Immunology

Mast cell-derived BH4 is a critical mediator of postoperative pain

1. Philipp Starkl
2. Gustav Jonsson
3. Tyler Artner
4. Bruna Lenfers Turnes
5. Nadine Serhan
6. Tiago Oliveira
7. Laura-Marie Gail
8. Karel Stejskal
9. Keith M. Channon
10. Thomas Köcher
11. Georg Stary
12. Victoria Klang
13. Nicolas Gaudenzio
14. Sylvia Knapp
15. Clifford J. Woolf
16. Josef M. Penninger
17. Shane J.F. Cronin

Reviewed by Arcadia Science

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

1. Luna Dillemans
2. Karen Yu
3. Alexandra De Zutter
4. Sam Noppen
5. Mieke Gouwy
6. Nele Berghmans
7. Mirre De Bondt
8. Lotte Vanbrabant
9. Stef Brusselmans
10. Erik Martens
11. Dominique Schols
12. Pedro Elias Marques
13. Sofie Struyf
14. Paul Proost

Reviewed by Review Commons

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

1. MC Rice
2. JS Kim
3. M Imun
4. SW Jung
5. CY Park
6. RW Lai
7. CR Barr
8. JM Son
9. K Tor
10. E Kim
11. RJ Lu
12. I Cohen
13. BA Benayoun
14. C Lee

• Curated by eLife

  eLife assessment

  This valuable study presents findings on the mode of action of MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c), and its impact on monocyte-derived macrophages. The authors present solid evidence for its increased expression in stimulated monocytes/macrophages, its direct bactericidal functions, as well as its role in the modulation of monocyte differentiation into macrophages. Since most of the data were generated from a cell line (THP1), future work is required to validate observations in primary cells and to further support the claims of this work.

Reviewed by eLife

Quantitative analyses of T cell motion in tissue reveals factors driving T cell search in tissues

1. David J Torres
2. Paulus Mrass
3. Janie Byrum
4. Arrick Gonzales
5. Dominick N Martinez
6. Evelyn Juarez
7. Emily Thompson
8. Vaiva Vezys
9. Melanie E Moses
10. Judy L Cannon

• Curated by eLife

  eLife assessment

  This is a valuable study that quantifies CD8 T cell movement in different tissue environments and concludes that T cells display more confined movement in the inflamed lung than in lymph nodes or intestinal villi. The evidence supporting conclusions is solid with well-defined measurements and sufficient statistical analysis. The work will stimulate further efforts to understand the mechanisms behind the different behaviour of T cells that are important in host defence against intracellular pathogens and cancer.

Reviewed by eLife

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

1. Aarathy Ravi Sundar Jose Geetha
2. Katrin Fischer
3. Georg Smesnik
4. Alex Vogt
5. Ekaterini Platanitis
6. Mathias Müller
7. Matthias Farlik
8. Thomas Decker

Reviewed by Review Commons

Decoupled neoantigen cross-presentation by dendritic cells limits anti-tumor immunity against tumors with heterogeneous neoantigen expression

1. Kim Bich Nguyen
2. Malte Roerden
3. Christopher J Copeland
4. Coralie M Backlund
5. Nory G Klop-Packel
6. Tanaka Remba
7. Byungji Kim
8. Nishant K Singh
9. Michael E Birnbaum
10. Darrell J Irvine
11. Stefani Spranger

• Curated by eLife

  eLife assessment

  This important work advances our understanding of the import of clonal heterogeneity in cancers in immune response to individual antigens. The evidence supporting the conclusions is convincing, and uses interesting tools, although the mechanistic basis of the observations is unclear. The work will be of broad interest to immunologists including cancer immunologists.

Reviewed by eLife

A simple protein-based surrogate neutralization assay for SARS-CoV-2

1. Kento T. Abe
2. Zhijie Li
3. Reuben Samson
4. Payman Samavarchi-Tehrani
5. Emelissa J. Valcourt
6. Heidi Wood
7. Patrick Budylowski
8. Alan P. Dupuis
9. Roxie C. Girardin
10. Bhavisha Rathod
11. Jenny H. Wang
12. Miriam Barrios-Rodiles
13. Karen Colwill
14. Allison J. McGeer
15. Samira Mubareka
16. Jennifer L. Gommerman
17. Yves Durocher
18. Mario Ostrowski
19. Kathleen A. McDonough
20. Michael A. Drebot
21. Steven J. Drews
22. James M. Rini
23. Anne-Claude Gingras

Reviewed by ScreenIT

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

1. Els Wauters
2. Pierre Van Mol
3. Abhishek Dinkarnath Garg
4. Sander Jansen
5. Yannick Van Herck
6. Lore Vanderbeke
7. Ayse Bassez
8. Bram Boeckx
9. Bert Malengier-Devlies
10. Anna Timmerman
11. Thomas Van Brussel
12. Tina Van Buyten
13. Rogier Schepers
14. Elisabeth Heylen
15. Dieter Dauwe
16. Christophe Dooms
17. Jan Gunst
18. Greet Hermans
19. Philippe Meersseman
20. Dries Testelmans
21. Jonas Yserbyt
22. Sabine Tejpar
23. Walter De Wever
24. Patrick Matthys
25. CONTAGIOUS collaborators
26. Maria Bosisio
27. Michael Casaer
28. Frederik De Smet
29. Paul De Munter
30. Stephanie Humblet-Baron
31. Adrian Liston
32. Natalie Lorent
33. Kim Martinod
34. Paul Proost
35. Jeroen Raes
36. Karin Thevissen
37. Robin Vos
38. Birgit Weynand
39. Carine Wouters
40. Johan Neyts
41. Joost Wauters
42. Junbin Qian
43. Diether Lambrechts

Reviewed by ScreenIT

Which animals are at risk? Predicting species susceptibility to Covid-19

1. MR Alexander
2. CT Schoeder
3. JA Brown
4. CD Smart
5. C Moth
6. JP Wikswo
7. JA Capra
8. J Meiler
9. W Chen
10. MS Madhur

Reviewed by ScreenIT

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice

1. James Brett Case
2. Paul W. Rothlauf
3. Rita E. Chen
4. Natasha M. Kafai
5. Julie M. Fox
6. Brittany K. Smith
7. Swathi Shrihari
8. Broc T. McCune
9. Ian B. Harvey
10. Shamus P. Keeler
11. Louis-Marie Bloyet
12. Haiyan Zhao
13. Meisheng Ma
14. Lucas J. Adams
15. Emma S. Winkler
16. Michael J. Holtzman
17. Daved H. Fremont
18. Sean P.J. Whelan
19. Michael S. Diamond

Reviewed by ScreenIT