Developmental Biology

Unveiling Vertebrate Development Dynamics in Frog Xenopus laevis using Micro-CT Imaging

1. Laznovsky Jakub
2. Kavkova Michaela
3. Reis Alice
4. Robovska-Havelkova Pavla
5. Krivanek Jan
6. Zikmund Tomas
7. Kaiser Jozef
8. Buchtova Marcela
9. Harnos Jakub

Reviewed by GigaScience

Lepidopteran scale cells derive from sensory organ precursors through a canonical lineage

1. Ling S. Loh
2. Kyle A. DeMarr
3. Martina Tsimba
4. Christa Heryanto
5. Alejandro Berrio
6. Nipam H. Patel
7. Arnaud Martin
8. W. Owen McMillan
9. Gregory A. Wray
10. Joseph J. Hanly

Reviewed by Arcadia Science

SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

1. Rula Sha
2. Ruochen Guo
3. Huimin Duan
4. Qian Peng
5. Ningyang Yuan
6. Zhenzhen Wang
7. Zhigang Li
8. Zhiqin Xie
9. Xue You
10. Ying Feng

• Curated by eLife

  eLife assessment

  This important work provides interesting datasets of myofiber differentiation. The evidence supporting the involvement of SRF2 in selected biological processes is convincing, however, additional evidence to pin-point the major action of SRF2 during muscle differentiation is appreciated. The work will be of broad interest to developmental biologists in general and molecular biologists in the field of gene regulation.

Reviewed by eLife

Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

1. Archana Kamalakar
2. Brendan Tobin
3. Sundus Kaimari
4. M Hope Robinson
5. Afra I Toma
6. Timothy Cha
7. Samir Chihab
8. Irica Moriarity
9. Surabhi Gautam
10. Pallavi Bhattaram
11. Shelly Abramowicz
12. Hicham Drissi
13. Andres Garcia
14. Levi Wood
15. Steven L Goudy

• Curated by eLife

  eLife assessment

  Therapeutic treatments for congenital and acquired craniofacial (CF) bone abnormalities are not well developed. This study provides convincing evidence for an innovative regenerative treatment for pediatric craniofacial bone loss using Jagged1-PEG-MAL hydrogel with pediatric human bone cells. The report is a valuable advance in this field.

Reviewed by eLife

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

1. Emily Delgouffe
2. Samuel Madureira Silva
3. Frédéric Chalmel
4. Wilfried Cools
5. Camille Raets
6. Kelly Tilleman
7. Guy T'Sjoen
8. Yoni Baert
9. Ellen Goossens

• Curated by eLife

  eLife assessment

  This important study presents new knowledge of the spermatogonial stem cell (SSC) niche in trans women after gender-affirming hormone therapy (GAHT). The evidence supporting the claims is convincing. The work will be of interest to researchers and clinicians working in the field of reproductive medicine and andrology.

Reviewed by eLife

FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

1. Yuki Kaneda
2. Haruhiko Miyata
3. Zoulan Xu
4. Keisuke Shimada
5. Maki Kamoshita
6. Tatsuya Nakagawa
7. Chihiro Emori
8. Masahito Ikawa

• Curated by eLife

  eLife assessment

  This important study reports that FBXO24 is essential for the normal formation and function of the sperm flagellum, motility, and male fertility in mice. The evidence supporting the direct role of this protein in preventing RNP granule formation in the sperm flagellum is compelling. This work will be of interest to biomedical researchers who work on testicular biology and male fertility.

Reviewed by eLife

Gestational exposure to high heat-humidity conditions impairs mouse embryonic development

1. Avinchal Manhas
2. Amritesh Sarkar
3. SRIMONTA GAYEN

Reviewed by preLights

Dynamic readout of the Hh gradient in the Drosophila wing disc reveals pattern-specific tradeoffs between robustness and precision

1. Rosalío Reyes
2. Arthur D Lander
3. Marcos Nahmad

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on the precision conferred by dynamical interpretation of morphogen gradients. The evidence supporting the claims of the authors is convincing, with compelling theoretical analysis and solid yet incomplete experimental data. With the experimental part strengthened, the work could be of interest to the developmental biology and developmental systems biology communities.

Reviewed by eLife

BMP signalling facilitates transit amplification in the developing chick and human cerebellum

1. Victoria Rook
2. Parthiv Haldipur
3. Kathleen J Millen
4. Thomas Butts
5. Richard J Wingate

• Curated by eLife

  eLife assessment

  This study investigates BMP signaling mechanisms in the developing chick cerebellum to better understand germinal layer formation, cellular amplification and neuronal differentiation. The data from human tissue is compelling and lends support to the possible links of these processes to medulloblastoma, although this study does raise exciting questions regarding the generalized role of BMP signaling during normal development and malignant growth. Overall, this is an important study with beautifully presented findings.

Reviewed by eLife

TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

1. Jing Wang
2. Yingying Yin
3. Lei Yang
4. Junchao Qin
5. Zixiang Wang
6. Chunhong Qiu
7. Yuan Gao
8. Gang Lu
9. Fei Gao
10. Zi-Jiang Chen
11. Xiyu Zhang
12. Hongbin Liu
13. Zhaojian Liu

• Curated by eLife

  eLife assessment

  This study reports an important discovery highlighting the essential role of the putative ion channel, TMC7, in acrosome formation during sperm development and thus male fertility. The evidence for the requirement of TMC7 in acrosome biogenesis and sperm function is convincing, although its function as an ion channel remains to be further determined. Overall, this work will be of great interest to developmental biologists and ion channel physiologists alike.

Reviewed by eLife