Cell Biology

Bilateral regulation of EGFR activity and local PI dynamics observed with superresolution microscopy

1. Mitsuhiro Abe
2. Masataka Yanagawa
3. Michio Hiroshima
4. Toshihide Kobayashi
5. Yasushi Sako

Reviewed by Review Commons

Activation of the mitochondrial unfolded protein response regulates the formation of stress granules

1. Marta Lopez-Nieto
2. Zhaozhi Sun
3. Emily Relton
4. Rahme Safakli
5. Brian D. Freibaum
6. J Paul Taylor
7. Alessia Ruggieri
8. Ioannis Smyrnias
9. Nicolas Locker

Reviewed by Review Commons

Katanin, kinesin-13, and ataxin-2 inhibit premature interaction between maternal and paternal genomes in C. elegans zygotes

1. Elizabeth A Beath
2. Cynthia Bailey
3. Meghana Mahantesh Magadam
4. Shuyan Qiu
5. Karen L McNally
6. Francis J McNally

• Curated by eLife

  eLife assessment

  This is a valuable paper that identifies a potential challenge for embryos during fertilization: holding sperm contents in the fertilized embryos away from the oocyte meiotic spindle so that they don't get ejected into the polar body during meiotic chromosome segregation. The authors identify proteins involved in cytoplasmic streaming and maintaining the grouping of paternal organelles as being critical for this process. There remain minor weaknesses in the data presented but the paper provides solid evidence for the majority of its claims, and while the findings may pertain to a narrow audience the tools used and basic characterization shown will likely be relied upon by many in the community and therefore is of high value.

Reviewed by eLife

Human receptive endometrial organoid for deciphering the implantation window

1. Yu Zhang
2. Rusong Zhao
3. Chaoyan Yang
4. Jinzhu Song
5. Peishu Liu
6. Yan Li
7. Boyang Liu
8. Tao Li
9. Changjian Yin
10. Minghui Lu
11. Zhenzhen Hou
12. Chuanxin Zhang
13. Zi-Jiang Chen
14. Keliang Wu
15. Han Zhao

• Curated by eLife

  eLife assessment

  This study presents a valuable development of endometrial organoid culture methodology that mimics the window of implantation. Functional validation to demonstrate its robustness is lacking; therefore, the study is considered incomplete. The data may be interesting to embryologists and investigators working on reproductive biology and medicine.

Reviewed by eLife

Mapping the human hematopoietic stem and progenitor cell hierarchy through integrated single-cell proteomics and transcriptomics

1. Benjamin Furtwängler
2. Nil Üresin
3. Sabrina Richter
4. Mikkel Bruhn Schuster
5. Despoina Barmpouri
6. Henrietta Holze
7. Anne Wenzel
8. Kirsten Grønbæk
9. Kim Theilgaard-Mönch
10. Fabian J. Theis
11. Erwin M. Schoof
12. Bo T Porse

Reviewed by Arcadia Science

Coherent Raman microscopy detects nucleolar defects through amide I peak shifts originating from β-sheets: an application to visualizing ongoing cellular senescence

1. Shigeo Ishibashi
2. Akihito Inoko
3. Yuki Oka
4. Philippe Leproux
5. Hideaki Kano

Reviewed by Arcadia Science

Cell cycle-dependent mRNA localization in P-bodies

1. Adham Safieddine
2. Marie-Noëlle Benassy
3. Thomas Bonte
4. Floric Slimani
5. Oriane Pourcelot
6. Michel Kress
7. Michèle Ernoult-Lange
8. Maïté Courel
9. Emeline Coleno
10. Arthur Imbert
11. Antoine Laine
12. Annie Munier Godebert
13. Angelique Vinit
14. Corinne Blugeon
15. Guillaume Chevreux
16. Daniel Gautheret
17. Thomas Walter
18. Edouard Bertrand
19. Marianne Bénard
20. Dominique Weil

Reviewed by preLights

A progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans

1. Raquel Romero-Bueno
2. Adrian Fragoso-Luna
3. Cristina Ayuso
4. Nina Mellmann
5. Alan Kavsek
6. Christian G. Riedel
7. Jordan D Ward
8. Peter Askjaer

Reviewed by Review Commons

Adventitial fibroblasts direct smooth muscle cell-state transition in pulmonary vascular disease

1. Slaven Crnkovic
2. Helene Thekkekara Puthenparampil
3. Shirin Mulch
4. Valentina Biasin
5. Jochen Wilhelm
6. Marek Bartkuhn
7. Ehsan Bonyadi Rad
8. Alicja Wawrzen
9. Ingrid Matzer
10. Ankita Mitra
11. Ryan Leib
12. Bence M Nagy
13. Anita Sahu-Osen
14. Francesco Valzano
15. Natalie Bordag
16. Matthias Evermann
17. Konrad Hoetzenecker
18. Andrea Olschewski
19. Senka Ljubojevic-Holzer
20. Malgorzata Wygrecka
21. Kurt Stenmark
22. Leigh M Marsh
23. Vinicio de Jesus Perez
24. Grazyna Kwapiszewska

• Curated by eLife

  eLife assessment

  This important study explored a molecular comparison of smooth muscle and neighboring fibroblast cells found in lung blood vessels afflicted by a disease called pulmonary arterial hypertension. In doing so, the authors described distinct disease-associated states of each of these cell types with further insights into the cellular communication and crosstalk between them. The strength of evidence was convincing through the use of complementary and sophisticated tools, accompanied by rare isolation of human diseased lung blood vessel cells that were source-matched to the same donor for direct comparison.

Reviewed by eLife

Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteins

1. Kristina Ehring
2. Sophia Friederike Ehlers
3. Jurij Froese
4. Fabian Gude
5. Janna Puschmann
6. Kay Grobe

• Curated by eLife

  eLife assessment

  This useful manuscript presents an analysis of different factors that are required for release of the lipid-linked morphogen Shh from cellular membranes. The evidence is still incomplete, as experiments rely on over-expression of Shh in a single cell line and are sometimes of a correlative nature. The study, which otherwise confirms and extends previous findings, will be of interest to developmental biologists who work on Hedgehog signaling.

Reviewed by eLife