Immunology

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

1. Daniela Bottero
2. Erika Rudi
3. Pablo Martin Aispuro
4. Eugenia Zurita
5. Emilia Gaillard
6. Maria M. Gonzalez Lopez Ledesma
7. Juan Malito
8. Matthew Stuible
9. Nicolas Ambrosis
10. Yves Durocher
11. Andrea V. Gamarnik
12. Andrés Wigdorovitz
13. Daniela Hozbor

Reviewed by Rapid Reviews Infectious Diseases

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

1. Zhengyang Lei
2. Shiyao Zhai
3. Xi Yuan
4. Runming Wang
5. Yunpeng Wang
6. Vijay Pandey
7. Can Yang Zhang
8. Jiansong Ji
9. Dongmei Yu
10. Zhenglin Chen
11. Sumin Bian
12. Peiwu Qin

Reviewed by Rapid Reviews Infectious Diseases

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants

1. Qian Wang
2. Yicheng Guo
3. Anthony Bowen
4. Ian A. Mellis
5. Riccardo Valdez
6. Carmen Gherasim
7. Aubree Gordon
8. Lihong Liu
9. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

1. Ruth Connor
2. Mrunal Sakharkar
3. Garrett Rappazzo
4. Chengzi Kaku
5. Nicholas Curtis
6. Seungmin Shin
7. Wendy Wieland-Alter
8. Jordan Wentworth
9. Daniel Mielcarz
10. Joshua Weiner
11. Margaret Ackerman
12. Laura Walker
13. Jiwon Lee
14. Peter Wright

Reviewed by Rapid Reviews Infectious Diseases

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

1. Natalia Duque-Wilckens
2. Dimitri Joseph
3. Meesum Syed
4. Brianna Smith
5. Nidia Maradiaga
6. Szu-Ying Yeh
7. Vidhula Srinivasan
8. Fabiola Sotomayor
9. Kait Durga
10. Eric Nestler
11. Adam J Moesers
12. A.J. Robison

Reviewed by Arcadia Science

Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

1. Jitian He
2. Le Gao
3. Peiying Wang
4. Wing Keung Chan
5. Yiran Zheng
6. Yumo Zhang
7. Jiaman Sun
8. Xue Li
9. Jiming Wang
10. Xiao-Hong Li
11. Huaiyong Chen
12. Zhouxin Yang
13. Youwei Wang

• Curated by eLife

  eLife assessment

  The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

Reviewed by eLife

Control of Inflammatory Response by Tissue Microenvironment

1. Zhongyang Wu
2. Scott D. Pope
3. Nasiha S. Ahmed
4. Diana L. Leung
5. Stephanie Hajjar
6. Qiuyu Yue
7. Diya M. Anand
8. Elizabeth B. Kopp
9. Daniel Okin
10. Weiyi Ma
11. Jonathan C. Kagan
12. Diana C. Hargreaves
13. Ruslan Medzhitov
14. Xu Zhou

Reviewed by preLights

Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

1. Mariano Maio
2. Joaquina Barros
3. Marine Joly
4. Zoi Vahlas
5. José Luis Marín Franco
6. Melanie Genoula
7. Sarah C Monard
8. María Belén Vecchione
9. Federico Fuentes
10. Virginia Gonzalez Polo
11. María Florencia Quiroga
12. Mónica Vermeulen
13. Thien-Phong Vu Manh
14. Rafael J Argüello
15. Sandra Inwentarz
16. Rosa Musella
17. Lorena Ciallella
18. Pablo González Montaner
19. Domingo Palmero
20. Geanncarlo Lugo Villarino
21. María del Carmen Sasiain
22. Olivier Neyrolles
23. Christel Vérollet
24. Luciana Balboa

• Curated by eLife

  eLife assessment

  This useful study tests the hypothesis that monocytes purified from tuberculosis patients differentiate into dendritic cells with different migratory capacities. The authors conclude that these monocytes are metabolically pre-conditioned to differentiate, with reduced expression of Hif1a and a glycolytically exhaustive phenotype, resulting in low migratory and immunologic potential. Overall, the evidence provided is convincing, advancing the field substantively and providing novel insights.

Reviewed by eLife

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

1. Jyotsna
2. Binayak Sarkar
3. Mohit Yadav
4. Alvina Deka
5. Manasvini Markandey
6. Priyadarshini Sanyal
7. Perumal Nagarajan
8. Nilesh Gaikward
9. Vineet Ahuja
10. Debasisa Mohanty
11. Soumen Basak
12. Rajesh S Gokhale

• Curated by eLife

  eLife assessment

  The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

Reviewed by eLife

The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

1. Pinanong Na-Phatthalung
2. Shumin Sun
3. Enjun Xie
4. Jia Wang
5. Junxia Min
6. Fudi Wang

• Curated by eLife

  eLife assessment

  Work described in this manuscript reveals the importance of the zinc transporter SLC30A1 in the antimicrobial function of macrophages, specifically against Salmonella. Cell-targeted deletion of the zinc transporter increased susceptibility of mice to systemic infection with Salmonella, leading to decreases in several cell functions such as nos2 expression. The authors argue that zinc homeostasis promotes macrophage cell function that is not conductive to the intracellular proliferation of Salmonella. This study provides novel and supportive evidence for a new pathway in nutritional immunity.

Reviewed by eLife