Cell Biology

CROP2, a Retriever-PROPPIN Complex Mediating Protein Export from Endosomes to the Plasma Membrane

1. Maria Giovanna De Leo
2. Andreas Mayer

• Curated by eLife

  eLife Assessment

  The authors present evidence for a WIPI2-Retriever complex (termed CROP2) that couples cargo selection to carrier fission at endosomes. CROP2 appears to function analogously to the previously described CROP1 complex, formed by WIPI1 and Retromer, with which it shares structural similarities. They provide convincing evidence that CROP1 and CROP2 regulate the trafficking of distinct subsets of cargoes; however, the cellular evidence for the existence of these distinct complexes remains incomplete. Overall, the findings are important and expand our understanding of how cargo selection by Retriever and Retromer is orchestrated at endosomes.

Reviewed by eLife

Disruption of Iron Metabolism Resulting from Dmt1/Slc11A2 Deficiency Compromises Notch Protein Degradation and Transcriptional Activation

1. Rui Zhang
2. Somaieh Ahmadian
3. Jolanda Piepers
4. Florian Bock
5. Tom Keulers
6. Marc A. Vooijs

Reviewed by PREreview

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

1. Mohamad Youness
2. Onne A.H.O. Ronda
3. Ankit Pradhan
4. Filip Rega
5. Karin R. Sipido
6. H. Llewelyn Roderick

Reviewed by preLights

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity

1. Emma C. Murray
2. Gillian M. Hodge
3. Khanh Pham
4. Leighton S. Lee
5. Cameron A.R. Mitchell
6. Yongho Bae
7. Andrew T. Lombardo

Reviewed by Review Commons

Centrosome Loss in Embryonic Development Disrupts Axonal Pathfinding and Muscle Integrity

1. Beatriz González
2. Júlia Sellés-Altés
3. Jèrica Pla-Parron
4. Judith Castro-Ribera
5. Sofia J. Araújo

Reviewed by Review Commons

MAP7-driven microtubule remodeling builds the Sertoli apical domain that supports timely meiotic progression

1. Koji Kikuchi
2. Toshihiko Fujimori
3. Mami Nakagawa
4. Keisuke Ohta
5. Ryuki Shimada
6. Sayoko Fujimura
7. Kei-ichiro Yasunaga
8. Shingo Usuki
9. Naoki Tani
10. Akira Nakamura
11. Kimi Araki
12. Kei-ichiro Ishiguro

Reviewed by Review Commons

The Rhizarian amoeba Filoreta ramosa develops a neuron-like arborized network using conserved cytoskeletal mechanisms

1. Sarah L. Guest
2. Scott C. Dawson

Reviewed by Arcadia Science

TRIM32 controls timely cell cycle exit in muscular differentiation through c-Myc down-regulation

1. Lu Xiong
2. Elisa Lazzari
3. Sabrina Pacor
4. Simeone Dal Monego
5. Erica Piovesan
6. Danilo Licastro
7. Germana Meroni

Reviewed by Review Commons

Cross-species evaluation of TANGO2 homologs, including HRG-9 and HRG-10 in Caenorhabditis elegans, challenges a proposed role in heme trafficking

1. Sarah E Sandkuhler
2. Kayla S Youngs
3. Olivia Gottipalli
4. Laura D Owlett
5. Monica B Bandora
6. Aaliya Naaz
7. Euri Kim
8. Lili Wang
9. Andrew Wojtovich
10. Vandana Gupta
11. Michael Sacher
12. Samuel J Mackenzie

• Curated by eLife

  eLife Assessment

  This valuable study provides solid evidence that supports TANGO2 homologs, including HRG-9 and HRG-10, can play a role in cellular bioenergetics and oxidative stress homeostasis. It also challenges the previously reported role of TANGO in heme transport and paves the way for future mechanistic studies addressing the mechanisms of how TANGO2 regulates oxidative stress homeostasis. The strengths include the use of different model systems, genetic tools, behavioral assays and efforts by the authors in using the same reagents to reproduce results of other groups.

Reviewed by eLife

Extracellular vesicle-mediated release of bis(monoacylglycerol)phosphate is regulated by LRRK2 and glucocerebrosidase activity

1. Elsa Meneses-Salas
2. Moises Castellá
3. Marianna Arnold
4. Frank Hsieh
5. Rubén Fernández-Santiago
6. Mario Ezquerra
7. Alicia Garrido
8. María-José Martí
9. Carlos Enrich
10. Suzanne R Pfeffer
11. Kalpana Merchant
12. Albert Lu

• Curated by eLife

  eLife Assessment

  This useful study presents the potentially interesting idea that LRRK2 regulates cellular BMP levels and their release via extracellular vesicles, with GCase activity further modulating this process in mutant LRRK2-expressing cells. However, some of the evidence supporting these conclusions remains incomplete, and additional work is suggested under certain conditions. Overall, the study will be of interest to cell biologists working on Parkinson's disease.

Reviewed by eLife