Immunology

Early resident NK cell response to local HIV infection in lymphoid tissue

1. David Perea
2. Alba Gonzalez
3. Nerea Sanchez-Gaona
4. Felix Pumarola
5. Nuria Ortiz
6. Ines Llano
7. Juan Lorente
8. Vicenc Falco
9. Meritxell Genesca
10. Maria J Buzon

Reviewed by preLights

Single-cell profiling of the lung immune cells of diabetes-tuberculosis comorbidity reveals reduced type-II interferon and elevated Th17 responses

1. Shweta Chaudhary
2. Mothe Sravya
3. Falak Pahwa
4. Sureshkumar V
5. Prateek Singh
6. Shivam Chaturvedi
7. Debasisa Mohanty
8. Debasis Dash
9. Ranjan Kumar Nanda

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the intersection between tuberculosis and diabetes and the impact on immune responses, notably T cell and myeloid cell responses. The single-cell data collected and analyzed are convincing and provide a rich dataset to develop a more detailed understanding of cellular responses during Mtb infection of diabetic mice. Some of the mechanistic claims are incomplete, as there are no experiments performed to clearly define a role for IL-16 or IL-17 in disease. Inclusion of analysis of human samples would have strengthened the conclusions in the paper for translational impact, as well as the inclusion of a DM group alone in addition to DM-TB vs TB in some of the experiments.

Reviewed by eLife

Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis

1. Weilun Guo
2. Shruti S Apte
3. Mary S Dickinson
4. So Young Kim
5. Miriam Kutsch
6. Jörn Coers

• Curated by eLife

  eLife Assessment

  This is a fundamental discovery revealing two independent IFNγ-induced pathways that restrict bacterial motility: one GBP1-dependent and the other GVIN1-dependent. The findings are supported by compelling evidence. While the paper is already very strong, there are a few points that could be addressed editorially or through the addition of a few key experiments.

Reviewed by eLife

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

1. Asya Dolgikh
2. Samuel Rommelaere
3. Aseel Ghanem
4. Bianca Petrignani
5. Mickael Poidevin
6. Estee Kurant
7. Bruno Lemaitre

Reviewed by Review Commons

TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni

1. Juan M Inclan-Rico
2. Adriana Stephenson
3. Camila M Napuri
4. Heather L Rossi
5. Li-Yin Hung
6. Christopher F Pastore
7. Wenqin Luo
8. De’Broski R Herbert

Reviewed by Arcadia Science

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

1. Erin F. McCaffrey
2. Alea C. Delmastro
3. Isobel Fitzhugh
4. Jolene S. Ranek
5. Sarah Douglas
6. Joshua M. Peters
7. Christine Camacho Fullaway
8. Marc Bosse
9. Candace C. Liu
10. Craig Gillen
11. Noah F. Greenwald
12. Sarah Anzick
13. Craig Martens
14. Seth Winfree
15. Yunhao Bai
16. Cameron Sowers
17. Mako Goldston
18. Alex Kong
19. Potchara Boonrat
20. Carolyn L. Bigbee
21. Roopa Venugopalan
22. Pauline Maiello
23. Edwin Klein
24. Mark A. Rodgers
25. Charles A. Scanga
26. Philana Ling Lin
27. Denise Kirschner
28. Sarah Fortune
29. Bryan D. Bryson
30. J. Russell Butler
31. Joshua T. Mattila
32. JoAnne L. Flynn
33. Michael Angelo

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Longitudinal analysis of drift in the circulating human antibody repertoire over four years

1. Collin Joyce
2. Benjamin Nemoz
3. Raiza Bastidas
4. Bryan Briney
5. Dennis R. Burton

Reviewed by PREreview