Developmental Biology

Loss of ninein interferes with osteoclast formation and causes premature ossification

1. Thierry Gilbert
2. Camille Gorlt
3. Merlin Barbier
4. Benjamin Duployer
5. Marianna Plozza
6. Ophélie Dufrancais
7. Laure-Elene Martet
8. Elisa Dalbard
9. Loelia Segot
10. Christophe Tenailleau
11. Laurence Haren
12. Christel Vérollet
13. Christiane Bierkamp
14. Andreas Merdes

• Curated by eLife

  eLife assessment

  This valuable study offers new insight into the role of centrosome protein ninein in skeletal development through an analysis of the skeletal phenotype of ninein-deficient mice. While there is solid evidence supporting the conclusion that the absence of ninein leads to transient skeletal abnormalities and a lasting reduction in osteoclastogenesis, the evidence to substantiate the claim that enhanced ossification is attributed to reduced osteoclast formation/activity is insufficient. This work will be of interest to scientists in bone biology and skeletal development field.

Reviewed by eLife

Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

1. Yongfeng Luo
2. Ke Cao
3. Joanne Chiu
4. Hui Chen
5. Hong-Jun Wang
6. Matthew E Thornton
7. Brendan H Grubbs
8. Martin Kolb
9. Michael S Parmacek
10. Yuji Mishina
11. Wei Shi

• Curated by eLife

  eLife assessment

  This valuable paper characterizes a murine model for congenital cystic airway abnormalities (CPAM). In contrast to previous assumptions that only epithelial cells are involved in the formation of pulmonary cysts, the authors provide compelling new evidence that defective BMP signaling in lung mesenchymal cells can disrupt airway development. Knowing that proper BMP signaling in mesenchymal cells is required for normal cyst-free lungs could potentially pave the way to understanding and preventing CPAM in infants at risk for this common disorder, which can be fatal if untreated. The relevance of the murine model could be enhanced by further molecular and histological comparison with human cysts.

Reviewed by eLife

Differential regulation of the proteome and phosphoproteome along the dorso-ventral axis of the early Drosophila embryo

1. Juan Manuel Gomez
2. Hendrik Nolte
3. Elisabeth Vogelsang
4. Bipasha Dey
5. Michiko Takeda
6. Girolamo Giudice
7. Miriam Faxel
8. Theresa Haunold
9. Alina Cepraga
10. Robert P Zinzen
11. Marcus Krüger
12. Evangelia Petsalaki
13. Yu-Chiun Wang
14. Maria Leptin

Reviewed by Review Commons

SMAD4 promotes somatic-germline contact during murine oocyte growth

1. Sofia Granados-Aparici
2. Qin Yang
3. Hugh J Clarke

• Curated by eLife

  eLife assessment

  This study reports an important mechanism through which the TGF-beta signaling pathway promotes contacts between oocytes and their surrounding somatic cells by regulating the number of transzonal projections (TZPs) in mice. Convincing data support the conclusions. The work will be of interest to biomedical researchers who work on ovarian biology and female fertility.

Reviewed by eLife

FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis

1. Meng-Hao Pan
2. Kun-Huan Zhang
3. Si-Le Wu
4. Zhen-Nan Pan
5. Ming-Hong Sun
6. Xiao-Han Li
7. Jia-Qian Ju
8. Shi-Ming Luo
9. Xiang-Hong Ou
10. Shao-Chen Sun

• Curated by eLife

  eLife assessment

  This study presents useful findings regarding the role of formin-like 2 in mouse oocyte meiosis. Some of the data are supported by incomplete methodological details and analyses, and several conclusions are overstated. This paper would be of interest to reproductive biologists.

Reviewed by eLife

Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

1. Maiko Kawasaki
2. Katsushige Kawasaki
3. Finsa Tisna Sari
4. Takehisa Kudo
5. Jun Nihara
6. Madoka Kitamura
7. Takahiro Nagai
8. Vanessa Utama
9. Yoko Ishida
10. Fumiya Meguro
11. Alex Kesuma
12. Akira Fujita
13. Takayuki Nishimura
14. Yuan Kogure
15. Satoshi Maruyama
16. Jun-ichi Tanuma
17. Yoshito Kakihara
18. Takeyasu Maeda
19. Sarah Ghafoor
20. Roman H Khonsari
21. Pierre Corre
22. Paul T Sharpe
23. Martyn Cobourne
24. Brunella Franco
25. Atsushi Ohazama

• Curated by eLife

  eLife assessment

  The investigation of the functional significance of the X-linked ciliary protein OFD1 gene in regulating the fate of cranial neural crest-derived cells (CNCCs) and its potential effect on myogenic progenitors during tongue development is interesting because the Ofd1 conditional knockout mouse model has a very striking phenotype and nicely mimics the phenotype in humans. It is a valuable model to understand human disease. This study will require additional experiments to support their conclusions.

Reviewed by eLife

Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

1. Filip Knop
2. Apolena Zounarová
3. Vojtěch Šabata
4. Teije Corneel Middelkoop
5. Marie Macůrková

• Curated by eLife

  eLife assessment

  This useful study defines developmental roles for a protein kinase involved in endocytosis and reports a surprising finding that the kinase catalytic activity is unnecessary. However, several claims of the authors are only partially supported by the data. Although in its current form, this work is incomplete, it will be of broad interest to cell biologists and biochemists because this kinase was previously suggested to be a target of drug design efforts.

Reviewed by eLife

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

1. Vartika Sharma
2. Nalani Sachan
3. Bappi Sarkar
4. Mousumi Mutsuddi
5. Ashim Mukherjee

• Curated by eLife

  eLife assessment

  This is a useful study of the connection between the ubiquitin ligase protein deltex and the wingless signaling pathway. Two different links are inferred from genetic interactions in vivo between loss-of-function mutations and overexpression. While the genetic data are solid, the precise mechanism underlying either effect remains to be established.

Reviewed by eLife

Temporal constraints on enhancer usage shape the regulation of limb gene transcription

1. Raquel Rouco
2. Antonella Rauseo
3. Guillaume Sapin
4. Olimpia Bompadre
5. Fabrice Darbellay
6. Guillaume Andrey

Reviewed by preLights

ERK signalling orchestrates metachronous transition from naïve to formative pluripotency

1. Carla Mulas
2. Melanie Stammers
3. Siiri I. Salomaa
4. Constanze Heinzen
5. David M. Suter
6. Austin Smith
7. Kevin J. Chalut

Reviewed by Review Commons