Genomics

A complex Plasmodium falciparum cryptotype circulating at low frequency across the African continent

1. Olivo Miotto
2. Alfred Amambua-Ngwa
3. Lucas Amenga-Etego
4. Muzamil M Abdel Hamid
5. Ishag Adam
6. Enoch Aninagyei
7. Tobias Apinjoh
8. Gordon A Awandare
9. Philip Bejon
10. Gwladys I Bertin
11. Marielle Bouyou-Akotet
12. Antoine Claessens
13. David J Conway
14. Umberto D’Alessandro
15. Mahamadou Diakite
16. Abdoulaye Djimdé
17. Arjen M Dondorp
18. Patrick Duffy
19. Rick M Fairhurst
20. Caterina I Fanello
21. Anita Ghansah
22. Deus Ishengoma
23. Mara Lawniczak
24. Oumou Maïga-Ascofaré
25. Sarah Auburn
26. Anna Rosanas-Urgell
27. Varanya Wasakul
28. Nina FD White
29. Jacob Almagro-Garcia
30. Richard D Pearson
31. Sonia Goncalves
32. Cristina Ariani
33. Zbynek Bozdech
34. William Hamilton
35. Victoria Simpson
36. Dominic P Kwiatkowski

Reviewed by preLights

Integrated multiplexed assays of variant effect reveal cis -regulatory determinants of catechol- O -methyltransferase gene expression

1. Ian Hoskins
2. Shilpa Rao
3. Charisma Tante
4. Can Cenik

Reviewed by Review Commons

Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity

1. Luciana I. Gómez Acuña
2. Ilya Flyamer
3. Shelagh Boyle
4. Elias Friman
5. Wendy A. Bickmore

Reviewed by Review Commons

Post-meiotic mechanism of facultative parthenogenesis in gonochoristic whiptail lizard species

1. David V Ho
2. Duncan Tormey
3. Aaron Odell
4. Aracely A Newton
5. Robert R Schnittker
6. Diana P Baumann
7. William B Neaves
8. Morgan R Schroeder
9. Rutendo F Sigauke
10. Anthony J Barley
11. Peter Baumann

Reviewed by Review Commons

YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing

1. Joseph S Bowness
2. Mafalda Almeida
3. Tatyana B Nesterova
4. Neil Brockdorff

Reviewed by Review Commons

DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variants

1. Simon C Biddie
2. Giovanna Weykopf
3. Elizabeth F. Hird
4. Elias T. Friman
5. Wendy A Bickmore

Reviewed by Review Commons

An improved chromosome-level genome assembly of perennial ryegrass ( Lolium perenne L.)

1. Yutang Chen
2. Roland Kölliker
3. Martin Mascher
4. Dario Copetti
5. Axel Himmelbach
6. Nils Stein
7. Bruno Studer

• Curated by GigaByte

  Editors Assessment:

  This Data Release paper presents an updated genome assembly of the doubled haploid perennial ryegrass (Lolium perenne L.) genotype Kyuss (Kyuss v2.0). To correct for structural the authors de novo assembled the genome again with ONT long-reads and generated 50-fold coverage high-throughput chromosome conformation capture (Hi-C) data to assist pseudo-chromosome construction. After being asked for some more improvements to gene and repeat annotation the authors now demonstrate the new assembly is more contiguous, more complete, and more accurate than Kyuss v1.0 and shows the correct pseudo-chromosome structure. This more accurate data have great potential for downstream genomic applications, such as read mapping, variant calling, genome-wide association studies, comparative genomics, and evolutionary biology. These future analyses being able to benefit forage and turf grass research and breeding.

  This evaluation refers to version 1 of the preprint

Reviewed by GigaByte

Switching of RNA splicing regulators in immature neuroblasts: a key step in adult neurogenesis

1. Corentin Bernou
2. Marc-André Mouthon
3. Mathieu Daynac
4. Thierry Kortulewski
5. Benjamin Demaille
6. Vilma Barroca
7. Sébastien Couillard-Despres
8. Nathalie Dechamps
9. Véronique Ménard
10. Léa Bellenger
11. Christophe Antoniewski
12. Alexandra Chicheportiche
13. François D. Boussin

• Curated by eLife

  eLife assessment

  This useful manuscript presents an intriguing potential refinement of models for adult SVZ neurogenesis, and highlights the role of RNA splicing at specific stages in the lineage. Unfortunately, the evidence does not fully support the claims, leaving it currently incomplete. The proposed role of RNA splicing in neuronal differentiation, though interesting, remains unexplored and would benefit significantly from targeted gene manipulation studies.

Reviewed by eLife

NERD-seq: A novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs

1. Luke Saville
2. Yubo Cheng
3. Babita Gollen
4. Liam Mitchell
5. Matthew Stuart-Edwards
6. Travis Haight
7. Majid Mohajerani
8. Athanasios Zovoilis

Reviewed by Review Commons

Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results

1. Reese Richardson
2. Heliodoro Tejedor Navarro
3. Luis A Nunes Amaral
4. Thomas Stoeger

• Curated by eLife

  eLife assessment

  This study investigated the factors related to understudied genes in biomedical research. It showed that understudied genes are largely abandoned at the writing stage, and it identified a number of biological and experimental factors that influence which genes are selected for investigation. The study is an important contribution to this branch of meta-research, and the evidence in support of the findings is solid.

Reviewed by eLife