Immunology

The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

1. Arijit Chakraborty
2. Arunava Bandyopadhaya
3. Vijay K Singh
4. Filip Kovacic
5. Sujin Cha
6. William M Oldham
7. A Aria Tzika
8. Laurence G Rahme

• Curated by eLife

  eLife assessment

  This important study demonstrates that the Pseudomonas aeruginosa-derived quorum sensing signal, 2-aminoacetophenone, induces immune tolerization in macrophages by perturbing metabolism, particularly in the context of mitochondrial respiration and bioenergetics. The authors present convincing evidence for 2-aminoacetophenone-mediated reduction of pyruvate transport into mitochondria, with downstream effects that result in reduced ATP production in tolerized macrophages. The work will be of interest to those studying host-pathogen interactions.

Reviewed by eLife

Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

1. Nicolas Aubert
2. Madeleine Purcarea
3. Julien Novarino
4. Julien Schopp
5. Alexis Audibert
6. Wangtianrui Li
7. Marie Fornier
8. Léonie Cagnet
9. Marie Naturel
10. Armanda Casrouge
11. Marie-Caroline Dieu-Nosjean
12. Nicolas Blanchard
13. Gilles Dietrich
14. Cedric Peirs
15. Gilles Marodon

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on a new role of Foxp3+ regulatory T cells in sensory perception, which may have an impact on our understanding of somatosensory perception. The authors identified a previously unappreciated action of enkephalins released by immune cells in the resolution of pain and several upstream signals that can regulate the expression of the proenkephalin gene PENK in Foxp3+ Tregs. The generation of transgenic mice with conditional deletion of PENK in Foxp3+ cells and PENK fate-mapping is novel and generates compelling data; they also show a comprehensive analysis of Tregs in control and transgenic mice, longitudinal data on heat sensitivity and co-localization of PENK+ Tregs with thermal sensory neurons in the skin further supporting their hypothesis. The study would be of interest to the biologists working in the field of neuroimmunology and inflammation.

Reviewed by eLife

Circadian rhythms of macrophages are altered by the acidic tumor microenvironment

1. Amelia M Knudsen-Clark
2. Daniel Mwangi
3. Juliana Cazarin
4. Kristina Morris
5. Cameron Baker
6. Lauren M Hablitz
7. Matthew N McCall
8. Minsoo Kim
9. Brian J Altman

Reviewed by Review Commons

Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

1. Bethany Moyse
2. Joanna Moss
3. Laura Bevan
4. Aaron Scott
5. Valérie Wittamer
6. Rebecca J Richardson

• Curated by eLife

  eLife assessment

  The manuscript presented by Moyse and colleagues provides valuable insight into the origin, morphology, dynamics, and behavior of several populations of mononuclear phagocytes in the zebrafish heart. The study presents solid evidence through the use of transgenic lines and live imaging, although some limitations related to lineage tracing and molecular profiles should be considered. This work exemplifies the use of zebrafish as a model to study the role of leukocytes in cardiac development and regeneration and potentially draw broader interest to biologists working in immunology fields.

Reviewed by eLife

Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

1. Matias A Medina
2. Francisco Fuentes-Villalobos
3. Claudio Quevedo
4. Felipe Aguilera
5. Raul Riquelme
6. Maria Luisa Rioseco
7. Sebastian Barria
8. Yazmin Pinos
9. Mario Calvo
10. Ian Burbulis
11. Camila Kossack
12. Raymond A Alvarez
13. Jose Luis Garrido
14. Maria Ines Barria

• Curated by eLife

  eLife assessment

  This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

Reviewed by eLife

REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

1. Astrid Hoermann
2. Paolo Capriotti
3. Giuseppe Del Corsano
4. Maria Grazia Inghilterra
5. Tibebu Habtewold
6. Julia A. Cai
7. Gauri Sachiko Saini
8. Huong Nguyen
9. Nikolai Windbichler
10. George K. Christophides

Reviewed by PREreview

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Amphibian mast cells serve as barriers to chytrid fungus infections

1. Kelsey A Hauser
2. Christina N Garvey
3. Ryley S Crow
4. Muhammad RH Hossainey
5. Dustin T Howard
6. Netra Ranganathan
7. Lindsey K Gentry
8. Amulya Yaparla
9. Namarta Kalia
10. Mira Zelle
11. Elizabeth J Jones
12. Anju N Duttargi
13. Louise A Rollins-Smith
14. Carly R Muletz-Wolz
15. Leon Grayfer

• Curated by eLife

  eLife assessment

  This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

Reviewed by eLife

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

1. Kely C Matteucci
2. Patricia A Assis
3. Isabella C Hirako
4. Nathalia PS Leite
5. Franciele Pioto
6. Ogooluwa Ojelabi
7. Juliana E Toller-Kawahisa
8. Diego L Costa
9. João S Da Silva
10. José C Alves-Filho
11. Ricardo T Gazzinelli

• Curated by eLife

  eLife assessment

  This important study examines the role of TNF in modulating energy metabolism during parasite infection. The authors perform an elegant set of studies, however the evidence supporting the major claims of the manuscript is incomplete. This work integrates an interesting set of observations that will be of interest to the Plasmodium and pathogenesis communities with an expanded set of experiments.

Reviewed by eLife

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice

1. Juan Manuel Leyva-Castillo
2. Maria Strakosha
3. Sophia E.M. Smith
4. Daniela Vega-Mendoza
5. Megan Elkins
6. Janet Chou
7. Peter Vogel
8. Nathalie Boulanger

Reviewed by Arcadia Science