Immunology

Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation

1. J E Parkinson
2. M Ghafoor
3. R J Dodd
4. H E Tompkins
5. M Fergie
6. M Rattray
7. J E Allen
8. T E Sutherland

Reviewed by Review Commons

Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

1. Jian Cui
2. Hua Li
3. Dien Ye
4. Guoying Zhang
5. Yan Zhang
6. Ling Yang
7. Martha MS Sim
8. Jeremy P Wood
9. Yinan Wei
10. Zhenyu Li
11. Congqing Wu

• Curated by eLife

  eLife Assessment

  The authors aim to elucidate the mechanism by which pyroptosis (through the formation of Gasdermin D (GSDMD) pores in the plasma membrane) contributes to increased release of procoagulant Tissue Factor-containing microvesicles. The data offers solid mechanistic insights as to the interplay between pyroptosis and microvesicle release with NINJ1. The study provides useful insights into the potential of targeting Ninj1 as a therapeutic strategy.

Reviewed by eLife

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

1. Kevin Wilhelmsen
2. Aditi Deshpande
3. Sarah Tronnes
4. Maitriyee Mahanta
5. Matthew Banicki
6. Mary Cochran
7. Samantha Cowdin
8. Kristen Fortney
9. George Hartman
10. Robert Hughes
11. Rusty Montgomery
12. Claudia Portillo
13. Paul Rubin
14. Yan Wang
15. Shijun Yan
16. Barry A Morgan
17. Assem Duisembekova
18. Romane Riou
19. Michael Marleaux
20. Inga V. Hochheiser
21. Hannes Buthmann
22. Dominic Ferber
23. Wei Wang
24. Melanie Cranston
25. Chloe M. McKee
26. Thea Mawhinney
27. Emma McKay
28. Bénédicte F. Py
29. Matthias Geyer
30. Rebecca C. Coll

Reviewed by preLights

SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

1. Hiroyuki Yamamoto
2. Tetsuro Matano

Reviewed by eLife

Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

1. Adam Kim
2. Megan R McMullen
3. Annette Bellar
4. David Streem
5. Jaividhya Dasarathy
6. Nicole Welch
7. Srinivasan Dasarathy

Reviewed by eLife

Unraveling the power of NAP-CNB’s machine learning-enhanced tumor neoantigen prediction

1. Almudena Mendez-Perez
2. Andres M Acosta-Moreno
3. Carlos Wert-Carvajal
4. Pilar Ballesteros-Cuartero
5. Ruben Sánchez-García
6. Jose R Macias
7. Rebeca Sanz-Pamplona
8. Ramon Alemany
9. Carlos Oscar Sorzano
10. Arrate Munoz-Barrutia
11. Esteban Veiga

Reviewed by eLife

Expression of a single inhibitory member of the Ly49 receptor family is sufficient to license NK cells for effector functions

1. Sytse J Piersma
2. Shasha Li
3. Pamela Wong
4. Michael D Bern
5. Jennifer Poursine-Laurent
6. Liping Yang
7. Diana L Beckman
8. Bijal A Parikh
9. Wayne M Yokoyama

Reviewed by eLife

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

1. Alexander J Knights
2. Easton C Farrell
3. Olivia M Ellis
4. Michelle J Song
5. C Thomas Appleton
6. Tristan Maerz

• Curated by eLife

  eLife assessment

  This study provides useful information by identifying the cell type (macrophages) in synovial tissues involved in the pathogenesis of post-traumatic osteoarthritis (OA) and clarifying distinct transcriptomic signatures that may be a good therapeutic target for OA. However, the analysis performed so far is incomplete, with a main weakness being the lack of data to confirm the authors' speculation about the underlying mechanisms.

Reviewed by eLife

Acquisition of an immunosuppressive microenvironment after CAR-T therapy drives T-cell dysfunction and resistance

1. Marianna Ponzo
2. Lorenzo Drufuca
3. Chiara Buracchi
4. Marco M. Sindoni
5. Silvia Nucera
6. Cristina Bugarin
7. Ramona Bason
8. Grazisa Rossetti
9. Raoul Bonnal
10. Cristian Meli
11. Benedetta Rambaldi
12. Federico Lussana
13. Silvia Ferrari
14. Alex Moretti
15. Giulia Risca
16. Christian Pellegrino
17. Markus G. Manz
18. Stefania Galimberti
19. Alessandro Rambaldi
20. Giuseppe Gaipa
21. Andrea Biondi
22. Massimiliano Pagani
23. Chiara F. Magnani

Reviewed by PREreview

T3SS translocon induces pyroptosis by direct interaction with NLRC4/NAIP inflammasome

1. Yan Zhao
2. Hanshuo Zhu
3. Jinqian Li
4. Hang Xu
5. Li Sun

Reviewed by eLife