Genetics

A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1

1. Natalia Felipe-Medina
2. Sandrine Caburet
3. Fernando Sánchez-Sáez
4. Yazmine B Condezo
5. Dirk G de Rooij
6. Laura Gómez-H
7. Rodrigo Garcia-Valiente
8. Anne Laure Todeschini
9. Paloma Duque
10. Manuel Adolfo Sánchez-Martin
11. Stavit A Shalev
12. Elena Llano
13. Reiner A Veitia
14. Alberto M Pendás

Reviewed by eLife

Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans

1. Karen I. Lange
2. Sofia Tsiropoulou
3. Katarzyna Kucharska
4. Oliver E. Blacque

Reviewed by eLife

Dominant negative effects on H3K27 methylation by Weaver syndrome-associated EZH2 variants

1. Orla Deevy
2. Craig Monger
3. Francesca Matrà
4. Ellen Tuck
5. Eric Conway
6. Mihaly Badonyi
7. Darragh Nimmo
8. Simona Rodighiero
9. Qi Zhang
10. Chen Davidovich
11. Joseph A. Marsh
12. Diego Pasini
13. Adrian P. Bracken

Reviewed by PREreview

Regulation of defective mitochondrial DNA accumulation and transmission in C. elegans by the programmed cell death and aging pathways

1. Sagen Flowers
2. Rushali Kothari
3. Yamila N Torres Cleuren
4. Melissa R Alcorn
5. Chee Kiang Ewe
6. Geneva Alok
7. Samantha L Fiallo
8. Pradeep M Joshi
9. Joel H Rothman

• Curated by eLife

  eLife assessment

  This manuscript suggests a novel mechanism of purifying selection by which programmed cell death contributes to the selective removal of mtDNA deletion mutations in C. elegans. The evidence for this mechanism of removal is strong although questions remain regarding the underlying mechanism and the role of canonical ageing pathways. Because of the likely central role of mtDNA deletions in ageing and age-dependent diseases, this work will be of interest to scientists in the field of mitochondrial biology as well as ageing.

Reviewed by eLife

DNA methylation rates scale with maximum lifespan across mammals

1. Samuel J. C. Crofts
2. Eric Latorre-Crespo
3. Tamir Chandra

Reviewed by preLights

Mitotic heritability of DNA methylation at intermediately methylated sites is imprecise

1. Amir D. Hay
2. Noah J. Kessler
3. Daniel Gebert
4. Nozomi Takahashi
5. Hugo Tavares
6. Felipe K. Teixeira
7. Anne C. Ferguson-Smith

Reviewed by preLights

Domestication of different varieties in the cheese-making fungus Geotrichum candidum

1. Bastien Bennetot
2. Jean-Philippe Vernadet
3. Vincent Perkins
4. Sophie Hautefeuille
5. Ricardo C. Rodríguez de la Vega
6. Samuel O’Donnell
7. Alodie Snirc
8. Cécile Grondin
9. Marie-Hélène Lessard
10. Anne-Claire Peron
11. Steve Labrie
12. Sophie Landaud
13. Tatiana Giraud
14. Jeanne Ropars

Reviewed by Peer Community in Evolutionary Biology

PTC2 region genotypes counteract Biomphalaria glabrata population differences between M-line and BS90 in resistance to infection by Schistosoma mansoni

1. Michael S. Blouin
2. Stephanie R. Bollmann
3. Jacob A. Tennessen

Reviewed by PeerJ

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

1. Tomas Pachano
2. Víctor Sánchez-Gaya
3. Thais Ealo
4. Maria Mariner-Faulí
5. Tore Bleckwehl
6. Helena G. Asenjo
7. Patricia Respuela
8. Sara Cruz-Molina
9. María Muñoz-San Martín
10. Endika Haro
11. Wilfred F. J. van IJcken
12. David Landeira
13. Alvaro Rada-Iglesias

Reviewed by preLights

Saturation variant interpretation using CRISPR prime editing

1. Steven Erwood
2. Teija M. I. Bily
3. Jason Lequyer
4. Joyce Yan
5. Nitya Gulati
6. Reid A. Brewer
7. Liangchi Zhou
8. Laurence Pelletier
9. Evgueni A. Ivakine
10. Ronald D. Cohn

Reviewed by preLights