Immunology

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

1. Raphael A. Reyes
2. Louise Turner
3. Isaac Ssewanyana
4. Prasanna Jagannathan
5. Margaret E. Feeney
6. Thomas Lavstsen
7. Bryan Greenhouse
8. Sebastiaan Bol
9. Evelien M. Bunnik

Reviewed by Review Commons

The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

1. Alexandra a Aybar-Torres
2. Lennon A Saldarriaga
3. Ann T Pham
4. Amir M Emtiazjoo
5. Ashish K Sharma
6. Andrew j Bryant
7. Lei Jin

• Curated by eLife

  eLife assessment

  This study describes useful mouse models of knock-ins of human STING1 variants and an assessment of these variants' action in mouse immune cells. While the implications of the variants in the inflammatory response are of significant interest, limitations are still found in the authors' interpretation and conclusions made, and the evidence for the conclusion remains incomplete.

Reviewed by eLife

CCL28 modulates neutrophil responses during infection with mucosal pathogens

1. Gregory T Walker
2. Araceli Perez-Lopez
3. Steven Silva
4. Michael H Lee
5. Elisabet Bjånes
6. Nicholas Dillon
7. Stephanie L Brandt
8. Romana R Gerner
9. Karine Melchior
10. Grant J Norton
11. Felix A Argueta
12. Frenchesca Dela Pena
13. Lauren Park
14. Victor A Sosa-Hernandez
15. Rodrigo Cervantes-Diaz
16. Sandra Romero-Ramirez
17. Monica Cartelle Gestal
18. Jose L Maravillas-Montero
19. Sean-Paul Nuccio
20. Victor Nizet
21. Manuela Raffatellu

• Curated by eLife

  eLife assessment

  In this study, Perez-Lopez and colleagues examine an important function of the chemokine CCL28 in mucosal host defenses against the gut bacterial pathogen Salmonella Typhimurium and lung pathogen Acinetobacter baumanii. They find that CCL28-CCR3 axis regulates neutrophil recruitment and function, and promotes bacterial clearance in one infectious context but exacerbates disease against the other pathogen. Therefore, CCL28 plays a critical role in mucosal immunity and neutrophil biology that differentially affects host defenses against pathogens.

Reviewed by eLife

IL-2 enhances effector function but suppresses follicular localization of CD8+ T cells in chronic infection

1. Yaping Chen
2. Pengcheng Zhou
3. Patrick Marc Gubser
4. Yew Ann Leong
5. Jing He
6. Yunbo Wei
7. Fadzai Victor Makota
8. Mehrdad Pazhouhandeh
9. Ting Zheng
10. Joseph Yunis
11. Zhanguo Li
12. Axel Kallies
13. Di Yu

• Curated by eLife

  eLife assessment

  This paper provides valuable findings related to the impact and timing of exogenous interleukin 2 on the balance of exhausted (Tex) versus effector (Teff) that differentiate from precursors T cells (Tpex) during chronic viral infection. While the data appear solid, the overall claims that IL-2 suppresses Tpex are only partially supported, with the rationale for the timing of IL-2 treatment and its underlying mechanisms remaining unclear.

Reviewed by eLife

Inflammation and IL-4 regulate Parkinson’s and Crohn’s disease associated kinase LRRK2

1. Dina Dikovskaya
2. Rebecca Pemberton
3. Matthew Taylor
4. Anna Tasegian
5. Purbasha Bhattacharya
6. Karolina Zeneviciute
7. Esther M Sammler
8. Andrew J M Howden
9. Dario R Alessi
10. Mahima Swamy

Reviewed by Review Commons

Dynamic chromatin architecture identifies new autoimmune-associated enhancers for IL2 and novel genes regulating CD4+ T cell activation

1. Matthew C Pahl
2. Prabhat Sharma
3. Rajan M Thomas
4. Zachary Thompson
5. Zachary Mount
6. James A Pippin
7. Peter A Morawski
8. Peng Sun
9. Chun Su
10. Daniel Campbell
11. Struan FA Grant
12. Andrew D Wells

• Curated by eLife

  eLife assessment

  This is a solid study that follows a well-established canvas for variant-to-gene prioritisation using 3D genomics, applying it to activated T cells. The authors go some way in validating the lists of candidate genes, as well as exploring the regulatory architecture of a candidate GWAS locus. Jointly with data from previous studies performing variant-to-gene assignment in activated CD4 T cells (and other immune cells), this work provides a useful additional resource for interpreting autoimmune disease-associated genetic variation.

Reviewed by eLife

Direct pharmacological AMPK activation inhibits mucosal SARS-CoV-2 infection by reducing lipid metabolism, restoring autophagy flux and the type I IFN response

1. Andrea Cottignies-Calamarte
2. Flora Marteau
3. Feifan He
4. Sandrine Belouzard
5. Jean Dubuisson
6. Daniela Tudor
7. Benoit Viollet
8. Morgane Bomsel

Reviewed by Review Commons

Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

1. Alessandra Machado Araujo
2. Joseph D Dekker
3. Kendra Garrison
4. Zhe Su
5. Catherine Rhee
6. Zicheng Hu
7. Bum-Kyu Lee
8. Daniel Osorio
9. Jiwon Lee
10. Vishwanath R Iyer
11. Lauren IR Ehrlich
12. George Georgiou
13. Gregory Ippolito
14. Stephen Yi
15. Haley O Tucker

• Curated by eLife

  eLife assessment

  This valuable study reports that while most plasmacytoid dendritic cells (pDCs) originate from common dendritic cell precursors, approximately 20% are derived from lymphoid progenitors shared with B cells. The methodology used and the evidence are solid, and further demonstrate the distinct transcription factor requirements and activities of this subset of pDCs, although the functional significance of this dendritic cell subset will require further elucidation. The findings will be of great interest for those interested in the developmental and functional biology of the immune system.

Reviewed by eLife

SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

1. Somen K Mistri
2. Brianna M Hilton
3. Katherine J Horrigan
4. Emma S Andretta
5. Remi Savard
6. Oliver Dienz
7. Kenneth J Hampel
8. Diana L Gerrard
9. Joshua T Rose
10. Nikoletta Sidiropoulos
11. Dev Majumdar
12. Jonathan E Boyson

• Curated by eLife

  eLife assessment

  This important study highlights the importance of SLAM-SAP signaling in determining innate gamma-delta T cell sublineages and their T cell receptor repertoires. It uncovers the complex role of the SLAM-SAP pathway in developing specific gamma-delta T cell subsets. The evidence presented is compelling, backed by high-quality data obtained through advanced single cell proteogenomics techniques.This work will be of broad interest to immunologists.

Reviewed by eLife

CD4 T cells and CD8α+ lymphocytes are necessary for intravenous BCG-induced protection against tuberculosis in macaques

1. Andrew W. Simonson
2. Joseph J. Zeppa
3. Allison N. Bucsan
4. Michael C. Chao
5. Supriya Pokkali
6. Forrest Hopkins
7. Michael R. Chase
8. Andrew J. Vickers
9. Matthew S. Sutton
10. Caylin G. Winchell
11. Amy J. Myers
12. Cassaundra L. Ameel
13. Ryan Kelly
14. Ben Krouse
15. Luke E. Hood
16. Jiaxiang Li
17. Chelsea C. Lehman
18. Megha Kamath
19. Jaime Tomko
20. Mark A. Rodgers
21. Rachel Donlan
22. Harris Chishti
23. H. Jacob Borish
24. Edwin Klein
25. Charles A. Scanga
26. Sarah Fortune
27. Philana Ling Lin
28. Pauline Maiello
29. Mario Roederer
30. Patricia A. Darrah
31. Robert A. Seder
32. JoAnne L. Flynn

Reviewed by Rapid Reviews Infectious Diseases