Immunology

DGKα and ζ Deficiency Causes Regulatory T-Cell Dysregulation, Destabilization, and Conversion to Pathogenic T-Follicular Helper Cells to Trigger IgG1-Predominant Autoimmunity

1. Lei Li
2. Hongxiang Huang
3. Hongxia Wang
4. Yun Pan
5. Huishan Tao
6. Shimeng Zhang
7. Peer WF Karmaus
8. Michael B Fessler
9. John W Sleasman
10. Xiao-Ping Zhong

• Curated by eLife

  eLife Assessment

  This study presents an important finding on the signaling mechanisms underlying Treg cell homeostasis by identifying the simultaneous requirement of diacylglycerol (DAG) kinases (DGK) alpha and zeta for Foxp3+ Treg cell function and follicular responses, with implications for the pathogenesis of some autoimmune diseases. Whereas data based on the characterization of double knock-out mice (for DGK alpha and zeta) is solid, showing the emergence of autoimmune manifestations, the study has gaps in its experimental approaches since it is not clear what can be attributed to the simultaneous DKGα and ζ deficiency, versus the individual deficiency of either one. Experiments on the pathogenic potential of the DKO Tregs in the absence of other T-cells were not presented and results on the role of CD25 downregulation and CD28-independent activation of Treg cells were not properly discussed. Nonetheless, the reported data would be of interest to immunologists working on T-cell intracellular signaling and autoimmunity.

Reviewed by eLife

Tumor-infiltrating CD27 ^- IgD ^- regulatory B cells suppress cytotoxic CD8 ⁺ T cell responses in renal cell carcinoma

1. Zara Baig
2. Isabella Withnell
3. Joseph C.F. Ng
4. Christopher J.M. Piper
5. Hannah F. Bradford
6. Antonio Rullan
7. Edward H. Arbe-Barnes
8. Camila G.X. de Brito
9. Alessandro Di Tullio
10. Thomas J. Mitchell
11. Hans J. Stauss
12. Maxine G.B. Tran
13. Franca Fraternali
14. Claudia Mauri

Reviewed by preLights