1. PD-1 negatively regulates helper T cell differentiation into Th2

    This article has 9 authors:
    1. Masaki Tajima
    2. Naoko Ikuta
    3. Yuka Nakajima
    4. Kensuke Suzuki
    5. Yosuke Tokumaru
    6. Peng Li
    7. Hiroshi Kiyonari
    8. Tasuku Honjo
    9. Akio Ohta
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for the treatment of allergies. However, whereas the series of well-designed experiments using OVA-specific CD4 T cells from DO.11.10 mice and the use of an allergy model generated compelling data, the study is still incomplete since it shows gaps in the rationale for the experimental protocols, contradictory data regarding IFN-gamma and IL-4 production, and the lack of in vivo experiments on Th2 differentiation to further support the main hypothesis. Nonetheless, the reported data would be of interest to immunologists working on T cell differentiation and allergy.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

    This article has 19 authors:
    1. Frédéric Fercoq
    2. Gemma S. Cairns
    3. Marco De Donatis
    4. John B. G. Mackey
    5. Alessia Floerchinger
    6. Amanda McFarlane
    7. Ximena L. Raffo-Iraolagoitia
    8. Declan Whyte
    9. Lindsey W. G. Arnott
    10. Colin Nixon
    11. Robert Wiesheu
    12. Anna Kilbey
    13. Leah Brown
    14. Sarwah Al-Khalidi
    15. Jim C. Norman
    16. Edward W. Roberts
    17. Karen Blyth
    18. Seth B. Coffelt
    19. Leo M. Carlin

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response

    This article has 16 authors:
    1. Anna Andrusaite
    2. Olivia Ridgewell
    3. Anna Ahlback
    4. Holly Webster
    5. Hiroki Yamaguchi
    6. Molly Peel
    7. Annika Frede
    8. Sarwah Al-Khalidi
    9. Andrew Farthing
    10. Anna Heawood
    11. Annabelle Smith
    12. Edward Roberts
    13. Allan Mowat
    14. Richard Maizels
    15. Georgia Perona-Wright
    16. Simon Milling

    Reviewed by Arcadia Science

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  4. A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

    This article has 19 authors:
    1. Yuji Miyatake
    2. Tomokatsu Ikawa
    3. Ryo Yanagiya
    4. Ryutaro Kotaki
    5. Kazuaki Kameda
    6. Ryo Koyama-Nasu
    7. Kazuki Okuyama
    8. Ken-ichi Hirano
    9. Hiroyuki Hosokawa
    10. Katsuto Hozumi
    11. Masato Ohtsuka
    12. Takahiro Kishikawa
    13. Chikako Shibata
    14. Motoyuki Otsuka
    15. Reo Maruyama
    16. Kiyoshi Ando
    17. Tomohiro Kurosaki
    18. Hiroshi Kawamoto
    19. Ai Kotani
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful study reports that the exogenous expression of the microRNA miR-195 can partially compensate in early B cell development for the loss of EBF1, one of the key transcription factors in B cells. While this finding will be of interest to those studying lymphocyte development, the evidence, particularly with regard to the molecular mechanisms that underpin the effect of miR-195, is currently incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis

    This article has 16 authors:
    1. Matthew Yorek
    2. Xingshan Jiang
    3. Shanshan Liu
    4. Jiaqing Hao
    5. Jianyu Yu
    6. Anthony Avellino
    7. Zhanxu Liu
    8. Melissa Curry
    9. Henry Keen
    10. Jianqiang Shao
    11. Anand Kanagasabapathy
    12. Maying Kong
    13. Yiqin Xiong
    14. Edward R Sauter
    15. Sonia L Sugg
    16. Bing Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper uses elegant models, including genetic knock outs, to demonstrate that FABP4 contributes to lipid accumulation in tumor-associated macrophages, which seems to increase breast cancer migration. While the work is of high interest, the strength of the evidence relating to some of the conclusions is incomplete and the paper would benefit from some refinement. The work will be of interest to those researchers trying to link metabolism, the immune system, and cancer.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Functional identification of soluble uric acid as an endogenous inhibitor of CD38

    This article has 6 authors:
    1. Shijie Wen
    2. Hiroshi Arakawa
    3. Shigeru Yokoyama
    4. Yoshiyuki Shirasaka
    5. Haruhiro Higashida
    6. Ikumi Tamai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study shows that soluble uric acid is an endogenous inhibitor of CD38, a regulator of inflammatory responses. The convincing evidence draws both on biochemical analyses and in vivo models. This work provides insights into NAD+ metabolism, with significant implications for inflammation and potential roles in metabolic diseases and aging.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  7. A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

    This article has 5 authors:
    1. Shuyu Olivia Zhou
    2. Jonathan P Day
    3. Bart Deplancke
    4. Alexandre B Leitão
    5. Francis M Jiggins
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study reports an extensive analysis of the way a humoral immune response to parasitoid wasp is expressed and regulated, building on previous work from the authors on an anti-parasitoid effector lectin. The solid evidence uses two complementary approaches to show which innate immune pathways are involved in the regulation of the anti-parasitoid response. The evidence would be stronger if some analytical and related concerns can be addressed. The work will be of relevance to the community of investigators studying insect immune cells as well as researchers interested in host defense against parasitism.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  8. Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen

    This article has 6 authors:
    1. David Verhoeven
    2. Brett A. Sponseller
    3. James E. Crowe
    4. Sandhya Bangaru
    5. Richard J. Webby
    6. Brian Lee

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

    This article has 16 authors:
    1. Donal J Cox
    2. Sarah A Connolly
    3. Cilian Ó Maoldomhnaigh
    4. Aenea AI Brugman
    5. Olivia Sandby Thomas
    6. Emily Duffin
    7. Karl M Gogan
    8. Oisin Ó Gallchobhair
    9. Dearbhla M Murphy
    10. Sinead A O'Rourke
    11. Finbarr O'Connell
    12. Parthiban Nadarajan
    13. James J Phelan
    14. Laura E Gleeson
    15. Sharee A Basdeo
    16. Joseph Keane
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors investigate how inflammatory priming and exposure to irradiated Mycobacterium tuberculosis or the bacterial endotoxin LPS impact the metabolism of primary human airway macrophages and monocyte-derived macrophages. The work shows that metabolic plasticity is greater in monocyte-derived macrophages than alveolar macrophages, with solid experimental methods and overall evidence. The findings are relevant to the field of immunometabolism.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  10. Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    This article has 21 authors:
    1. Priya Sharma
    2. Raman Deep Sharma
    3. Mrinmoy Das
    4. Binayak Sarkar
    5. Lakshyaveer Singh
    6. Neharika Jain
    7. Shivam Chaturvedi
    8. Lalita Mehra
    9. Aditya Rathee
    10. Shilpa Sharma
    11. Shihui Foo
    12. Andrea Lee
    13. N Pavan kumar
    14. Prasenjit Das
    15. Vijay Viswanathan
    16. Hardy Kornfeld
    17. Shanshan W Howland
    18. Subash Babu
    19. Vinay Nandicoori
    20. Amit Singhal
    21. Dhiraj Kumar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This potentially valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors report that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. Although the authors suggest that targeting these pathways may improve disease outcomes in humans, the evidence as it stands is incomplete and requires additional experimentation for the study to realise its full impact.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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