Cell Biology

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

1. Janik Engelmann
2. Jennifer Zarrer
3. Max Schmerder
4. Christian Mess
5. Deniz Ragipoglu
6. Kristoffer Riecken
7. Tal Burstyn-Cohen
8. Emily J. Alberto
9. Sourav Ghosh
10. Carla Rothlin
11. Klaus Pantel
12. Carsten Bokemeyer
13. Eric Hesse
14. Hanna Taipaleenmäki
15. Sonja Loges
16. Isabel Ben-Batalla

Reviewed by preLights

Membrane potential modulates ERK activity and cell proliferation in human cells

1. Mari Sasaki
2. Masanobu Nakahara
3. Takuya Hashiguchi
4. Fumihito Ono

• Curated by eLife

  eLife Assessment

  This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The evidence now presented is solid and the data support the conclusions. This paper should be of interest to a broad readershp in the areas of cell and developemental biology and electrophysiology.

Reviewed by eLife

Co-option of lysosomal machinery shapes the symbiosis supporting coral reefs

1. Shumpei Maruyama
2. Catherine F Henderson
3. Natalie Swinhoe
4. Griffin P Kowalewski
5. Emily K Meier
6. Ty R Engelke
7. Phillip A Cleves

Reviewed by Arcadia Science

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

1. Chengrui Shi
2. Chaofei Su
3. Kaixiang Zhang
4. Hang Yin

• Curated by eLife

  eLife Assessment

  This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

Reviewed by eLife

Explainable machine learning-assisted exploration of chromatin dynamics reveals chromosome-specific response to serum starvation

1. Taras Redchuk
2. Antti Pennanen
3. Harri Jäälinoja
4. Olli Natri
5. Lassi Paavolainen
6. Maria K Vartiainen

• Curated by eLife

  eLife Assessment

  This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the experiments are well controlled, and the data are solid. The study would be greatly strengthened by testing key predictions made using perturbation experiments. This work will be of interest to those studying chromosome biology and gene expression patterns.

Reviewed by eLife

The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism

1. Ana Lapão
2. Lauren Sophie Johnson
3. Laura Trachsel-Moncho
4. Samuel J Rodgers
5. Sakshi Singh
6. Matthew YW Ng
7. Sigve Nakken
8. Eeva-Liisa Eskelinen
9. Anne Simonsen

• Curated by eLife

  eLife Assessment

  This study by Lapao et al. uncovers a novel role for the Rab27A effector SYTL5 in regulating mitochondrial function and mitophagy under hypoxic conditions. Using a range of imaging and functional assays, the authors demonstrate that SYTL5 localizes to mitochondria in a Rab27A-dependent manner and impacts mitochondrial respiration and metabolic reprogramming. While the findings are solid and valuable in the area of cancer biology, further mechanistic clarity and improved imaging would strengthen the conclusions.

Reviewed by eLife

The Multifaceted Role of EXOC6A in Ciliogenesis

1. Te-Lin Lin
2. Chien-Ting Wu
3. Tang K Tang

• Curated by eLife

  eLife Assessment

  This important study elucidates the role of the exocyst component EXOC6A at distinct stages of ciliogenesis, which advances our understanding of ciliary membrane remodeling and cilium formation. The authors provide solid evidence that EXOC6A interacts with myosin-Va and is dynamically recruited via dynein-, microtubule-, and actin-dependent mechanisms, to support proper formation of the ciliary membrane. The study will be of interest to cell biologists and other researchers interested in vesicular trafficking, organellar membrane dynamics, and ciliogenesis.

Reviewed by eLife

JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux

1. Layla M. Nassar
2. Xiaojian Shi
3. Agnes Roczniak-Ferguson
4. Hongying Shen
5. Shawn M. Ferguson

Reviewed by Arcadia Science

Stress response of membrane-based cell organelles in budding yeast

1. Sheng Peng
2. Bai Li-zhe
3. Cao Hong
4. Li Dan

Reviewed by Arcadia Science

Cell membrane glycan contents are biochemical factors that constitute a kinetic barrier to viral particle uptake in a protein-nonspecific manner

1. Yoshihisa Kaizuka
2. Rika Machida

• Curated by eLife

  eLife Assessment

  This fundamental work substantially advances our understanding of how the glycocalyx of cells provide a non-specific barrier for the interaction of viruses with cell-surface receptors. Using both in vitro experiments and in vivo manipulations they provide compelling evidence for the properties of the glycocalyx to serve as an energy barrier as a main attribute of its mode of action. The work will be of broad interest to virologists and the cell biology community that studies host-pathogen interactions.

Reviewed by eLife