Immunology

RBM39 shapes innate immunity through transcriptional and splicing control of key factors of the interferon response

1. Teng-Feng Li
2. Paul Rothhaar
3. Arthur Lang
4. Oliver Grünvogel
5. Ombretta Colasanti
6. Santa Mariela Olivera Ugarte
7. Jannik Traut
8. Antonio Piras
9. Nelson Acosta-Rivero
10. Vladimir Gonçalves Magalhães
11. Emely Springer
12. Andreas Betz
13. Hao-En Huang
14. Jeongbin Park
15. Ruiyue Qiu
16. Gnimah Eva Gnouamozi
17. Ann-Kathrin Mehnert
18. Viet Loan Dao Thi
19. Stephan Urban
20. Martina Muckenthaler
21. Matthias Schlesner
22. Dirk Wohlleber
23. Marco Binder
24. Ralf Bartenschlager
25. Andreas Pichlmair
26. Volker Lohmann

Reviewed by Review Commons

Thymic self-recognition-mediated TCR signal strength modulates antigen-specific CD8+ T cell pathogenicity in non-obese diabetic mice

1. Chia-Lo Ho
2. Li-Tzu Yeh
3. Yu-Wen Liu
4. Jia-Ling Dong
5. Huey-Kang Sytwu

• Curated by eLife

  eLife assessment

  This valuable study explores T cell receptor activation during autoreactive T cell development and how the strength of T cell receptor engagement in naïve cells can predispose T cells to develop into effector/memory T cells. Solid evidence confirms published data that naïve T cells with higher CD5 expression were poised for activation and more pathogenic in the mouse model of autoimmune diabetes. However, the evidence regarding the regulation of differentiation of these cells during development is still incomplete.

Reviewed by eLife

Amphibian mast cells serve as barriers to chytrid fungus infections

1. Kelsey A Hauser
2. Christina N Garvey
3. Ryley S Crow
4. Muhammad RH Hossainey
5. Dustin T Howard
6. Netra Ranganathan
7. Lindsey K Gentry
8. Amulya Yaparla
9. Namarta Kalia
10. Mira Zelle
11. Elizabeth J Jones
12. Anju N Duttargi
13. Louise A Rollins-Smith
14. Carly R Muletz-Wolz
15. Leon Grayfer

• Curated by eLife

  eLife assessment

  This important study reveals the role of skin-resident mast cells in amphibians in mediating antimicrobial responses. The data are compelling and highlight species-specific biology that can cross-inform human mast cell biology in a species that does not rely on IgE as a primary mechanism for antimicrobial skin responses.

Reviewed by eLife

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to Plasmodium infection

1. Kely C Matteucci
2. Patricia A Assis
3. Isabella C Hirako
4. Nathalia PS Leite
5. Franciele Pioto
6. Ogooluwa Ojelabi
7. Juliana E Toller-Kawahisa
8. Diego L Costa
9. João S Da Silva
10. José C Alves-Filho
11. Ricardo T Gazzinelli

• Curated by eLife

  eLife assessment

  This important study examines the role of TNF in modulating energy metabolism during parasite infection. The authors perform an elegant set of studies, however the evidence supporting the major claims of the manuscript is incomplete. This work integrates an interesting set of observations that will be of interest to the Plasmodium and pathogenesis communities with an expanded set of experiments.

Reviewed by eLife

Ixodes ricinus bites promote allergic skin inflammation and intestinal tuft and mast cell expansion in mice

1. Juan Manuel Leyva-Castillo
2. Maria Strakosha
3. Sophia E.M. Smith
4. Daniela Vega-Mendoza
5. Megan Elkins
6. Janet Chou
7. Peter Vogel
8. Nathalie Boulanger

Reviewed by Arcadia Science

Tissue inflammation induced by constitutively active STING is mediated by enhanced TNF signaling

1. Hella Luksch
2. Felix Schulze
3. David Geißler-Lösch
4. David Sprott
5. Lennart Höfs
6. Eva M Szegö
7. Wulf Tonnus
8. Stefan Winkler
9. Claudia Günther
10. Andreas Linkermann
11. Rayk Behrendt
12. Lino L Teichmann
13. Björn H Falkenburger
14. Angela Rösen-Wolff

Reviewed by Review Commons

Heterologous booster with a novel formulation containing glycosylated trimeric S protein is effective against Omicron

1. Daniela Bottero
2. Erika Rudi
3. Pablo Martin Aispuro
4. Eugenia Zurita
5. Emilia Gaillard
6. Maria M. Gonzalez Lopez Ledesma
7. Juan Malito
8. Matthew Stuible
9. Nicolas Ambrosis
10. Yves Durocher
11. Andrea V. Gamarnik
12. Andrés Wigdorovitz
13. Daniela Hozbor

Reviewed by Rapid Reviews Infectious Diseases

Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice

1. Zhengyang Lei
2. Shiyao Zhai
3. Xi Yuan
4. Runming Wang
5. Yunpeng Wang
6. Vijay Pandey
7. Can Yang Zhang
8. Jiansong Ji
9. Dongmei Yu
10. Zhenglin Chen
11. Sumin Bian
12. Peiwu Qin

Reviewed by Rapid Reviews Infectious Diseases

XBB.1.5 monovalent mRNA vaccine booster elicits robust neutralizing antibodies against emerging SARS-CoV-2 variants

1. Qian Wang
2. Yicheng Guo
3. Anthony Bowen
4. Ian A. Mellis
5. Riccardo Valdez
6. Carmen Gherasim
7. Aubree Gordon
8. Lihong Liu
9. David D. Ho

Reviewed by Rapid Reviews Infectious Diseases

Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

1. Ruth Connor
2. Mrunal Sakharkar
3. Garrett Rappazzo
4. Chengzi Kaku
5. Nicholas Curtis
6. Seungmin Shin
7. Wendy Wieland-Alter
8. Jordan Wentworth
9. Daniel Mielcarz
10. Joshua Weiner
11. Margaret Ackerman
12. Laura Walker
13. Jiwon Lee
14. Peter Wright

Reviewed by Rapid Reviews Infectious Diseases