Immunology

Epitope Mapping of SARS-CoV-2 Spike Protein Reveals Distinct Antibody Binding Activity of Vaccinated and Infected Individuals

1. Nathaniel Felbinger
2. David Trudil
3. Lawrence Loomis
4. Richard Ascione
5. Gregory Siragusa
6. Seiji Haba
7. Shruti Rastogi
8. Aidan Mucci
9. Mark Claycomb
10. Sebastian Snowberger
11. Brian Luke
12. Stephen Francesconi
13. Shirley Tsang

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Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

1. Mingxi Li
2. Yifei Ren
3. Zhen Qin Aw
4. Bo Chen
5. Ziqing Yang
6. Yuqing Lei
7. Lin Cheng
8. Qingtai Liang
9. Junxian Hong
10. Yiling Yang
11. Jing Chen
12. Yi Hao Wong
13. Sisi Shan
14. Senyan Zhang
15. Jiwan Ge
16. Ruoke Wang
17. Xuanling Shi
18. Qi Zhang
19. Zheng Zhang
20. Justin Jang Hann Chu
21. Xinquan Wang
22. Linqi Zhang

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The SARS-CoV-2 receptor-binding domain facilitates neutrophil transepithelial migration and nanoparticle uptake in the mice airways

1. Elena L. Bolkhovitina
2. Julia D. Vavilova
3. Andrey O. Bogorodskiy
4. Yuliya A. Zagryadskaya
5. Ivan S. Okhrimenko
6. Alexander M. Sapozhnikov
7. Valentin I. Borshchevskiy
8. Marina A. Shevchenko

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An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

1. Nathalie M Schmidt
2. Peter AC Wing
3. Rory Peters
4. Rachel Brown
5. Hao Wang
6. Leo Swadling
7. COVIDsortium Investigators
8. Joseph Newman
9. Nazia Thakur
10. Kaho Shionoya
11. Sophie B Morgan
12. Timothy SC Hinks
13. Koichi Watashi
14. Dalan Bailey
15. Scott B Hansen
16. Mala K Maini
17. Jane A McKeating

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Broadly neutralizing antibodies target the coronavirus fusion peptide

1. Cherrelle Dacon
2. Courtney Tucker
3. Linghang Peng
4. Chang-Chun D. Lee
5. Ting-Hui Lin
6. Meng Yuan
7. Yu Cong
8. Lingshu Wang
9. Lauren Purser
10. Jazmean K. Williams
11. Chul-Woo Pyo
12. Ivan Kosik
13. Zhe Hu
14. Ming Zhao
15. Divya Mohan
16. Andrew J. R. Cooper
17. Mary Peterson
18. Jeff Skinner
19. Saurabh Dixit
20. Erin Kollins
21. Louis Huzella
22. Donna Perry
23. Russell Byrum
24. Sanae Lembirik
25. David Drawbaugh
26. Brett Eaton
27. Yi Zhang
28. Eun Sung Yang
29. Man Chen
30. Kwanyee Leung
31. Rona S. Weinberg
32. Amarendra Pegu
33. Daniel E. Geraghty
34. Edgar Davidson
35. Iyadh Douagi
36. Susan Moir
37. Jonathan W. Yewdell
38. Connie Schmaljohn
39. Peter D. Crompton
40. Michael R. Holbrook
41. David Nemazee
42. John R. Mascola
43. Ian A. Wilson
44. Joshua Tan

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Tongue immune compartment analysis reveals spatial macrophage heterogeneity

1. Ekaterini Maria Lyras
2. Karin Zimmermann
3. Lisa Katharina Wagner
4. Dorothea Dörr
5. Christoph SN Klose
6. Cornelius Fischer
7. Steffen Jung
8. Simon Yona
9. Avi-Hai Hovav
10. Werner Stenzel
11. Steffen Dommerich
12. Thomas Conrad
13. Achim Leutz
14. Alexander Mildner

• Curated by eLife

  Evaluation Summary:

  In this manuscript, the authors map the cellular landscape in the tongue, which is an underrated immunological organ, with a main focus on tissue-resident myeloid cells under homeostatic and inflammatory conditions. They identify two major subsets of macrophages, which occupy distinct anatomical niches and develop from local precursors, while under immune compromised conditions they can also be replenished from circulating hematopoietic precursors. These findings provide an important basis for future investigations of the tongue immune function in the context of infection, inflammation, and neoplastic diseases.

  (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

Reviewed by eLife

SARS-CoV-2 mutations affect proteasome processing to alter CD8 ⁺ T cell responses

1. Dannielle Wellington
2. Zixi Yin
3. Zhanru Yu
4. Raphael Heilig
5. Simon Davis
6. Roman Fischer
7. Suet Ling Felce
8. Philip Hublitz
9. Ryan Beveridge
10. Danning Dong
11. Guihai Liu
12. Xuan Yao
13. Yanchun Peng
14. Benedikt M Kessler
15. Tao Dong

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SARS-CoV-2 and its variants, but not Omicron, induces thymic atrophy and impaired T cell development

1. Zaigham Abbas Rizvi
2. Srikanth Sadhu
3. Jyotsna Dandotiya
4. Akshay Binyka
5. Puja Sharma
6. Virendra Singh
7. Vinayaka Das
8. Ritika Khatri
9. Rajesh Kumar
10. Sweety Samal
11. Manjula Kalia
12. Amit Awasthi

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NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4 ⁺ and CD8 ⁺ T cell responses

1. Carolyn Rydyznski Moderbacher
2. Christina Kim
3. Jose Mateus
4. Joyce Plested
5. Mingzhu Zhu
6. Shane Cloney-Clark
7. Daniela Weiskopf
8. Alessandro Sette
9. Louis Fries
10. Gregory Glenn
11. Shane Crotty

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Plant-produced RBD and cocktail-based vaccine candidates are highly effective against SARS-CoV-2, independently of its emerging variants

1. Tarlan Mamedov
2. Damla Yuksel
3. Irem Gurbuzaslan
4. Merve Ilgin
5. Burcu Gulec
6. Gulshan Mammadova
7. Aykut Ozdarendeli
8. Shaikh Terkis Islam Pavel
9. Hazel Yetiskin
10. Busra Kaplan
11. Muhammet Ali Uygut
12. Gulnara Hasanova

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