Immunology

Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function

1. Rajan M Thomas
2. Matthew C Pahl
3. Liqing Wang
4. Struan FA Grant
5. Wayne W Hancock
6. Andrew D Wells

• Curated by eLife

  eLife assessment

  This comprehensive study provides valuable information on the cooperation of Ikaros with Foxp3 to establish and regulate a major portion of the epigenome and transcriptome of T-regulatory cells. While the data are compelling, the evidence that these features are solely intrinsic, independent of the micro-environment, could be strengthened.

Reviewed by eLife

Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice

1. Emily E. Whitaker
2. Neal E. Mecum
3. Riley C. Cott
4. Diana J. Goode

Reviewed by Review Commons

Tribbles1 is host protective during in vivo mycobacterial infection

1. Ffion R Hammond
2. Amy Lewis
3. Gabriele Pollara
4. Gillian S Tomlinson
5. Mahdad Noursadeghi
6. Endre Kiss-Toth
7. Philip M Elks

Reviewed by Review Commons

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T-cell recognition by targeting CIITA

1. Fabienne Maaßen
2. Vu Thuy Khanh Le-Trilling
3. Luisa Betke
4. Thilo Bracht
5. Corinna Schuler
6. Malte Bayer
7. Antonia Belter
8. Tanja Becker
9. Benjamin Katschinski
10. Lori Frappier
11. Barbara Sitek
12. Katharina Fleischhauer
13. Mirko Trilling

Reviewed by Review Commons

Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

1. Tatyana O Nakonechnaya
2. Bruno Moltedo
3. Ekaterina V Putintseva
4. Sofya Leyn
5. Dmitry A Bolotin
6. Olga V Britanova
7. Mikhail Shugay
8. Dmitriy M Chudakov

• Curated by eLife

  eLife assessment

  This manuscript presents a valuable approach to exploring CD4+ T-cell response in mice across stimuli and tissues through the analysis of their T-cell receptor repertoires. The authors use a transgenic mouse model with reduced diversity of the T-cell receptor repertoire to elicit more consistent T-cell responses across individuals, demonstrating challenge-specific and tissue-specific responses of regulatory T-cells. The evidence for the authors' conclusions is solid, and the work will be of interest to immunologists studying T cell responses.

Reviewed by eLife

Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

1. Toyoshi Yanagihara
2. Kentaro Hata
3. Keisuke Matsubara
4. Kazufumi Kunimura
5. Kunihiro Suzuki
6. Kazuya Tsubouchi
7. Satoshi Ikegame
8. Yoshihiro Baba
9. Yoshinori Fukui
10. Isamu Okamoto

• Curated by eLife

  eLife assessment

  This study presents a valuable inventory of immune signatures that are correlated with cancer treatment-related pneumonitis. The data were collected and analysed using validated methodology and can be used as a starting point for further prospective studies. The authors have provided a scRNA-Seq analysis with an HD baseline using publicly available dataset and the evidence for their claims is convincing.

Reviewed by eLife

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

1. Mark S Lee
2. Peter J Tuohy
3. Caleb Y Kim
4. Philip P Yost
5. Katrina Lichauco
6. Heather L Parrish
7. Koenraad Van Doorslaer
8. Michael S Kuhns

• Curated by eLife

  eLife assessment

  This study provides valuable new insights as to how two evolutionary conserved motifs in CD4 contribute to the CD4-mediated enhancement of TCR signaling independently of the CD4-LCK interaction. The data at hand are convincing, even if confined to a cell line model and not substantiated in vivo and with little new mechanistic insight provided regarding the domains of CD4 shown to have significant roles in the signaling process. Without the data from primary cells it is difficult to make statements about the quantitative contribution of LCK-dependent and independent functions of CD4 in TCR signaling.

Reviewed by eLife

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

1. Chongbin Hu
2. Nan Zhang
3. Yun Hong
4. Ruxiu Tie
5. Dongdong Fan
6. Aifu Lin
7. Ye Chen
8. Li-xin Xiang
9. Jian-zhong Shao

• Curated by eLife

  eLife assessment

  This study characterizes the composition and immune diversity of the zebrafish kidney, the immune organ equivalent to human bone marrow, with convincing single-cell transcriptomic data of hematopoietic cells and immunocytes. The key findings suggest that zebrafish kidney is a secondary lymphatic organ, and that hematopoietic stem cells in zebrafish may exhibit trained immunity, which are the unique features of the fish immune system. This study provides new and valuable insights into the antiviral response in teleost fish, which will be of interest to biologists in general, and to immunologists and cancer researchers in particular.

Reviewed by eLife

Distinct T Cell Receptor (TCR) gene segment usage and MHC-restriction between foetal and adult thymus

1. Jasmine Rowell
2. Ching-In Lau
3. Susan Ross
4. Diana C. Yanez
5. Oscar A. Peña
6. Benny Chain
7. Tessa Crompton

• Curated by eLife

  eLife assessment

  This manuscript provides potentially valuable information suggesting that the earliest appearing T-cells during ontogeny may have properties that are fundamentally distinct from those appearing later in life. At this stage, weaknesses in the experimental design and data interpretation provide inadequate support for the conclusions. With modifications, the paper should be of interest to those interested in T-cell development.

Reviewed by eLife

A novel MARV glycoprotein-specific antibody with potentials of broad-spectrum neutralization to filovirus

1. Yuting Zhang
2. Min Zhang
3. Haiyan Wu
4. Xinwei Wang
5. Hang Zheng
6. Junjuan Feng
7. Jing Wang
8. Longlong Luo
9. He Xiao
10. Chunxia Qiao
11. Xinying Li
12. Yuanqiang Zheng
13. Weijin Huang
14. Youchun Wang
15. Yi Wang
16. Yanchun Shi
17. Jiannan Feng
18. Guojiang Chen

• Curated by eLife

  eLife assessment

  In this valuable study, the discovery and subsequent design of the AF03-NL chimeric antibody led to a tool for studying filoviruses and provides a possible blueprint for future therapeutics. In general, the data presented are solid, although further improvements can be made in the overall presentation of the results. The work will be of interest to virologists studying antibodies.

Reviewed by eLife