Immunology

  1. Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation

    1. Nazar Beirag
    2. Chandan Kumar
    3. Taruna Madan
    4. Mohamed H. Shamji
    5. Roberta Bulla
    6. Daniel Mitchell
    7. Valarmathy Murugaiah
    8. Martin Mayora Neto
    9. Nigel Temperton
    10. Susan Idicula-Thomas
    11. Praveen M. Varghese
    12. Uday Kishore

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters

    1. Geraldine Nouailles
    2. Julia M. Adler
    3. Peter Pennitz
    4. Stefan Peidli
    5. Luiz Gustavo Teixeira Alves
    6. Morris Baumgardt
    7. Judith Bushe
    8. Anne Voss
    9. Alina Langenhagen
    10. Christine Langner
    11. Ricardo Martin Vidal
    12. Fabian Pott
    13. Julia Kazmierski
    14. Aileen Ebenig
    15. Mona V. Lange
    16. Michael D. Mühlebach
    17. Cengiz Goekeri
    18. Szandor Simmons
    19. Na Xing
    20. Azza Abdelgawad
    21. Susanne Herwig
    22. Günter Cichon
    23. Daniela Niemeyer
    24. Christian Drosten
    25. Christine Goffinet
    26. Markus Landthaler
    27. Nils Blüthgen
    28. Haibo Wu
    29. Martin Witzenrath
    30. Achim D. Gruber
    31. Samantha D. Praktiknjo
    32. Nikolaus Osterrieder
    33. Emanuel Wyler
    34. Dusan Kunec
    35. Jakob Trimpert

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity

  3. Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV

    1. Tongcui Ma
    2. Matthew McGregor
    3. Leila Giron
    4. Guorui Xie
    5. Ashley F George
    6. Mohamed Abdel-Mohsen
    7. Nadia R Roan

    • Curated by eLife

      Evaluation Summary:

      This study applies a new novel method of single cell detection to biologically relevant systems to try to understand whether glycans on the surface of CD4+T cells impact HIV susceptibility. They find that cells expressing higher levels of fucose and sialic acid are more likely to be infected with to HIV than those with low levels. The findings point to glycans as a biomarker and potential determinant for HIV cells susceptibility and open the door to new avenues for studies the interplay between cell surface glycans and viral infections.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  4. Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors

    1. Matheswaran Kandasamy
    2. Uzi Gileadi
    3. Pramila Rijal
    4. Tiong Kit Tan
    5. Lian N Lee
    6. Jili Chen
    7. Gennaro Prota
    8. Paul Klenerman
    9. Alain Townsend
    10. Vincenzo Cerundolo

    • Curated by eLife

      Evaluation Summary:

      This paper describes an approach in which a non-replicating influenza virus expressing a cancer testis antigen is used to induce a systemic and mucosal antigen specific T cell responses. The authors find that this immune response is sufficient to reduce tumor burden following intravenous or subcutaneous tumor challenge. This paper is potentially interesting to tumor-immunity researchers.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife

    3 evaluationsAppears in 2 listsLatest version Latest activity

  5. Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody

    1. Sanjeev Kumar
    2. Anamika Patel
    3. Lilin Lai
    4. Chennareddy Chakravarthy
    5. Rajesh Valanparambil
    6. Elluri Seetharami Reddy
    7. Kamalvishnu Gottimukkala
    8. Meredith E. Davis-Gardner
    9. Venkata Viswanadh Edara
    10. Susanne Linderman
    11. Kaustuv Nayak
    12. Kritika Dixit
    13. Pragati Sharma
    14. Prashant Bajpai
    15. Vanshika Singh
    16. Filipp Frank
    17. Narayanaiah Cheedarla
    18. Hans P. Verkerke
    19. Andrew S. Neish
    20. John D. Roback
    21. Grace Mantus
    22. Pawan Kumar Goel
    23. Manju Rahi
    24. Carl W. Davis
    25. Jens Wrammert
    26. Sucheta Godbole
    27. Amy R. Henry
    28. Daniel C. Douek
    29. Mehul S. Suthar
    30. Rafi Ahmed
    31. Eric Ortlund
    32. Amit Sharma
    33. Kaja Murali-Krishna
    34. Anmol Chandele

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  6. Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

    1. Zijun Wang
    2. Frauke Muecksch
    3. Friederike Muenn
    4. Alice Cho
    5. Shuai Zong
    6. Raphael Raspe
    7. Victor Ramos
    8. Brianna Johnson
    9. Tarek Ben Tanfous
    10. Justin DaSilva
    11. Eva Bednarski
    12. Camila Guzman-Cardozo
    13. Martina Turroja
    14. Katrina G. Millard
    15. Pinkus Tober-Lau
    16. David Hillus
    17. Kai-Hui Yao
    18. Irina Shimeliovich
    19. Juan Dizon
    20. Anna Kaczynska
    21. Mila Jankovic
    22. Anna Gazumyan
    23. Thiago Y. Oliveira
    24. Marina Caskey
    25. Paul D. Bieniasz
    26. Theodora Hatziioannou
    27. Florian Kurth
    28. Leif Erik Sander
    29. Michel C. Nussenzweig
    30. Christian Gaebler

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Three-doses of BNT162b2 COVID-19 mRNA vaccine establishes long-lasting CD8 + T cell immunity in CLL and MDS patients

    1. Susana Patricia Amaya Hernandez
    2. Ditte Stampe Hersby
    3. Kamilla Kjærgaard Munk
    4. Tripti Tamhane
    5. Darya Trubach
    6. Maria Tagliamonte
    7. Luigi Buonaguro
    8. Anne Ortved Gang
    9. Sine Reker Hadrup
    10. Sunil Kumar Saini

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-CoV-2 Delta Variant

    1. Ke Huang
    2. Na Li
    3. Yingwen Li
    4. Jiafeng Zhu
    5. Qianyi Fan
    6. Jiali Yang
    7. Yinjia Gao
    8. Yupin Liu
    9. Qiangbo Hou
    10. Shufeng Gao
    11. Ke Wei
    12. Chao Deng
    13. Chijian Zuo
    14. Zhenhua Sun

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. A Mathematical Model of the Within-Host Kinetics of SARS-CoV-2 Neutralizing Antibodies Following COVID-19 Vaccination

    1. Lisette de Pillis
    2. Rebecca Caffrey
    3. Ge Chen
    4. Mark D. Dela
    5. Leif Eldevik
    6. Joseph McConnell
    7. Shahrokh Shabahang
    8. Stephen A. Varvel

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. A Bispecific Antibody Targeting RBD and S2 Potently Neutralizes SARS-CoV-2 Omicron and Other Variants of Concern

    1. Mengqi Yuan
    2. Xiangyu Chen
    3. Yanzhi Zhu
    4. Xiaoqing Dong
    5. Yan Liu
    6. Zhaohui Qian
    7. Lilin Ye
    8. Pinghuang Liu

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity
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