Immunology

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

1. Si Sun
2. Entao Li
3. Gan Zhao
4. Jie Tang
5. Qianfei Zuo
6. Larry Cai
7. Chuanfei Xu
8. Cheng Sui
9. Yangxue Ou
10. Chang Liu
11. Haibo Li
12. Yuan Ding
13. Chao Li
14. Dongshui Lu
15. Weijun Zhang
16. Ping Luo
17. Ping Cheng
18. Yuwei Gao
19. Changchun Tu
20. Bruno Pitard
21. Joseph Rosenecker
22. Bin Wang
23. Yan Liu
24. Quanming Zou
25. Shan Guan

Reviewed by ScreenIT

Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer

1. Yuexin Wang
2. Hui Yang
3. Anna Jia
4. Yufei Wang
5. Qiuli Yang
6. Yingjie Dong
7. Yueru Hou
8. Yejin Cao
9. Lin Dong
10. Yujing Bi
11. Guangwei Liu

• Curated by eLife

  Evaluation Summary:

  Wang and colleagues report that the expression of Piezo1 (an ion channel and mechanical sensor) is upregulated on dendritic cells (DC) under conditions of inflammation/high environmental stiffness resulting in DC activation, maturation, and skewing in DC functional polarity and metabolism. They show that Piezo1 knockout results in faster tumor progression and accumulation of more regulatory T cells, and that Smad3 and STAT4 are involved in DC-mediated differentiation of Th1 and Treg. Overall this represents a mechanistic advance in our understanding of DC biology as it relates to cancer and other human pathologies.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

Reviewed by eLife

Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

1. Valentina Stolz
2. Rafael de Freitas e Silva
3. Ramona Rica
4. Ci Zhu
5. Teresa Preglej
6. Patricia Hamminger
7. Daniela Hainberger
8. Marlis Alteneder
9. Lena Müller
10. Monika Waldherr
11. Darina Waltenberger
12. Anastasiya Hladik
13. Benedikt Agerer
14. Michael Schuster
15. Tobias Frey
16. Thomas Krausgruber
17. Sylvia Knapp
18. Clarissa Campbell
19. Klaus Schmetterer
20. Michael Trauner
21. Andreas Bergthaler
22. Christoph Bock
23. Nicole Boucheron
24. Wilfried Ellmeier

• Curated by eLife

  Evaluation Summary:

  The study shows that the LXRbeta - NCOR1 axis restricts the terminal differentiation of Treg cells into effector Tregs. It also suggests that, in addition to an impact on effector Treg differentiation, loss of NCOR1 leads to impaired suppression function in Treg cells. The results may contribute to our understanding of Treg cell differentiation and function.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

1. Jacob A Van Winkle
2. Stefan T Peterson
3. Elizabeth A Kennedy
4. Michael J Wheadon
5. Harshad Ingle
6. Chandni Desai
7. Rachel Rodgers
8. David A Constant
9. Austin P Wright
10. Lena Li
11. Maxim N Artyomov
12. Sanghyun Lee
13. Megan T Baldridge
14. Timothy J Nice

• Curated by eLife

  Evaluation Summary:

  The paper provides information about the relative importance of the type I and type III interferon-driven gene expression and anti-viral responses, particularly focused on the role of the Intestinal microbiota to maintain background levels of type III (interferon lambda) signaling. Type III-driven gene expression is highly discontinuous in the epithelial layer and mainly at the villous tips with consequent effects on the kinetics of rotavirus model infections.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

Reviewed by eLife

Towards a unified model of naive T cell dynamics across the lifespan

1. Sanket Rane
2. Thea Hogan
3. Edward Lee
4. Benedict Seddon
5. Andrew J Yates

• Curated by eLife

  Evaluation Summary:

  This paper is of broad interest to cellular biologists and immunologists. It offers new insights into how T cell compartments are regulated in vivo defining a new perspective on how the T cell compartment is regulated to maintain immune homeostasis and afford long-term immune protection. By assessing data from a range of mouse model systems, the key deduction is that a simple hypothesis, one which notably does not have complex feedback regulation of cell numbers, provides a remarkably good explanation of the data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

Development of a Novel SARS-CoV-2 Immune Complex Vaccine Candidate (CRCx) with Broad Immune Responses: A Preclinical Trial in Animal Model

1. Sherif Salah
2. Abdula Mubarki
3. Khalid Zayed
4. Khaled Omar

Reviewed by ScreenIT

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

1. Roberta Angioni
2. Matteo Bonfanti
3. Nicolò Caporale
4. Ricardo Sánchez-Rodríguez
5. Fabio Munari
6. Aurora Savino
7. Sebastiano Pasqualato
8. Damiano Buratto
9. Isabel Pagani
10. Nicole Bertoldi
11. Carlo Zanon
12. Paolo Ferrari
13. Eugenia Ricciardelli
14. Cristina Putaggio
15. Silvia Ghezzi
16. Francesco Elli
17. Luca Rotta
18. Alessandro Scardua
19. Janine Weber
20. Valentina Cecatiello
21. Francesco Iorio
22. Francesco Zonta
23. Anna Maria Cattelan
24. Elisa Vicenzi
25. Alessandro Vannini
26. Barbara Molon
27. Carlo Emanuele Villa
28. Antonella Viola
29. Giuseppe Testa

Reviewed by ScreenIT

Anti-chemokine antibodies after SARS-CoV-2 infection correlate with favorable disease course

1. Jonathan Muri
2. Valentina Cecchinato
3. Andrea Cavalli
4. Akanksha A. Shanbhag
5. Milos Matkovic
6. Maira Biggiogero
7. Pier Andrea Maida
8. Jacques Moritz
9. Chiara Toscano
10. Elaheh Ghovehoud
11. Raffaello Furlan
12. Franca Barbic
13. Antonio Voza
14. Guendalina De Nadai
15. Carlo Cervia
16. Yves Zurbuchen
17. Patrick Taeschler
18. Lilly A. Murray
19. Gabriela Danelon-Sargenti
20. Simone Moro
21. Tao Gong
22. Pietro Piffaretti
23. Filippo Bianchini
24. Virginia Crivelli
25. Lucie Podešvová
26. Mattia Pedotti
27. David Jarrossay
28. Jacopo Sgrignani
29. Sylvia Thelen
30. Mario Uhr
31. Enos Bernasconi
32. Andri Rauch
33. Antonio Manzo
34. Adrian Ciurea
35. Marco B.L. Rocchi
36. Luca Varani
37. Bernhard Moser
38. Barbara Bottazzi
39. Marcus Thelen
40. Brian A. Fallon
41. Onur Boyman
42. Alberto Mantovani
43. Christian Garzoni
44. Alessandra Franzetti-Pellanda
45. Mariagrazia Uguccioni
46. Davide F. Robbiani

Reviewed by ScreenIT

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys

1. Cyril Le Nouën
2. Christine E. Nelson
3. Xueqiao Liu
4. Hong-Su Park
5. Yumiko Matsuoka
6. Cindy Luongo
7. Celia Santos
8. Lijuan Yang
9. Richard Herbert
10. Ashley Castens
11. Ian N. Moore
12. Temeri Wilder-Kofie
13. Rashida Moore
14. April Walker
15. Peng Zhang
16. Paolo Lusso
17. Reed F. Johnson
18. Nicole L. Garza
19. Laura E. Via
20. Shirin Munir
21. Daniel L. Barber
22. Ursula J. Buchholz

Reviewed by ScreenIT

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

1. Xuesen Zhao
2. Danying Chen
3. Xiaohua Hao
4. Yaruo Qiu
5. Juan Du
6. Yuanyuan Zhang
7. Fan Xiao
8. Xinglin Li
9. Yanjun Song
10. Rui Song
11. Xi Wang
12. Ronghua Jin

Reviewed by ScreenIT