Immunology

Longitudinal analysis of drift in the circulating human antibody repertoire over four years

1. Collin Joyce
2. Benjamin Nemoz
3. Raiza Bastidas
4. Bryan Briney
5. Dennis R. Burton

Reviewed by PREreview

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

1. Hicham Sid
2. Theresa von Heyl
3. Sabrina Schleibinger
4. Romina Klinger
5. Leah Heymelot Nabel
6. Hanna Vikkula
7. Rodrigo Guabiraba
8. Vanaique Guillory
9. Ryan Scicluna
10. Mohanned Naif Alhussien
11. Brigitte Böhm
12. Benjamin Schade
13. Daniel Elleder
14. Samantha Sives
15. Lonneke Vervelde
16. Sascha Trapp
17. Benjamin Schusser

Reviewed by PREreview

Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

1. Jan Stuchly
2. David Novak
3. Nadezda Brdickova
4. Petra Hadlova
5. Vojen Sadilek
6. Ahmad Iksi
7. Daniela Kuzilkova
8. Michael Svaton
9. George Alehandro Saad
10. Pablo Engel
11. Herve Luche
12. Ana E Sousa
13. Afonso RM Almeida
14. Tomas Kalina

• Curated by eLife

  eLife Assessment

  The authors present an algorithm and workflow for the inference of developmental trajectories from single-cell data, including a mathematical approach to increase computational efficiency. In this latest version, the authors addressed the benchmarking of the novel method, but the absence of quantitative comparisons to state-of-the-art methods still make this study incomplete. Based on the shown validation approaches, one can neither ultimately judge if the shown method will be an advance over previous work nor whether the approach will be of general useful applicability.

Reviewed by eLife