Immunology

PD-1 negatively regulates helper T cell differentiation into Th2

1. Masaki Tajima
2. Naoko Ikuta
3. Yuka Nakajima
4. Kensuke Suzuki
5. Yosuke Tokumaru
6. Peng Li
7. Hiroshi Kiyonari
8. Tasuku Honjo
9. Akio Ohta

• Curated by eLife

  eLife Assessment

  This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for the treatment of allergies. However, whereas the series of well-designed experiments using OVA-specific CD4 T cells from DO.11.10 mice and the use of an allergy model generated compelling data, the study is still incomplete since it shows gaps in the rationale for the experimental protocols, contradictory data regarding IFN-gamma and IL-4 production, and the lack of in vivo experiments on Th2 differentiation to further support the main hypothesis. Nonetheless, the reported data would be of interest to immunologists working on T cell differentiation and allergy.

Reviewed by eLife

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer

1. Frédéric Fercoq
2. Gemma S. Cairns
3. Marco De Donatis
4. John B. G. Mackey
5. Alessia Floerchinger
6. Amanda McFarlane
7. Ximena L. Raffo-Iraolagoitia
8. Declan Whyte
9. Lindsey W. G. Arnott
10. Colin Nixon
11. Robert Wiesheu
12. Anna Kilbey
13. Leah Brown
14. Sarwah Al-Khalidi
15. Jim C. Norman
16. Edward W. Roberts
17. Karen Blyth
18. Seth B. Coffelt
19. Leo M. Carlin

Reviewed by preLights

Intestinal helminth skews DC2 development towards regulatory phenotype to counter the anti-helminth immune response

1. Anna Andrusaite
2. Olivia Ridgewell
3. Anna Ahlback
4. Holly Webster
5. Hiroki Yamaguchi
6. Molly Peel
7. Annika Frede
8. Sarwah Al-Khalidi
9. Andrew Farthing
10. Anna Heawood
11. Annabelle Smith
12. Edward Roberts
13. Allan Mowat
14. Richard Maizels
15. Georgia Perona-Wright
16. Simon Milling

Reviewed by Arcadia Science

A single microRNA miR-195 rescues the arrested B cell development induced by EBF1 deficiency

1. Yuji Miyatake
2. Tomokatsu Ikawa
3. Ryo Yanagiya
4. Ryutaro Kotaki
5. Kazuaki Kameda
6. Ryo Koyama-Nasu
7. Kazuki Okuyama
8. Ken-ichi Hirano
9. Hiroyuki Hosokawa
10. Katsuto Hozumi
11. Masato Ohtsuka
12. Takahiro Kishikawa
13. Chikako Shibata
14. Motoyuki Otsuka
15. Reo Maruyama
16. Kiyoshi Ando
17. Tomohiro Kurosaki
18. Hiroshi Kawamoto
19. Ai Kotani

• Curated by eLife

  eLife Assessment

  This useful study reports that the exogenous expression of the microRNA miR-195 can partially compensate in early B cell development for the loss of EBF1, one of the key transcription factors in B cells. While this finding will be of interest to those studying lymphocyte development, the evidence, particularly with regard to the molecular mechanisms that underpin the effect of miR-195, is currently incomplete.

Reviewed by eLife

FABP4-mediated lipid accumulation and lipolysis in tumor-associated macrophages promote breast cancer metastasis

1. Matthew Yorek
2. Xingshan Jiang
3. Shanshan Liu
4. Jiaqing Hao
5. Jianyu Yu
6. Anthony Avellino
7. Zhanxu Liu
8. Melissa Curry
9. Henry Keen
10. Jianqiang Shao
11. Anand Kanagasabapathy
12. Maying Kong
13. Yiqin Xiong
14. Edward R Sauter
15. Sonia L Sugg
16. Bing Li

• Curated by eLife

  eLife Assessment

  This important paper uses elegant models, including genetic knock outs, to demonstrate that FABP4 contributes to lipid accumulation in tumor-associated macrophages, which seems to increase breast cancer migration. While the work is of high interest, the strength of the evidence relating to some of the conclusions is incomplete and the paper would benefit from some refinement. The work will be of interest to those researchers trying to link metabolism, the immune system, and cancer.

Reviewed by eLife

Functional identification of soluble uric acid as an endogenous inhibitor of CD38

1. Shijie Wen
2. Hiroshi Arakawa
3. Shigeru Yokoyama
4. Yoshiyuki Shirasaka
5. Haruhiro Higashida
6. Ikumi Tamai

• Curated by eLife

  eLife Assessment

  This important study shows that soluble uric acid is an endogenous inhibitor of CD38, a regulator of inflammatory responses. The convincing evidence draws both on biochemical analyses and in vivo models. This work provides insights into NAD+ metabolism, with significant implications for inflammation and potential roles in metabolic diseases and aging.

Reviewed by eLife

A humoral immune response to parasitoid wasps in Drosophila is regulated by JAK/STAT, NF-κB and GATA

1. Shuyu Olivia Zhou
2. Jonathan P Day
3. Bart Deplancke
4. Alexandre B Leitão
5. Francis M Jiggins

• Curated by eLife

  eLife Assessment

  This valuable study reports an extensive analysis of the way a humoral immune response to parasitoid wasp is expressed and regulated, building on previous work from the authors on an anti-parasitoid effector lectin. The solid evidence uses two complementary approaches to show which innate immune pathways are involved in the regulation of the anti-parasitoid response. The evidence would be stronger if some analytical and related concerns can be addressed. The work will be of relevance to the community of investigators studying insect immune cells as well as researchers interested in host defense against parasitism.

Reviewed by eLife

Use of equine H3N8 hemagglutinin as a broadly protective influenza vaccine immunogen

1. David Verhoeven
2. Brett A. Sponseller
3. James E. Crowe
4. Sandhya Bangaru
5. Richard J. Webby
6. Brian Lee

Reviewed by PREreview

Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

1. Donal J Cox
2. Sarah A Connolly
3. Cilian Ó Maoldomhnaigh
4. Aenea AI Brugman
5. Olivia Sandby Thomas
6. Emily Duffin
7. Karl M Gogan
8. Oisin Ó Gallchobhair
9. Dearbhla M Murphy
10. Sinead A O'Rourke
11. Finbarr O'Connell
12. Parthiban Nadarajan
13. James J Phelan
14. Laura E Gleeson
15. Sharee A Basdeo
16. Joseph Keane

• Curated by eLife

  eLife Assessment

  In this valuable study, the authors investigate how inflammatory priming and exposure to irradiated Mycobacterium tuberculosis or the bacterial endotoxin LPS impact the metabolism of primary human airway macrophages and monocyte-derived macrophages. The work shows that metabolic plasticity is greater in monocyte-derived macrophages than alveolar macrophages, with solid experimental methods and overall evidence. The findings are relevant to the field of immunometabolism.

Reviewed by eLife

Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

1. Priya Sharma
2. Raman Deep Sharma
3. Mrinmoy Das
4. Binayak Sarkar
5. Lakshyaveer Singh
6. Neharika Jain
7. Shivam Chaturvedi
8. Lalita Mehra
9. Aditya Rathee
10. Shilpa Sharma
11. Shihui Foo
12. Andrea Lee
13. N Pavan kumar
14. Prasenjit Das
15. Vijay Viswanathan
16. Hardy Kornfeld
17. Shanshan W Howland
18. Subash Babu
19. Vinay Nandicoori
20. Amit Singhal
21. Dhiraj Kumar

• Curated by eLife

  eLife assessment

  This potentially valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors report that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. Although the authors suggest that targeting these pathways may improve disease outcomes in humans, the evidence as it stands is incomplete and requires additional experimentation for the study to realise its full impact.

Reviewed by eLife