Immunology

  1. Pre-Omicron Immunity Generates IgG⁺ but Not IgA⁺ Memory B Cells Reactive to Omicron Spike Protein

    1. T Tsoleridis
    2. I Singh
    3. D Onion
    4. JG Chappell
    5. A Kelly
    6. J Nightingale
    7. AM Valdes
    8. BJ Ollivere
    9. KB Hoehn
    10. RA Urbanowicz
    11. JK Ball

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  2. Layers of immunity: Deconstructing the Drosophila effector response

    1. Faustine Ryckebusch
    2. Yao Tian
    3. Mylene Rapin
    4. Fanny Schüpfer
    5. Mark Austin Hanson
    6. Bruno Lemaitre

    • Curated by eLife

      eLife Assessment

      This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  3. IRF2 degradation tunes the innate immune response

    1. Cristhian Cadena
    2. Rohit Reja
    3. Emma Bolech
    4. Joshua D. Webster
    5. Vasumathi Kameswaran
    6. Marco de Simone
    7. Cynthia Chen
    8. Jian Jiang
    9. Kathy Hotzel
    10. Kamela Alegre
    11. Zhenyu Tan
    12. Raymond Newland
    13. Ryan Kelly
    14. Spyros Darmanis
    15. Bence Daniel
    16. Ishan Deshpande
    17. Kim Newton
    18. Nobuhiko Kayagaki
    19. Vishva M. Dixit

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity

  4. Epidermal resident memory T cell fitness requires antigen encounter in the skin

    1. Eric S Weiss
    2. Toshiro Hirai
    3. Haiyue Li
    4. Andrew Liu
    5. Shannon Baker
    6. Ian Magill
    7. Jacob Gillis
    8. Youran R Zhang
    9. Torben Ramcke
    10. Kazuo Kurihara
    11. The ImmGen Consortium OpenSource T cell Project
    12. David Masopust
    13. Niroshana Anandasabapathy
    14. Harinder Singh
    15. David Zemmour
    16. Laura K Mackay
    17. Daniel H Kaplan

    • Curated by eLife

      eLife Assessment

      This manuscript advances the prior finding that antigen recognition in the skill helps establish skin resident memory in CD8 T cells by elucidating the role of TGFBR3 in regulating CD8+ TRM skin persistence upon topical antigen exposure. Key novelty of the your work lies in generation and use of the CD8+ T cell-specific TGFBR3 knockout model, which allows them to demonstrate the role of TGFBR3 in fine tuning the degree of CD8+ T cell skin persistence and that TGFBR3 expression is promoted by CD8+ TRM encountering their cognate antigen upon initial skin entry. This is an important finding and is supported by convincing evidence. There are concerns about the use of FTY720 and the need to establish active TGFbeta limiting conditions to further test this working model.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  5. CD4+ T cells promote fibrosis during metabolic dysfunction–associated steatohepatitis

    1. Lucía Valenzuela-Pérez
    2. Hyun Se Kim Lee
    3. Rachel L. Bayer
    4. Dina F. Manna
    5. Shravan K. Mishra
    6. Alexander M. Washington
    7. Adna A. Hassan
    8. Malaz M. Sidahmed
    9. Edward Ssali
    10. Ece Janet Dinc
    11. Benie K. Manwana
    12. Ahmed Ibrahim
    13. Qianqian Guo
    14. Adam Herman
    15. Rondell P. Graham
    16. Kevin D. Pavelko
    17. Gregory J. Gores
    18. Patrick Starlinger
    19. Xavier S. Revelo
    20. Samar H. Ibrahim
    21. Enis Kostallari
    22. Adebowale O. Bamidele
    23. Petra Hirsova

    Reviewed by PREreview

    2 evaluationsAppears in 1 listLatest version Latest activity

  6. The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

    1. Rahul K Suryawanshi
    2. Priyadarshini Jaishankar
    3. Galen J Correy
    4. Moira M Rachman
    5. Patrick C O'Leary
    6. Taha Y Taha
    7. Yusuke Matsui
    8. Francisco J Zapatero-Belinchón
    9. Maria McCavitt-Malvido
    10. Yagmur U Doruk
    11. Maisie GV Stevens
    12. Morgan E Diolaiti
    13. Manasi P Jogalekar
    14. Huadong Chen
    15. Alicia L Richards
    16. Pornparn Kongpracha
    17. Sofia Bali
    18. Mauricio Montano
    19. Julia Rosecrans
    20. Michael Matthay
    21. Takaya Togo
    22. Ryan L Gonciarz
    23. Saumya Gopalkrishnan
    24. R Jeffrey Neitz
    25. Nevan J Krogan
    26. Danielle L Swaney
    27. Brian K Shoichet
    28. Melanie Ott
    29. Adam R Renslo
    30. Alan Ashworth
    31. James S Fraser

    • Curated by eLife

      eLife Assessment

      This important study presents the development of a novel inhibitor for SARS-CoV-2 Mac1 that has potential utility both as an antiviral therapeutic and as a tool for probing the molecular mechanisms by which infection-induced ADP-ribosylation triggers robust host antiviral responses. Though minor gaps in understanding the compound's precise molecular mechanism of action and its ability to target Mac1 from other coronaviruses remain, the evidence for its effects on SARS-CoV-2 in relevant biological models is compelling.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  7. scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues

    1. Yuanyuan Xu
    2. Qi Peng
    3. Xiaoping Lu
    4. Long Ma
    5. Jun Li
    6. Xinsheng Yao

    • Curated by eLife

      eLife Assessment

      This study reanalyzed previously published scRNA-seq and TCR-seq data to examine the proportion and characteristics of dual-TCR-expressing Treg cells in mice, presenting some useful insights into TCR diversity and immune regulation. However, the evidence is incomplete, particularly with respect to data interpretation, statistical rigor, and the functionality of dual -TCR Treg cells. The study is potentially of interest to immunologists studying T-cell biology.

    Reviewed by eLife

    12 evaluationsAppears in 1 listLatest version Latest activity

  8. Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications

    1. Basma Shabana
    2. Nouraldeen Ali Ramadan
    3. Manar Mosad Marey
    4. Mervat Mohamed Shaban

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  9. The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

    1. Anthony E. Jones
    2. Amy Rios
    3. Neira Ibrahimovic
    4. Carolina Chavez
    5. Nicholas A. Bayley
    6. Andréa B. Ball
    7. Wei Yuan Hsieh
    8. Alessandro Sammarco
    9. Amber R. Bianchi
    10. Angel A. Cortez
    11. Thomas G. Graeber
    12. Alexander Hoffmann
    13. Steven J. Bensinger
    14. Ajit S. Divakaruni

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  10. Label-free in-line characterization of immune cell culture using quantitative phase imaging

    1. Caroline E. Serafini
    2. Viswanath Gorti
    3. Paloma Casteleiro Costa
    4. Aaron D. Silva Trenkle
    5. Bharat Kanwar
    6. Bryan Wang
    7. Brian Wicker
    8. Linda E. Kippner
    9. Isaac LeCompte
    10. Rui Qi Chen
    11. Benjamin Joffe
    12. Ye Li
    13. Annie C. Bowles-Welch
    14. Jing Li
    15. Christine E. Brown
    16. Gabriel A. Kwong
    17. Stephen Balakirsky
    18. Krishnendu Roy
    19. Francisco E. Robles

    Reviewed by Arcadia Science

    2 evaluationsAppears in 1 listLatest version Latest activity
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