Cell Biology

Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

1. Kanako Shinno
2. Yuri Miura
3. Koichi M Iijima
4. Emiko Suzuki
5. Kanae Ando

• Curated by eLife

  eLife Assessment

  In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteomics. Neuronal overexpression of eIF2β phenocopied aspects of neuronal dysfunction observed when axonal transport of mitochondria was compromised. Conversely, lowering eIF2β expression suppressed aspects of neuronal dysfunction. While these are intriguing and useful observations, technical weaknesses limit the interpretation. On balance, the evidence supporting the current claims is suggestive but incomplete, especially concerning the characterization of the eIF2 heterotrimer and the data regarding translational regulation.

Reviewed by eLife

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

1. Devon E Mason
2. Paula Camacho
3. Megan E Goeckel
4. Brendan R Tobin
5. Sebastián L Vega
6. Pei-Hsun Wu
7. Dymonn Johnson
8. Su-Jin Heo
9. Denis Wirtz
10. Jason A Burdick
11. Levi Wood
12. Brian Y Chow
13. Amber N Stratman
14. Joel D Boerckel

• Curated by eLife

  eLife Assessment

  This fundamental study substantially advances our current understanding of mechanotransduction within endothelial cells. The evidence provided by the authors in the revised manuscript is compelling, which taken together, provides strong support for the authors' major findings. The work will be of broad interest to cell biologists and vascular biologists.

Reviewed by eLife

Dominant spinal muscular atrophy linked mutations in the cargo binding domain of BICD2 result in altered interactomes and dynein hyperactivity

1. Hannah Neiswender
2. Jessica E Pride
3. Rajalakshmi Veeranan-Karmegam
4. Phylicia Allen
5. Grace Neiswender
6. Avneesh Prabakar
7. Caili Hao
8. Xingjun Fan
9. Graydon B Gonsalvez

• Curated by eLife

  eLife Assessment

  In their study, Neiswender et al. provide important insights into how BicD2 variants linked to spinal muscular atrophy alter dynein activity and cargo specificity. The authors present convincing evidence that disease-associated mutations lead to interactome changes, supported by additional validation of the BicD2/HOPS complex and discussion of their functional implications. This well-executed study offers invaluable datasets and a strong foundation for future exploration of disease mechanisms.

Reviewed by eLife

Suppression of interferon signaling via small-molecule modulation of TFAM

1. Dionisia Sideris
2. Husan Lee
3. Lyndsay Olson
4. Kalyan Nallaparaju
5. Keiichiro Okuyama
6. Jeffrey Ciavarri
7. Robert Lafyatis
8. Mads Larsen
9. Bo Lin
10. Irene Alfaras
11. Jason Kennerdell
12. Toren Finkel
13. Yuan Liu
14. Bill Chen
15. Lin Lyu

• Curated by eLife

  eLife Assessment

  Using high-throughput small-molecule screening, this study discloses novel modulators of the mitochondrial transcription factor A (TFAM), a key regulator of mitochondrial function. Reviewers viewed the targeting of TFAM as innovative and the study's conclusions as potentially important (especially the effects on inflammation). However, the lack of evidence for a direct effect of the compounds on TFAM activity weakens the paper's key conclusion and renders the study incomplete.

Reviewed by eLife

Condensation of Sidekick at tricellular junctions organizes mechanical forces for cell-cell adhesion remodeling

1. Hiroyuki Uechi
2. Daxiao Sun
3. Yuki Saeki
4. Tetsuya Hiraiwa
5. Alf Honigmann
6. Anthony A. Hyman
7. Erina Kuranaga

Reviewed by preLights

Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

1. Gonzalo Quiroga-Artigas
2. Pauline Fontanié
3. Benjamin Lacroix
4. Maria Dolores Molina
5. María Moriel-Carretero

Reviewed by Review Commons

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

1. Yoichi Miyamoto
2. Reo Kisanuki
3. Rieko Oshima
4. Shige H Yoshimura
5. Mutsumi Yokota
6. Kazumitsu Maehara
7. Chiaki Hata
8. Taro Tachibana
9. Hiroshi Kimura
10. Masato Koike
11. Yasuyuki Ohkawa
12. Toyomasa Katagiri
13. Yoshihiro Yoneda
14. Masahiro Oka
15. Hisato Saitoh

Reviewed by Review Commons

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

1. Haihui Zhang
2. Zhengyang Lei
3. Fatemeh Momen-Heravi
4. Peiwu Qin

• Curated by eLife

  eLife Assessment

  This study provides valuable information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis, as well as on telomere dynamics through live cell imaging. However, the conclusions remain inadequately supported by the current data, and several of the major technical concerns raised in the first round have not yet been fully resolved.

Reviewed by eLife

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

1. Alexandra C. Belfi
2. Sage G. Aviles
3. Rachel Forman-Rubinsky
4. Hasreet K. Gill
5. Jennifer D. Cohen
6. Aleksandra Nawrocka
7. Axelle Bourez
8. Pierre van Antwerpen
9. Patrick Laurent
10. Meera V. Sundaram

Reviewed by Review Commons

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

1. Janik Engelmann
2. Jennifer Zarrer
3. Max Schmerder
4. Christian Mess
5. Deniz Ragipoglu
6. Kristoffer Riecken
7. Tal Burstyn-Cohen
8. Emily J. Alberto
9. Sourav Ghosh
10. Carla Rothlin
11. Klaus Pantel
12. Carsten Bokemeyer
13. Eric Hesse
14. Hanna Taipaleenmäki
15. Sonja Loges
16. Isabel Ben-Batalla

Reviewed by preLights