Cell Biology

Codon-specific ribosome stalling reshapes translational dynamics during branched-chain amino acid starvation

1. Lina Worpenberg
2. Cédric Gobet
3. Felix Naef

Reviewed by Review Commons

Insulin-like peptide secretion is mediated by peroxisome-Golgi interplay

1. Marie A. König
2. Nicole Kucharowski
3. Darla P. Dancourt Ramos
4. Hannah Soyka
5. Klaus Wunderling
6. Torsten R. Bülow
7. Mohamed H. Yaghmour
8. Christoph Thiele
9. Jan M. Ache
10. Lars Kuerschner
11. Margret H. Bülow

Reviewed by PREreview

Xrp1 drives damage-induced cellular plasticity of enteroendocrine cells in the adult Drosophila midgut

1. Qingyin Qian
2. Hiroki Nagai
3. Yuya Sanaki
4. Makoto Hayashi
5. Kenichi Kimura
6. Yu-ichiro Nakajima
7. Ryusuke Niwa

Reviewed by Review Commons

Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI

1. Alexander N Kapustin
2. Sofia Serena Tsakali
3. Meredith Whitehead
4. George Chennell
5. Meng-Ying Wu
6. Chris Molenaar
7. Anton Kutikhin
8. Yimeng Chen
9. Sadia Ahmad
10. Leo Bogdanov
11. Maxim Sinitsky
12. Kseniya Rubina
13. Aled Clayton
14. Frederik J Verweij
15. Dirk Michiel Pegtel
16. Simona Zingaro
17. Arseniy Lobov
18. Bozhana Zainullina
19. Dylan Owen
20. Maddy Parsons
21. Richard E Cheney
22. Derek T Warren
23. Martin James Humphries
24. Thomas Iskratsch
25. Mark Holt
26. Catherine M Shanahan

• Curated by eLife

  eLife Assessment

  This paper explores the role of extracellular vesicles in providing extracellular matrix signals for migration of vascular smooth muscle cells. The evidence, based on cell culture experiments and supporting imaging of human samples, is mostly convincing. The paper will be valuable for researchers investigating cell migration during vessel repair and atherogenesis.

Reviewed by eLife

Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

1. Akinori Endo
2. Chikage Takahashi
3. Naoko Ishibashi
4. Yasumasa Nishito
5. Koji Yamano
6. Keiji Tanaka
7. Yukiko Yoshida

• Curated by eLife

  eLife Assessment

  This study presents the important finding that lysosomal damage triggers inflammatory signaling through ubiquitination and the TAB-TAK1-IKK-NF-kB axis. The data obtained from the unbiased transcriptomic and proteomic analyses are convincing and provide invaluable information to the field. Although further experiments will be required to clarify how TAB2/3 are recruited after various types of lysosome damage, this work will be of interest to researchers in the fields of organelle biology and inflammation.

Reviewed by eLife

A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites

1. Steven P Maher
2. Malina A Bakowski
3. Amélie Vantaux
4. Erika L Flannery
5. Chiara Andolina
6. Mohit Gupta
7. Yevgeniya Antonova-Koch
8. Magdalena Argomaniz
9. Monica Cabrera-Mora
10. Brice Campo
11. Alexander T Chao
12. Arnab K Chatterjee
13. Wayne T Cheng
14. Vorada Chuenchob
15. Caitlin A Cooper
16. Karissa Cottier
17. Mary R Galinski
18. Anke Harupa-Chung
19. Hana Ji
20. Sean B Joseph
21. Todd Lenz
22. Stefano Lonardi
23. Jessica Matheson
24. Sebastian A Mikolajczak
25. Timothy Moeller
26. Agnes Orban
27. Vivian Padín-Irizarry
28. Kastin Pan
29. Julie Péneau
30. Jacques Prudhomme
31. Camille Roesch
32. Anthony Ruberto
33. Saniya S Sabnis
34. Celia L Saney
35. Jetsumon Sattabongkot
36. Saleh Sereshki
37. Sangrawee Suriyakan
38. Ratawan Ubalee
39. Yinsheng Wang
40. Praphan Wasisakun
41. Jiekai Yin
42. Jean Popovici
43. Case W McNamara
44. Chester Joyner
45. François H Nosten
46. Benoît Witkowski
47. Karine G Le Roch
48. Dennis E Kyle

• Curated by eLife

  eLife assessment

  This paper reports a large drug repurposing screen based on an in vitro culture platform to identify compounds that can kill Plasmodium hypnozoites. This valuable work adds to the current repertoire of anti-hypnozoites agents and uncovers targetable epigenetic pathways to enhance our understanding of this mysterious stage of the Plasmodium life cycle. The data presented here are based on solid methodology and represent a starting point for further investigation of epigenetic inhibitors to treat P. vivax infection. This paper will be of interest to Plasmodium researchers and more broadly to readers in the fields of host-pathogen interactions and drug development.

Reviewed by eLife

High resolution mapping of the actin fusion focus reveals myosin V-dependent transport of formin for actin aster compaction

1. Valentine Thomas
2. Hikari Mase
3. Laetitia Michon
4. Andrea Picco
5. Marko Kaksonen
6. Sophie G Martin

Reviewed by Review Commons

A TRPV4-dependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration

1. Ernest Iu
2. Alexander Bogatch
3. Wenjun Deng
4. Jonathan D. Humphries
5. Changsong Yang
6. Fernando R. Valencia
7. Chengyin Li
8. Christopher A. McCulloch
9. Guy Tanentzapf
10. Tatyana M. Svitkina
11. Martin J. Humphries
12. Sergey V. Plotnikov

Reviewed by PREreview

Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

1. David Jones
2. Hugo Belda
3. Malgorzata Broncel
4. Gwendolin Fuchs
5. David Anaguano
6. Stephanie D Nofal
7. Moritz Treeck

• Curated by eLife

  eLife Assessment

  This important study provides compelling evidence that fever-like temperatures enhance the export of Plasmodium falciparum transmembrane proteins, including the cytoadherence protein PfEMP1 and the nutrient channel PSAC, to the red blood cell surface, thereby increasing cytoadhesion. Using rigorous and well-controlled experiments, the authors convincingly demonstrate that this effect results from accelerated protein trafficking rather than changes in protein production or parasite development. These findings significantly advance our understanding of parasite virulence mechanisms and offer insights into how febrile episodes may exacerbate malaria severity.

Reviewed by eLife

Post-translational modifications of microtubules are crucial for malaria parasite transmission

1. Kodzo Atchou
2. Magali Roques
3. Ruth Rehmann
4. Reto Caldelari
5. Melanie Schmid
6. Simone Grossi
7. Bianca Manuela Berger
8. Torsten Ochsenreiter
9. Friedrich Frischknecht
10. Volker Heussler

• Curated by eLife

  eLife Assessment

  This study provides valuable insights into microtubule remodeling during liver-stage Plasmodium berghei development, demonstrating that deletion of the alpha-tubulin C-terminal tail impairs parasite growth in mosquitoes and abolishes infection in HeLa cells. The work is technically ambitious, employing advanced microscopy, genetic mutants, and pharmacological approaches. However, key claims are only partially supported due to incomplete evidence linking tubulin modifications to microtubule dynamics and uncertain antibody-based PTM detection.

Reviewed by eLife