Immunology

Layers of immunity: Deconstructing the Drosophila effector response

1. Faustine Ryckebusch
2. Yao Tian
3. Mylene Rapin
4. Fanny Schüpfer
5. Mark A Hanson
6. Bruno Lemaitre

• Curated by eLife

  eLife Assessment

  This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are convincing, and the tools provided can be used as they are, or built upon, in various contexts.

Reviewed by eLife

Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

1. Upneet K Sokhi
2. Ruoxi Yuan
3. Bikash Mishra
4. Yurii Chinenov
5. Anvita Singaraju
6. Karmela K Chan
7. Anne Bass
8. Richard D Bell
9. Laura Donlin
10. Lionel B Ivashkiv

• Curated by eLife

  eLife Assessment

  The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with compelling evidence the effects of PGE2 on TNF signaling. This work will be of broad interest to immunologists and cell biologists.

Reviewed by eLife

Class A Scavenger Receptor MARCO negatively regulates Ace expression and aldosterone production

1. Conan JO O’Brien
2. Giorgio Ratti
3. Hellen Veida-Silva
4. Emma Haberman
5. Charles Sweeney
6. Siamon Gordon
7. Ana I Domingos

• Curated by eLife

  eLife Assessment

  O'Brien and co-authors addressed how statins reduce levels of aldosterone in humans and provide important data demonstrating that tissue-resident macrophages can exert physiological functions and influence endocrine systems. However, the strength of evidence, as of now, is incomplete, as the sole description of the phenotype of MARCO-deficient mice is insufficient to claim that MARCO in alveolar macrophages can negatively regulate ACE expression and aldosterone production at steady-state. The work will be of broad interest to cell biologists and immunologists.

Reviewed by eLife

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

1. Jasper Braun
2. Elliot D. Hill
3. Elisa Contreras
4. Michie Yasuda
5. Alexandra Morgan
6. Sarah Ditelberg
7. Ethan Winter
8. Cody Callahan
9. Gabrielle Mazzoni
10. Andrea Kirmaier
11. Ghee Rye Lee
12. Hamid Mirebrahim
13. Hosseinali Asgharian
14. Dilduz Telman
15. Ai-Ris Y. Collier
16. Dan H. Barouch
17. Stefan Riedel
18. Sanjucta Dutta
19. Florian Rubelt
20. Ramy Arnaout

Reviewed by Review Commons

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

1. Toru Tanaka
2. Naoto Sasaki
3. Aga Krisnanda
4. Hilman Zulkifli Amin
5. Ken Ito
6. Sayo Horibe
7. Kazuhiko Matsuo
8. Ken-ichi Hirata
9. Takashi Nakayama
10. Yoshiyuki Rikitake

• Curated by eLife

  eLife Assessment

  This valuable study provides in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays a role in this process, shedding light on mechanisms that may be of interest to medical biologists, biochemists, cell biologists, and immunologists. The work is currently considered incomplete pending textual changes and the inclusion of proper controls.

Reviewed by eLife

Photoreceptor loss does not recruit neutrophils despite strong microglial activation

1. Derek Power
2. Justin Elstrott
3. Jesse Schallek

• Curated by eLife

  eLife Assessment

  The study by Power and colleagues is important, as elucidating the dynamic immune responses to photoreceptor damage in vivo potentiates future work in the field to better understand the disease process. The evidence supporting the authors' claims is compelling.

Reviewed by eLife

Pre-existing YFV-17D immunity mediates T cell cross-protection against DENV-2 infection

1. Prince Baffour Tonto
2. Sebastian Gallon
3. Reem Alatrash
4. Wei-Kung Wang
5. Bobby Brooke Herrera

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Neutrophil KLF2 regulates inflammasome-dependent neonatal mortality from endotoxemia

1. Devashis Mukherjee
2. Sriram Satyavolu
3. Asha Thomas
4. Sarah Cioffi
5. Yuexin Li
6. E Ricky Chan
7. Katherine Wen
8. Alex Y Huang
9. Mukesh K Jain
10. George R Dubyak
11. Lalitha Nayak

Reviewed by preLights

A randomized controlled trial of the effectiveness of a community-based rabies vaccination strategy

1. Felix Lankester
2. Ahmed Lugelo
3. Joel Changalucha
4. Danni Anderson
5. Christian Tetteh Duamor
6. Anna Czupryna
7. Kennedy Lushasi
8. Elaine Ferguson
9. Emmanuel S. Swai
10. Hezron Nonga
11. Maganga Sambo
12. Sarah Cleaveland
13. Sally Wyke
14. Paul C. D. Johnson
15. Katie Hampson

Reviewed by PREreview

Temperature-based MHC class-I multimer peptide exchange for human HLA-A, B and C

1. Cilia R Pothast
2. Ian Derksen
3. Anneloes van der Plas - van Duijn
4. Angela el Hebieshy
5. Wesley Huisman
6. Kees LMC Franken
7. Jacques Neefjes
8. Jolien J Luimstra
9. Marieke Griffioen
10. Michel Kester
11. Maarten H Vermeer
12. Mirjam HM Heemskerk
13. Ferenc A Scheeren

• Curated by eLife

  eLife Assessment

  This study presents an alternative to conventional and UV-based tetramers, which are easy to use and reliable for the identification of antigen-specific CD8 T cells. The authors demonstrate that tetramers for HLA alleles A0301, A1101, B0702, and C0702 can be subjected to specific temperatures that facilitate peptide exchange, whilst maintaining structural integrity. Whilst the strength of the evidence is currently incomplete, further development and validation of this approach is likely to provide a useful alternative to generating reagents for examining T cell specificities.

Reviewed by eLife