Developmental Biology

Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

1. Morgane Djebar
2. Isabelle Anselme
3. Guillaume Pezeron
4. Pierre-Luc Bardet
5. Yasmine Cantaut-Belarif
6. Alexis Eschstruth
7. Diego López-Santos
8. Hélène Le Ribeuz
9. Arnim Jenett
10. Hanane Khoury
11. Joelle Veziers
12. Caroline Parmentier
13. Aurélie Hirschler
14. Christine Carapito
15. Ruxandra Bachmann-Gagescu
16. Sylvie Schneider-Maunoury
17. Christine Vesque

• Curated by eLife

  eLife assessment

  This valuable study analyzes the role of rpgrip1l encoding a ciliary transition zone component in the development of neuroinflammation and scoliotic phenotypes in zebrafish. Through proteomic and experimental validation in vivo, the authors demonstrated increased Annexin A2 expression and astrogliosis in the brains of scoliosis fish. Anti-inflammatory drug treatment restored normal spine development in these mutant fish, thus providing additional convincing evidence for the role of neuroinflammation in the development of scoliosis in zebrafish.

Reviewed by eLife

The role of Imp and Syp RNA-binding proteins in precise neuronal elimination by apoptosis through the regulation of transcription factors

1. Wenyue Guan
2. Ziyan Nie
3. Anne Laurençon
4. Mathilde Bouchet
5. Christophe Godin
6. Chérif Kabir
7. Aurelien Darnas
8. Jonathan Enriquez

• Curated by eLife

  eLife assessment

  Guan and colleagues present solid arguments to address the question of how a single neural stem cell produces a defined number of progeny, and what influences its decommissioning. The focus of the experiments are two well-studied RNA-binding proteins: Imp and Syp. This is valuable work that will be of interest to the scientific community.

Reviewed by eLife

Genetic gradual reduction of OGT activity unveils the essential role of O-GlcNAc in the mouse embryo

1. Sara Formichetti
2. Agnieszka Sadowska
3. Michela Ascolani
4. Julia Hansen
5. Kerstin Ganter
6. Christophe Lancrin
7. Neil Humphreys
8. Mathieu Boulard

Reviewed by Review Commons

TGF-β signaling in the cranial neural crest affects late-stage mandibular bone resorption and length

1. Claire J. Houchen
2. Saif Ghanem
3. Vesa Kaartinen
4. Erin Ealba Bumann

Reviewed by preLights

The Rich Evolutionary History of the Reactive Oxygen Species Metabolic Arsenal Shapes Its Mechanistic Plasticity at the Onset of Metazoan Regeneration

1. Aurore Vullien
2. Aldine R Amiel
3. Loeiza Baduel
4. Dilara Diken
5. Cécile Renaud
6. Gabriel Krasovec
7. Michel Vervoort
8. Eric Röttinger
9. Eve Gazave

Reviewed by Arcadia Science

A Lgr5-independent developmental lineage is involved in mouse intestinal regeneration

1. Maryam Marefati
2. Valeria Fernandez-Vallone
3. Morgane Leprovots
4. Gabriella Vasile
5. Frédérick Libert
6. Anne Lefort
7. Gilles Dinsart
8. Achim Weber
9. Jasna Jetzer
10. Marie-Isabelle Garcia
11. Gilbert Vassart

Reviewed by Review Commons

Bellymount-pulsed tracking: a novel approach for real-time in vivo imaging of Drosophila abdominal tissues

1. Shruthi Balachandra
2. Amanda A Amodeo

Reviewed by Review Commons

Lineage-specific CDK activity dynamics characterize early mammalian development

1. Bechara Saykali
2. Andy D. Tran
3. James A. Cornwell
4. Matthew A. Caldwell
5. Paniz Rezvan Sangsari
6. Nicole Y. Morgan
7. Michael J. Kruhlak
8. Steven D. Cappell
9. Sergio Ruiz

Reviewed by preLights

Ciliary biology intersects autism and congenital heart disease

1. Nia Teerikorpi
2. Kate E. McCluskey
3. Ethel Bader
4. Micaela C. Lasser
5. Sheng Wang
6. Catherine H. Nguyen
7. James D. Schmidt
8. Elina Kostyanovskaya
9. Nawei Sun
10. Jeanselle Dea
11. Tomasz J. Nowakowski
12. A. Jeremy Willsey
13. Helen Rankin Willsey

Reviewed by Arcadia Science

UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

1. Pengfei Liu
2. Xinyi Liu
3. Bin Qi

• Curated by eLife

  eLife assessment

  This valuable work uses unbiased approaches to discover critical molecules in C. elegans and its bacterial food for nutrition sensing and food choice, providing a framework for other studies. The data convincingly support their model that C. elegans uses UPRER and immune response pathways to evaluate sugar contents in the bacteria to change their behaviors.

Reviewed by eLife