Immunology

Tissue-resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

1. Jodie Chandler
2. M Elise Bullock
3. Arpit C Swain
4. Cayman Williams
5. Christiaan H van Dorp
6. Benedict Seddon
7. Andrew J Yates

• Curated by eLife

  eLife Assessment

  This paper provides a compelling and rigorous quantitative analysis of the turnover and maintenance of CD4+ tissue-resident memory T cell clones, in the skin and the lamina propria. It provides a fundamental advance in our understanding of CD4 T cell regulation. Interestingly, in both tissues, maintenance involves an influx from progenitors on the time scale of months. The evidence that is based on fate mapping and mathematical inference is strong, although open questions on the interpretation of the Ki67-based fate mapping remain.

Reviewed by eLife

Human giant GTPase GVIN1 forms an antimicrobial coatomer around the intracellular bacterial pathogen Burkholderia thailandensis

1. Weilun Guo
2. Shruti S Apte
3. Mary S Dickinson
4. So Young Kim
5. Miriam Kutsch
6. Jörn Coers

• Curated by eLife

  eLife Assessment

  This is a fundamental discovery revealing two independent IFNγ-induced pathways that restrict bacterial motility: one GBP1-dependent and the other GVIN1-dependent. The findings are supported by compelling evidence. While the paper is already very strong, there are a few points that could be addressed editorially or through the addition of a few key experiments.

Reviewed by eLife

CARD8 inflammasome activation during HIV-1 cell-to-cell transmission

1. Jessie Kulsuptrakul
2. Michael Emerman
3. Patrick S Mitchell

• Curated by eLife

  eLife Assessment

  In this study, the authors investigated whether HIV-1 cell-to-cell transmission activates the CARD8 inflammasome in macrophages. The data convincingly support the idea that CARD8 is activated by the viral protease, promoting inflammation. The study's significance is further enhanced by including time-course analyses in primary T cells and macrophages and provides valuable insights into the role of CARD8 in HIV-induced inflammation.

Reviewed by eLife

The secreted Nimrod protein NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

1. Asya Dolgikh
2. Samuel Rommelaere
3. Aseel Ghanem
4. Bianca Petrignani
5. Mickael Poidevin
6. Estee Kurant
7. Bruno Lemaitre

Reviewed by Review Commons

TRPV1+ neurons promote cutaneous immunity against Schistosoma mansoni

1. Juan M. Inclan-Rico
2. Adriana Stephenson
3. Camila M. Napuri
4. Heather L. Rossi
5. Li-Yin Hung
6. Christopher F. Pastore
7. Wenqin Luo
8. De’Broski R. Herbert

Reviewed by Arcadia Science

The immunometabolic topography of tuberculosis granulomas governs cellular organization and bacterial control

1. Erin F. McCaffrey
2. Alea C. Delmastro
3. Isobel Fitzhugh
4. Jolene S. Ranek
5. Sarah Douglas
6. Joshua M. Peters
7. Christine Camacho Fullaway
8. Marc Bosse
9. Candace C. Liu
10. Craig Gillen
11. Noah F. Greenwald
12. Sarah Anzick
13. Craig Martens
14. Seth Winfree
15. Yunhao Bai
16. Cameron Sowers
17. Mako Goldston
18. Alex Kong
19. Potchara Boonrat
20. Carolyn L. Bigbee
21. Roopa Venugopalan
22. Pauline Maiello
23. Edwin Klein
24. Mark A. Rodgers
25. Charles A. Scanga
26. Philana Ling Lin
27. Denise Kirschner
28. Sarah Fortune
29. Bryan D. Bryson
30. J. Russell Butler
31. Joshua T. Mattila
32. JoAnne L. Flynn
33. Michael Angelo

Reviewed by Rapid Reviews Infectious Diseases, PREreview

Longitudinal analysis of drift in the circulating human antibody repertoire over four years

1. Collin Joyce
2. Benjamin Nemoz
3. Raiza Bastidas
4. Bryan Briney
5. Dennis R. Burton

Reviewed by PREreview

Genetic Reinstatement of RIG-I in Chickens Reveals Insights into Avian Immune Evolution and Influenza Interaction

1. Hicham Sid
2. Theresa von Heyl
3. Sabrina Schleibinger
4. Romina Klinger
5. Leah Heymelot Nabel
6. Hanna Vikkula
7. Rodrigo Guabiraba
8. Vanaique Guillory
9. Ryan Scicluna
10. Mohanned Naif Alhussien
11. Brigitte Böhm
12. Benjamin Schade
13. Daniel Elleder
14. Samantha Sives
15. Lonneke Vervelde
16. Sascha Trapp
17. Benjamin Schusser

Reviewed by PREreview

Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

1. Jan Stuchly
2. David Novak
3. Nadezda Brdickova
4. Petra Hadlova
5. Vojen Sadilek
6. Ahmad Iksi
7. Daniela Kuzilkova
8. Michael Svaton
9. George Alehandro Saad
10. Pablo Engel
11. Herve Luche
12. Ana E Sousa
13. Afonso RM Almeida
14. Tomas Kalina

• Curated by eLife

  eLife Assessment

  The authors present an algorithm and workflow for the inference of developmental trajectories from single-cell data, including a mathematical approach to increase computational efficiency. In this latest version, the authors addressed the benchmarking of the novel method, but the absence of quantitative comparisons to state-of-the-art methods still make this study incomplete. Based on the shown validation approaches, one can neither ultimately judge if the shown method will be an advance over previous work nor whether the approach will be of general useful applicability.

Reviewed by eLife

β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury

1. Renaud Prevel
2. Erwan Pernet
3. Kim A Tran
4. Abderrahmane Sadek
5. Mina Sadeghi
6. Elizabeth Lapshina
7. Leonardo F Jurado
8. Arnold S Kristof
9. Mohieddine Moumni
10. Jeremie Poschmann
11. Maziar Divangahi

• Curated by eLife

  eLife Assessment

  This important study advances our understanding of maladaptive innate immune training. The experimental evidence supporting the conclusions is convincing and the expert reviewers strongly endorse the manuscript. The work will be of high interest to both researchers in the trained immunity field and clinician scientists.

Reviewed by eLife