Immunology

  3. During an inflammatory response, zebrafish tnfa and tnfb are expressed by different cell types and have distinct expression kinetics

    1. Kaylee SE van Dijk
    2. Christina Begon-Pescia
    3. Boudewijn A de Bruin
    4. Resul Özbilgiç
    5. Philip M Elks
    6. Mai E Nguyen-Chi
    7. Maria Forlenza

    • Curated by eLife

      eLife Assessment

      This study provides a valuable contribution to the field of zebrafish immunology by demonstrating that the two TNF paralogs tnfa and tnfb show distinct cellular sources and temporal expression patterns during inflammation. These findings are potentially significant because they suggest regulatory divergence and functional specialization within the TNF signaling system in teleosts. While the evidence supporting differential expression is convincing, the work remains largely observational and would benefit from functional experiments and deeper mechanistic insight to determine whether these differences translate into distinct roles in inflammatory signaling. This work will be of interest to immunologists interested in inflammatory cytokine evolution and immune regulation in vertebrates.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

    1. Jordan Z Zhou
    2. Bihui Huang
    3. Bo Pei
    4. Guang Wen Sun
    5. Michael D Pawlitz
    6. Wei Zhang
    7. Xinyang Li
    8. Kati C Hokynar
    9. Fayi Yao
    10. Madusha LW Perera
    11. Shanqiao Wei
    12. Simin Zheng
    13. Lisa A Polin
    14. Janet M Poulik
    15. Annamari Ranki
    16. Kai Krohn
    17. Charlotte Cunningham-Rundles
    18. Naibo Yang
    19. Ashok S Bhagwat
    20. Kefei Yu
    21. Pärt Peterson
    22. Kai Kisand
    23. Bao Q Vuong
    24. Andrea Cerutti
    25. Kang Chen

    • Curated by eLife

      eLife Assessment

      AIRE has been well known to contribute to immune self-tolerance in the thymus by expressing auto-antigens; in this manuscript, the authors describe unexpected findings about the interaction of AIRE with AID in B cells, and its function in the immune system, thereby contributing to a fundamental understanding of the broader functions of AIRE. The strength of this manuscript is that, by employing biochemical and genetic experiments, the authors convincingly show interaction between AIRE and AID and subsequent AIRE's function in the GC responses. However, two weak points exist: first, the connection between AIRE, auto-anti IL17 Abs, and IL17-positive effector T cells, and second, like the thymus, expression of auto-antigens by AIRE in the GC B cells has not been tested.

    Reviewed by eLife

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. Daytime variation in SARS-CoV-2 infection and cytokine production

    1. Aïssatou Bailo Diallo
    2. Laetitia Gay
    3. Benjamin Coiffard
    4. Marc Leone
    5. Soraya Mezouar
    6. Jean-Louis Mege

    Reviewed by Rapid Reviews Infectious Diseases, ScreenIT

    4 evaluationsAppears in 2 listsLatest version Latest activity
Previous Page 5 of 176 Next