Developmental Biology

Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification

1. Nikola Sekulovski
2. Jenna C Wettstein
3. Amber E Carleton
4. Lauren N Juga
5. Linnea E Taniguchi
6. Xiaolong Ma
7. Sridhar Rao
8. Jenna K Schmidt
9. Thaddeus G Golos
10. Chien-Wei Lin
11. Kenichiro Taniguchi

• Curated by eLife

  eLife assessment

  This study presents an important dataset that captures the transition from epiblast to amnion using a novel in vitro model of human amnion formation. The supporting evidence for the authors' claims is convincing. Key strengths of the study include the efficiency and purity of the cell populations produced, a high degree of synchrony in the differentiation process, comprehensive benchmarking with single-cell data and immunocytochemistry from primate embryos, and the identification of critical markers for specific differentiation phases. A notable limitation, however, is the model's exclusion of other embryonic tissues.

Reviewed by eLife

A microRNA that controls the emergence of embryonic movement

1. Jonathan AC Menzies
2. André Maia Chagas
3. Tom Baden
4. Claudio R Alonso

• Curated by eLife

  eLife assessment

  This important study presents a new quantitative imaging pipeline that describes with high temporal precision and throughput the movements of late-stage Drosophila embryos, a critical moment when motion first appears. A new approach is used to explore the role of miRNAs in motion onset and presents solid evidence that shows a role for miR-2b-1 and its target Motor in embryonic motion. The data are well supported even if the mechanistic insight into the emergence of movement remains to be explored.

Reviewed by eLife

Topology changes of the regenerating Hydra define actin nematic defects as mechanical organizers of morphogenesis

1. Yamini Ravichandran
2. Matthias Vogg
3. Karsten Kruse
4. Daniel JG Pearce
5. Aurélien Roux

Reviewed by Arcadia Science, preLights

Scaling between cell cycle duration and wing growth is regulated by Fat-Dachsous signaling in Drosophila

1. Andrew Liu
2. Jessica O’Connell
3. Farley Wall
4. Richard W Carthew

• Curated by eLife

  eLife assessment

  This important research article provides a novel approach to measure imaginal disc growth and uses this approach to explore the roles of Fat and Dachsous, two conserved protocadherins, in late larval development. The authors have addressed all referee concerns and the evidence supporting the authors' findings overall are compelling.

Reviewed by eLife

Limited column formation in the embryonic growth plate implies divergent growth mechanisms during pre- and postnatal bone development

1. Sarah Rubin
2. Ankit Agrawal
3. Anne Seewald
4. Meng-Jia Lian
5. Olivia Gottdenker
6. Paul Villoutreix
7. Adrian Baule
8. Tomer Stern
9. Elazar Zelzer

• Curated by eLife

  eLife assessment

  The study presents a valuable finding on quantifying the orientation and organization of chondrocyte columns in the prenatal and postnatal growth plate cartilage using advanced 3D imaging and a sophisticated image analysis pipeline. The evidence supporting the authors' conclusions regarding the lack of columns in the fetal growth plate is considered inadequate due to technical caveats, inconsistencies in the data and corresponding model, and failure to correctly put the findings in context.

Reviewed by eLife

Development of a hepatic cryoinjury model to study liver regeneration

1. Marcos Sande-Melon
2. David Bergemann
3. Miriam Fernández-Lajarín
4. Juan Manuel González-Rosa
5. Andrew G. Cox

Reviewed by Review Commons

The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila central nervous system

1. Sanjay Kumar Sukumar
2. Vimala Antonydhason
3. Linnea Molander
4. Jawdat Sandakly
5. Malak Kleit
6. Ganesh Umapathy
7. Patricia Mendoza-Garcia
8. Tafheem Masudi
9. Andreas Schlosser
10. Dick R Nässel
11. Christian Wegener
12. Margret Shirinian
13. Ruth H Palmer

• Curated by eLife

  eLife assessment:

  This paper characterises a novel gene (Spar), and presenting valuable findings in the field of insect biology and behaviour. The experiments are well designed, with attention to detail, showcasing the potential of the Drosophila melanogaster model and the use of online resources. The mixed approach presents a convincing argument for a genetic interaction between Alk and Spar.

Reviewed by eLife

Jag1 Insufficiency Disrupts Neonatal T Cell Differentiation and Impairs Hepatocyte Maturation, Leading to Altered Liver Fibrosis

1. Jan Mašek
2. Iva Filipovic
3. Noémi Van Hul
4. Lenka Belicová
5. Markéta Jiroušková
6. Daniel V. Oliveira
7. Anna Maria Frontino
8. Simona Hankeova
9. Jingyan He
10. Fabio Turetti
11. Afshan Iqbal
12. Igor Červenka
13. Lenka Sarnová
14. Elisabeth Verboven
15. Tomáš Brabec
16. Niklas K. Björkström
17. Martin Gregor
18. Jan Dobeš
19. Emma R. Andersson

Reviewed by Review Commons

Deep learning based reconstruction of embryonic cell-division cycle from label-free microscopy time-series of evolutionarily diverse nematodes

1. Dhruv Khatri
2. Chaitanya A. Athale

Reviewed by Arcadia Science

Haploidy-linked cell proliferation defects limit larval growth in zebrafish

1. Kan Yaguchi
2. Daiki Saito
3. Triveni Menon
4. Akira Matsura
5. Miyu Hosono
6. Takeomi Mizutani
7. Tomoya Kotani
8. Sreelaja Nair
9. Ryota Uehara

Reviewed by Review Commons