Immunology

Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

1. Sofia V Krasik
2. Ekaterina A Bryushkova
3. George V Sharonov
4. Daria S Myalik
5. Elizaveta V Shurganova
6. Dmitry V Komarov
7. Irina A Shagina
8. Polina S Shpudeiko
9. Maria A Turchaninova
10. Maria T Vakhitova
11. Igor V Samoylenko
12. Dimitr T Marinov
13. Lev V Demidov
14. Vladimir E Zagaynov
15. Dmitriy M Chudakov
16. Ekaterina O Serebrovskaya

• Curated by eLife

  eLife Assessment

  This useful paper systematically evaluates B-cell receptor (BCR) repertoires across tumors, tumor-draining lymph nodes, and peripheral blood in patients with melanoma, lung adenocarcinoma, and colorectal cancer. It investigates the interplay between the tumor microenvironment and immune responses, revealing differences in BCR clonotype maturity, hypermutation, and spatial distribution. The study highlights the heterogeneity in immune responses and provides solid insights into the potential of tumor-infiltrating B cells for therapeutic applications, despite limitations in patient cohort size and sequencing methodology.

Reviewed by eLife

UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

1. Mykhailo Vladymyrov
2. Luca Marchetti
3. Sidar Aydin
4. Sasha GN Soldati
5. Adrien Mossu
6. Arindam Pal
7. Laurent Gueissaz
8. Akitaka Ariga
9. Britta Engelhardt

• Curated by eLife

  eLife Assessment

  This work is important because it elucidates how immune cells migrate across the blood brain barrier. In the revised version of this study, the authors present a convincing framework to visualize, recognize and track the movement of different immune cells across primary human and mouse brain microvascular endothelial cells without the need for fluorescence-based imaging using microfluidic devices. This work will be of broad interest to the cancer biology, immunology and medical therapeutics fields.

Reviewed by eLife

Investigating the antimicrobial and immunomodulatory effects of honeybee venom peptide apamin in the Drosophila genetic platform

1. Yanan Wei
2. Wenjie Jia
3. Yanying Sun
4. Tianmu Zhang
5. Hongyu Miao
6. Zekun Wu
7. Ran Dong
8. Fangyong Ning
9. Woo Jae Kim

Reviewed by Review Commons

Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

1. Zoï Vahlas
2. Natacha Faivre
3. Sarah C. Monard
4. Quentin Hertel
5. Mariano Maio
6. Joaquina Barros
7. Alexandre Lucas
8. Thien-Phong Vu Manh
9. Myriam Ben Neji
10. Marcelo Corti
11. Renaud Poincloux
12. Fabien Blanchet
13. Brigitte Raynaud-Messina
14. Fabien Letisse
15. Olivier Neyrolles
16. Geanncarlo Lugo-Villarino
17. Luciana Balboa
18. Christel Vérollet

Reviewed by Review Commons

Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

1. Miki Kume
2. Hanako Koguchi-Yoshioka
3. Shuichi Nakai
4. Yutaka Matsumura
5. Atsushi Tanemura
6. Kazunori Yokoi
7. Shoichi Matsuda
8. Yuumi Nakamura
9. Naoya Otani
10. Mifue Taminato
11. Koichi Tomita
12. Tateki Kubo
13. Mari Wataya-Kaneda
14. Atsushi Kumanogoh
15. Manabu Fujimoto
16. Rei Watanabe

• Curated by eLife

  eLife Assessment

  This paper advances an important new concept in psoriasis pathogenesis and implicates Sema4a as a homeostatic regulator that is highly epithelial-specific. The findings are convincing and lend support for the biology described here as a mechanism with therapeutic implications.

Reviewed by eLife

Identification of a Neuroimmune Circuit that Regulates Allergic Inflammation in the Esophagus

1. Kendall Kellerman
2. Mia Natale
3. Eddie Gerstner
4. Yrina Rochman
5. Mark Rochman
6. Michael P. Jankowski
7. Marc E. Rothenberg

Reviewed by Arcadia Science

Proximity labeling defines the phagosome lumen proteome of murine and primary human macrophages

1. Benjamin L. Allsup
2. Supriya Gharpure
3. Bryan D. Bryson

Reviewed by Arcadia Science

NK cell exhaustion in Wilson’s disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis

1. Yong Jin
2. Jiayu Xing
3. Chenyu Dai
4. Lei Jin
5. Wanying Zhang
6. Qianqian Tao
7. Mei Hou
8. Ziyi Li
9. Wen Yang
10. Qiyu Feng
11. Hongyang Wang
12. Qingsheng Yu

• Curated by eLife

  eLife Assessment

  This study presents valuable findings, based on solid methods, to link metabolic dysfunction in Wilson's disease to immune cell dysregulation and poor cholecystitis outcomes. The integration of clinical data and single-cell analyses highlights NK cell exhaustion as a key factor, offering insights with potential therapeutic implications. The work will be of interest to colleagues in inflammatory and metabolic diseases.

Reviewed by eLife

Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns

1. Ole Bæk
2. Tik Muk
3. Ziyuan Wu
4. Yongxin Ye
5. Bekzod Khakimov
6. Alessandra Maria Casano
7. Bagirath Gangadharan
8. Ivan Bilic
9. Anders Brunse
10. Per Torp Sangild
11. Duc Ninh Nguyen

• Curated by eLife

  eLife Assessment

  The study follows up on previous work suggesting that lower glucose concentrations are protective from sepsis but put the patient at risk for hypoglycemia. In this paper, the authors identify that a slightly higher dose of glucose is still protective but no longer puts the patients at risk for hypoglycemia. The study is important, supported by convincing data, and will be of interest to a broad audience.

Reviewed by eLife

Syngeneic natural killer cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases

1. Shih-Wen Huang
2. Yein-Gei Lai
3. Hao-Ting Liao
4. Chin-Ling Chang
5. Ruo-Yu Ma
6. Yung-Hsiang Chen
7. Yae-Huei Liou
8. Zhen-Qi Wu
9. Yu-Chen Wu
10. Ko-Jiunn Liu
11. Yen-Tsung Huang
12. Jen-Lung Yang
13. Ming-Shen Dai
14. Nan-Shih Liao

• Curated by eLife

  eLife Assessment

  In this important study the authors develop an elegant lung metastasis mouse model that closely mimics the events in human patients. They provide convincing evidence for the effectiveness of IL-15/12-conditioned NK cells in this design, which was also critical for the authors being able to conclusively reveal the T cell-dependency of NK-cell-mediated long-term control of experimental metastasis. Of note, an investigator-initiated clinical trial demonstrated that similar NK cell infusions in cancer patients after resections were safe and showed signs of efficacy, which is of promising clinical application value.

Reviewed by eLife