Immunology

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male mice

1. Natalia Duque-Wilckens
2. Dimitri Joseph
3. Meesum Syed
4. Brianna Smith
5. Nidia Maradiaga
6. Szu-Ying Yeh
7. Vidhula Srinivasan
8. Fabiola Sotomayor
9. Kait Durga
10. Eric Nestler
11. Adam J Moesers
12. A.J. Robison

Reviewed by Arcadia Science

Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

1. Jitian He
2. Le Gao
3. Peiying Wang
4. Wing Keung Chan
5. Yiran Zheng
6. Yumo Zhang
7. Jiaman Sun
8. Xue Li
9. Jiming Wang
10. Xiao-Hong Li
11. Huaiyong Chen
12. Zhouxin Yang
13. Youwei Wang

• Curated by eLife

  eLife assessment

  The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

Reviewed by eLife

Control of Inflammatory Response by Tissue Microenvironment

1. Zhongyang Wu
2. Scott D. Pope
3. Nasiha S. Ahmed
4. Diana L. Leung
5. Stephanie Hajjar
6. Qiuyu Yue
7. Diya M. Anand
8. Elizabeth B. Kopp
9. Daniel Okin
10. Weiyi Ma
11. Jonathan C. Kagan
12. Diana C. Hargreaves
13. Ruslan Medzhitov
14. Xu Zhou

Reviewed by preLights

Elevated glycolytic metabolism of monocytes limits the generation of HIF1A-driven migratory dendritic cells in tuberculosis

1. Mariano Maio
2. Joaquina Barros
3. Marine Joly
4. Zoi Vahlas
5. José Luis Marín Franco
6. Melanie Genoula
7. Sarah C Monard
8. María Belén Vecchione
9. Federico Fuentes
10. Virginia Gonzalez Polo
11. María Florencia Quiroga
12. Mónica Vermeulen
13. Thien-Phong Vu Manh
14. Rafael J Argüello
15. Sandra Inwentarz
16. Rosa Musella
17. Lorena Ciallella
18. Pablo González Montaner
19. Domingo Palmero
20. Geanncarlo Lugo Villarino
21. María del Carmen Sasiain
22. Olivier Neyrolles
23. Christel Vérollet
24. Luciana Balboa

• Curated by eLife

  eLife assessment

  This useful study tests the hypothesis that monocytes purified from tuberculosis patients differentiate into dendritic cells with different migratory capacities. The authors conclude that these monocytes are metabolically pre-conditioned to differentiate, with reduced expression of Hif1a and a glycolytically exhaustive phenotype, resulting in low migratory and immunologic potential. Overall, the evidence provided is convincing, advancing the field substantively and providing novel insights.

Reviewed by eLife

A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis

1. Jyotsna
2. Binayak Sarkar
3. Mohit Yadav
4. Alvina Deka
5. Manasvini Markandey
6. Priyadarshini Sanyal
7. Perumal Nagarajan
8. Nilesh Gaikward
9. Vineet Ahuja
10. Debasisa Mohanty
11. Soumen Basak
12. Rajesh S Gokhale

• Curated by eLife

  eLife assessment

  The current version of the study presents important findings on how the RelA/Stat3-dependent gene program in the liver influences intestinal homeostasis. The evidence supporting the conclusions is solid, with new data added compared to an earlier version of the study. The work will be of interest to scientists in gastrointestinal research fields.

Reviewed by eLife

The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

1. Pinanong Na-Phatthalung
2. Shumin Sun
3. Enjun Xie
4. Jia Wang
5. Junxia Min
6. Fudi Wang

• Curated by eLife

  eLife assessment

  Work described in this manuscript reveals the importance of the zinc transporter SLC30A1 in the antimicrobial function of macrophages, specifically against Salmonella. Cell-targeted deletion of the zinc transporter increased susceptibility of mice to systemic infection with Salmonella, leading to decreases in several cell functions such as nos2 expression. The authors argue that zinc homeostasis promotes macrophage cell function that is not conductive to the intracellular proliferation of Salmonella. This study provides novel and supportive evidence for a new pathway in nutritional immunity.

Reviewed by eLife

Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

1. Zhixin Jing
2. Phillip Galbo
3. Luis Ovando
4. Megan Demouth
5. Skylar Welte
6. Rosa Park
7. Kartik Chandran
8. Yinghao Wu
9. Thomas MacCarthy
10. Deyou Zheng
11. David Fooksman

• Curated by eLife

  eLife assessment

  Despite the importance of long-lived plasma cells (LLPCs), particularly for the infection and vaccination field, it is still unclear how they acquire their longevity. With a solid genetic approach, the authors demonstrate quite convincingly a requirement for chemokine/chemokine receptor-mediated interaction in LLPC longevity. The data are very valuable for the development of new types of vaccines.

Reviewed by eLife

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

1. Dominik Trzupek
2. Melanie Dunstan
3. Antony J. Cutler
4. Mercede Lee
5. Leila Godfrey
6. Lorna Jarvis
7. Daniel B. Rainbow
8. Dominik Aschenbrenner
9. Joanne L. Jones
10. Holm H. Uhlig
11. Linda S. Wicker
12. John A. Todd
13. Ricardo C. Ferreira

Reviewed by PREreview

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

1. Hee Young Kim
2. Yeon Jun Kang
3. Dong Hyun Kim
4. Jiyeon Jang
5. Su Jeong Lee
6. Gwanghun Kim
7. Hee Byung Koh
8. Ye Eun Ko
9. Hyun Mu Shin
10. Hajeong Lee
11. Tae-Hyun Yoo
12. Won-Woo Lee

• Curated by eLife

  eLife assessment

  The authors expand the concept of a new layer to training immunity, which is currently being highlighted by several colleagues in the field. The work provides important hints to understand end-stage renal disease. Overall, the rational approach leads to experimental results that are solid.

Reviewed by eLife

Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

1. Irini Papazian
2. Maria Kourouvani
3. Anastasia Dagkonaki
4. Vasileios Gouzouasis
5. Lila Dimitrakopoulou
6. Nikolaos Markoglou
7. Fotis Badounas
8. Theodore Tselios
9. Maria Anagnostouli
10. Lesley Probert

• Curated by eLife

  eLife assessment

  The humanized model of EAE represents a valuable model in which to evaluate mechanisms that may drive EAE-like processes in vivo. The data are solid given the revisions and expansion of numbers of mice to yield more statistical rigor. This model will be used by the greater community studying EAE.

Reviewed by eLife