Genetics

Polygenic prediction of school performance in children with and without psychiatric disorders

1. Veera M. Rajagopal
2. Betina B Trabjerg
3. Jakob Grove
4. Henriette T. Horsdal
5. Liselotte Petersen
6. Cynthia M. Bulik
7. Jonas Bybjerg-Grauholm
8. Marie Bækvad-Hansen
9. David M Hougaard
10. Ole Mors
11. Merete Nordentoft
12. Thomas Werge
13. Preben Bo Mortensen
14. Esben Agerbo
15. Anders D. Borglum
16. Ditte Demontis

• Curated by eLife

  Summary: This is an interesting study researching how educational achievement (EA) can be predicted using genomic data when the sample is stratified to those without and those with diagnoses of common psychiatric disorders. The study is well powered using an impressive and representative sample and offers insights into the etiology of associations between psychiatric traits and educational achievement. The authors find evidence that the influence of common variants on EA is attenuated in individuals with a diagnosis of autism spectrum disorder (ASD) or ADHD.

Reviewed by eLife

A home and rescue gene drive efficiently spreads and persists in populations

1. Nikolay P. Kandul
2. Junru Liu
3. Jared B. Bennett
4. John M. Marshall
5. Omar S. Akbari

Reviewed by eLife

Quantitative spatial and temporal assessment of regulatory element activity in zebrafish

1. Shipra Bhatia
2. Dirk Jan Kleinjan
3. Kirsty Uttley
4. Anita Mann
5. Nefeli Dellepiane
6. Wendy A Bickmore

Reviewed by Review Commons

Mutation density changes in SARS-CoV-2 are related to the pandemic stage but to a lesser extent in the dominant strain with mutations in spike and RdRp

1. Doğa Eskier
2. Aslı Suner
3. Gökhan Karakülah
4. Yavuz Oktay

Reviewed by PeerJ, ScreenIT

Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution

1. M. J. Higgs
2. M. J. Hill
3. R. M. John
4. A. R. Isles

• Curated by eLife

  Summary: The reviewers appreciated the effort to merge most of the available datasets to make a precise survey of the sites of imprinted gene expression and the great resource it could bring to the community. However, the reviewers also felt that the study suffered from methodological bias, was preliminary (no allelic information in particular), and that the conclusions did not go beyond previous reports. The general lack of citation of the name of imprinted genes made it difficult to judge whether conclusions were consistent among the different datasets. Highlighting specific imprinted genes would bring a clearer focus and narrative.

Reviewed by eLife

A robust and flexible CRISPR/Cas9-based system for neutrophil-specific gene inactivation in zebrafish

1. Yueyang Wang
2. Alan Y. Hsu
3. Eric M. Walton
4. Sung Jun Park
5. Ramizah Syahirah
6. Tianqi Wang
7. Wenqing Zhou
8. Chang Ding
9. Abby Pei Lemke
10. GuangJun Zhang
11. David M. Tobin
12. Qing Deng

Reviewed by eLife

Paternal multigenerational exposure to an obesogenic diet drives epigenetic predisposition to metabolic diseases in mice

1. Georges Raad
2. Fabrizio Serra
3. Luc Martin
4. Marie-Alix Derieppe
5. Jérôme Gilleron
6. Vera L Costa
7. Didier F Pisani
8. Ez-Zoubir Amri
9. Michele Trabucchi
10. Valerie Grandjean

Reviewed by eLife

Fluorescent in vivo editing reporter (FIVER): A novel multispectral reporter of in vivo genome editing

1. Peter A. Tennant
2. Robert G. Foster
3. Daniel O. Dodd
4. Ieng Fong Sou
5. Fraser McPhie
6. Nicholas Younger
7. Laura C. Murphy
8. Matthew Pearson
9. Bertrand Vernay
10. Margaret A. Keighren
11. Peter Budd
12. Stephen L. Hart
13. Roly Megaw
14. Luke Boulter
15. Pleasantine Mill

Reviewed by eLife

A catalog of homoplasmic and heteroplasmic mitochondrial DNA variants in humans

1. Alexandre Bolze
2. Fernando Mendez
3. Simon White
4. Francisco Tanudjaja
5. Magnus Isaksson
6. Ruomu Jiang
7. Andrew Dei Rossi
8. Elizabeth T. Cirulli
9. Misha Rashkin
10. William J. Metcalf
11. Joseph J. Grzymski
12. William Lee
13. James T. Lu
14. Nicole L. Washington

Reviewed by eLife

A simple and effective F0 knockout method for rapid screening of behaviour and other complex phenotypes

1. François Kroll
2. Gareth T Powell
3. Marcus Ghosh
4. Gaia Gestri
5. Paride Antinucci
6. Timothy J Hearn
7. Hande Tunbak
8. Sumi Lim
9. Harvey W Dennis
10. Joseph M Fernandez
11. David Whitmore
12. Elena Dreosti
13. Stephen W Wilson
14. Ellen J Hoffman
15. Jason Rihel

Reviewed by eLife