Immunology

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

1. Zhixin Jing
2. Phillip Galbo
3. Luis Ovando
4. Megan Demouth
5. Skylar Welte
6. Rosa Park
7. Kartik Chandran
8. Yinghao Wu
9. Thomas MacCarthy
10. Deyou Zheng
11. David Fooksman

• Curated by eLife

  eLife assessment

  Despite the importance of long-lived plasma cells (LLPCs), particularly for the infection and vaccination field, it is still unclear how they acquire their longevity. With a solid genetic approach, the authors demonstrate quite convincingly a requirement for chemokine/chemokine receptor-mediated interaction in LLPC longevity. The data are very valuable for the development of new types of vaccines.

Reviewed by eLife

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

1. Dominik Trzupek
2. Melanie Dunstan
3. Antony J. Cutler
4. Mercede Lee
5. Leila Godfrey
6. Lorna Jarvis
7. Daniel B. Rainbow
8. Dominik Aschenbrenner
9. Joanne L. Jones
10. Holm H. Uhlig
11. Linda S. Wicker
12. John A. Todd
13. Ricardo C. Ferreira

Reviewed by PREreview

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

1. Hee Young Kim
2. Yeon Jun Kang
3. Dong Hyun Kim
4. Jiyeon Jang
5. Su Jeong Lee
6. Gwanghun Kim
7. Hee Byung Koh
8. Ye Eun Ko
9. Hyun Mu Shin
10. Hajeong Lee
11. Tae-Hyun Yoo
12. Won-Woo Lee

• Curated by eLife

  eLife assessment

  The authors expand the concept of a new layer to training immunity, which is currently being highlighted by several colleagues in the field. The work provides important hints to understand end-stage renal disease. Overall, the rational approach leads to experimental results that are solid.

Reviewed by eLife

Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

1. Irini Papazian
2. Maria Kourouvani
3. Anastasia Dagkonaki
4. Vasileios Gouzouasis
5. Lila Dimitrakopoulou
6. Nikolaos Markoglou
7. Fotis Badounas
8. Theodore Tselios
9. Maria Anagnostouli
10. Lesley Probert

• Curated by eLife

  eLife assessment

  The humanized model of EAE represents a valuable model in which to evaluate mechanisms that may drive EAE-like processes in vivo. The data are solid given the revisions and expansion of numbers of mice to yield more statistical rigor. This model will be used by the greater community studying EAE.

Reviewed by eLife

Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

1. Xiaobing Lu
2. Meisheng Yi
3. Zhe Hu
4. Taoran Yang
5. Wanwan Zhang
6. E. Neil G. Marsh
7. Kuntong Jia

Reviewed by preLights

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

1. Yi-Hong Li
2. Yi-Sen Yang
3. Yan-Bo Xue
4. Hao Lei
5. Sai-Sai Zhang
6. Junbin Qian
7. Yushi Yao
8. Ruhong Zhou
9. Liquan Huang

• Curated by eLife

  eLife assessment

  This, in principle, useful study suggests that the G-protein subunit Gng13 is required for limiting injury and inflammation following H1N1 influenza infection via anti-inflammatory effects from ectopic tuft cells. While support for Gng13 helping to limit influenza injury in the transgenic mouse models used here is solid, evidence for these effects being mediated by normal tuft cells remains incomplete, giving conflicting data from mice that lack tuft cells entirely.

Reviewed by eLife

RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia

1. Xiaozhuo Yu
2. Wen Zhou
3. Xiaodong Chen
4. Shunyu He
5. Mengting Qin
6. Meng Yuan
7. Yang Wang
8. Woodvine Otieno Odhiambo
9. Yinsha Miao
10. Yanhong Ji

• Curated by eLife

  eLife assessment

  Using a set of animal models, this valuable paper shows tumor suppressive function of the non-core regions of RAG1/2 recombinases. The conclusions are supported by solid evidence.

Reviewed by eLife

Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

1. Leen Farhat-Younis
2. Manho Na
3. Amichai Zarfin
4. Aseel Khateeb
5. Nadine Santana-Magal
6. Alon Richter
7. Amit Gutwillig
8. Diana Rasoulouniriana
9. Annette Gleiberman
10. Lir Beck
11. Tamar Giger
12. Avraham Ashkenazi
13. Adi Barzel
14. Peleg Rider
15. Yaron Carmi

• Curated by eLife

  eLife assessment

  The findings are fundamental for understanding IgM signaling in myeloid cells. The work is compelling in its ability to manipulate and harness myeloid cells to further anti-tumor immunity.

Reviewed by eLife

Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping

1. Aceer Nadeem
2. Sarah Lyons
3. Aidan Kindopp
4. Amanda Jamieson
5. Daniel Roxbury

Reviewed by Arcadia Science