1. Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent

    This article has 12 authors:
    1. Alannah Lejeune
    2. Chunyi Zhou
    3. Defne Ercelen
    4. Gregory Putzel
    5. Xiaomin Yao
    6. Alyson R Guy
    7. Miranda Pawline
    8. Magdalena Podkowik
    9. Alejandro Pironti
    10. Victor J Torres
    11. Bo Shopsin
    12. Ken Cadwell
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study highlights potential mechanisms underlying the sex-dependent bias in susceptibility to gut colonization by Methicillin-resistant Staphylococcus aureus (MRSA). The evidence supporting the conclusion is compelling. The work will interest biologists who study intestinal infection and immunity.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Deciphering the preeclampsia-specific immune microenvironment and the role of pro-inflammatory macrophages at the maternal–fetal interface

    This article has 13 authors:
    1. Haiyi Fei
    2. Xiaowen Lu
    3. Zhan Shi
    4. Xiu Liu
    5. Cuiyu Yang
    6. Xiaohong Zhu
    7. Yuhan Lin
    8. Ziqun Jiang
    9. Jianmin Wang
    10. Dong Huang
    11. Liu Liu
    12. Songying Zhang
    13. Lingling Jiang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates the immune system's role in pre-eclampsia. The authors map the immune cell landscape of the human placenta and find an increase in macrophages and Th17 cells in patients with pre-eclampsia. Following mouse studies, the authors suggest that the IGF1-IGF1R pathway might play a role in how macrophages influence T cells, potentially driving the pathology of pre-eclampsia. There is convincing evidence in this study that will be of interest to immunologists and developmental biologists.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    This article has 12 authors:
    1. Darren Wethington
    2. Saeed Ahmad
    3. Marc Potempa
    4. Giuseppe Giuliani
    5. Oscar A Aguilar
    6. Maheshwor Poudel
    7. Simon Grassmann
    8. William Stewart
    9. Nicholas M Adams
    10. Joseph C Sun
    11. Lewis L Lanier
    12. Jayajit Das
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study combines mathematical models and experimental data to analyse the emergence of heterogeneity within clonal NK cell responses during antigen-specific cell expansion. Although it comprises different experimental data and tests different theoretical hypotheses, the main claims remain incomplete and would benefit from the consideration of several previous findings about clonal immune responses and corresponding mathematical approaches. The study presents valuable findings with the potential to provide key insights about NK cell development if proposed claims could be confirmed by additional analyses.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Soluble immune mediators orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages

    This article has 6 authors:
    1. Ainhoa Arbués
    2. Sarah Schmidiger
    3. Miriam Reinhard
    4. Sonia Borrell
    5. Sebastien Gagneux
    6. Damien Portevin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study describes the impact of mycobacterial genetic diversity on host-infection phenotypes by assessing the effect of different M. tuberculosis lineages on granulomatous inflammation using a 3D in vitro granuloma model. Despite being descriptive and showing mostly correlative relationships, the findings are useful and provide some solid support regarding the functional impact of M. tuberculosis's natural diversity on host-pathogen interactions. The study will interest researchers working on mycobacteria and motivate future studies to understand how genetic diversity influences virulence and immunity outcomes.

    Reviewed by eLife

    This article has 12 evaluationsAppears in 1 listLatest version Latest activity
  5. Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

    This article has 13 authors:
    1. Sabelo Hadebe
    2. Anca Flavia Savulescu
    3. Jermaine Khumalo
    4. Katelyn Jones
    5. Sandisiwe Mangali
    6. Nontobeko Mthembu
    7. Fungai Musaigwa
    8. Welcome Maepa
    9. Hlumani Ndlovu
    10. Amkele Ngomti
    11. Martyna Scibiorek
    12. Javan Okendo
    13. Frank Brombacher
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Studying several allergens in different mouse strains, the authors assessed the role of IgM in airway inflammatory responses and show that IgM deficient mice have reduced airway hyperresponsiveness. Although the findings are useful and interesting and among others show the expression of a protein that regulates actin in smooth cells, the study remains incomplete as the data and analyses only partly support their primary claim.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  6. Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation

    This article has 8 authors:
    1. J E Parkinson
    2. M Ghafoor
    3. R J Dodd
    4. H E Tompkins
    5. M Fergie
    6. M Rattray
    7. J E Allen
    8. T E Sutherland

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  7. Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    This article has 11 authors:
    1. Jian Cui
    2. Hua Li
    3. Dien Ye
    4. Guoying Zhang
    5. Yan Zhang
    6. Ling Yang
    7. Martha MS Sim
    8. Jeremy P Wood
    9. Yinan Wei
    10. Zhenyu Li
    11. Congqing Wu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors aim to elucidate the mechanism by which pyroptosis (through the formation of Gasdermin D (GSDMD) pores in the plasma membrane) contributes to increased release of procoagulant Tissue Factor-containing microvesicles. The data offers solid mechanistic insights as to the interplay between pyroptosis and microvesicle release with NINJ1. The study provides useful insights into the potential of targeting Ninj1 as a therapeutic strategy.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  8. Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

    This article has 30 authors:
    1. Kevin Wilhelmsen
    2. Aditi Deshpande
    3. Sarah Tronnes
    4. Maitriyee Mahanta
    5. Matthew Banicki
    6. Mary Cochran
    7. Samantha Cowdin
    8. Kristen Fortney
    9. George Hartman
    10. Robert Hughes
    11. Rusty Montgomery
    12. Claudia Portillo
    13. Paul Rubin
    14. Yan Wang
    15. Shijun Yan
    16. Barry A Morgan
    17. Assem Duisembekova
    18. Romane Riou
    19. Michael Marleaux
    20. Inga V. Hochheiser
    21. Hannes Buthmann
    22. Dominic Ferber
    23. Wei Wang
    24. Melanie Cranston
    25. Chloe M. McKee
    26. Thea Mawhinney
    27. Emma McKay
    28. Bénédicte F. Py
    29. Matthias Geyer
    30. Rebecca C. Coll

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant

    This article has 2 authors:
    1. Hiroyuki Yamamoto
    2. Tetsuro Matano
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      Yamamoto and Matano provide convincing evidence that a G63E/R CD8+ T-cell escape mutation in the accessory viral protein Nef promote the induction of neutralizing antibody (nAb) responses in rhesus macaques infected with SIVmac239, which is usually largely resistant to neutralization. Functional analyses support that this mutation specifically impairs Nef`s ability to stimulate PI3K/Akt/mTORC2 signalling. This important study suggests that the accessory viral protein Nef impairs B cell function and effective humoral immune responses and is of interest for researchers and physicians interested in HIV/AIDS and vaccine development.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  10. Genome Restructuring around Innate Immune Genes in Monocytes in Alcohol-associated Hepatitis

    This article has 7 authors:
    1. Adam Kim
    2. Megan R McMullen
    3. Annette Bellar
    4. David Streem
    5. Jaividhya Dasarathy
    6. Nicole Welch
    7. Srinivasan Dasarathy
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the concept and methodological approach are appealing, the evidence is incomplete as a result of insufficient sample sizes as well as other significant analytical concerns.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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