Immunology

Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

1. Xiaobing Lu
2. Meisheng Yi
3. Zhe Hu
4. Taoran Yang
5. Wanwan Zhang
6. E. Neil G. Marsh
7. Kuntong Jia

Reviewed by preLights

G protein subunit Gγ13-mediated signaling pathway is critical to the inflammation resolution and functional recovery of severely injured lungs

1. Yi-Hong Li
2. Yi-Sen Yang
3. Yan-Bo Xue
4. Hao Lei
5. Sai-Sai Zhang
6. Junbin Qian
7. Yushi Yao
8. Ruhong Zhou
9. Liquan Huang

• Curated by eLife

  eLife assessment

  This, in principle, useful study suggests that the G-protein subunit Gng13 is required for limiting injury and inflammation following H1N1 influenza infection via anti-inflammatory effects from ectopic tuft cells. While support for Gng13 helping to limit influenza injury in the transgenic mouse models used here is solid, evidence for these effects being mediated by normal tuft cells remains incomplete, giving conflicting data from mice that lack tuft cells entirely.

Reviewed by eLife

An Evaluation of the Tumor Microenvironment through CALR, IL1R1, IFNB1, and IFNG to Assess Prognosis and Immunotherapy Response in Bladder Cancer Patients

1. Liu Lilong
2. Liu Zhenghao
3. Fan Lei
4. Yao Zhipeng
5. Hu Junyi
6. Hou Yaxin
7. Li Yang
8. Ding Yuhong
9. Kuang Yingchun
10. Chen Ke
11. Hao Yi
12. Liu Zheng

• Curated by eLife

  eLife assessment

  This study investigates the associations of four ICD-related genes in bladder cancer with increased immune cell infiltration and more prolonged survival. The study is valuable because it identifies a risk-scoring model, showing a correlation between high-risk scores based on four ICD-related genes and weak anti-tumour immune function. However, the evidence supporting the association of these genes and immunotherapy response is incomplete.

Reviewed by eLife

RAG1 and RAG2 non-core regions are implicated in leukemogenesis and off-target V(D)J recombination in BCR-ABL1-driven B-cell lineage lymphoblastic leukemia

1. Xiaozhuo Yu
2. Wen Zhou
3. Xiaodong Chen
4. Shunyu He
5. Mengting Qin
6. Meng Yuan
7. Yang Wang
8. Woodvine Otieno Odhiambo
9. Yinsha Miao
10. Yanhong Ji

• Curated by eLife

  eLife assessment

  Using a set of animal models, this valuable paper shows tumor suppressive function of the non-core regions of RAG1/2 recombinases. The conclusions are supported by solid evidence.

Reviewed by eLife

Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

1. Leen Farhat-Younis
2. Manho Na
3. Amichai Zarfin
4. Aseel Khateeb
5. Nadine Santana-Magal
6. Alon Richter
7. Amit Gutwillig
8. Diana Rasoulouniriana
9. Annette Gleiberman
10. Lir Beck
11. Tamar Giger
12. Avraham Ashkenazi
13. Adi Barzel
14. Peleg Rider
15. Yaron Carmi

• Curated by eLife

  eLife assessment

  The findings are fundamental for understanding IgM signaling in myeloid cells. The work is compelling in its ability to manipulate and harness myeloid cells to further anti-tumor immunity.

Reviewed by eLife

Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

1. Phillip A Erice
2. Xinyan Huang
3. Matthew J Seasock
4. Matthew J Robertson
5. Hui-Ying Tung
6. Melissa A Perez-Negron
7. Shivani L Lotlikar
8. David B Corry
9. Farrah Kheradmand
10. Antony Rodriguez

• Curated by eLife

  eLife assessment

  This important study indicates a significant role for individual let-7 miRNA clusters in regulating generation of Tc17 CD8 cells and emphysema severity in a mouse model. The authors provide convincing evidence for let-7-mediated repression of the transcription factor RORgt and consequent modulation of IL-17-producing CD8 T cells, with correlated data from human emphysema material, though some of the effective let-7 clusters remain to be tested for the ability to modulate disease. The findings, which substantially advance the understanding of roles that let-7 miRNA clusters play in modulating both T cell responses and emphysematous lung disease, will be of interest to T cell and lung disease researchers.

Reviewed by eLife

Machine Learning Assisted Spectral Fingerprinting for Immune Cell Phenotyping

1. Aceer Nadeem
2. Sarah Lyons
3. Aidan Kindopp
4. Amanda Jamieson
5. Daniel Roxbury

Reviewed by Arcadia Science

Early acquisition of S-specific Tfh clonotypes after SARS-CoV-2 vaccination is associated with the longevity of anti-S antibodies

1. Xiuyuan Lu
2. Hiroki Hayashi
3. Eri Ishikawa
4. Yukiko Takeuchi
5. Julian Vincent Tabora Dychiao
6. Hironori Nakagami
7. Sho Yamasaki

• Curated by eLife

  eLife assessment

  This important study by Lu et al aimed to determine the key factors of T cell responses associated with durable antibody responses following the initial two shots of COVID-19 mRNA vaccinations. By comparing the SARS-CoV-2 spike protein (S)-specific T cell subsets between "Ab sustainers" and "Ab decliners" that were present post-vaccination, the authors concluded that S-specific CD4+ T cells in "Ab sustainers" were enriched with Tfh cells. There is solid evidence as the authors applied multiple methods and approaches to address the key questions, and the presented data are robust.

Reviewed by eLife

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

1. João Paulo Portela Catani
2. Anouk Smet
3. Tine Ysenbaert
4. Marnik Vuylsteke
5. Guy Bottu
6. Janick Mathys
7. Alexander Botzki
8. Guadalupe Cortes-Garcia
9. Tod Strugnell
10. Raul Gomila
11. John Hamberger
12. John Catalan
13. Irina V Ustyugova
14. Timothy Farrell
15. Svetlana Stegalkina
16. Satyajit Ray
17. Lauren LaRue
18. Xavier Saelens
19. Thorsten U Vogel

• Curated by eLife

  eLife assessment

  This study presents valuable data on the antigenic properties of neuraminidase proteins of human A/H3N2 influenza viruses sampled between 2009 and 2017. The antigenic properties are found to be generally concordant with genetic groups. Compared to a previous version, additional analyses have strengthened the work, with solid evidence supporting the claims of the authors.

Reviewed by eLife

RIPK3 coordinates RHIM domain-dependent inflammatory transcription in neurons

1. Sigal B. Kofman
2. Lan H. Chu
3. Joshua M. Ames
4. Suny Dayane Chavarria
5. Katrina Lichauco
6. Brian P. Daniels
7. Andrew Oberst

Reviewed by preLights