Immunology

  1. An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

    1. Shang Geng
    2. Xing Lv
    3. Weiwei Zheng
    4. Tianjun Xu

    • Curated by eLife

      eLife assessment

      This important study shows that in teleost fish, the RIG-I-like protein MDA5 can compensate for the absence of RIG-I by detecting 5'-triphosphorylated RNA. A fish virus containing such RNA can nevertheless evade MDA5 detection through a mechanism involving m6A methylation-induced silencing. The conclusions, which are supported by solid data, advance our understanding of antiviral immunity and virus-host conflicts in vertebrates.

    Reviewed by eLife

    13 evaluationsAppears in 1 listLatest version Latest activity

  2. Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

    1. Carolin T. Turner
    2. Joshua Rosenheim
    3. Clare Thakker
    4. Aneesh Chandran
    5. Holly Wilson
    6. Cristina Venturini
    7. Gabriele Pollara
    8. Benjamin M. Chain
    9. Gillian S. Tomlinson
    10. Mahdad Noursadeghi

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  3. The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

    1. Arijit Chakraborty
    2. Arunava Bandyopadhaya
    3. Vijay K Singh
    4. Filip Kovacic
    5. Sujin Cha
    6. William M Oldham
    7. A Aria Tzika
    8. Laurence G Rahme

    • Curated by eLife

      eLife assessment

      This important study demonstrates that the Pseudomonas aeruginosa-derived quorum sensing signal, 2-aminoacetophenone, induces immune tolerization in macrophages by perturbing metabolism, particularly in the context of mitochondrial respiration and bioenergetics. The authors present convincing evidence for 2-aminoacetophenone-mediated reduction of pyruvate transport into mitochondria, with downstream effects that result in reduced ATP production in tolerized macrophages. The work will be of interest to those studying host-pathogen interactions.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Enkephalin-mediated modulation of basal somatic sensitivity by regulatory T cells in mice

    1. Nicolas Aubert
    2. Madeleine Purcarea
    3. Julien Novarino
    4. Julien Schopp
    5. Alexis Audibert
    6. Wangtianrui Li
    7. Marie Fornier
    8. Léonie Cagnet
    9. Marie Naturel
    10. Armanda Casrouge
    11. Marie-Caroline Dieu-Nosjean
    12. Nicolas Blanchard
    13. Gilles Dietrich
    14. Cedric Peirs
    15. Gilles Marodon

    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on a new role of Foxp3+ regulatory T cells in sensory perception, which may have an impact on our understanding of somatosensory perception. The authors identified a previously unappreciated action of enkephalins released by immune cells in the resolution of pain and several upstream signals that can regulate the expression of the proenkephalin gene PENK in Foxp3+ Tregs. The generation of transgenic mice with conditional deletion of PENK in Foxp3+ cells and PENK fate-mapping is novel and generates compelling data; they also show a comprehensive analysis of Tregs in control and transgenic mice, longitudinal data on heat sensitivity and co-localization of PENK+ Tregs with thermal sensory neurons in the skin further supporting their hypothesis. The study would be of interest to the biologists working in the field of neuroimmunology and inflammation.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  5. Circadian rhythms of macrophages are altered by the acidic tumor microenvironment

    1. Amelia M Knudsen-Clark
    2. Daniel Mwangi
    3. Juliana Cazarin
    4. Kristina Morris
    5. Cameron Baker
    6. Lauren M Hablitz
    7. Matthew N McCall
    8. Minsoo Kim
    9. Brian J Altman

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  6. Defining mononuclear phagocyte distribution and behaviour in the zebrafish heart

    1. Bethany Moyse
    2. Joanna Moss
    3. Laura Bevan
    4. Aaron Scott
    5. Valérie Wittamer
    6. Rebecca J Richardson

    • Curated by eLife

      eLife assessment

      The manuscript presented by Moyse and colleagues provides valuable insight into the origin, morphology, dynamics, and behavior of several populations of mononuclear phagocytes in the zebrafish heart. The study presents solid evidence through the use of transgenic lines and live imaging, although some limitations related to lineage tracing and molecular profiles should be considered. This work exemplifies the use of zebrafish as a model to study the role of leukocytes in cardiac development and regeneration and potentially draw broader interest to biologists working in immunology fields.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  7. Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

    1. Matias A Medina
    2. Francisco Fuentes-Villalobos
    3. Claudio Quevedo
    4. Felipe Aguilera
    5. Raul Riquelme
    6. Maria Luisa Rioseco
    7. Sebastian Barria
    8. Yazmin Pinos
    9. Mario Calvo
    10. Ian Burbulis
    11. Camila Kossack
    12. Raymond A Alvarez
    13. Jose Luis Garrido
    14. Maria Ines Barria

    • Curated by eLife

      eLife assessment

      This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

    Reviewed by eLife

    8 evaluationsAppears in 1 listLatest version Latest activity

  8. Broadly inhibitory antibodies against severe malaria virulence proteins

    1. Raphael A. Reyes
    2. Sai Sundar Rajan Raghavan
    3. Nicholas K. Hurlburt
    4. Viola Introini
    5. Ikhlaq Hussain Kana
    6. Rasmus W. Jensen
    7. Elizabeth Martinez-Scholze
    8. Maria Gestal-Mato
    9. Cristina Bancells Bau
    10. Monica Lisa Fernández-Quintero
    11. Johannes R. Loeffler
    12. James Alexander Ferguson
    13. Wen-Hsin Lee
    14. Greg Michael Martin
    15. Thor G. Theander
    16. Isaac Ssewanyana
    17. Margaret E. Feeney
    18. Bryan Greenhouse
    19. Sebastiaan Bol
    20. Andrew B. Ward
    21. Maria Bernabeu
    22. Marie Pancera
    23. Louise Turner
    24. Evelien M. Bunnik
    25. Thomas Lavstsen

    Reviewed by Rapid Reviews Infectious Diseases

    3 evaluationsAppears in 1 listLatest version Latest activity

  9. REL2 overexpression in the Anopheles gambiae midgut causes major transcriptional changes but fails to induce an immune response

    1. Astrid Hoermann
    2. Paolo Capriotti
    3. Giuseppe Del Corsano
    4. Maria Grazia Inghilterra
    5. Tibebu Habtewold
    6. Julia A. Cai
    7. Gauri Sachiko Saini
    8. Huong Nguyen
    9. Nikolai Windbichler
    10. George K. Christophides

    Reviewed by PREreview

    2 evaluationsAppears in 2 listsLatest version Latest activity

  10. RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

    1. Teng-Feng Li
    2. Paul Rothhaar
    3. Arthur Lang
    4. Oliver Grünvogel
    5. Ombretta Colasanti
    6. Santa Mariela Olivera Ugarte
    7. Jannik Traut
    8. Antonio Piras
    9. Nelson Acosta-Rivero
    10. Vladimir Gonçalves Magalhães
    11. Emely Springer
    12. Andreas Betz
    13. Hao-En Huang
    14. Jeongbin Park
    15. Ruiyue Qiu
    16. Gnimah Eva Gnouamozi
    17. Ann-Kathrin Mehnert
    18. Viet Loan Dao Thi
    19. Stephan Urban
    20. Martina Muckenthaler
    21. Matthias Schlesner
    22. Dirk Wohlleber
    23. Marco Binder
    24. Ralf Bartenschlager
    25. Andreas Pichlmair
    26. Volker Lohmann

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity
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