Immunology

Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques

1. Anil Verma
2. Chase E Hawes
3. Sonny R Elizaldi
4. Justin C Smith
5. Dhivyaa Rajasundaram
6. Gabriel Kristian Pedersen
7. Xiaoying Shen
8. LaTonya D Williams
9. Georgia D Tomaras
10. Pamela A Kozlowski
11. Rama R Amara
12. Smita S Iyer

• Curated by eLife

  eLife assessment

  The authors' findings have theoretical or practical deep implications, which makes them important. The methods, data, and analyzes support the authors' arguments with only minor weaknesses, and overall they are solid. In vitro culture experiments could provide evidence to strengthen the evidence for the functional significance of Th1-mediated cytokines in the observed B cell responses.

Reviewed by eLife

Novel Association of Lyme disease, Age, and Atopic Dermatitis

1. Brandon T. Lee
2. Sarah D. Galloway
3. Qingying Feng
4. Satu Strausz
5. Maia Shoham
6. Paige Hansen
7. Laughing Bear Torrez Dulgeroff
8. Grace Blacker
9. Ying Y. Yiu
10. Paul Mansfield
11. FinnGen
12. Atif Saleem
13. Eric Gars
14. Erin C. Sanders
15. Irving L. Weissman
16. Hanna M. Ollila
17. Michal Caspi Tal

Reviewed by Arcadia Science

Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells

1. Chinky Shiu Chen Liu
2. Tithi Mandal
3. Parijat Biswas
4. Md Asmaul Hoque
5. Purbita Bandopadhyay
6. Bishnu Prasad Sinha
7. Jafar Sarif
8. Ranit D'Rozario
9. Deepak Kumar Sinha
10. Bidisha Sinha
11. Dipyaman Ganguly

• Curated by eLife

  eLife assessment

  This study provides useful insights into the subcellular localization, interaction with integrins, and functional importance of the cell surface receptor Piezo1 in migrating human T-cells. Whether Piezo1 is critically sensing mechano-physical cues during T-cell migration is however not well supported by direct experimental evidence. The data collected is solid otherwise.

Reviewed by eLife

NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

1. Jasper Iske
2. Rachid El Fatimy
3. Yeqi Nian
4. Amina Ghouzlani
5. Siawosh K Eskandari
6. Hector Rodriguez Cetina Biefer
7. Anju Vasudevan
8. Abdallah Elkhal

• Curated by eLife

  eLife assessment

  In this valuable contribution, the authors demonstrate that the infusion of NAD+ may prevent death and reduce disease severity from lethal experimental bacterial sepsis, possibly through inflammasome inhibition, without reducing bacterial load. They provide solid evidence for these protective effects of NAD+, though the precise mechanisms involved remain unclear and need further support and elucidation. The core findings may well have clinical implications but, in addition to mechanistic clarifications, contextualised interpretation as metabolic adaptation to sepsis would create wider interest.

Reviewed by eLife

Ym1 protein crystals promote type 2 immunity

1. Ines Heyndrickx
2. Kim Deswarte
3. Kenneth Verstraete
4. Koen HG Verschueren
5. Ursula Smole
6. Helena Aegerter
7. Ann Dansercoer
8. Hamida Hammad
9. Savvas N Savvides
10. Bart N Lambrecht

• Curated by eLife

  eLife assessment

  This is an important and interesting account of the ability of Ym1 crystals to promote type 2 immunity in vivo, in mice. The data presented are compelling, building on and significantly advancing evidence this group has previously published on the type 2 immunogenicity of other protein crystals. The work will be of relevant interest to immunologists and researchers working on type 2 inflammatory disease, in the lung and in others tissues.

Reviewed by eLife

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

1. Hui Yan
2. Yao Liu
3. Xipeng Li
4. Bing Yu
5. Jun He
6. Xiangbing Mao
7. Jie Yu
8. Zhiqing Huang
9. Yuheng Luo
10. Junqiu Luo
11. Aimin Wu
12. Daiwen Chen

• Curated by eLife

  eLife assessment

  The study has added value to what we have already known in the potential pharmacological immunomodulatory therapies in LPS-induced sepsis, and especially the use of oral leucine might be of great interest to the readers engaged in this field. We believe this study is important and provides solid evidence on the potential use of leucine in sepsis.

Reviewed by eLife

IL-27 maintains cytotoxic Ly6C ⁺ γδ T cells that arise from immature precursors

1. Robert Wiesheu
2. Sarah C. Edwards
3. Ann Hedley
4. Marie Tosolini
5. Marcelo Gregorio Filho Fares da Silva
6. Nital Sumaria
7. Yasmin Optaczy
8. David G. Hill
9. Alan J. Hayes
10. Jodie Hay
11. Anna Kilbey
12. Alison M. Michie
13. Gerard J. Graham
14. Anand Manoharan
15. Christina Halsey
16. Gareth W. Jones
17. Karen Blyth
18. Jean-Jacques Fournie
19. Daniel J. Pennington
20. Vasileios Bekiaris
21. Seth B. Coffelt

Reviewed by Review Commons

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

1. Alexander J. Knights
2. Easton C. Farrell
3. Olivia M. Ellis
4. Michelle J. Song
5. C. Thomas Appleton
6. Tristan Maerz

• Curated by eLife

  eLife assessment

  This study provides useful information by identifying the cell type (macrophages) in synovial tissues involved in the pathogenesis of post-traumatic osteoarthritis (OA) and clarifying distinct transcriptomic signatures that may be a good therapeutic target for OA. However, the analysis performed so far is incomplete, with a main weakness being the lack of data to confirm the authors' speculation about the underlying mechanisms.

Reviewed by eLife

Protective non-neutralizing mAbs Ab94 and Ab81 retain high-affinity and potent Fc-mediated function against SARS-CoV-2 variants from Omicron to XBB1.5

1. Arman Izadi
2. Magdalena Godzwon
3. Mats Ohlin
4. Pontus Nordenfelt

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection

1. Alexander Lercher
2. Jin-Gyu Cheong
3. Chenyang Jiang
4. Hans-Heinrich Hoffmann
5. Alison W. Ashbrook
6. Yue S. Yin
7. Corrine Quirk
8. Emma J. DeGrace
9. Luis Chiriboga
10. Brad R. Rosenberg
11. Steven Z. Josefowicz
12. Charles M. Rice

Reviewed by PREreview