Immunology

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

1. Conor J. Crawford
2. Livia Liporagi-Lopes
3. Carolina Coelho
4. Samuel R. Santos Junior
5. André Moraes Nicola
6. Maggie P. Wear
7. Raghav Vij
8. Stefan Oscarson
9. Arturo Casadevall

Reviewed by Rapid Reviews Infectious Diseases

Therapeutic DNA Vaccine Targeting Mycobacterium tuberculosis Persisters Shortens Curative Tuberculosis Treatment

1. Styliani Karanika
2. Tianyin Wang
3. Addis Yilma
4. Jennie Ruelas Castillo
5. James T. Gordy
6. Hannah Bailey
7. Darla Quijada
8. Kaitlyn Fessler
9. Rokeya Tasneen
10. Elisa M. Rouse Salcido
11. Harley T. Harris
12. Rowan E. Bates
13. Heemee Ton
14. Jacob Meza
15. Yangchen Li
16. Alannah D. Taylor
17. Jean J. Zheng
18. Jiaqi Zhang
19. J David Peske
20. Theodoros Karantanos
21. Amanda R. Maxwell
22. Eric Nuermberger
23. Richard B. Markham
24. Petros C. Karakousis

Reviewed by Rapid Reviews Infectious Diseases

Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

1. Arman Izadi
2. Magdalena Godzwon
3. Mats Ohlin
4. Pontus Nordenfelt

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

1. Adam Kim
2. Megan R McMullen
3. Annette Bellar
4. David Streem
5. Jaividhya Dasarathy
6. Nicole Welch
7. Srinivasan Dasarathy

• Curated by eLife

  eLife Assessment

  This potentially useful manuscript addresses the 3D chromatin architecture in monocytes from a few patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the concept and methodological approach are interesting in principle, the evidence is incomplete as a result of insufficient sample sizes as well as other substantive analytical concerns.

Reviewed by eLife

Programmed Delayed Splicing: A Mechanism for Timed Inflammatory Gene Expression

1. Jacob S Dearborn
2. Luke Frankiw
3. Damas W Limoge
4. Christian H Burns
5. Logan Vlach
6. Patricia Turpin
7. Tylar Kirch
8. Zachary D Miller
9. William Dowell
10. Sylvester Languon
11. Yvette Garcia-Flores
12. Robert C Cockrell
13. David Baltimore
14. Devdoot Majumdar

• Curated by eLife

  eLife Assessment

  This study analyzes the temporal dynamics of gene expression following TNF stimulation in macrophages. The work brings valuable data and new methodological approaches to implicate the splicing rate of certain introns as a mechanism regulating mature mRNA expression. This will be of interest to audiences in RNA biology and innate immune response regulation. The experimental design is solid for the core findings, although in places the data limit the conclusions.

Reviewed by eLife