Immunology

Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses

1. Susanna E Barouch
2. Taras M Chicz
3. Ross Blanc
4. Domenic R Barbati
5. Lily J Parker
6. Xin Tong
7. Wenjun Li
8. Ryan P McNamara

Reviewed by PREreview

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

1. Huiyun Lyu
2. Guohua Yuan
3. Xinyi Liu
4. Xiaobo Wang
5. Shuang Geng
6. Tie Xia
7. Xuyu Zhou
8. Yinqing Li
9. Xiaoyu Hu
10. Yan Shi

• Curated by eLife

  eLife assessment

  This study presents the valuable finding that sustained calcium signaling in induced-Treg (iTreg) cells can lead to the loss of Foxp3 expression and iTreg identity by altering the chromatin landscape. The evidence supporting the claims of the authors is convincing. The work will be of interest to immunologists working on Treg cell therapy.

Reviewed by eLife

Apoptotic signaling clears engineered Salmonella in an organ-specific manner

1. Taylor J Abele
2. Zachary P Billman
3. Lupeng Li
4. Carissa K Harvest
5. Alexia K Bryan
6. Gabrielle R Magalski
7. Joseph P Lopez
8. Heather N Larson
9. Xiao-Ming Yin
10. Edward A Miao

• Curated by eLife

  eLife assessment

  Host cell death is an effective strategy to protect against infection, and is believed to function primarily by the elimination of the intracellular niche for pathogen replication. Abele and colleagues address an important question: does the mode of cell death affect its effectiveness in pathogen clearance? Consistent with prior observations, the authors provide compelling new evidence that the answer can depend on the cell type and/or tissue involved.

Reviewed by eLife

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

1. Musleh M Muthana
2. Xuexiang Du
3. Mingyue Liu
4. Xu Wang
5. Wei Wu
6. Chunxia Ai
7. Lishan Su
8. Pan Zheng
9. Yang Liu

• Curated by eLife

  eLife assessment

  This valuable study presents presents solid evidence that an anti-CTLA-4 antibody drug conjugate transiently depletes circulating B cells in a mouse model, showing how dysregulation of the T cell immune system can impact B cell homeostasis. The work will be of broad interest to immunologists and medical biologists, but a major limitation is that the mechanism of B-cell reduction remains unclear, as evidence of killing of B-cells by T-cells is not presented.

Reviewed by eLife

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

1. Rami Musharrafieh
2. Yana Safonova
3. Ge Song
4. Ryan S. Roark
5. Fang-Hua Lee
6. Shiyu Zhang
7. Jonathan Hurtado
8. Peter Yong
9. Shuyi Wang
10. Ronnie M. Russell
11. Wenge Ding
12. Yingying Li
13. Juliette Rando
14. Alexander I. Murphy
15. Emily Lindemuth
16. Chengyan Zhao
17. Andrew Jesse Connell
18. Wen-Hsin Lee
19. Nitesh Mishra
20. Gabriel Avillion
21. Wanting He
22. Sean Callaghan
23. Katharina Dueker
24. Anh L. Vo
25. Xuduo Li
26. Tazio Capozzola
27. Collin Joyce
28. Fangzhu Zhao
29. Fabio Anzanello
30. Weimin Liu
31. Frederic Bibollet-Ruche
32. Alejandra Ramos
33. Hui Li
34. Mark G. Lewis
35. Gabriel Ozorowski
36. Elise Landais
37. Brian T. Foley
38. Kshitij Wagh
39. Devin Sok
40. Bryan Briney
41. Andrew B. Ward
42. Beatrice H. Hahn
43. Dennis R. Burton
44. George M. Shaw
45. Raiees Andrabi

Reviewed by Rapid Reviews Infectious Diseases

Regulation of pDC fate determination by histone deacetylase 3

1. Yijun Zhang
2. Tao Wu
3. Zhimin He
4. Wenlong Lai
5. Xiangyi Shen
6. Jiaoyan Lv
7. Yuanhao Wang
8. Li Wu

• Curated by eLife

  eLife assessment

  This study examines the expression of HDAC3 within DC compartment. Taking advantage of tamoxifen inducible ERT2-cre mouse model they observe the dependency of pDCs but not cDCs on HDAC3. The requirement of this histone modifier appears to occur during development around the CLP stage. Tamoxifen treated mice lack almost all pDC besides lymphoid progenitors. RNA seq studies identify multiple DC specific target genes within the remaining pDC - using Cut and Tag technology they validate some of the identified targets of HDAC3. Taken together, this study shows the requirement of HDAC3 on pDC but not cDC, congruent with the recent findings of a lymphoid origin of pDC.

Reviewed by eLife

H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

1. Robin A. Welsh
2. Nianbin Song
3. Chan-Su Park
4. J. David Peske
5. Scheherazade Sadegh-Nasseri

• Curated by eLife

  eLife assessment

  This paper seeks to understand how the presentation of peptides by medullary thymic epithelial cells may be regulated by the MHCII peptide loading modulator, H2-O, and how this may affect the selection of regulatory T (Treg) cells. Further work is needed to ensure that the findings are robust: currently the analysis of data is inadequate and inconsistencies in the reported findings are not placed in context with results from other groups. The current version does not provide sufficient support for the claims regarding the effects on Treg cell selection.

Reviewed by eLife

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

1. Jaemoon Koh
2. Yeon Duk Woo
3. Hyun Jung Yoo
4. Jun-Pyo Choi
5. Sae Hoon Kim
6. Yoon-Seok Chang
7. Kyeong Cheon Jung
8. Ji Hyung Kim
9. Yoon Kyung Jeon
10. Hye Young Kim
11. Doo Hyun Chung

• Curated by eLife

  eLife assessment

  The study's results offer a fundamental insight into how ACC1-mediated fatty-acid synthesis affects the survival and pathogenicity of iNKT cells in allergic asthma. The inclusion of mouse models, involving genetic adjustments and reconstitution experiments, along with the disparities found in iNKT cells between allergic asthma patients and control subjects in human studies, adds compelling evidence that substantiates these findings.

Reviewed by eLife

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections

1. Björn Klabunde
2. André Wesener
3. Wilhelm Bertrams
4. Isabell Beinborn
5. Nicole Paczia
6. Kristin Surmann
7. Sascha Blankenburg
8. Jochen Wilhelm
9. Javier Serrania
10. Kèvin Knoops
11. Eslam M. Elsayed
12. Katrin Laakmann
13. Anna Lena Jung
14. Andreas Kirschbaum
15. Sven Hammerschmidt
16. Belal Alshaar
17. Nicolas Gisch
18. Mobarak Abu Mraheil
19. Anke Becker
20. Uwe Völker
21. Evelyn Vollmeister
22. Birke J. Benedikter
23. Bernd Schmeck

Reviewed by preLights

Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

1. Jian Cui
2. Hua Li
3. Guoying Zhang
4. Yan Zhang
5. Ling Yang
6. Martha M.S. Sim
7. Jeremy P. Wood
8. Yinan Wei
9. Zhenyu Li
10. Congqing Wu

• Curated by eLife

  eLife assessment

  The authors aim to elucidate the mechanism by which pyroptosis contributes to the increased release of procoagulant tissue factor-containing microvesicles. The data are intriguing and attempt to shed light on the mechanism by which GSDMD plays a role in releasing tissue factor-containing microvesicles, albeit incomplete. The manuscript offers valuable information to unveil new therapeutic targets in human diseases such as sepsis, which can be further strengthened by consulting the reviewers' suggestions.

Reviewed by eLife