Immunology

Pneumocystis murina Promotes Inflammasome Formation and NETosis during Pneumocystis Pneumonia

1. Steven G. Sayson
2. Alan Ashbaugh
3. Aleksey Porollo
4. Melanie T. Cushion

Reviewed by Rapid Reviews Infectious Diseases

Crosstalk between the RNA-binding proteins Regnase-1 and -3 shapes mast cell survival and cytokine expression

1. Marian Bataclan
2. Cristina Leoni
3. Simone G. Moro
4. Matteo Pecoraro
5. Elaine H. Wong
6. Vigo Heissmeyer
7. Silvia Monticelli

Reviewed by Review Commons

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

1. Yoshiaki Yasumizu
2. Makoto Kinoshita
3. Martin Jinye Zhang
4. Daisuke Motooka
5. Koichiro Suzuki
6. Daisuke Okuzaki
7. Satoshi Nojima
8. Soichiro Funaki
9. Yasushi Shintani
10. Naganari Ohkura
11. Eiichi Morii
12. Tatsusada Okuno
13. Hideki Mochizuki

Reviewed by preLights

Combining mutation and recombination statistics to infer clonal families in antibody repertoires

1. Natanael Spisak
2. Gabriel Athènes
3. Thomas Dupic
4. Thierry Mora
5. Aleksandra M Walczak

• Curated by eLife

  eLife assessment

  This important study provides a new, apparently high-performance algorithm for B cell clonal family inference. The new algorithm is highly innovative and based on a rigorous probabilistic analysis of the relevant biological processes and their imprint on the resulting sequences, however, the strength of evidence regarding the algorithm's performance is incomplete, due to (1) a lack of clarity regarding how different data sets were used for different steps during algorithm development and validation, resulting in concerns of circularity, (2) a lack of detail regarding the settings for competitor programs during benchmarking, and (3) method development, data simulation for method validation, and empirical analyses all based on the B cell repertoire of a single subject. With clarity around these issues and application to a more diverse set of real samples, this paper could be fundamental to immunologists and important to any researcher or clinician utilizing B cell receptor repertoires in their field (e.g., cancer immunology).

Reviewed by eLife

Semi-synthetic glycoconjugate vaccine candidate against Cryptococcus neoformans

1. Conor J. Crawford
2. Livia Liporagi-Lopes
3. Carolina Coelho
4. Samuel R. Santos Junior
5. André Moraes Nicola
6. Maggie P. Wear
7. Raghav Vij
8. Stefan Oscarson
9. Arturo Casadevall

Reviewed by Rapid Reviews Infectious Diseases

Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

1. Rajan M Thomas
2. Matthew C Pahl
3. Liqing Wang
4. Struan FA Grant
5. Wayne W Hancock
6. Andrew D Wells

• Curated by eLife

  eLife assessment

  This comprehensive study provides valuable information on the cooperation of Ikaros with Foxp3 to establish and regulate a major portion of the epigenome and transcriptome of T-regulatory cells. While the data are compelling, the evidence that these features are solely intrinsic, independent of the micro-environment, could be strengthened.

Reviewed by eLife

Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

1. Emily E. Whitaker
2. Neal E. Mecum
3. Riley C. Cott
4. Diana J. Goode

Reviewed by Review Commons

Tribbles1 is host protective during in vivo mycobacterial infection

1. Ffion R Hammond
2. Amy Lewis
3. Gabriele Pollara
4. Gillian S Tomlinson
5. Mahdad Noursadeghi
6. Endre Kiss-Toth
7. Philip M Elks

Reviewed by Review Commons

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

1. Fabienne Maassen
2. Vu Thuy Khanh Le-Trilling
3. Luisa Betke
4. Thilo Bracht
5. Corinna Siegmund
6. Malte Bayer
7. Benjamin Katschinski
8. Antonia Belter
9. Tanja Becker
10. Denise Mennerich
11. Sebastian Voigt
12. Lori Frappier
13. Barbara Sitek
14. Katharina Fleischhauer
15. Mirko Trilling

Reviewed by Review Commons

Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

1. Tatyana O Nakonechnaya
2. Bruno Moltedo
3. Ekaterina V Putintseva
4. Sofya Leyn
5. Dmitry A Bolotin
6. Olga V Britanova
7. Mikhail Shugay
8. Dmitriy M Chudakov

• Curated by eLife

  eLife assessment

  This manuscript presents a valuable approach to exploring CD4+ T-cell response in mice across stimuli and tissues through the analysis of their T-cell receptor repertoires. The authors use a transgenic mouse model with reduced diversity of the T-cell receptor repertoire to elicit more consistent T-cell responses across individuals, demonstrating challenge-specific and tissue-specific responses of regulatory T-cells. The evidence for the authors' conclusions is solid, and the work will be of interest to immunologists studying T cell responses.

Reviewed by eLife