1. Regulatory genome annotation of 33 insect species

    This article has 8 authors:
    1. Hasiba Asma
    2. Ellen Tieke
    3. Kevin D Deem
    4. Jabale Rahmat
    5. Tiffany Dong
    6. Xinbo Huang
    7. Yoshinori Tomoyasu
    8. Marc S Halfon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In the revised version of this important study, the authors present a convincing pipeline for insect genome regulatory annotation across 33 insect genomes spanning 5 orders. Despite technical limitations in the field owing to the lack of comprehensive knowledge of enhancer content in any system, the authors employ several independent downstream analyses to support the validity of their enhancer predictions for a subset of these genomes. Taken together, the revised results suggest that this prediction pipeline may have uses in identifying functional enhancers across large phylogenetic distances. Reviewers note caveats that an experimental validation is not yet available in the field to validate a large class of newly identified enhancers across such evolutionary distances, and other pipelines might be of use to compare. This work will be of interest to the computational genomics, evolutionary biology, and gene regulation fields.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profiling

    This article has 3 authors:
    1. Chen Weng
    2. Jonathan S. Weissman
    3. Vijay G. Sankaran

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Essentiality and dynamic expression of the human tRNA pool during viral infection

    This article has 5 authors:
    1. Noa Aharon-Hefetz
    2. Michal Schwartz
    3. Orna Dahan
    4. Noam Stern-Ginossar
    5. Yitzhak Pilpel

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow

    This article has 13 authors:
    1. Sila Gerlevik
    2. Nogayhan Seymen
    3. Shan Hama
    4. Warisha Mumtaz
    5. I Richard Thompson
    6. Seyed R Jalili
    7. Deniz E Kaya
    8. Alfredo Iacoangeli
    9. Andrea Pellagatti
    10. Jacqueline Boultwood
    11. Giorgio Napolitani
    12. Ghulam J Mufti
    13. Mohammad M Karimi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript uses public datasets of myelodysplastic syndrome (MDS) patients to undertake a multi-omics analysis of clinical, genomic, and transcriptomic datasets. Useful findings are provided by way of interesting correlations of specific mutations with inflammation and differing clinical outcomes. The evidence is solid and interesting, and the manuscript is of substantive value to hematologists and clinical immunologists.

    Reviewed by eLife

    This article has 6 evaluationsAppears in 1 listLatest version Latest activity
  5. A rapid phylogeny-based method for accurate community profiling of large-scale metabarcoding datasets

    This article has 2 authors:
    1. Lenore Pipes
    2. Rasmus Nielsen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This potentially important work presents a tool for performing phylogenetic taxonomic classification of DNA sequences. In terms of methodology, the work is compelling. The authors perform a benchmark experiment against current state-of-the-art tools using real and simulated datasets to demonstrate where the novel tool stands in the context of existing methods. However, the experimentation is still incomplete. It would benefit from a more thorough exploration of existing methods as well as data sets that better represent real-world use cases.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  6. Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

    This article has 14 authors:
    1. Shaohua Gu
    2. Yuanzhe Shao
    3. Karoline Rehm
    4. Laurent Bigler
    5. Di Zhang
    6. Ruolin He
    7. Ruichen Xu
    8. Jiqi Shao
    9. Alexandre Jousset
    10. Ville-Petri Friman
    11. Xiaoying Bian
    12. Zhong Wei
    13. Rolf Kümmerli
    14. Zhiyuan Li
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study presents a novel pipeline for the large-scale genomic prediction of members of the non-ribosomal peptide group of pyoverdines based on a dataset from nearly 2000 Pseudomonas genomes. The advance presented in this study is based on convincing evidence. This study of bacterial siderophores has broad theoretical and practical implications beyond a singular subfield.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  7. Kinship analysis and pedigree reconstruction by RAD sequencing in cattle

    This article has 8 authors:
    1. Yiming Xu
    2. Wanqiu Wang
    3. Jiefeng Huang
    4. Minjie Xu
    5. Binhu Wang
    6. Yingsong Wu
    7. Yongzhong Xie
    8. Jianbo Jian
    This article has been curated by 1 group:
    • Curated by GigaByte

      Editors Assessment:

      RAD-Seq (Restriction-site-associated DNA sequencing) is a cost-effective method for single nucleotide polymorphism (SNP) discovery and genotyping. In this study the authors performed a kinship analysis and pedigree reconstruction for two different cattle breeds (Angus and Xiangxi yellow cattle). A total of 975 cattle, including 923 offspring with 24 known sires and 28 known dams, were sampled and subjected to SNP discovery and genotyping using RAD-Seq. Producing a SNP panel with 7305 SNPs capturing the maximum difference between paternal and maternal genome information, and being able to distinguish between the F1 and F2 generation with 90% accuracy. Peer review helped highlight better the practical applications of this work. The combination of the efficiency of RNA-seq and advances in kinship analysis here can helpfully help improve breed management, local resource utilization, and conservation of livestock.

      This evaluation refers to version 1 of the preprint

    Reviewed by GigaByte

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  8. Chromosomal-level genome assembly and single-nucleotide polymorphism sites of black-faced spoonbill Platalea minor

    This article has 20 authors:
    1. Hong Kong Biodiversity Genomics Consortium
    2. Jerome H.L. Hui
    3. Ting Fung Chan
    4. Leo L. Chan
    5. Siu Gin Cheung
    6. Chi Chiu Cheang
    7. James K.H. Fang
    8. Juan Diego Gaitan-Espitia
    9. Stanley C.K. Lau
    10. Yik Hei Sung
    11. Chris K.C. Wong
    12. Kevin Y.L. Yip
    13. Yingying Wei
    14. Wai Lok So
    15. Wenyan Nong
    16. Sean T.S. Law
    17. Paul Crow
    18. Aiko Leong
    19. Liz Rose-Jeffreys
    20. Ho Yin Yip
    This article has been curated by 1 group:
    • Curated by GigaByte

      Editors Assessment: This work is part of a series of papers from the Hong Kong Biodiversity Genomics Consortium sequencing the rich biodiversity of species in Hong Kong (see https://doi.org/10.46471/GIGABYTE_SERIES_0006). This example assembles the genome of the black-faced spoonbill (Platalea minor), an emblematic wading bird from East Asia that is classified as globally endangered by the IUCN. This Data Release reporting a 1.24Gb chromosomal-level genome assembly produced using a combination of PacBio SMRT and Omni-C scaffolding technologies. BUSCO and Merqury validation were carried out, gene models created, and peer reviewers also requested MCscan synteny analysis. This showed the genome assembly had high sequence continuity with scaffold length N50=53 Mb. Presenting data from 14 individuals this will hopefully be a useful and valuable resources for future population genomic studies aimed at better understanding spoonbill species numbers and conservation.

      *This evaluation refers to version 1 of the preprint

    Reviewed by GigaByte

    This article has 2 evaluationsAppears in 2 listsLatest version Latest activity
  9. Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral

    This article has 11 authors:
    1. Maria Valadez-Ingersoll
    2. Hanny E. Rivera
    3. JK Da-Anoy
    4. Matthew R. Kanke
    5. Kelly Gomez-Campo
    6. M. Isabel Martinez-Rugerio
    7. Julian Kwan
    8. Ryan Hekman
    9. Andrew Emili
    10. Thomas D. Gilmore
    11. Sarah W. Davies

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

    This article has 10 authors:
    1. Teresa Attenborough
    2. Kate A Rawlinson
    3. Carmen L Diaz Soria
    4. Kirsty Ambridge
    5. Geetha Sankaranarayanan
    6. Jennie Graham
    7. James A Cotton
    8. Stephen R Doyle
    9. Gabriel Rinaldi
    10. Matthew Berriman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is a valuable study in which the authors provide an expression profile of the human blood fluke, Schistosoma mansoni. A strength of this solid study is in its inclusion of in situ hybridisation to validate the predictions of the transcript analysis.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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