1. The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA

    This article has 15 authors:
    1. Fabienne Maassen
    2. Vu Thuy Khanh Le-Trilling
    3. Luisa Betke
    4. Thilo Bracht
    5. Corinna Siegmund
    6. Malte Bayer
    7. Benjamin Katschinski
    8. Antonia Belter
    9. Tanja Becker
    10. Denise Mennerich
    11. Sebastian Voigt
    12. Lori Frappier
    13. Barbara Sitek
    14. Katharina Fleischhauer
    15. Mirko Trilling

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

    This article has 8 authors:
    1. Tatyana O Nakonechnaya
    2. Bruno Moltedo
    3. Ekaterina V Putintseva
    4. Sofya Leyn
    5. Dmitry A Bolotin
    6. Olga V Britanova
    7. Mikhail Shugay
    8. Dmitriy M Chudakov
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript presents a valuable approach to exploring CD4+ T-cell response in mice across stimuli and tissues through the analysis of their T-cell receptor repertoires. The authors use a transgenic mouse model with reduced diversity of the T-cell receptor repertoire to elicit more consistent T-cell responses across individuals, demonstrating challenge-specific and tissue-specific responses of regulatory T-cells. The evidence for the authors' conclusions is solid, and the work will be of interest to immunologists studying T cell responses.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

    This article has 10 authors:
    1. Toyoshi Yanagihara
    2. Kentaro Hata
    3. Keisuke Matsubara
    4. Kazufumi Kunimura
    5. Kunihiro Suzuki
    6. Kazuya Tsubouchi
    7. Satoshi Ikegame
    8. Yoshihiro Baba
    9. Yoshinori Fukui
    10. Isamu Okamoto
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable inventory of immune signatures that are correlated with cancer treatment-related pneumonitis. The data were collected and analysed using validated methodology and can be used as a starting point for further prospective studies. The authors have provided a scRNA-Seq analysis with an HD baseline using publicly available dataset and the evidence for their claims is convincing.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  4. The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

    This article has 8 authors:
    1. Mark S Lee
    2. Peter J Tuohy
    3. Caleb Y Kim
    4. Philip P Yost
    5. Katrina Lichauco
    6. Heather L Parrish
    7. Koenraad Van Doorslaer
    8. Michael S Kuhns
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides valuable new insights as to how two evolutionary conserved motifs in CD4 contribute to the CD4-mediated enhancement of TCR signaling independently of the CD4-LCK interaction. The data at hand are convincing, even if confined to a cell line model and not substantiated in vivo and with little new mechanistic insight provided regarding the domains of CD4 shown to have significant roles in the signaling process. Without the data from primary cells it is difficult to make statements about the quantitative contribution of LCK-dependent and independent functions of CD4 in TCR signaling.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

    This article has 9 authors:
    1. Chongbin Hu
    2. Nan Zhang
    3. Yun Hong
    4. Ruxiu Tie
    5. Dongdong Fan
    6. Aifu Lin
    7. Ye Chen
    8. Li-xin Xiang
    9. Jian-zhong Shao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study characterizes the composition and immune diversity of the zebrafish kidney, the immune organ equivalent to human bone marrow, with convincing single-cell transcriptomic data of hematopoietic cells and immunocytes. The key findings suggest that zebrafish kidney is a secondary lymphatic organ, and that hematopoietic stem cells in zebrafish may exhibit trained immunity, which are the unique features of the fish immune system. This study provides new and valuable insights into the antiviral response in teleost fish, which will be of interest to biologists in general, and to immunologists and cancer researchers in particular.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

    This article has 18 authors:
    1. Yuting Zhang
    2. Min Zhang
    3. Haiyan Wu
    4. Xinwei Wang
    5. Hang Zheng
    6. Junjuan Feng
    7. Jing Wang
    8. Longlong Luo
    9. He Xiao
    10. Chunxia Qiao
    11. Xinying Li
    12. Yuanqiang Zheng
    13. Weijin Huang
    14. Youchun Wang
    15. Yi Wang
    16. Yanchun Shi
    17. Jiannan Feng
    18. Guojiang Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, the discovery and subsequent design of the AF03-NL chimeric antibody led to a tool for studying filoviruses and provides a possible blueprint for future therapeutics. In general, the data presented are solid, although further improvements can be made in the overall presentation of the results. The work will be of interest to virologists studying antibodies.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  7. Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

    This article has 26 authors:
    1. Tobias Weinberger
    2. Messerer Denise
    3. Markus Joppich
    4. Maximilian Fischer
    5. Clarisabel Garcia Rodriguez
    6. Konda Kumaraswami
    7. Vanessa Wimmler
    8. Sonja Ablinger
    9. Saskia Räuber
    10. Jiahui Fang
    11. Lulu Liu
    12. Wing Han Liu
    13. Julia Winterhalter
    14. Johannes Lichti
    15. Lukas Thomas
    16. Dena Esfandyari
    17. Guelce Percin
    18. Sandra Matin
    19. Andrés Hidalgo
    20. Claudia Waskow
    21. Stefan Engelhardt
    22. Andrei Todica
    23. Ralf Zimmer
    24. Clare Pridans
    25. Elisa Gomez Perdiguero
    26. Christian Schulz
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Using state-of-the-art fate-mapping models and genetic and pharmacological targeting approaches, this study provides important findings on the distinct functions exerted by resident and recruited macrophages during cardiac healing after myocardial ischemia. Evidence supporting the conclusions are solid with the use of the FIRE mouse model in combination with fate-mapping to target fetal-derived macrophages. This study will be of interest for the macrophage biologists working in the heart but also in others tissues in the context of inflammation.

    Reviewed by eLife

    This article has 11 evaluationsAppears in 1 listLatest version Latest activity
  8. Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

    This article has 12 authors:
    1. Izumi Ohigashi
    2. Andrea J White
    3. Mei-Ting Yang
    4. Sayumi Fujimori
    5. Yu Tanaka
    6. Alison Jacques
    7. Hiroshi Kiyonari
    8. Yosuke Matsushita
    9. Sevilay Turan
    10. Michael C Kelly
    11. Graham Anderson
    12. Yousuke Takahama
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study provides new insights into the development and function of medullary thymus epithelial cells (mTEC). The authors provide compelling evidence to support their claims as to the differentiation and lineage outcomes of CCL21+ mTEC progenitors, which further our understanding of how central tolerance of T cells is enforced within the thymus.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus

    This article has 25 authors:
    1. Thomas Morgan Li
    2. Victoria Zyulina
    3. Ethan S Seltzer
    4. Marija Dacic
    5. Yurii Chinenov
    6. Andrea R Daamen
    7. Keila R Veiga
    8. Noa Schwartz
    9. David J Oliver
    10. Pamela Cabahug-Zuckerman
    11. Jose Lora
    12. Yong Liu
    13. William D Shipman
    14. William G Ambler
    15. Sarah F Taber
    16. Karen B Onel
    17. Jonathan H Zippin
    18. Mehdi Rashighi
    19. James G Krueger
    20. Niroshana Anandasabapathy
    21. Inez Rogatsky
    22. Ali Jabbari
    23. Carl P Blobel
    24. Peter E Lipsky
    25. Theresa T Lu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a useful assessment of the possible role of type I interferons in inhibiting Adam17 protease/sheddase activity and their correlation with decreased Langerhans Cells signature in lesional and nonlesional CLE and murine models as cause of photosensitive lupus. The data were collected and analyzed using a solid methodology. This work will be of interest to scientists interested in photosensitivity in the setting of lupus.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation

    This article has 6 authors:
    1. Hyereen Kang
    2. Seong Woo Choi
    3. Joo Young Kim
    4. Soo-Jin Oh
    5. Sung Joon Kim
    6. Myung-Shik Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study proposes a role of lysosomal Ca2+ release in inflammasome signaling and metabolic inflammation. While the proposed model would be of considerable interest to the field of immunology if validated, the experimental approaches to study calcium dynamics are problematic, with one of several concerns being the transfection efficiency. The major claims of the paper are thus only incompletely supported.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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