Immunology

  1. Impaired immune response drives age-dependent severity of COVID-19

    1. Julius Beer
    2. Stefania Crotta
    3. Angele Breithaupt
    4. Annette Ohnemus
    5. Jan Becker
    6. Benedikt Sachs
    7. Lisa Kern
    8. Miriam Llorian
    9. Nadine Ebert
    10. Fabien Labroussaa
    11. Tran Thi Nhu Thao
    12. Bettina Salome Trueeb
    13. Joerg Jores
    14. Volker Thiel
    15. Martin Beer
    16. Jonas Fuchs
    17. Georg Kochs
    18. Andreas Wack
    19. Martin Schwemmle
    20. Daniel Schnepf

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection

    1. Chen Xi Yang
    2. Michael Tomchaney
    3. Manuel F. Landecho
    4. Borja R. Zamacona
    5. Marta Marin Oto
    6. Javier Zulueta
    7. Joshua Malo
    8. Steve Knoper
    9. Marco Contoli
    10. Alberto Papi
    11. Dragoş M. Vasilescu
    12. Maor Sauler
    13. Christof Straub
    14. Cheryl Tan
    15. Fernando D. Martinez
    16. Deepta Bhattacharya
    17. Ivan O. Rosas
    18. Farrah Kheradmand
    19. Tillie-Louise Hackett
    20. Francesca Polverino

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  3. Vγ9Vδ2 T cells are potent inhibitors of SARS-CoV-2 replication and exert effector phenotypes in COVID-19 patients

    1. Laetitia Gay
    2. Marie-Sarah Rouviere
    3. Soraya Mezouar
    4. Manon Richaud
    5. Laurent Gorvel
    6. Etienne Foucher
    7. Loui Madakamutil
    8. Bernard La Scola
    9. Amélie Menard
    10. Jérôme Allardet-Servent
    11. Philippe Halfon
    12. Paul Frohna
    13. Carla Cano
    14. Jean-Louis Mege
    15. Daniel Olive

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  4. Low-dose bivalent mRNA vaccine is highly effective against different SARS-CoV-2 variants in a transgenic mouse model

    1. Björn Corleis
    2. Donata Hoffmann
    3. Susanne Rauch
    4. Charlie Fricke
    5. Nicole Roth
    6. Janina Gergen
    7. Kristina Kovacikova
    8. Kore Schlottau
    9. Nico Joel Halwe
    10. Lorenz Ulrich
    11. Jacob Schön
    12. Kerstin Wernike
    13. Marek Widera
    14. Sandra Ciesek
    15. Stefan O. Mueller
    16. Thomas C. Mettenleiter
    17. Benjamin Petsch
    18. Martin Beer
    19. Anca Dorhoi

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  5. Broadly neutralizing antibodies against Omicron variants of SARS-CoV-2 derived from mRNA-lipid nanoparticle-immunized mice

    1. Ruei-Min Lu
    2. Kang-Hao Liang
    3. Hsiao-Ling Chiang
    4. Fu-Fei Hsu
    5. Hsiu-Ting Lin
    6. Wan-Yu Chen
    7. Feng-Yi Ke
    8. Monika Kumari
    9. Yu-Chi Chou
    10. Mi-Hua Tao
    11. Yi-Ling Lin
    12. Han-Chung Wu

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    3 evaluationsAppears in 2 listsLatest version Latest activity

  6. BCG vaccination of Diversity Outbred mice induces cross-reactive antibodies to SARS-CoV-2 spike protein

    1. Aubrey G. Specht
    2. Sherry L. Kurtz
    3. Karen L. Elkins
    4. Harrison Specht
    5. Gillian Beamer

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  7. An intranasal nanoparticle STING agonist has broad protective immunity against respiratory viruses and variants

    1. Ankita Leekha
    2. Arash Saeedi
    3. Monish Kumar
    4. Samiur Rahman Sefat
    5. Melisa Martinez-Paniagua
    6. Mohsen Fathi
    7. Rohan Kulkarni
    8. Sujit Biswas
    9. Daphne Tsitoura
    10. Xinli Liu
    11. Laurence J.N. Cooper
    12. Manu Sebastian
    13. Brett L. Hurst
    14. Navin Varadarajan

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  8. Antibody escape and cryptic cross-domain stabilization in the SARS-CoV-2 Omicron spike protein

    1. Kamyab Javanmardi
    2. Thomas H. Segall-Shapiro
    3. Chia-Wei Chou
    4. Daniel R. Boutz
    5. Randall J. Olsen
    6. Xuping Xie
    7. Hongjie Xia
    8. Pei-Yong Shi
    9. Charlie D. Johnson
    10. Ankur Annapareddy
    11. Scott Weaver
    12. James M. Musser
    13. Andrew D. Ellington
    14. Ilya J. Finkelstein
    15. Jimmy D. Gollihar

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  9. The SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity

    1. Chihiro Motozono
    2. Mako Toyoda
    3. Toong Seng Tan
    4. Hiroshi Hamana
    5. Yoshiki Aritsu
    6. Yusuke Miyashita
    7. Hiroyuki Oshiumi
    8. Kimitoshi Nakamura
    9. Seiji Okada
    10. Keiko Udaka
    11. Mizuki Kitamatsu
    12. Hiroyuki Kishi
    13. Takamasa Ueno

    Reviewed by ScreenIT

    1 evaluationAppears in 1 listLatest version Latest activity

  10. Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response

    1. Antonio Astorga-Gamaza
    2. Judith Grau-Expósito
    3. Joaquín Burgos
    4. Jordi Navarro
    5. Adrià Curran
    6. Bibiana Planas
    7. Paula Suanzes
    8. Vicenç Falcó
    9. Meritxell Genescà
    10. Maria J Buzon

    • Curated by eLife

      Evaluation Summary:

      Persistence of the viral reservoir is hampering HIV cure and thus understanding how these cells persist is important. This study describes a possible way that HIV-infected cells in the reservoir may escape antibody killing. The reservoir cells tend to have less availability of a receptor that binds HIV antibodies that would ordinarily help in killing. These cells are not only less susceptible to antibody killing but also seem to be susceptible to proliferation, which helps maintain the reservoir.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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