Immunology

Cytokine-induced reprogramming of human macrophages toward Alzheimer’s disease-relevant molecular and cellular phenotypes in vitro

1. Anna Podlesny-Drabiniok
2. Carmen Romero-Molina
3. Tulsi Patel
4. Wen Yi See
5. Yiyuan Liu
6. Edoardo Marcora
7. Alison M. Goate

Reviewed by Arcadia Science

Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

1. Chika Mochizuki
2. Yoshitaka Taketomi
3. Atsushi Irie
4. Kuniyuki Kano
5. Yuki Nagasaki
6. Yoshimi Miki
7. Takashi Ono
8. Yasumasa Nishito
9. Takahiro Nakajima
10. Yuri Tomabechi
11. Kazuharu Hanada
12. Mikako Shirouzu
13. Takashi Watanabe
14. Kosuke Hata
15. Yoshihiro Izumi
16. Takeshi Bamba
17. Jerold Chun
18. Kai Kudo
19. Ai Kotani
20. Yusuke Endo
21. Junken Aoki
22. Makoto Murakami

Reviewed by Arcadia Science

Evaluation of tick salivary and midgut extracellular vesicles as anti-tick vaccines in White-tailed deer ( Odocoileus virginianus )

1. Julia Gonzalez
2. Cristina Harvey
3. Cárita de Souza Ribeiro-Silva
4. Brenda Leal-Galvan
5. Kelly A. Persinger
6. Pia U. Olafson
7. Tammi L. Johnson
8. Adela Oliva Chavez

Reviewed by Arcadia Science

Terminal tracheal cells of Drosophila are immune privileged to maintain their Foxo-dependent structural plasticity

1. Judith Bossen
2. Reshmi Raveendran
3. Jingjing He
4. Thomas Roeder

• Curated by eLife

  eLife Assessment

  This is a valuable report of tracheal terminal cells (TTCs) in Drosophila being immune privileged. The authors demonstrated that TTCs lack the expression of membrane-associated peptidoglycan recognition receptor PGRP-LC, which protects these cells from activating immune pathway or JNK-mediated cell death to maintain TTC homeostasis. While genetic experiments using RNAi and overexpression are mostly convincing, the data on the expression of PGRP-LCx and cell death phenotypes following immune activation are currently incomplete. The work will be of interest to researchers in innate immunity across various model systems.

Reviewed by eLife

Therapeutic DNA Vaccine Targeting Mycobacterium tuberculosis Persisters Shortens Curative Tuberculosis Treatment

1. Styliani Karanika
2. Tianyin Wang
3. Addis Yilma
4. Jennie Ruelas Castillo
5. James T. Gordy
6. Hannah Bailey
7. Darla Quijada
8. Kaitlyn Fessler
9. Rokeya Tasneen
10. Elisa M. Rouse Salcido
11. Harley T. Harris
12. Rowan E. Bates
13. Heemee Ton
14. Jacob Meza
15. Yangchen Li
16. Alannah D. Taylor
17. Jean J. Zheng
18. Jiaqi Zhang
19. J David Peske
20. Theodoros Karantanos
21. Amanda R. Maxwell
22. Eric Nuermberger
23. Richard B. Markham
24. Petros C. Karakousis

Reviewed by Rapid Reviews Infectious Diseases

Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity

1. Hong Yu
2. Hiroshi Nishio
3. Joseph Barbi
4. Marisa Mitchell-Flack
5. Paolo DA Vignali
6. Ying Zheng
7. Andriana Lebid
8. Kwang-Yu Chang
9. Juan Fu
10. Makenzie Higgins
11. Ching-Tai Huang
12. Xuehong Zhang
13. Zhiguang Li
14. Lee Blosser
15. Ada Tam
16. Charles Drake
17. Drew Pardoll

• Curated by eLife

  eLife Assessment

  The neurotrophic factor Neuritin can moderate T-cell tolerance and immunity through both regulatory T (Treg) and effector T cells, promoting Treg cell expansion and suppression while dampening effector T cells to mediate the inflammatory response. Neuritin expression influences the membrane potential, ion channels, and nutrient transporter expression patterns of CD4+ T cells, contributing to differential metabolic states in Treg and effector T cells. These findings are solid and important for understanding immune regulation involving Treg cells and effector T cells.

Reviewed by eLife

Macrophages redeploy functional cancer cell surface proteins following phagocytosis

1. Regan F. Volk
2. Sara W. Casebeer
3. Andrew C. Condon
4. Bahar Zirak
5. Nayelis Manon
6. Iryna Irkliyenko
7. Huajun Liao
8. Shao Tao
9. Tommaso Pollini
10. Vijay Ramani
11. Ajay V. Maker
12. Trevor Fidler
13. Hani Goodarzi
14. Balyn W. Zaro

Reviewed by PREreview

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

1. Fatima Tleiss
2. Martina Montanari
3. Romane Milleville
4. Olivier Pierre
5. Julien Royet
6. Dani Osman
7. Armel Gallet
8. C Leopold Kurz

• Curated by eLife

  eLife Assessment

  This article describes a novel mechanism allows Drosophila to combat enteric pathogens while also preserving the beneficial indigenous microbiota. The authors provide compelling evidence that oral infection of Drosophila larvae by pathogenic bacteria activate a valve that traps the intruders in the anterior midgut, allowing them to be killed by antimicrobial peptides. This is an important finding revealing a new mechanism of host defense in the gut of insects.

Reviewed by eLife

Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

1. Jo-Chiao Wang
2. Theo Crosson
3. Amin Reza Nikpoor
4. Surbhi Gupta
5. Moutih Rafei
6. Sebastien Talbot

• Curated by eLife

  eLife Assessment

  The study is a valuable addition to the field, showing how particulate matter may be acting via nociceptor neurons towards neutrophilic asthma exacerbations. The solid evidence for the role of a nociceptive pathway in model systems is relevant to human asthma in its current form but would be further strengthened by mechanistic insights. This would be particularly relevant to further translational research towards blocking the exacerbating effect of air pollution on asthma.

Reviewed by eLife

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

1. Florent Colomb
2. Abhishek Jamwal
3. Adefunke Ogunkanbi
4. Tania Frangova
5. Alice R Savage
6. Sarah Kelly
7. Gavin J Wright
8. Matthew K Higgins
9. Henry J McSorley

• Curated by eLife

  eLife Assessment

  This important study uses in vitro and in vivo methods to identify HpARI proteins from H. polygyrus as modulators of the host immune system. The data from comprehensive approaches for investigating differential roles of HpARI proteins are convincing. This paper is relevant to those who investigate host-pathogen interactions at the systems and molecular levels.

Reviewed by eLife