Immunology

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

1. Trung The Tran
2. Eline Benno Vaage
3. Adi Mehta
4. Adity Chopra
5. Anette Kolderup
6. Aina Anthi
7. Marton König
8. Gro Nygaard
9. Andreas Lind
10. Fredrik Müller
11. Lise Sofie Nissen-Meyer
12. Per Magnus
13. Lill Trogstad
14. Siri Mjaaland
15. Arne Søraas
16. Karsten Midtvedt
17. Anders Åsberg
18. Andreas Barratt-Due
19. Asle W. Medhus
20. Marte Lie Høivk
21. Knut Lundin
22. Randi Fuglaas Karlsen
23. Reidun Dahle
24. Karin Danielsson
25. Kristine Stien Thomassen
26. Grete Birkeland Kro
27. Rebecca J. Cox
28. Fan Zhou
29. Nina Langeland
30. Pål Aukrust
31. Espen Melum
32. Tone Lise Åvitsland
33. Kristine Wiencke
34. Jan Cato Holter
35. Ludvig A. Munthe
36. Gunnveig Grødeland
37. Jan-Terje Andersen
38. John Torgils Vaage
39. Fridtjof Lund-Johansen

Reviewed by ScreenIT

Unique molecular signatures sustained in circulating monocytes and regulatory T cells in convalescent COVID-19 patients

1. Andrew D. Hoffmann
2. Sam E. Weinberg
3. Suchitra Swaminathan
4. Shuvam Chaudhuri
5. Hannah Faisal Almubarak
6. Matthew J. Schipma
7. Chengsheng Mao
8. Xinkun Wang
9. Lamiaa El-Shennawy
10. Nurmaa K. Dashzeveg
11. Juncheng Wei
12. Paul J. Mehl
13. Laura J. Shihadah
14. Ching Man Wai
15. Carolina Ostiguin
16. Yuzhi Jia
17. Paolo D'Amico
18. Neale R. Wang
19. Yuan Luo
20. Alexis R. Demonbreun
21. Michael G. Ison
22. Huiping Liu
23. Deyu Fang

Reviewed by ScreenIT

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

1. David J Turner
2. Alexander Saveliev
3. Fiamma Salerno
4. Louise S Matheson
5. Michael Screen
6. Hannah Lawson
7. David Wotherspoon
8. Kamil R Kranc
9. Martin Turner

• Curated by eLife

  Evaluation Summary:

  This paper utilizes an elegant Crispr-Cas9 screen to identify RNA binding proteins that may regulate B cell differentiation. With some additional work to verify that the identified proteins are important in vivo, the paper will be of interest to a broad audience of immunologists studying the signals regulating B cell differentiation during an immune response.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife

B cell receptor repertoire analysis unveils dynamic antibody response and severity markers in COVID-19 patients

1. Soumya Rao
2. Kriti Srivastava
3. Anupriya Verma
4. Achintya Das

Reviewed by ScreenIT

Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice

1. Alex Moshensky
2. Cameron S Brand
3. Hasan Alhaddad
4. John Shin
5. Jorge A Masso-Silva
6. Ira Advani
7. Deepti Gunge
8. Aditi Sharma
9. Sagar Mehta
10. Arya Jahan
11. Sedtavut Nilaad
12. Jarod Olay
13. Wanjun Gu
14. Tatum Simonson
15. Daniyah Almarghalani
16. Josephine Pham
17. Samantha Perera
18. Kenneth Park
19. Rita Al-Kolla
20. Hoyoung Moon
21. Soumita Das
22. Min Kwang Byun
23. Zahoor Shah
24. Youssef Sari
25. Joan Heller Brown
26. Laura E Crotty Alexander

• Curated by eLife

  Evaluation Summary:

  This is a potentially important paper that aimed to investigate the effects of vaping on multiple organs. The authors show multi-organ inflammatory responses of JUUL exposure in mice. While the rationale of the current study if of high interest and timely, the manuscript in its current form remains largely descriptive and some of the conclusions are not clearly supported by the data. A major limitation is the lack of investigation of (causal) pathophysiological consequences/general organ outcomes that might be driven by the reposted inflammatory response.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

1. Sara E Vazquez
2. Sabrina A Mann
3. Aaron Bodansky
4. Andrew F Kung
5. Zoe Quandt
6. Elise MN Ferré
7. Nils Landegren
8. Daniel Eriksson
9. Paul Bastard
10. Shen-Ying Zhang
11. Jamin Liu
12. Anthea Mitchell
13. Irina Proekt
14. David Yu
15. Caleigh Mandel-Brehm
16. Chung-Yu Wang
17. Brenda Miao
18. Gavin Sowa
19. Kelsey Zorn
20. Alice Y Chan
21. Veronica M Tagi
22. Chisato Shimizu
23. Adriana Tremoulet
24. Kara Lynch
25. Michael R Wilson
26. Olle Kämpe
27. Kerry Dobbs
28. Ottavia M Delmonte
29. Rosa Bacchetta
30. Luigi D Notarangelo
31. Jane C Burns
32. Jean-Laurent Casanova
33. Michail S Lionakis
34. Troy R Torgerson
35. Mark S Anderson
36. Joseph L DeRisi

• Curated by eLife

  Evaluation Summary:

  This work presents a series of enhancements to the PhIP-seq method of autoantibody discovery, with the goal of improving scaling to larger cohorts and increasing disease specificity. The strength of the paper is the validation of the high throughput format, although results from screening patient samples confirm or only modestly extend previous data.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

Reviewed by eLife, ScreenIT

Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice

1. Irene González-Domínguez
2. Jose Luis Martínez
3. Stefan Slamanig
4. Nicholas Lemus
5. Yonghong Liu
6. Tsoi Ying Lai
7. Juan Manuel Carreño
8. Gagandeep Singh
9. Gagandeep Singh
10. Michael Schotsaert
11. Ignacio Mena
12. Stephen McCroskery
13. Lynda Coughlan
14. Florian Krammer
15. Adolfo García-Sastre
16. Peter Palese
17. Weina Sun

Reviewed by ScreenIT

SARS-CoV-2 neutralizing camelid heavy-chain-only antibodies as powerful tools for diagnostic and therapeutic applications

1. Anja Schlör
2. Stefan Hirschberg
3. Ghada Ben Amor
4. Toni Luise Meister
5. Prerna Arora
6. Stefan Pöhlmann
7. Markus Hoffmann
8. Stephanie Pfaender
9. Omar Kamal Eddin
10. Julian Kamhieh-Milz
11. Katja Hanack

Reviewed by ScreenIT

A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability

1. Emily A. Voigt
2. Alana Gerhardt
3. Derek Hanson
4. Madeleine F. Jennewein
5. Peter Battisti
6. Sierra Reed
7. Jasneet Singh
8. Raodoh Mohamath
9. Julie Bakken
10. Samuel Beaver
11. Christopher Press
12. Patrick Soon-Shiong
13. Christopher J. Paddon
14. Christopher B. Fox
15. Corey Casper

Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice

1. Shyamala Ganesan
2. Hugo Acosta
3. Chris Brigolin
4. Kallista Orange
5. Kevin Trabbic
6. Charles Chen
7. Chia-En Lien
8. Yi-Jiun Lin
9. Meei-Yun Lin
10. Ya-Shan Chuang
11. Ali Fattom
12. Vira Bitko

Reviewed by ScreenIT