Immunology

Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity

1. Yue Yang
2. Bin Huang
3. Yimeng Qin
4. Danwei Wang
5. Yinuo Jin
6. Linmin Su
7. Qingxin Wang
8. Yi Pan
9. Yanfeng Zhang
10. Yumeng Shen
11. Wenjun Hu
12. Zhengyu Cao
13. Liang Jin
14. Fangfang Zhang

• Curated by eLife

  eLife assessment

  This important study utilizes a comprehensive array of animal and cellular models, alongside various techniques, to elucidate the mechanism by which adipose tissue miR-802 contributes to inflammation and metabolic dysfunction in obesity. The data is solid, with clear, reproducible changes showing low variability among biological replicates and consistency across different models. However, some conclusions should be further substantiated with additional data to enhance the scope and strength of the manuscript.

Reviewed by eLife

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

1. Youxi Liu
2. Meimei Yin
3. Xiaoting Mao
4. Shuai Wu
5. Shuangping Wei
6. Shujun Heng
7. Yichun Yang
8. Jinwen Huang
9. Zhuolin Guo
10. Chuan Li
11. Chao Ji
12. Liu Hu
13. Wenjie Liu
14. Ling-juan Zhang

• Curated by eLife

  eLife assessment

  This important study uses single-cell RNA-seq to obtain a more granular understanding of cell subsets within allergic contact dermatitis in a model system with DNFB. The convincing data revela unique subpopulations of dermal fibroblasts as key responders to interferon gamma and likely as mediators of dermatitis. This study has many novel aspects and provides a unique resource as well.

Reviewed by eLife

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

1. Raphael A. Reyes
2. Louise Turner
3. Isaac Ssewanyana
4. Prasanna Jagannathan
5. Margaret E. Feeney
6. Thomas Lavstsen
7. Bryan Greenhouse
8. Sebastiaan Bol
9. Evelien M. Bunnik

Reviewed by Review Commons

The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

1. Alexandra a Aybar-Torres
2. Lennon A Saldarriaga
3. Ann T Pham
4. Amir M Emtiazjoo
5. Ashish K Sharma
6. Andrew j Bryant
7. Lei Jin

• Curated by eLife

  eLife assessment

  This study describes useful mouse models of knock-ins of human STING1 variants and an assessment of these variants' action in mouse immune cells. While the implications of the variants in the inflammatory response are of significant interest, limitations are still found in the authors' interpretation and conclusions made, and the evidence for the conclusion remains incomplete.

Reviewed by eLife

CCL28 modulates neutrophil responses during infection with mucosal pathogens

1. Gregory T Walker
2. Araceli Perez-Lopez
3. Steven Silva
4. Michael H Lee
5. Elisabet Bjånes
6. Nicholas Dillon
7. Stephanie L Brandt
8. Romana R Gerner
9. Karine Melchior
10. Grant J Norton
11. Felix A Argueta
12. Frenchesca Dela Pena
13. Lauren Park
14. Victor A Sosa-Hernandez
15. Rodrigo Cervantes-Diaz
16. Sandra Romero-Ramirez
17. Monica Cartelle Gestal
18. Jose L Maravillas-Montero
19. Sean-Paul Nuccio
20. Victor Nizet
21. Manuela Raffatellu

• Curated by eLife

  eLife assessment

  In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

Reviewed by eLife

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

1. Yaping Chen
2. Pengcheng Zhou
3. Patrick Marc Gubser
4. Yew Ann Leong
5. Jing He
6. Yunbo Wei
7. Fadzai Victor Makota
8. Mehrdad Pazhouhandeh
9. Ting Zheng
10. Joseph Yunis
11. Zhanguo Li
12. Axel Kallies
13. Di Yu

• Curated by eLife

  eLife assessment

  This paper provides valuable findings related to the impact and timing of exogenous interleukin 2 on the balance of exhausted (Tex) versus effector (Teff) that differentiate from precursors T cells (Tpex) during chronic viral infection. While the data appear solid, the overall claims that IL-2 suppresses Tpex are only partially supported, with the rationale for the timing of IL-2 treatment and its underlying mechanisms remaining unclear.

Reviewed by eLife

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

1. Dina Dikovskaya
2. Rebecca Pemberton
3. Matthew Taylor
4. Anna Tasegian
5. Purbasha Bhattacharya
6. Karolina Zeneviciute
7. Esther M Sammler
8. Andrew J M Howden
9. Dario R Alessi
10. Mahima Swamy

Reviewed by Review Commons

Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

1. Matthew C Pahl
2. Prabhat Sharma
3. Rajan M Thomas
4. Zachary Thompson
5. Zachary Mount
6. James A Pippin
7. Peter A Morawski
8. Peng Sun
9. Chun Su
10. Daniel Campbell
11. Struan FA Grant
12. Andrew D Wells

• Curated by eLife

  eLife assessment

  This is a solid study that follows a well-established canvas for variant-to-gene prioritisation using 3D genomics, applying it to activated T cells. The authors go some way in validating the lists of candidate genes, as well as exploring the regulatory architecture of a candidate GWAS locus. Jointly with data from previous studies performing variant-to-gene assignment in activated CD4 T cells (and other immune cells), this work provides a useful additional resource for interpreting autoimmune disease-associated genetic variation.

Reviewed by eLife

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

1. Andrea Cottignies-Calamarte
2. Flora Marteau
3. Feifan He
4. Sandrine Belouzard
5. Jean Dubuisson
6. Daniela Tudor
7. Benoit Viollet
8. Morgane Bomsel

Reviewed by Review Commons

Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

1. Alessandra Machado Araujo
2. Joseph D Dekker
3. Kendra Garrison
4. Zhe Su
5. Catherine Rhee
6. Zicheng Hu
7. Bum-Kyu Lee
8. Daniel Osorio
9. Jiwon Lee
10. Vishwanath R Iyer
11. Lauren IR Ehrlich
12. George Georgiou
13. Gregory Ippolito
14. Stephen Yi
15. Haley O Tucker

• Curated by eLife

  eLife assessment

  This valuable study reports that while most plasmacytoid dendritic cells (pDCs) originate from common dendritic cell precursors, approximately 20% are derived from lymphoid progenitors shared with B cells. The methodology used and the evidence are solid, and further demonstrate the distinct transcription factor requirements and activities of this subset of pDCs, although the functional significance of this dendritic cell subset will require further elucidation. The findings will be of great interest for those interested in the developmental and functional biology of the immune system.

Reviewed by eLife