1. Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity

    This article has 16 authors:
    1. Donal J Cox
    2. Sarah A Connolly
    3. Cilian Ó Maoldomhnaigh
    4. Aenea AI Brugman
    5. Olivia Sandby Thomas
    6. Emily Duffin
    7. Karl M Gogan
    8. Oisin Ó Gallchobhair
    9. Dearbhla M Murphy
    10. Sinead A O'Rourke
    11. Finbarr O'Connell
    12. Parthiban Nadarajan
    13. James J Phelan
    14. Laura E Gleeson
    15. Sharee A Basdeo
    16. Joseph Keane
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study, the authors investigate how inflammatory priming and exposure to irradiated Mycobacterium tuberculosis or the bacterial endotoxin LPS impact the metabolism of primary human airway macrophages and monocyte-derived macrophages. The work shows that metabolic plasticity is greater in monocyte-derived macrophages than alveolar macrophages, with solid experimental methods and overall evidence. The findings are relevant to the field of immunometabolism.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  2. Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    This article has 21 authors:
    1. Priya Sharma
    2. Raman Deep Sharma
    3. Mrinmoy Das
    4. Binayak Sarkar
    5. Lakshyaveer Singh
    6. Neharika Jain
    7. Shivam Chaturvedi
    8. Lalita Mehra
    9. Aditya Rathee
    10. Shilpa Sharma
    11. Shihui Foo
    12. Andrea Lee
    13. N Pavan kumar
    14. Prasenjit Das
    15. Vijay Viswanathan
    16. Hardy Kornfeld
    17. Shanshan W Howland
    18. Subash Babu
    19. Vinay Nandicoori
    20. Amit Singhal
    21. Dhiraj Kumar
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This potentially valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors report that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. Although the authors suggest that targeting these pathways may improve disease outcomes in humans, the evidence as it stands is incomplete and requires additional experimentation for the study to realise its full impact.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. A novel bioinformatics pipeline for the identification of immune inhibitory receptors as potential therapeutic targets

    This article has 11 authors:
    1. Akashdip Singh
    2. Alberto Miranda Bedate
    3. Helen J von Richthofen
    4. Saskia V Vijver
    5. Michiel van der Vlist
    6. Raphael Kuhn
    7. Alexander Yermanos
    8. Jürgen J Kuball
    9. Can Kesmir
    10. M Ines Pascoal Ramos
    11. Linde Meyaard
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors presented a valuable bioinformatics pipeline for screening and identifying inhibitory receptors for potential drug targets. They provided solid evidence showing a sequential reduction in the search space through various screening tools and algorithms and demonstrated that this pipeline can be used to "rediscover" known targets. Further experimental validation on putative and unknown inhibitory receptors will strengthen the evidence reported in this work. This study will be of interest to bioinformaticians and computational biologists working on immune regulation, sequence screening, and target identification of immune checkpoint inhibitors.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  4. Chemokine expression profile of an innate granuloma

    This article has 5 authors:
    1. Megan E Amason
    2. Cole J Beatty
    3. Carissa K Harvest
    4. Daniel R Saban
    5. Edward A Miao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study advances the understanding of granuloma formation by identifying a key chemokine receptors in containing infection by a specific species of bacteria. The evidence supporting this is solid, providing a spatial transcriptomic dataset spanning granuloma formation and resolution by a specific species of bacteria. The work should be of interest to microbiologists and immunologists.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  5. Cell state and transcription factor modulation during extended ex vivo CD8 + T-cell expansion

    This article has 9 authors:
    1. Yuan Lui
    2. Edward Jenkins
    3. Emily Zhi Qing Ng
    4. Mateusz Kotowski
    5. Sydney J Mullin
    6. Joseph Clarke
    7. Simon J Davis
    8. Ana Mafalda Santos
    9. Sumana Sharma

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived stem cell factor

    This article has 16 authors:
    1. Chenchen Mao
    2. Yanyu Chen
    3. Dong Xing
    4. Teming Zhang
    5. Yangxuan Lin
    6. Cong Long
    7. Jiaye Yu
    8. Yunhui Luo
    9. Tao Ming
    10. Wangkai Xie
    11. Zheng Han
    12. Dianfeng Mei
    13. Dan Xiang
    14. Mingdong Lu
    15. Xian Shen
    16. Xiangyang Xue
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study draws on published single-cell and spatial transcriptomic data of colon cancer liver metastasis to clarify the pro- and anti-tumorigenic properties of NK cells. The authors discover increased GZMK+ resting NK cells in the tumor tissue and reduced abundance of KIR2DL4+ activated NK cells. However, the evidence is currently incomplete, as the models used to validate the hypothesis and claims are not adequate and lack the necessary controls.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  7. Exposure to live saprophytic Leptospira before challenge with a pathogenic serovar prevents severe leptospirosis and promotes kidney homeostasis

    This article has 3 authors:
    1. Suman Kundu
    2. Advait Shetty
    3. Maria Gomes-Solecki
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study contributes to our understanding on how prior exposure to a non-pathogenic Leptospira strain could prime the host to prevent severe leptospirosis following infection with a pathogenic strain. The work described is solid and broadly supports the claims, with minor weaknesses that could be addressed in future studies. The work will be of interest to scientists interested in host-pathogen interactions and leptospirosis.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

    This article has 17 authors:
    1. Axelle Amen
    2. Randy Yoo
    3. Amanda Fabra-García
    4. Judith Bolscher
    5. William JR Stone
    6. Isabelle Bally
    7. Sebastián Dergan-Dylon
    8. Iga Kucharska
    9. Roos M de Jong
    10. Marloes de Bruijni
    11. Teun Bousema
    12. C Richter King
    13. Randall S MacGill
    14. Robert W Sauerwein
    15. Jean-Philippe Julien
    16. Pascal Poignard
    17. Matthijs M Jore
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study reports important results and new insights into humoral immune responses to Plasmodium falciparum sexual stage proteins. The experiments are based on the use of target-agnostic memory B cell sorting and screening approaches as well as several state-of-the-art technologies. The authors present compelling evidence that one antibody, B1E11K, is cross-reactive with multiple proteins containing glutamate-rich repeats through homotypic interactions, a process similar to what has been observed for Plasmodium circumsporozoite protein repeat-directed antibodies.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  9. Transposable elements may enhance antiviral resistance in HIV-1 elite controllers

    This article has 6 authors:
    1. Manvendra Singh
    2. Sabrina M. Leddy
    3. Luis Pedro Iñiguez
    4. Matthew L. Bendall
    5. Douglas F. Nixon
    6. Cédric Feschotte

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted

    This article has 20 authors:
    1. Miguel Reina-Campos
    2. Alexander Monell
    3. Amir Ferry
    4. Vida Luna
    5. Kitty P. Cheung
    6. Giovanni Galletti
    7. Nicole E. Scharping
    8. Kennidy K. Takehara
    9. Sara Quon
    10. Peter P. Challita
    11. Brigid Boland
    12. Yun Hsuan Lin
    13. William H. Wong
    14. Cynthia S. Indralingam
    15. Hayley Neadeau
    16. Suzie Alarcón
    17. Gene W. Yeo
    18. John T. Chang
    19. Maximilian Heeg
    20. Ananda W. Goldrath

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
Previous Page 15 of 170 Next