1. The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense Peptide

    This article has 14 authors:
    1. Michelle C Rice
    2. Maria Imun
    3. Sang Wun Jung
    4. Chan Yoon Park
    5. Jessica S Kim
    6. Rochelle W Lai
    7. Casey R Barr
    8. Jyung Mean Son
    9. Kathleen Tor
    10. Emmeline Kim
    11. Ryan J Lu
    12. Ilana Cohen
    13. Bérénice A Benayoun
    14. Changhan Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study presents findings on the mode of action of MOTS-c (mitochondrial open reading frame from the twelve S rRNA type-c), and its impact on monocyte-derived macrophages. The authors present solid evidence for its increased expression in stimulated monocytes/macrophages, its direct bactericidal functions, as well as its role in the modulation of monocyte differentiation into macrophages. Since most of the data were generated from a cell line (THP1), future work is required to validate observations in primary cells and to further support the claims of this work.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  2. A pair of congenic mice for imaging of transplants by positron emission tomography using anti-transferrin receptor nanobodies

    This article has 12 authors:
    1. Thomas Balligand
    2. Claire Carpenet
    3. Sergi Olive-Palau
    4. Tom Jaspers
    5. Pavana Suresh
    6. Xin Liu
    7. Himadri Medhi
    8. Yoon Ho Lee
    9. Mohammad Rashidian
    10. Bart De Strooper
    11. Hidde L. Ploegh
    12. Maarten Dewilde
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this innovative study, Carpenet C et al explore the use of nanobody-based PET imaging to track proliferative cells after in vivo transplantation in mice, in a fully immunocompetent setting. The development of a unique set of PET tracers and mouse strains to track genetically-unmodified transplanted cells in vivo is an important novel asset that could potentially facilitate cell tracking. The evidence provided is compelling as the new method proposed might facilitate overcoming certain limitations of alternative approaches, such as full sized immunoglobulins and small molecules, while the specific claims would gain further support by additional experimentation and methodological details.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Early and delayed STAT1-dependent responses drive local trained immunity of macrophages in the spleen

    This article has 8 authors:
    1. Aryeh Solomon
    2. Noa Bossel Ben-Moshe
    3. Dotan Hoffman
    4. Sébastien Trzebanski
    5. Dror Yehezkel
    6. Leia Vainman
    7. Mihai G Netea
    8. Roi Avraham
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work advances our understanding of the contribution of tissue-resident immune cells to trained immunity phenotypes. The evidence supporting the claims is convincing, with results that will be of interest to immunologists and scientists studying the host-pathogen interface.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Role of hepatocyte RIPK1 in maintaining liver homeostasis during metabolic challenges

    This article has 16 authors:
    1. Weigao Zhang
    2. Hu Liu
    3. Danyang Zhang
    4. Yuguo Yi
    5. Liang Tao
    6. Yunfeng Zhu
    7. Shuxian Huang
    8. Xunan Zhao
    9. Qianchao Shao
    10. Peiqi Li
    11. Yiwen Weng
    12. Wei Lu
    13. Jianfa Zhang
    14. Haibing Zhang
    15. Yuxin Chen
    16. Dan Weng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study provides insights into the physiological role of RIPK1 in liver physiology, particularly during short-term fasting. The discovery that RIPK1 deficiency sensitizes the liver to acute injury and hepatocyte apoptosis is based on convincing evidence, highlighting the importance of RIPK1 in maintaining liver homeostasis under metabolic stress. The work will be of relevance to anyone studying liver pathologies.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  5. SICKO: Systematic Imaging of Caenorhabditis Killing Organisms

    This article has 12 authors:
    1. Luis S Espejo
    2. Samuel Freitas
    3. Vanessa Hofschneider
    4. Leah Chang
    5. Angelo Antenor
    6. Jonah Balsa
    7. Anne Haskins
    8. Destiny DeNicola
    9. Hope Dang
    10. Sage Hamming
    11. Delaney Kelser
    12. George L Sutphin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work describes a valuable method, SICKO, for real-time longitudinal quantification of bacterial colonization in the gut of individual C. elegans. The authors present convincing evidence to support the validity of the approach. SICKO provides an experimental framework that will enable progress in our understanding of host-microbe interactions.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  6. Systematic evaluation of intratumoral and peripheral BCR repertoires in three cancers

    This article has 16 authors:
    1. Sofia V Krasik
    2. Ekaterina A Bryushkova
    3. George V Sharonov
    4. Daria S Myalik
    5. Elizaveta V Shurganova
    6. Dmitry V Komarov
    7. Irina A Shagina
    8. Polina S Shpudeiko
    9. Maria A Turchaninova
    10. Maria T Vakhitova
    11. Igor V Samoylenko
    12. Dimitr T Marinov
    13. Lev V Demidov
    14. Vladimir E Zagaynov
    15. Dmitriy M Chudakov
    16. Ekaterina O Serebrovskaya
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This useful paper systematically evaluates B-cell receptor (BCR) repertoires across tumors, tumor-draining lymph nodes, and peripheral blood in patients with melanoma, lung adenocarcinoma, and colorectal cancer. It investigates the interplay between the tumor microenvironment and immune responses, revealing differences in BCR clonotype maturity, hypermutation, and spatial distribution. The study highlights the heterogeneity in immune responses and provides solid insights into the potential of tumor-infiltrating B cells for therapeutic applications, despite limitations in patient cohort size and sequencing methodology.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  7. UFMTrack, an Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

    This article has 9 authors:
    1. Mykhailo Vladymyrov
    2. Luca Marchetti
    3. Sidar Aydin
    4. Sasha GN Soldati
    5. Adrien Mossu
    6. Arindam Pal
    7. Laurent Gueissaz
    8. Akitaka Ariga
    9. Britta Engelhardt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This work is important because it elucidates how immune cells migrate across the blood brain barrier. In the revised version of this study, the authors present a convincing framework to visualize, recognize and track the movement of different immune cells across primary human and mouse brain microvascular endothelial cells without the need for fluorescence-based imaging using microfluidic devices. This work will be of broad interest to the cancer biology, immunology and medical therapeutics fields.

    Reviewed by eLife

    This article has 13 evaluationsAppears in 1 listLatest version Latest activity
  8. Investigating the antimicrobial and immunomodulatory effects of honeybee venom peptide apamin in the Drosophila genetic platform

    This article has 9 authors:
    1. Yanan Wei
    2. Wenjie Jia
    3. Yanying Sun
    4. Tianmu Zhang
    5. Hongyu Miao
    6. Zekun Wu
    7. Ran Dong
    8. Fangyong Ning
    9. Woo Jae Kim

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  9. Inhibition of glycolysis in tuberculosis-mediated metabolic rewiring reduces HIV-1 spread across macrophages

    This article has 18 authors:
    1. Zoï Vahlas
    2. Natacha Faivre
    3. Sarah C. Monard
    4. Quentin Hertel
    5. Mariano Maio
    6. Joaquina Barros
    7. Alexandre Lucas
    8. Thien-Phong Vu Manh
    9. Myriam Ben Neji
    10. Marcelo Corti
    11. Renaud Poincloux
    12. Fabien Blanchet
    13. Brigitte Raynaud-Messina
    14. Fabien Letisse
    15. Olivier Neyrolles
    16. Geanncarlo Lugo-Villarino
    17. Luciana Balboa
    18. Christel Vérollet

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

    This article has 16 authors:
    1. Miki Kume
    2. Hanako Koguchi-Yoshioka
    3. Shuichi Nakai
    4. Yutaka Matsumura
    5. Atsushi Tanemura
    6. Kazunori Yokoi
    7. Shoichi Matsuda
    8. Yuumi Nakamura
    9. Naoya Otani
    10. Mifue Taminato
    11. Koichi Tomita
    12. Tateki Kubo
    13. Mari Wataya-Kaneda
    14. Atsushi Kumanogoh
    15. Manabu Fujimoto
    16. Rei Watanabe
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper advances an important new concept in psoriasis pathogenesis and implicates Sema4a as a homeostatic regulator that is highly epithelial-specific. The findings are convincing and lend support for the biology described here as a mechanism with therapeutic implications.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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