Immunology

  1. Interleukin 10 controls the balance between tolerance, pathogen elimination and immunopathology in birds

    1. Dominique Meunier
    2. Ricardo Corona-Torres
    3. Kay Boulton
    4. Zhiguang Wu
    5. Maeve Ballantyne
    6. Laura Glendinning
    7. Anum Ali Ahmad
    8. Dominika Borowska
    9. Lorna Taylor
    10. Lonneke Vervelde
    11. Jorge del Pozo
    12. Marili Vasilogianni
    13. José Jaramillo-Ortiz
    14. Gonzalo Sanchez-Arsuaga
    15. Androniki Psifidi
    16. Fiona Tomley
    17. Kellie A. Watson
    18. Michael J. McGrew
    19. Mark P. Stevens
    20. Damer P. Blake
    21. David A. Hume

    • Curated by eLife

      eLife Assessment

      Despite the conserved anti-inflammatory activity in birds, whether IL-10 also controls avian intestinal homeostasis remains unclear. Generating genetic knockouts, Meunier et al. firmly established that a complete lack of IL-10 strengthened immunity against enteric bacteria in chickens, while also aggravating infection-inflicted tissue damage upon parasite infection. The findings presented in this manuscript are valuable, and the strength of evidence is convincing; however, it is advised that the deficiencies and weaknesses pointed out by all the reviewers are meticulously addressed.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  2. CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

    1. Jessie Kulsuptrakul
    2. Michael Emerman
    3. Patrick S Mitchell

    • Curated by eLife

      eLife Assessment

      In this study, the authors investigated whether HIV-1 cell-to-cell transmission activates the CARD8 inflammasome in macrophages. The data convincingly support the idea that CARD8 is activated by the viral protease, promoting inflammation. The study's significance is further enhanced by including time-course analyses in primary T cells and macrophages and provides valuable insights into the role of CARD8 in HIV-induced inflammation.

    Reviewed by eLife

    6 evaluationsAppears in 1 listLatest version Latest activity

  3. The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

    1. Asya Dolgikh
    2. Samuel Rommelaere
    3. Aseel Ghanem
    4. Bianca Petrignani
    5. Mickael Poidevin
    6. Estee Kurant
    7. Bruno Lemaitre

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni

    1. Juan M. Inclan-Rico
    2. Adriana Stephenson
    3. Camila M. Napuri
    4. Heather L. Rossi
    5. Li-Yin Hung
    6. Christopher F. Pastore
    7. Wenqin Luo
    8. De’Broski R. Herbert

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  5. The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

    1. Erin F. McCaffrey
    2. Alea C. Delmastro
    3. Isobel Fitzhugh
    4. Jolene S. Ranek
    5. Sarah Douglas
    6. Joshua M. Peters
    7. Christine Camacho Fullaway
    8. Marc Bosse
    9. Candace C. Liu
    10. Craig Gillen
    11. Noah F. Greenwald
    12. Sarah Anzick
    13. Craig Martens
    14. Seth Winfree
    15. Yunhao Bai
    16. Cameron Sowers
    17. Mako Goldston
    18. Alex Kong
    19. Potchara Boonrat
    20. Carolyn L. Bigbee
    21. Roopa Venugopalan
    22. Pauline Maiello
    23. Edwin Klein
    24. Mark A. Rodgers
    25. Charles A. Scanga
    26. Philana Ling Lin
    27. Denise Kirschner
    28. Sarah Fortune
    29. Bryan D. Bryson
    30. J. Russell Butler
    31. Joshua T. Mattila
    32. JoAnne L. Flynn
    33. Michael Angelo

    Reviewed by Rapid Reviews Infectious Diseases, PREreview

    5 evaluationsAppears in 2 listsLatest version Latest activity

  6. Longitudinal analysis of drift in the circulating human antibody repertoire over four years

    1. Collin Joyce
    2. Benjamin Nemoz
    3. Raiza Bastidas
    4. Bryan Briney
    5. Dennis R. Burton

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  7. IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

    1. Daniel L. Aldridge
    2. Zachary Lanzar
    3. Anthony T. Phan
    4. David A. Christian
    5. Ryan Pardy
    6. Booki Min
    7. Ross M. Kedl
    8. Christopher A. Hunter

    • Curated by eLife

      eLife Assessment

      The article presents important findings describing the role of IL27 in maintaining HSCs at steady state, and in emergency haematopoiesis in response to T. goodii by limiting the inflammatory monocyte outcomes. However, the evidence is still incomplete, as not enough evidence is provided to support that IL27 only acts at the level of HSCs and not downstream. This study will be of interest to immunologists and hematologists, as well as infectious disease researchers.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  8. Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

    1. Hicham Sid
    2. Theresa von Heyl
    3. Sabrina Schleibinger
    4. Romina Klinger
    5. Leah Heymelot Nabel
    6. Hanna Vikkula
    7. Rodrigo Guabiraba
    8. Vanaique Guillory
    9. Mohanned Naif Alhussien
    10. Brigitte Böhm
    11. Benjamin Schade
    12. Daniel Elleder
    13. Samantha Sives
    14. Lonneke Vervelde
    15. Sascha Trapp
    16. Benjamin Schusser

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  9. Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

    1. Jan Stuchly
    2. David Novak
    3. Nadezda Brdickova
    4. Petra Hadlova
    5. Vojen Sadilek
    6. Ahmad Iksi
    7. Daniela Kuzilkova
    8. Michael Svaton
    9. George Alehandro Saad
    10. Pablo Engel
    11. Herve Luche
    12. Ana E Sousa
    13. Afonso RM Almeida
    14. Tomas Kalina

    • Curated by eLife

      eLife Assessment

      The authors present an algorithm and workflow for the inference of developmental trajectories from single-cell data, including a mathematical approach to increase computational efficiency. In this latest version, the authors addressed the benchmarking of the novel method, but the absence of quantitative comparisons to state-of-the-art methods still make this study incomplete. Based on the shown validation approaches, one can neither ultimately judge if the shown method will be an advance over previous work nor whether the approach will be of general useful applicability.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  10. β-glucan reprograms alveolar macrophages via neutrophil/IFNγ axis to promote lung injury

    1. Renaud Prével
    2. Erwan Pernet
    3. Kim A Tran
    4. Abderrahmane Sadek
    5. Mina Sadeghi
    6. Elizabeth Lapshina
    7. Leonardo Jurado
    8. Arnold S Kristof
    9. Mohieddine Moumni
    10. Jérémie Poschmann
    11. Maziar Divangahi

    • Curated by eLife

      eLife Assessment

      This important study advances our understanding of maladaptive innate immune training. The experimental evidence supporting the conclusions is convincing and the expert reviewers strongly endorse the manuscript. The work will be of high interest to both researchers in the trained immunity field and clinician scientists.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 4 of 170 Next