1. Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

    This article has 12 authors:
    1. Hee Young Kim
    2. Yeon Jun Kang
    3. Dong Hyun Kim
    4. Jiyeon Jang
    5. Su Jeong Lee
    6. Gwanghun Kim
    7. Hee Byung Koh
    8. Ye Eun Ko
    9. Hyun Mu Shin
    10. Hajeong Lee
    11. Tae-Hyun Yoo
    12. Won-Woo Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors expand the concept of a new layer to training immunity, which is currently being highlighted by several colleagues in the field. The work provides important hints to understand end-stage renal disease. Overall, the rational approach leads to experimental results that are solid.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  2. Spontaneous human CD8 T cell and autoimmune encephalomyelitis-induced CD4/CD8 T cell lesions in the brain and spinal cord of HLA-DRB1*15-positive multiple sclerosis humanized immune system mice

    This article has 10 authors:
    1. Irini Papazian
    2. Maria Kourouvani
    3. Anastasia Dagkonaki
    4. Vasileios Gouzouasis
    5. Lila Dimitrakopoulou
    6. Nikolaos Markoglou
    7. Fotis Badounas
    8. Theodore Tselios
    9. Maria Anagnostouli
    10. Lesley Probert
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The humanized model of EAE represents a valuable model in which to evaluate mechanisms that may drive EAE-like processes in vivo. The data are solid given the revisions and expansion of numbers of mice to yield more statistical rigor. This model will be used by the greater community studying EAE.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  3. Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

    This article has 7 authors:
    1. Xiaobing Lu
    2. Meisheng Yi
    3. Zhe Hu
    4. Taoran Yang
    5. Wanwan Zhang
    6. E. Neil G. Marsh
    7. Kuntong Jia

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  4. G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

    This article has 9 authors:
    1. Yi-Hong Li
    2. Yi-Sen Yang
    3. Yan-Bo Xue
    4. Hao Lei
    5. Sai-Sai Zhang
    6. Junbin Qian
    7. Yushi Yao
    8. Ruhong Zhou
    9. Liquan Huang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This, in principle, useful study suggests that the G-protein subunit Gng13 is required for limiting injury and inflammation following H1N1 influenza infection via anti-inflammatory effects from ectopic tuft cells. While support for Gng13 helping to limit influenza injury in the transgenic mouse models used here is solid, evidence for these effects being mediated by normal tuft cells remains incomplete, giving conflicting data from mice that lack tuft cells entirely.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

    This article has 12 authors:
    1. Liu Lilong
    2. Liu Zhenghao
    3. Fan Lei
    4. Yao Zhipeng
    5. Hu Junyi
    6. Hou Yaxin
    7. Li Yang
    8. Ding Yuhong
    9. Kuang Yingchun
    10. Chen Ke
    11. Hao Yi
    12. Liu Zheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study investigates the associations of four ICD-related genes in bladder cancer with increased immune cell infiltration and more prolonged survival. The study is valuable because it identifies a risk-scoring model, showing a correlation between high-risk scores based on four ICD-related genes and weak anti-tumour immune function. However, the evidence supporting the association of these genes and immunotherapy response is incomplete.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia

    This article has 10 authors:
    1. Xiaozhuo Yu
    2. Wen Zhou
    3. Xiaodong Chen
    4. Shunyu He
    5. Mengting Qin
    6. Meng Yuan
    7. Yang Wang
    8. Woodvine Otieno Odhiambo
    9. Yinsha Miao
    10. Yanhong Ji
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Using a set of animal models, this valuable paper shows tumor suppressive function of the non-core regions of RAG1/2 recombinases. The conclusions are supported by solid evidence.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  7. Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

    This article has 15 authors:
    1. Leen Farhat-Younis
    2. Manho Na
    3. Amichai Zarfin
    4. Aseel Khateeb
    5. Nadine Santana-Magal
    6. Alon Richter
    7. Amit Gutwillig
    8. Diana Rasoulouniriana
    9. Annette Gleiberman
    10. Lir Beck
    11. Tamar Giger
    12. Avraham Ashkenazi
    13. Adi Barzel
    14. Peleg Rider
    15. Yaron Carmi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The findings are fundamental for understanding IgM signaling in myeloid cells. The work is compelling in its ability to manipulate and harness myeloid cells to further anti-tumor immunity.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  8. Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

    This article has 10 authors:
    1. Phillip A Erice
    2. Xinyan Huang
    3. Matthew J Seasock
    4. Matthew J Robertson
    5. Hui-Ying Tung
    6. Melissa A Perez-Negron
    7. Shivani L Lotlikar
    8. David B Corry
    9. Farrah Kheradmand
    10. Antony Rodriguez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study indicates a significant role for individual let-7 miRNA clusters in regulating generation of Tc17 CD8 cells and emphysema severity in a mouse model. The authors provide convincing evidence for let-7-mediated repression of the transcription factor RORgt and consequent modulation of IL-17-producing CD8 T cells, with correlated data from human emphysema material, though some of the effective let-7 clusters remain to be tested for the ability to modulate disease. The findings, which substantially advance the understanding of roles that let-7 miRNA clusters play in modulating both T cell responses and emphysematous lung disease, will be of interest to T cell and lung disease researchers.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping

    This article has 5 authors:
    1. Aceer Nadeem
    2. Sarah Lyons
    3. Aidan Kindopp
    4. Amanda Jamieson
    5. Daniel Roxbury

    Reviewed by Arcadia Science

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  10. Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

    This article has 7 authors:
    1. Xiuyuan Lu
    2. Hiroki Hayashi
    3. Eri Ishikawa
    4. Yukiko Takeuchi
    5. Julian Vincent Tabora Dychiao
    6. Hironori Nakagami
    7. Sho Yamasaki
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study by Lu et al aimed to determine the key factors of T cell responses associated with durable antibody responses following the initial two shots of COVID-19 mRNA vaccinations. By comparing the SARS-CoV-2 spike protein (S)-specific T cell subsets between "Ab sustainers" and "Ab decliners" that were present post-vaccination, the authors concluded that S-specific CD4+ T cells in "Ab sustainers" were enriched with Tfh cells. There is solid evidence as the authors applied multiple methods and approaches to address the key questions, and the presented data are robust.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
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