Immunology

CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

1. Liangliang Fu
2. Chenghu Yin
3. Qin Zhao
4. Shuling Guo
5. Wenjun Shao
6. Ting Xia
7. Quan Sun
8. Liangwen Chen
9. Jinghan Li
10. Min Wang
11. Haibin Xia

• Curated by eLife

  eLife Assessment

  This valuable study identifies a population of CD81-positive fibroblasts showing senescence signatures that can activate neutrophils through the C3/C3aR1 axis, hence contributing to the inflammatory response in periodontitis. Solid evidence, combining in vitro and in vivo analyses and mouse and human data, supports these findings. The revised manuscript has addressed many concerns significantly. The work would be of interest to researchers working in the senescence and oral medicine fields.

Reviewed by eLife

Layilin regulates Treg motility and suppressive capacity in skin

1. Victoire Gouirand
2. Sean Clancy
3. Courtney Macon
4. Jose Valle
5. Mariela Pauli
6. Hong-An Truong
7. Jarish Cohen
8. Maxime Kinet
9. Margaret M Lowe
10. Samuel J Lord
11. Kristen Skruber
12. Hobart Harris
13. Esther Kim
14. Isaac Neuhaus
15. Karin Reif
16. Ali A Zarrin
17. R Dyche Mullins
18. Michael D Rosenblum

• Curated by eLife

  eLife Assessment

  This study reports valuable findings on the role of Layilin in the motility and suppressive capacity of clonal expanded regulatory T cells (Tregs) in the skin. Although the strength of the study is utilizing conditional knock-out mice and human skin samples, the analysis of the molecular mechanism by which Layilin affects Treg function is incomplete. The study will be of interest to medical scientists working on skin immunology.

Reviewed by eLife, Arcadia Science

Malnutrition drives infection susceptibility and dysregulated myelopoiesis that persists after refeeding intervention

1. Alisa Sukhina
2. Clemence Queriault
3. Saptarshi Roy
4. Elise Hall
5. Kelly Rome
6. Muskaan Aggarwal
7. Elizabeth Nunn
8. Ashley Weiss
9. Janet Nguyen
10. F Chris Bennett
11. Will Bailis

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of the impact of malnutrition on hematopoiesis and subsequently infection susceptibility. Support for the overall claims is convincing in some respects and incomplete in terms of identifying mechanism as highlighted by reviewers. This work will be of general interest to those in the fields of hematopoiesis, malnutrition, and dietary influence on immunity.

Reviewed by eLife

Coenzyme A governs proinflammatory macrophage metabolism

1. Greg. A Timblin
2. Kevin. M Tharp
3. Johanna ten Hoeve
4. Daniel S Kantner
5. Ilayda Baydemir
6. Eric A Noel
7. Chandra Khantwal
8. Pankaj K Singh
9. Joshua N Farahzad
10. Jorge Domínguez-Andrés
11. Russell E Vance
12. Nathaniel W Snyder
13. Valerie M Weaver

• Curated by eLife

  eLife Assessment

  This important study looks into the effect of exogenous CoA on the response of TLR4-activated macrophages. Specifically, CoA enhances the LPS response by examining metabolomics, 13C tracing, and assessments of transcription and acetylation. Together, these provide a compelling series of findings that show exogenous CoA is taken up by macrophages, and this facilitates histone acetylation and transcription associated with activation and antimicrobial activity.

Reviewed by eLife

Susceptibility of Kit-mutant mice to sepsis caused by enteral dysbiosis, not mast cell deficiency

1. Thorsten B Feyerabend
2. Fabienne Schochter
3. Alpaslan Tasdogan
4. Hans-Reimer Rodewald

• Curated by eLife

  eLife Assessment

  This study presents a useful finding showing that the high susceptibility to sepsis of Kit-mutant mice is due to dysbiosis. However, the data provided is incomplete and would benefit from more rigorous approaches. With the mechanism part strengthened, this paper would be of interest to researchers on mast cell biology and mucosal immunology.

Reviewed by eLife

Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

1. Upneet K Sokhi
2. Ruoxi Yuan
3. Bikash Mishra
4. Yurii Chinenov
5. Anvita Singaraju
6. Karmela K Chan
7. Anne Bass
8. Richard D Bell
9. Laura Donlin
10. Lionel B Ivashkiv

• Curated by eLife

  eLife Assessment

  The manuscript contains important findings regarding inflammatory macrophage subsets that have theoretical and/or practical applications beyond the field of rheumatology. The authors demonstrate with compelling evidence the effects of PGE2 on TNF signaling. This work will be of broad interest to immunologists and cell biologists.

Reviewed by eLife

Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

1. Conan JO O'Brien
2. Giorgio Ratti
3. Hellen Veida-Silva
4. Emma Haberman
5. Charles Sweeney
6. Siamon Gordon
7. Ana I Domingos

• Curated by eLife

  eLife Assessment

  O'Brien and co-authors provide important data demonstrating that tissue-resident macrophages can exert physiological functions and influence endocrine systems.Their model in which AMs negatively regulate aldosterone production via effects exerted in the lung is solid. The work will be of broad interest to cell biologists and immunologists.

Reviewed by eLife

Contrasting Effects of SARS-CoV-2 Vaccination vs. Infection on Antibody and TCR Repertoires

1. Jasper Braun
2. Elliot D. Hill
3. Elisa Contreras
4. Michie Yasuda
5. Alexandra Morgan
6. Sarah Ditelberg
7. Ethan Winter
8. Cody Callahan
9. Gabrielle Mazzoni
10. Andrea Kirmaier
11. Ghee Rye Lee
12. Hamid Mirebrahim
13. Hosseinali Asgharian
14. Dilduz Telman
15. Ai-Ris Y. Collier
16. Dan H. Barouch
17. Stefan Riedel
18. Sanjucta Dutta
19. Florian Rubelt
20. Ramy Arnaout

Reviewed by Review Commons

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

1. Toru Tanaka
2. Naoto Sasaki
3. Aga Krisnanda
4. Hilman Zulkifli Amin
5. Ken Ito
6. Sayo Horibe
7. Kazuhiko Matsuo
8. Ken-ichi Hirata
9. Takashi Nakayama
10. Yoshiyuki Rikitake

• Curated by eLife

  eLife Assessment

  This valuable study provides in-vivo evidence that CCR4 regulates the early inflammatory response during atherosclerotic plaque formation. The authors propose that altered T-cell response plays a role in this process, shedding light on mechanisms that may be of interest to medical biologists, biochemists, cell biologists, and immunologists. The work is currently considered incomplete pending textual changes and the inclusion of proper controls.

Reviewed by eLife

Photoreceptor loss does not recruit neutrophils despite strong microglial activation

1. Derek Power
2. Justin Elstrott
3. Jesse Schallek

• Curated by eLife

  eLife Assessment

  The study by Power and colleagues is important, as elucidating the dynamic immune responses to photoreceptor damage in vivo potentiates future work in the field to better understand the disease process. The evidence supporting the authors' claims is compelling.

Reviewed by eLife