Jeanne Chiaravalli
    12. Emilie Giraud
    13. Benjamin Vesin
    14. Laurine Conquet
    15. Ludivine Grzelak
    16. Delphine Planas
    17. Isabelle Staropoli
    18. Florence Guivel-Benhassine
    19. Thierry Hieu
    20. Mikaël Boullé
    21. Minerva Cervantes-Gonzalez
    22. Marie-Noëlle Ungeheuer
    23. Pierre Charneau
    24. Sylvie van der Werf
    25. Fabrice Agou
    26. French COVID Cohort Study Group
    27. Marie Bartoli
    28. Alpha Diallo
    29. Soizic Le Mestre
    30. Christelle Paul
    31. Ventzislava Petrov-Sanchez
    32. Yazdan Yazdanpanah
    33. Cécile Ficko
    34. Catherine Chirouze
    35. Claire Andrejak
    36. Denis Malvy
    37. François Goehringer
    38. Patrick Rossignol
    39. Tristan Gigante
    40. Morgane Gilg
    41. Bénédicte Rossignol
    42. Manuel Etienne
    43. Marine Beluze
    44. Delphine Bachelet
    45. Krishna Bhavsar
    46. Lila Bouadma
    47. Minerva Cervantes-Gonzalez
    48. Anissa Chair
    49. Charlotte Charpentier
    50. Léo Chenard
    51. Camille Couffignal
    52. Marie-Pierre Debray
    53. Diane Descamps
    54. Xavier Duval
    55. Philippine Eloy
    56. Marina Esposito-Farese
    57. Aline-Marie Florence
    58. Jade Ghosn
    59. Isabelle Hoffmann
    60. Ouifiya Kafif
    61. Antoine Khalil
    62. Nadhem Lafhej
    63. Cédric Laouénan
    64. Samira Laribi
    65. Minh Le
    66. Quentin Le Hingrat
    67. Sophie Letrou
    68. France Mentré
    69. Gilles Peytavin
    70. Valentine Piquard
    71. Carine Roy
    72. Marion Schneider
    73. Richa Su
    74. Coralie Tardivon
    75. Jean-François Timsit
    76. Sarah Tubiana
    77. Benoît Visseaux
    78. Dominique Deplanque
    79. Jean-Sébastien Hulot
    80. Jean-Luc Diehl
    81. Olivier Picone
    82. François Angoulvant
    83. Amal Abrous
    84. Sandrine Couffin-Cadiergues
    85. Fernanda Dias Da Silva
    86. Hélène Esperou
    87. Ikram Houas
    88. Salma Jaafoura
    89. Aurélie Papadopoulos
    90. Alexandre Gaymard
    91. Bruno Lina
    92. Manuel Rosa-Calatrava
    93. Céline Dorival
    94. Jérémie Guedj
    95. Guillaume Lingas
    96. Nadège Neant
    97. Laurent Abel
    98. Victoria Manda
    99. Sylvie Behillil
    100. Vincent Enouf
    101. Yves Levy
    102. Aurélie Wiedemann
    103. CORSER Study Group
    104. Laurence Arowas
    105. Blanca Liliana Perlaza
    106. Louise Perrin de Facci
    107. Sophie Chaouche
    108. Linda Sangari
    109. Charlotte Renaudat
    110. Sandrine Fernandes Pellerin
    111. Cassandre van Platen
    112. Nathalie Jolly
    113. Lucie Kuhmel
    114. Valentine Garaud
    115. Hantaniaina Rafanoson
    116. Soazic Gardais
    117. Nathalie de Parseval
    118. Claire Dugast
    119. Caroline Jannet
    120. Sandrine Ropars
    121. Fanny Momboisse
    122. Isabelle Porteret
    123. Isabelle Cailleau
    124. Bruno Hoen
    125. Laura Tondeur
    126. Camille Besombes
    127. Arnaud Fontanet
    128. Jordan D. Dimitrov
    129. Etienne Simon-Lorière
    130. Hervé Bourhy
    131. Xavier Montagutelli
    132. Félix A. Rey
    133. Olivier Schwartz
    134. Hugo Mouquet

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Antibody evolution to SARS-CoV-2 after single-dose Ad26.COV2.S vaccine in humans

    1. Alice Cho
    2. Frauke Muecksch
    3. Zijun Wang
    4. Tarek Ben Tanfous
    5. Justin DaSilva
    6. Raphael Raspe
    7. Brianna Johnson
    8. Eva Bednarski
    9. Victor Ramos
    10. Dennis Schaefer-Babajew
    11. Irina Shimeliovich
    12. Juan P. Dizon
    13. Kai-Hui Yao
    14. Fabian Schmidt
    15. Katrina G. Millard
    16. Martina Turroja
    17. Mila Jankovic
    18. Thiago Y. Oliveira
    19. Anna Gazumyan
    20. Christian Gaebler
    21. Marina Caskey
    22. Theodora Hatziioannou
    23. Paul D. Bieniasz
    24. Michel C. Nussenzweig

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

    1. Jasmin Quandt
    2. Alexander Muik
    3. Nadine Salisch
    4. Bonny Gaby Lui
    5. Sebastian Lutz
    6. Kimberly Krüger
    7. Ann-Kathrin Wallisch
    8. Petra Adams-Quack
    9. Maren Bacher
    10. Andrew Finlayson
    11. Orkun Ozhelvaci
    12. Isabel Vogler
    13. Katharina Grikscheit
    14. Sebastian Hoehl
    15. Udo Goetsch
    16. Sandra Ciesek
    17. Özlem Türeci
    18. Ugur Sahin

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. SARS-CoV-2 Accessory Protein ORF8 Decreases Antibody-Dependent Cellular Cytotoxicity

    1. Guillaume Beaudoin-Bussières
    2. Ariana Arduini
    3. Catherine Bourassa
    4. Halima Medjahed
    5. Gabrielle Gendron-Lepage
    6. Jonathan Richard
    7. Qinghua Pan
    8. Zhen Wang
    9. Chen Liang
    10. Andrés Finzi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

    1. Jun Siong Low
    2. Josipa Jerak
    3. M. Alejandra Tortorici
    4. Matthew McCallum
    5. Dora Pinto
    6. Antonino Cassotta
    7. Mathilde Foglierini
    8. Federico Mele
    9. Rana Abdelnabi
    10. Birgit Weynand
    11. Julia Noack
    12. Martin Montiel-Ruiz
    13. Siro Bianchi
    14. Fabio Benigni
    15. Nicole Sprugasci
    16. Anshu Joshi
    17. John E. Bowen
    18. Cameron Stewart
    19. Megi Rexhepaj
    20. Alexandra C. Walls
    21. David Jarrossay
    22. Diego Morone
    23. Philipp Paparoditis
    24. Christian Garzoni
    25. Paolo Ferrari
    26. Alessandro Ceschi
    27. Johan Neyts
    28. Lisa A. Purcell
    29. Gyorgy Snell
    30. Davide Corti
    31. Antonio Lanzavecchia
    32. David Veesler
    33. Federica Sallusto

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

    1. Sallieu Jalloh
    2. Judith Olejnik
    3. Jacob Berrigan
    4. Annuurun Nisa
    5. Ellen L. Suder
    6. Hisashi Akiyama
    7. Maohua Lei
    8. Sita Ramaswamy
    9. Sanjay Tyagi
    10. Yuri Bushkin
    11. Elke Mühlberger
    12. Suryaram Gummuluru

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells

    1. Chan-Su Park
    2. Jian Guan
    3. Peter Rhee
    4. Federico Gonzalez
    5. Hee-sung Lee
    6. Ji-hyun Park
    7. Laurent Coscoy
    8. Ellen A Robey
    9. Nilabh Shastri
    10. Scheherazade Sadegh-Nasseri

    • Curated by eLife

      Evaluation Summary:

      The Family with sequence similarity 49 member B (Fam49b) protein is a newly discovered negative regulator of TCR signaling that has been shown to suppress Rac-1 activity in cultured T cell lines. In this study, the authors investigate the role of Fam49a and Fam49b in T cell development. The phenotype of mice lacking Fam49b mice suggests that it may be due to increased negative selection. The experiments are well performed and the results are convincing. Including data from TCR transgenic mice will solidify the view of the authors and greatly improve the impact of the manuscript.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

    1. Noemia S. Lima
    2. Maryam Musayev
    3. Timothy S. Johnston
    4. Danielle A. Wagner
    5. Amy R. Henry
    6. Lingshu Wang
    7. Eun Sung Yang
    8. Yi Zhang
    9. Kevina Birungi
    10. Walker P. Black
    11. Sijy O’Dell
    12. Stephen D. Schmidt
    13. Damee Moon
    14. Cynthia G. Lorang
    15. Bingchun Zhao
    16. Man Chen
    17. Kristin L. Boswell
    18. Jesmine Roberts-Torres
    19. Rachel L. Davis
    20. Lowrey Peyton
    21. Sandeep R. Narpala
    22. Sarah O’Connell
    23. Leonid Serebryannyy
    24. Jennifer Wang
    25. Alexander Schrager
    26. Chloe Adrienna Talana
    27. Geoffrey Shimberg
    28. Kwanyee Leung
    29. Wei Shi
    30. Rawan Khashab
    31. Asaf Biber
    32. Tal Zilberman
    33. Joshua Rhein
    34. Sara Vetter
    35. Afeefa Ahmed
    36. Laura Novik
    37. Alicia Widge
    38. Ingelise Gordon
    39. Mercy Guech
    40. I-Ting Teng
    41. Emily Phung
    42. Tracy J. Ruckwardt
    43. Amarendra Pegu
    44. John Misasi
    45. Nicole A. Doria-Rose
    46. Martin Gaudinski
    47. Richard A. Koup
    48. Peter D. Kwong
    49. Adrian B. McDermott
    50. Sharon Amit
    51. Timothy W. Schacker
    52. Itzchak Levy
    53. John R. Mascola
    54. Nancy J. Sullivan
    55. Chaim A. Schramm
    56. Daniel C. Douek

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    1. Jing Zhang
    2. Zi Bo Han
    3. Yu Liang
    4. Xue Feng Zhang
    5. Yu Qin Jin
    6. Li Fang Du
    7. Shuai Shao
    8. Hui Wang
    9. Jun Wei Hou
    10. Ke Xu
    11. Wenwen Lei
    12. Ze Hua Lei
    13. Zhao Ming Liu
    14. Jin Zhang
    15. Ya Nan Hou
    16. Ning Liu
    17. Fu Jie Shen
    18. Jin Juan Wu
    19. Xiang Zheng
    20. Xin Yu Li
    21. Xin Li
    22. Wei Jin Huang
    23. Gui Zhen Wu
    24. Ji Guo Su
    25. Qi Ming Li

    • Curated by eLife

      Evaluation Summary:

      In this work, the authors test a multivalent vaccine design they term Mos-tri-RBD, consisting of three linked spike receptor binding domains, one based on Omicron sub-lineage BA.1 and the others with different SARS-CoV-2 variant mutations. Immunization with this construct either as a prime or booster vaccine resulted in better neutralization of the Omicron and Beta variants relative to the same design, but with the ancestral receptor binding domain, and supports the notion that vaccination with variant sequences may broaden the neutralization capacity of vaccines against divergent variants.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity
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