Developmental Biology

Patterned embryonic invagination evolved in response to mechanical instability

1. Bruno C. Vellutini
2. Marina B. Cuenca
3. Abhijeet Krishna
4. Alicja Szałapak
5. Carl D. Modes
6. Pavel Tomančák

Reviewed by preLights

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

1. Siyuan Cheng
2. Ivan Fan Xia
3. Renate Wanner
4. Javier Abello
5. Amber N Stratman
6. Stefania Nicoli

• Curated by eLife

  eLife assessment

  This study provides the first analysis of vascular stabilization on the critical and evolutionarily conserved structure around the Circle of Willis in the brain, strengthened by using parallel in vivo and in vitro experimental approaches. The evidence supporting the claims is solid and the work will be valuable for scientists studying developmental and disease-related vascular stabilization.

Reviewed by eLife

Modular control of vertebrate axis segmentation in time and space

1. Ali Seleit
2. Ian Brettell
3. Tomas Fitzgerald
4. Carina Vibe
5. Felix Loosli
6. Joachim Wittbrodt
7. Kiyoshi Naruse
8. Ewan Birney
9. Alexander Aulehla

Reviewed by preLights, Review Commons, Arcadia Science

Zebrafish reveal new roles for Fam83f in hatching and the DNA damage-mediated autophagic response

1. Rebecca A. Jones
2. Fay Cooper
3. Gavin Kelly
4. David Barry
5. Matthew J. Renshaw
6. Gopal Sapkota
7. James C. Smith

Reviewed by Review Commons

OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline

1. Leif Benner
2. Savannah Muron
3. Jillian G Gomez
4. Brian Oliver

• Curated by eLife

  eLife assessment

  This useful manuscript extends prior work to identify OVO as a major transcriptional activator of the female germline gene expression program. Using a combination of solid genomic strategies, the authors demonstrate that OVO binds to the promoters of hundreds of genes in the female germline and promotes their expression.

Reviewed by eLife

Symmetry breaking and fate divergence during lateral inhibition in Drosophila

1. Minh-Son Phan
2. Jang-mi Kim
3. Cara Picciotto
4. Lydie Couturier
5. Nisha Veits
6. Khallil Mazouni
7. François Schweisguth

Reviewed by Review Commons

The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient

1. Colby K. Schweibenz
2. Victoria C. Placentra
3. Kenneth H. Moberg

• Curated by eLife

  eLife assessment

  The authors study how cells with lower levels of the conserved steroid hormone signaling component Taiman (tai) are out-competed by neighboring wild-type cells with higher fitness in Drosophila imaginal discs. The findings are useful since they uncover an unexpected link between tai and Wingless signaling in cell competition. The evidence however is incomplete, since the tai loss-of-clone phenotype is based on one allele and the mechanism involved in cell competition through Dlp and Wg lacks adequate supporting data.

Reviewed by eLife

Notch3 is a genetic modifier of NODAL signalling for patterning asymmetry during mouse heart looping

1. Tobias Holm Bønnelykke
2. Marie-Amandine Chabry
3. Emeline Perthame
4. Audrey Desgrange
5. Sigolène M. Meilhac

Reviewed by preLights

Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon

1. Blandine Moucaud
2. Elodie Prince
3. Elia Ragot
4. Yoan Renaud
5. Krzysztof Jagla
6. Guillaume Junion
7. Cedric Soler

Reviewed by Review Commons

On the independent irritability of goldfish eggs and embryos – a living communication on the rhythmic yolk contractions in goldfish

1. Paul Gerald Layague Sanchez
2. Chen-Yi Wang
3. Ing-Jia Li
4. Kinya G. Ota

Reviewed by PREreview