Immunology

CD4 ⁺ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis

1. Lucía Valenzuela-Pérez
2. Hyun Se Kim Lee
3. Rachel L. Bayer
4. Shravan K. Mishra
5. Alexander M. Washington
6. Qianqian Guo
7. Adam Herman
8. Rondell P. Graham
9. Malaz M. Sidahmed
10. Edward Ssali
11. Adna A. Hassan
12. Ece Janet Dinc
13. Kevin D. Pavelko
14. Gregory J. Gores
15. Patrick Starlinger
16. Xavier S. Revelo
17. Samar H. Ibrahim
18. Enis Kostallari
19. Adebowale O. Bamidele
20. Petra Hirsova

Reviewed by PREreview

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

1. Rahul K Suryawanshi
2. Priyadarshini Jaishankar
3. Galen J Correy
4. Moira M Rachman
5. Patrick C O'Leary
6. Taha Y Taha
7. Yusuke Matsui
8. Francisco J Zapatero-Belinchón
9. Maria McCavitt-Malvido
10. Yagmur U Doruk
11. Maisie GV Stevens
12. Morgan E Diolaiti
13. Manasi P Jogalekar
14. Huadong Chen
15. Alicia L Richards
16. Pornparn Kongpracha
17. Sofia Bali
18. Mauricio Montano
19. Julia Rosecrans
20. Michael Matthay
21. Takaya Togo
22. Ryan L Gonciarz
23. Saumya Gopalkrishnan
24. R Jeffrey Neitz
25. Nevan J Krogan
26. Danielle L Swaney
27. Brian K Shoichet
28. Melanie Ott
29. Adam R Renslo
30. Alan Ashworth
31. James S Fraser

• Curated by eLife

  eLife Assessment

  This important study presents the development of a novel inhibitor for SARS-CoV-2 Mac1 that has potential utility both as an antiviral therapeutic and as a tool for probing the molecular mechanisms by which infection-induced ADP-ribosylation triggers robust host antiviral responses. Though minor gaps in understanding the compound's precise molecular mechanism of action and its ability to target Mac1 from other coronaviruses remain, the evidence for its effects on SARS-CoV-2 in relevant biological models is compelling.

Reviewed by eLife

scRNA+TCR-seq reveals the proportion and characteristics of dual TCR Treg cells in mouse lymphoid and non-lymphoid tissues

1. Yuanyuan Xu
2. Qi Peng
3. Xiaoping Lu
4. Long Ma
5. Jun Li
6. Xinsheng Yao

• Curated by eLife

  eLife Assessment

  This study reanalyzed previously published scRNA-seq and TCR-seq data to examine the proportion and characteristics of dual-TCR-expressing Treg cells in mice, presenting some useful insights into TCR diversity and immune regulation. However, the evidence is incomplete, particularly with respect to data interpretation, statistical rigor, and the functionality of dual -TCR Treg cells. The study is potentially of interest to immunologists studying T-cell biology.

Reviewed by eLife

Shared Immune and Epigenetic Pathways in Systemic Lupus Erythematosus and Melanoma Immunotherapy: A Cross-Disease Analysis with Prognostic and Therapeutic Implications

1. Basma Shabana
2. Nouraldeen Ali Ramadan
3. Manar Mosad Marey
4. Mervat Mohamed Shaban

Reviewed by PREreview

The metabolic cofactor Coenzyme A enhances alternative macrophage activation via MyD88-linked signaling

1. Anthony E. Jones
2. Amy Rios
3. Neira Ibrahimovic
4. Carolina Chavez
5. Nicholas A. Bayley
6. Andréa B. Ball
7. Wei Yuan Hsieh
8. Alessandro Sammarco
9. Amber R. Bianchi
10. Angel A. Cortez
11. Thomas G. Graeber
12. Alexander Hoffmann
13. Steven J. Bensinger
14. Ajit S. Divakaruni

Reviewed by Review Commons

Label-Free In-Line Characterization of Immune Cell Culture using Quantitative Phase Imaging

1. Caroline E. Serafini
2. Viswanath Gorti
3. Paloma Casteleiro Costa
4. Aaron D. Silva Trenkle
5. Bharat Kanwar
6. Bryan Wang
7. Brian Wicker
8. Linda E. Kippner
9. Isaac LeCompte
10. Rui Qi Chen
11. Benjamin Joffe
12. Ye Li
13. Annie C. Bowles-Welch
14. Jing Li
15. Christine E. Brown
16. Gabriel A. Kwong
17. Stephen Balakirsky
18. Krishnendu Roy
19. Francisco E. Robles

Reviewed by Arcadia Science

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ-dependent but monocyte-independent process

1. Marlene Magalhaes Pinto
2. Bert Malengier-Devlies
3. Guillaume Seuzaret
4. Anna Ahlback
5. Solvig Becker
6. Katelyn Patatsos
7. Georgios Drakoulis
8. Julia Karjalainen
9. Christiane Ruedl
10. David Voehringer
11. Calum C Bain
12. Elaine Emmerson
13. Barbora Schonfeldova
14. Kristina Zec
15. Irina Udalova
16. Theodoros Simakou
17. Lucy MacDonald
18. Mariola Kurowska-Stolarska
19. Jadwiga Zarebska
20. Tonia Vincent
21. Romeo Ricci
22. Eric Erbs
23. Jack Barrington
24. Barry W McColl
25. Georgiana Neag
26. Samuel Kemble
27. Christopher Mahony
28. Adam Croft
29. Louis Boon
30. Nicole Migotsky
31. Megan L Killian
32. Oumaima Ben Brahim
33. Stefan Uderhardt
34. Alexandre Gallerand
35. Stoyan Ivanov
36. Rebecca Gentek

Reviewed by Review Commons

Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

1. Rajneesh Rao
2. Alejandro Aballay
3. Jogender Singh

• Curated by eLife

  eLife Assessment

  In this valuable manuscript, Rao and colleagues investigate the UFD-1/NPL-4 complex, which is involved in extracting misfolded proteins in the plasma membrane and the accumulation of pathogenic bacteria in the intestine. Using convincing methods, the authors find that knockdown of the ufd-1 and npl-4 genes leads to shortened lifespan of the nematode C. elegans and reduced accumulation of the bacterial pathogen P. aeruginosa in the intestine.

Reviewed by eLife

IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion

1. Daniel L Aldridge
2. Zachary Lanzar
3. Anthony T Phan
4. David A Christian
5. Ryan D Pardy
6. Booki Min
7. Ross Kedl
8. Christopher A Hunter

• Curated by eLife

  eLife Assessment

  The article presents important findings describing the role of IL27 in maintaining HSCs at steady state, and in emergency haematopoiesis in response to T. goodii by limiting the inflammatory monocyte outcomes. The evidence provided are solid and support that IL27 acts at the level of HSCs and not downstream. This study will be of interest to immunologists and hematologists, as well as infectious disease researchers.

Reviewed by eLife

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

1. Alexandros Chatzis
2. Jakub Lukaszonek
3. Dimitris Lagos
4. Dave Boucher
5. Ioannis Kourtzelis

• Curated by eLife

  eLife Assessment

  This important study describes the effect of beta-glucan innate training of macrophages and its effect on uptake of tumour cells and on the production of inflammatory cytokines. The data are convincing and show decreased phagocytic activity of apoptotic tumour cells accompanied by lower levels of secreted IL-1β, and in vivo findings are also provided in the revision. This finding has potential impact on designing potential macrophage-targeted cancer immuno-therapeutic approaches.

Reviewed by eLife