Immunology

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Amphibian mast cells serve as barriers to chytrid fungus infections

1. Kelsey A Hauser
2. Christina N Garvey
3. Ryley S Crow
4. Muhammad RH Hossainey
5. Dustin T Howard
6. Netra Ranganathan
7. Lindsey K Gentry
8. Amulya Yaparla
9. Namarta Kalia
10. Mira Zelle
11. Elizabeth J Jones
12. Anju N Duttargi
13. Louise A Rollins-Smith
14. Carly R Muletz-Wolz
15. Leon Grayfer

• Curated by eLife

  eLife assessment

  This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

Reviewed by eLife

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

1. Kely C Matteucci
2. Patricia A Assis
3. Isabella C Hirako
4. Nathalia PS Leite
5. Franciele Pioto
6. Ogooluwa Ojelabi
7. Juliana E Toller-Kawahisa
8. Diego L Costa
9. João S Da Silva
10. José C Alves-Filho
11. Ricardo T Gazzinelli

• Curated by eLife

  eLife assessment

  This important study examines the role of TNF in modulating energy metabolism during parasite infection. The authors perform an elegant set of studies, however the evidence supporting the major claims of the manuscript is incomplete. This work integrates an interesting set of observations that will be of interest to the Plasmodium and pathogenesis communities with an expanded set of experiments.

Reviewed by eLife

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice

1. Juan Manuel Leyva-Castillo
2. Maria Strakosha
3. Sophia E.M. Smith
4. Daniela Vega-Mendoza
5. Megan Elkins
6. Janet Chou
7. Peter Vogel
8. Nathalie Boulanger

Reviewed by Arcadia Science

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

1. Hella Luksch
2. Felix Schulze
3. David Geißler-Lösch
4. David Sprott
5. Lennart Höfs
6. Eva M Szegö
7. Wulf Tonnus
8. Stefan Winkler
9. Claudia Günther
10. Andreas Linkermann
11. Rayk Behrendt
12. Lino L Teichmann
13. Björn H Falkenburger
14. Angela Rösen-Wolff

Reviewed by Review Commons

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

1. Natalia Duque-Wilckens
2. Dimitri Joseph
3. Meesum Syed
4. Brianna Smith
5. Nidia Maradiaga
6. Szu-Ying Yeh
7. Vidhula Srinivasan
8. Fabiola Sotomayor
9. Kait Durga
10. Eric Nestler
11. Adam J Moesers
12. A.J. Robison

Reviewed by Arcadia Science

Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

1. Jitian He
2. Le Gao
3. Peiying Wang
4. Wing Keung Chan
5. Yiran Zheng
6. Yumo Zhang
7. Jiaman Sun
8. Xue Li
9. Jiming Wang
10. Xiao-Hong Li
11. Huaiyong Chen
12. Zhouxin Yang
13. Youwei Wang

• Curated by eLife

  eLife assessment

  The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

Reviewed by eLife

Control of Inflammatory Response by Tissue Microenvironment

1. Zhongyang Wu
2. Scott D. Pope
3. Nasiha S. Ahmed
4. Diana L. Leung
5. Stephanie Hajjar
6. Qiuyu Yue
7. Diya M. Anand
8. Elizabeth B. Kopp
9. Daniel Okin
10. Weiyi Ma
11. Jonathan C. Kagan
12. Diana C. Hargreaves
13. Ruslan Medzhitov
14. Xu Zhou

Reviewed by preLights

Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

1. Mariano Maio
2. Joaquina Barros
3. Marine Joly
4. Zoi Vahlas
5. José Luis Marín Franco
6. Melanie Genoula
7. Sarah C Monard
8. María Belén Vecchione
9. Federico Fuentes
10. Virginia Gonzalez Polo
11. María Florencia Quiroga
12. Mónica Vermeulen
13. Thien-Phong Vu Manh
14. Rafael J Argüello
15. Sandra Inwentarz
16. Rosa Musella
17. Lorena Ciallella
18. Pablo González Montaner
19. Domingo Palmero
20. Geanncarlo Lugo Villarino
21. María del Carmen Sasiain
22. Olivier Neyrolles
23. Christel Vérollet
24. Luciana Balboa

• Curated by eLife

  eLife assessment

  This useful study tests the hypothesis that monocytes purified from tuberculosis patients differentiate into dendritic cells with different migratory capacities. The authors conclude that these monocytes are metabolically pre-conditioned to differentiate, with reduced expression of Hif1a and a glycolytically exhaustive phenotype, resulting in low migratory and immunologic potential. Overall, the evidence provided is convincing, advancing the field substantively and providing novel insights.

Reviewed by eLife

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

1. Jyotsna
2. Binayak Sarkar
3. Mohit Yadav
4. Alvina Deka
5. Manasvini Markandey
6. Priyadarshini Sanyal
7. Perumal Nagarajan
8. Nilesh Gaikward
9. Vineet Ahuja
10. Debasisa Mohanty
11. Soumen Basak
12. Rajesh S Gokhale

• Curated by eLife

  eLife assessment

  The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

Reviewed by eLife