Cell Biology

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract

1. Joan C. Smith
2. Erin L. Sausville
3. Vishruth Girish
4. Monet Lou Yuan
5. Anand Vasudevan
6. Kristen M. John
7. Jason M. Sheltzer

Reviewed by ScreenIT

The Nucleocapsid Protein of SARS-CoV-2 Abolished Pluripotency in Human Induced Pluripotent Stem Cells

1. Zebin Lin
2. Zhiming Wu
3. Jinlian Mai
4. Lishi Zhou
5. Yu Qian
6. Tian Cai
7. Zhenhua Chen
8. Ping Wang
9. Bin Lin

Reviewed by ScreenIT

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

1. Bing Zhao
2. Chao Ni
3. Ran Gao
4. Yuyan Wang
5. Li Yang
6. Jinsong Wei
7. Ting Lv
8. Jianqing Liang
9. Qisheng Zhang
10. Wei Xu
11. Youhua Xie
12. Xiaoyue Wang
13. Zhenghong Yuan
14. Junbo Liang
15. Rong Zhang
16. Xinhua Lin

Reviewed by ScreenIT

Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle

1. Manuela Richter
2. Lila Neahring
3. Jinghui Tao
4. Renaldo Sutanto
5. Nathan H Cho
6. Sophie Dumont

• Curated by eLife

  eLife assessment

  The authors compellingly demonstrate that k-fiber length and dynamics are regulated at the level of individual fibers, even in the absence of focused poles, but that unfocused spindles fail to accurately segregate chromosomes, suggesting that coordination of k-fiber length by pole focusing is important for spindle function. This study provides important new information on spindle scaling, extending in an original manner previous work on this topic.

Reviewed by eLife

Metformin regulates bone marrow stromal cells to accelerate bone healing in diabetic mice

1. Yuqi Guo
2. Jianlu Wei
3. Chuanju Liu
4. Xin Li
5. Wenbo Yan

• Curated by eLife

  eLife assessment

  This fundamental work advances our understanding of the effects of metformin on bone healing in hyperglycemic conditions. The evidence supporting the conclusion is convincing, using three different types of bone fracture models in type-2 diabetes (T2D) mice. This paper is of potential interest to skeletal biologists, orthopaedic surgeons, and endocrinologists who study the effects of metformin on fracture healing.

Reviewed by eLife

Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development

1. Anna R. Yeh
2. Gregory J. Hoeprich
3. Anthony McDougal
4. Bruce L. Goode
5. Adam C. Martin

Reviewed by Review Commons

A simple Turing reaction-diffusion model can explain how mother centrioles break symmetry to generate a single daughter

1. Zachary M. Wilmott
2. Alain Goriely
3. Jordan W. Raff

Reviewed by Review Commons

GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases

1. Gaoran Ge
2. Qianping Guo
3. Ying Zhou
4. Wenming Li
5. Wei Zhang
6. Jiaxiang Bai
7. Qing Wang
8. Huaqiang Tao
9. Wei Wang
10. Zhen Wang
11. Minfeng Gan
12. Yaozeng Xu
13. Huilin Yang
14. Bin Li
15. Dechun Geng

Reviewed by Review Commons

Distinct role of TGN-resident clathrin adaptors for Rab5 activation in the TGN-endosome trafficking pathway

1. Makoto Nagano
2. Kaito Aoshima
3. Hiroki Shimamura
4. Daria Elisabeth Siekhaus
5. Junko Y. Toshima
6. Jiro Toshima

Reviewed by Review Commons

Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast

1. John-Patrick Alao
2. Juhi Kumar
3. Despina Stamataki
4. Charalampos Rallis

Reviewed by Review Commons