Immunology

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

1. Alexandros Chatzis
2. Jakub Lukaszonek
3. Dimitris Lagos
4. Dave Boucher
5. Ioannis Kourtzelis

• Curated by eLife

  eLife Assessment

  This important study describes the effect of beta-glucan innate training of macrophages and its effect on uptake of tumour cells and on the production of inflammatory cytokines. The data are convincing and show decreased phagocytic activity of apoptotic tumour cells accompanied by lower levels of secreted IL-1β, and in vivo findings are also provided in the revision. This finding has potential impact on designing potential macrophage-targeted cancer immuno-therapeutic approaches.

Reviewed by eLife

Tumor-infiltrating CD27 ^- IgD ^- regulatory B cells suppress cytotoxic CD8 ⁺ T cell responses in renal cell carcinoma

1. Zara Baig
2. Isabella Withnell
3. Joseph C.F. Ng
4. Christopher J.M. Piper
5. Hannah F. Bradford
6. Antonio Rullan
7. Edward H. Arbe-Barnes
8. Camila G.X. de Brito
9. Alessandro Di Tullio
10. Thomas J. Mitchell
11. Hans J. Stauss
12. Maxine G.B. Tran
13. Franca Fraternali
14. Claudia Mauri

Reviewed by preLights