Immunology

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

1. Mohamed M. Shamseldin
2. Ashley Zani
3. Adam Kenney
4. Jack Evans
5. Cong Zeng
6. Kaitlin A. Read
7. Kyle Caution
8. Jesse M. Hall
9. Jessica M. Brown
10. Gilian Gunsch
11. Kara N. Corps
12. Supranee Chaiwatpongsakorn
13. KC Mahesh
14. Mijia Lu
15. Rajendar Deora
16. Mark E. Peeples
17. Jianrong Li
18. Kenneth J. Oestreich
19. Shan-Lu Liu
20. Jacob S. Yount
21. Purnima Dubey

Reviewed by ScreenIT

Delineating antibody escape from Omicron sublineages

1. Henning Gruell
2. Kanika Vanshylla
3. Michael Korenkov
4. Pinkus Tober-Lau
5. Matthias Zehner
6. Friederike Münn
7. Hanna Janicki
8. Max Augustin
9. Philipp Schommers
10. Leif Erik Sander
11. Florian Kurth
12. Christoph Kreer
13. Florian Klein

Reviewed by ScreenIT

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

1. Simone Parn
2. Kush Savsani
3. Sivanesan Dakshanamurthy

Reviewed by ScreenIT

Immunopharmacological evaluation of adjuvant efficacy of Monophosphoryl lipid-A and CpG ODN with SARS-CoV-2 RBD antigen

1. Shainy Sambyal
2. Vemireddy Sravanthi
3. Ritika Khatri
4. Gazala Siddqui
5. Shubbir Ahmed
6. Sweety Samal
7. Halmuthur M Sampath Kumar

Reviewed by ScreenIT

Impact of Prior Infection on SARS-CoV-2 Antibody Responses in Vaccinated Long-Term Care Facility Staff

1. Emily N. Gallichotte
2. Mary Nehring
3. Sophia Stromberg
4. Michael C. Young
5. Ashley Snell
6. Josh Daniels
7. Kristy L. Pabilonia
8. Sue VandeWoude
9. Nicole Ehrhart
10. Gregory D. Ebel

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EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

1. Lyra O Randzavola
2. Paige M Mortimer
3. Emma Garside
4. Elizabeth R Dufficy
5. Andrea Schejtman
6. Georgia Roumelioti
7. Lu Yu
8. Mercedes Pardo
9. Kerstin Spirohn
10. Charlotte Tolley
11. Cordelia Brandt
12. Katherine Harcourt
13. Esme Nichols
14. Mike Nahorski
15. Geoff Woods
16. James C Williamson
17. Shreehari Suresh
18. John M Sowerby
19. Misaki Matsumoto
20. Celio XC Santos
21. Cher Shen Kiar
22. Subhankar Mukhopadhyay
23. William M Rae
24. Gordon J Dougan
25. John Grainger
26. Paul J Lehner
27. Michael A Calderwood
28. Jyoti Choudhary
29. Simon Clare
30. Anneliese Speak
31. Giorgia Santilli
32. Alex Bateman
33. Kenneth GC Smith
34. Francesca Magnani
35. David C Thomas

• Curated by eLife

  Evaluation Summary:

  This study focus follows this group's previous work on EROS and NOX2. In this current study the authors examine neutrophil EROS in the generation of superoxide by the NADPH oxidase. They demonstrate how EROS is involved in the maturation of gp91phox and expand our knowledge on the role of EROS in regulating expression of the P2x7 ion channel.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

1. Shasha Li
2. Michael D Bern
3. Benpeng Miao
4. Changxu Fan
5. Xiaoyun Xing
6. Takeshi Inoue
7. Sytse J Piersma
8. Ting Wang
9. Marco Colonna
10. Tomohiro Kurosaki
11. Wayne M Yokoyama

• Curated by eLife

  Evaluation Summary:

  The strength of this paper is identifying a novel factor Bach2 that might be involved in the generation and/or maintenance of NK cells. To date, the full molecular network guiding the development, maturation and maintenance of NK cells has not been fully defined and Bach2 has not yet been investigated.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by PREreview, eLife

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

1. Ruofan Li
2. Michael Mor
3. Bingting Ma
4. Alex E. Clark
5. Joel Alter
6. Michal Werbner
7. Jamie Casey Lee
8. Sandra L. Leibel
9. Aaron F. Carlin
10. Moshe Dessau
11. Meital Gal-Tanamy
12. Ben A. Croker
13. Ye Xiang
14. Natalia T. Freund

Reviewed by ScreenIT

Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature upon SARS-CoV-2 sensing by monocytes in COVID-19

1. Allison K. Maher
2. Katie L. Burnham
3. Emma Jones
4. Laury Baillon
5. Claudia Selck
6. Nicolas Giang
7. Rafael Argüello
8. Charlotte-Eve Short
9. Rachael Quinlan
10. Wendy S. Barclay
11. Nichola Cooper
12. Graham P. Taylor
13. Emma E. Davenport
14. Margarita Dominguez-Villar

Reviewed by ScreenIT

Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells

1. Boyang Ren
2. Huan Xia
3. Yijun Liao
4. Hang Zhou
5. Zhongnan Wang
6. Yaoyao Shi
7. Mingzhao Zhu

• Curated by eLife

  Evaluation Summary:

  The primary audience that will be keenly interested in these findings will be those with an interest in T cell development and thymic function, however given the broad applicability of transendothelial migration, there will also likely be broader interest in these findings. The manuscript provides key new insight into the importation of hematopoietic progenitors into the thymus to initiate T cell development. Overall, the main claims of the paper are well supported by the studies presented, although some clarification is needed regarding some experimental details, in particular the thymus reconstitution model used to test the effects of CD47-SIRPa inhibition in immunotherapy.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

Reviewed by eLife