Cell Biology

Human myogenic progenitor cells display tenogenic differentiation potential and facilitate tendon regeneration

1. Xiexiang Shao
2. Xingzuan Lin
3. Hao Zhou
4. Lili Han
5. Xin Fu
6. Sheng Li
7. Siyuan Zhu
8. Shenao Zhou
9. Jianhua Wang
10. Ping Hu

• Curated by eLife

  eLife assessment

  The authors made an important finding that CD29+/CD56+ progenitor cells isolated from human muscles have the potential to differentiate to tendons in vitro and in vivo. The author's approach to testing the tenogenesis of the CD29+/CD56+ progenitors is solid, and the conclusion is supported by enough evidence with minor flaws. This work will be of interest to the population who need tendon regeneration from their injury.

Reviewed by eLife

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

1. Zewei Zhao
2. Longyun Hu
3. Bigui Song
4. Tao Jiang
5. Qian Wu
6. Jiejing Lin
7. Xiaoxiao Li
8. Yi Cai
9. Jin Li
10. Bingxiu Qian
11. Siqi Liu
12. Jilu Lang
13. Zhonghan Yang

• Curated by eLife

  eLife assessment

  This study reports the adhesion G-protein-coupled receptor A3 (ADGRA3) as a possible target for activating adaptive thermogenesis in white and brown adipose tissue. The study provides valuable insights for scientists who study metabolism, obesity, and adipose tissue biology. Meanwhile, the experimental evidence supporting the claim is incomplete, and more rigorous approaches are needed to demonstrate the relevance of this receptor in adipose tissue biology.

Reviewed by eLife

Membrane Curvature Promotes ER-PM Contact Formation via Junctophilin-EHD Interactions

1. Yang Yang
2. Luis A. Valencia
3. Chih-Hao Lu
4. Melissa L. Nakamoto
5. Ching-Ting Tsai
6. Chun Liu
7. Huaxiao Yang
8. Wei Zhang
9. Zeinab Jahed
10. Wan-Ru Lee
11. Francesca Santoro
12. Jen Liou
13. Joseph C. Wu
14. Bianxiao Cui

Reviewed by preLights

Neosynthesized polarized and non-polarized plasma membrane cargoes follow distinct trafficking routes in Aspergillus nidulans

1. Georgia Maria Sagia
2. Xenia Georgiou
3. George Chamilos
4. George Diallinas
5. Sofia Dimou

Reviewed by Review Commons

Mitochondrial Apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways

1. Melissa Lubeck
2. Ritam Naha
3. Yulia Schaumkessel
4. Philipp Westhoff
5. Anja Stefanski
6. Patrick Petzsch
7. Kai Stühler
8. Karl Köhrer
9. Andreas P. M. Weber
10. Ruchika Anand
11. Andreas S. Reichert
12. Arun Kumar Kondadi

Reviewed by Review Commons

Atlas of Fshr Expression from Novel Reporter Mice

1. Hong-Qian Chen
2. Hui-Qing Fang
3. Jin-Tao Liu
4. Shi-Yu Chang
5. Wen-huan Chai
6. Li-Ben Cheng
7. Ming-Xin Sun
8. Zhi-wei Yang
9. Jian-Rui Feng
10. Ze-Min Liu
11. Xiao-Li Li
12. Yong-Hong Zhang
13. Clifford Rosen
14. Peng Liu

• Curated by eLife

  eLife assessment

  These valuable findings develop a mouse model with trackable fusion Fshr protein, which will be of use to the field. The animal model helps to elucidate the expression and function of the FSH receptor in extra-gonadal tissues. The strength of the evidence is solid in most parts, although additional validation of the localization data would strengthen the study considerably.

Reviewed by eLife

Chaperone Complexes From The Endoplasmic Reticulum (ER) And The Cytosol Inhibit wt-p53 By Activation The ER To Cytosol Signaling

1. Salam Dabsan
2. Gali Zur
3. Ayelet Gilad
4. Aeid Igbaria

Reviewed by Review Commons

Ezrin defines TSC1 activation at endosomal compartments through EGFR-AKT signaling

1. Giuliana Giamundo
2. Daniela Intartaglia
3. Eugenio Del Prete
4. Elena Polishchuk
5. Fabrizio Andreone
6. Marzia Ognibene
7. Sara Buonocore
8. Francesco Giuseppe Salierno
9. Jlenia Monfregola
10. Dario Antonini
11. Paolo Grumati
12. Alessandra Eva
13. Rossella de Cegli
14. Ivan Conte

• Curated by eLife

  eLife assessment

  Giamundo et al. present valuable data with new insights new insight into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling mediators. The use of multiple state-of-the-art microscopy techniques, multiple cell lines and inhibitors, and in vivo models provides solid support for the majority of their conclusions. The findings are helpful for our understanding of EGF/mTOR signal transduction and support a critical role for the scaffolding protein Ezrin, in the upstream regulation of EGFR/AKT activity, TSC subcellular localization and mTORC1 signaling, thus contributing to our understanding of the regulation of endo-lysosomal signaling, alterations in which are implicated in many human diseases.

Reviewed by eLife

Disruption of WSB2-mediated NOXA Degradation Induces Synthetic Lethality to Anti-apoptotic BCL-2 Family Protein Inhibitors

1. Dongyue Jiao
2. Kun Chang
3. Yingji Chen
4. Jiamin Jin
5. Ren Mo
6. Yucong Zhang
7. Kun Gao
8. Yaoting Xu
9. Lixin Wang
10. Chenji Wang

• Curated by eLife

  eLife assessment

  This study reports a fundamental observation concerning cell death regulation by the anti-apoptotic BCL2 family NOXA. The authors convincingly demonstrate that NOXA is destabilized through the interaction with WSB2, a substrate receptor in CRL5 ubiquitin ligase complex, sensitizing the cells to treatments. These are key findings for cell biologists and cancer researchers as they identified a new target impacting drug responsiveness in cancer therapies.

Reviewed by eLife

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming in a metabolic enzyme independent manner

1. Mengjia Li
2. Hengchao Zhang
3. Xiuyun Wu
4. Mengqi Yu
5. Qianqian Yang
6. Lei Sun
7. Wei Li
8. Zhongxing Jiang
9. Fumin Xue
10. Ting Wang
11. Xiuli An
12. Lixiang Chen

• Curated by eLife

  eLife assessment

  This study presents an important finding on the metabolism-independent role of IDH1 in regulating nuclear chromatin during terminal erythropoiesis. The evidence supporting IDH1's role on chromatin regulation is solid, but the analysis of its proposed non-metabolic activity is incomplete. The mechanistic perspective of this work, along with other intriguing observations, such as the connection between NAD+-dependent deacetylase SIRT1 and IDH1, should be of great interest to researchers working on erythropoiesis and erythroid disorders.

Reviewed by eLife