Immunology

PD-1 negatively regulates helper T cell differentiation into Th2

1. Masaki Tajima
2. Naoko Ikuta
3. Yuka Nakajima
4. Kensuke Suzuki
5. Yosuke Tokumaru
6. Peng Li
7. Hiroshi Kiyonari
8. Tasuku Honjo
9. Akio Ohta

• Curated by eLife

  eLife Assessment

  This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for the treatment of allergies. However, whereas the series of well-designed experiments using OVA-specific CD4 T cells from DO.11.10 mice and the use of an allergy model generated compelling data, the study is still incomplete since it shows gaps in the rationale for the experimental protocols, contradictory data regarding IFN-gamma and IL-4 production, and the lack of in vivo experiments on Th2 differentiation to further support the main hypothesis. Nonetheless, the reported data would be of interest to immunologists working on T cell differentiation and allergy.

Reviewed by eLife

Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer

1. Frédéric Fercoq
2. Gemma S. Cairns
3. Victoria L. Bridgeman
4. Marco De Donatis
5. John B.G. Mackey
6. Alessia Floerchinger
7. Amanda J. McFarlane
8. Judith Secklehner
9. Ximena L. Raffo-Iraolagoitia
10. Madeline Harrington
11. Lynn McGarry
12. Demi Brownlie
13. Declan Whyte
14. Lindsey W.G. Arnott
15. Colin Nixon
16. Robert Wiesheu
17. Anna Kilbey
18. Leah Brown
19. Sarwah Al-Khalidi
20. Jim C. Norman
21. Edward W. Roberts
22. Ilaria Malanchi
23. Karen Blyth
24. Seth B. Coffelt
25. Leo M. Carlin

Reviewed by preLights

Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response

1. Anna Andrusaite
2. Olivia Ridgewell
3. Anna Ahlback
4. Holly Webster
5. Hiroki Yamaguchi
6. Molly Peel
7. Annika Frede
8. Sarwah Al-Khalidi
9. Andrew Farthing
10. Anna Heawood
11. Annabelle Smith
12. Edward Roberts
13. Allan Mowat
14. Richard Maizels
15. Georgia Perona-Wright
16. Simon Milling

Reviewed by Arcadia Science

A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

1. Shuyu Olivia Zhou
2. Jonathan P Day
3. Bart Deplancke
4. Alexandre B Leitão
5. Francis M Jiggins

• Curated by eLife

  eLife Assessment

  This valuable study reports an extensive analysis of the way a humoral immune response to parasitoid wasp is expressed and regulated, building on previous work from the authors on an anti-parasitoid effector lectin. The solid evidence uses two complementary approaches to show which innate immune pathways are involved in the regulation of the anti-parasitoid response. The evidence would be stronger if some analytical and related concerns can be addressed. The work will be of relevance to the community of investigators studying insect immune cells as well as researchers interested in host defense against parasitism.

Reviewed by eLife

Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen

1. David Verhoeven
2. Brett A. Sponseller
3. James E. Crowe
4. Sandhya Bangaru
5. Richard J. Webby
6. Brian Lee

Reviewed by PREreview