Cell Biology

A scalable, data analytics workflow for image-based morphological profiles

1. Edvin Forsgren
2. Olivier Cloarec
3. Pär Jonsson
4. Gillian Lovell
5. Johan Trygg

Reviewed by Arcadia Science

Actin contraction controls nuclear blebbing and rupture independent of actin confinement

1. Mai Pho
2. Yasmin Berrada
3. Aachal Gunda
4. Anya Lavallee
5. Katherine Chiu
6. Arimita Padam
7. Marilena L. Currey
8. Andrew D. Stephens

Reviewed by Review Commons

SUMOylation of ABCD3 restricts bile acid synthesis and regulates metabolic homeostasis

1. Vanessa Goyon
2. Aurèle Besse-Patin
3. Rodolfo Zunino
4. Mai Nguyen
5. Étienne Coyaud
6. Jonathan M. Lee
7. Bich N. Nguyen
8. Brian Raught
9. Heidi M. McBride

Reviewed by Review Commons

Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans

1. Elisabeth Jongsma
2. Anita Goyala
3. José Maria Mateos
4. Collin Yvès Ewald

• Curated by eLife

  eLife assessment

  Using a newly developed C. elegans model of Alzheimer's disease that expresses Abeta aggregates extracellularly, the authors provide convincing evidence of a disintegrin and an ortholog of human ADAM9 that participate in removing these extracellular aggregates. The worm model presented in this important paper may be very useful to the Alzheimer Disease field.

Reviewed by eLife

The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1

1. Maikel Castellano-Pozo
2. Georgios Sioutas
3. Consuelo Barroso
4. Josh P Prince
5. Pablo Lopez-Jimenez
6. Joseph Davy
7. Angel-Luis Jaso-Tamame
8. Oliver Crawley
9. Nan Shao
10. Jesus Page
11. Enrique Martinez-Perez

• Curated by eLife

  eLife assessment

  This important paper reveals distinct dynamics of two meiosis-specific cohesin complexes containing either REC-8 or CHO-3/4 in C. elegans: REC-8-cohesin is essential for sister chromatid cohesion in meiosis I and DNA double-strand break repair, while COH-3/4-cohesin, whose binding to meiotic chromosomes is stabilized by the cohesin accessory protein SCC-2, is necessary for loop-axis formation. The experimental evidence in the paper is solid based on cytological analysis using a conditional depletion of the gene. The work will be of interest to researchers working on meiosis and chromosome dynamics.

Reviewed by eLife

Centriole elimination during C. elegans oogenesis initiates with loss of the central tube protein SAS-1

1. Marie Pierron
2. Alexander Woglar
3. Coralie Busso
4. Keshav Jha
5. Tamara Mikeladze-Dvali
6. Marie Croisier
7. Pierre Gönczy

Reviewed by Review Commons

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1. Avi J. Samelson
2. Nabeela Ariqat
3. Justin McKetney
4. Gita Rohanitazangi
5. Celeste Parra Bravo
6. Rudra S. Bose
7. Kyle J. Travaglini
8. Victor L. Lam
9. Darrin Goodness
10. Thomas Ta
11. Gary Dixon
12. Emily Marzette
13. Julianne Jin
14. Ruilin Tian
15. Eric Tse
16. Romany Abskharon
17. Henry S. Pan
18. Emma C. Carroll
19. Rosalie E. Lawrence
20. Jason E. Gestwicki
21. Jessica E. Rexach
22. David S. Eisenberg
23. Nicholas M. Kanaan
24. Daniel R. Southworth
25. John D. Gross
26. Li Gan
27. Danielle L. Swaney
28. Martin Kampmann

Reviewed by preLights

Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2

1. Jeonghwan Youk
2. Taewoo Kim
3. Kelly V. Evans
4. Young-Il Jeong
5. Yongsuk Hur
6. Seon Pyo Hong
7. Je Hyoung Kim
8. Kijong Yi
9. Su Yeon Kim
10. Kwon Joong Na
11. Thomas Bleazard
12. Ho Min Kim
13. Mick Fellows
14. Krishnaa T. Mahbubani
15. Kourosh Saeb-Parsy
16. Seon Young Kim
17. Young Tae Kim
18. Gou Young Koh
19. Byeong-Sun Choi
20. Young Seok Ju
21. Joo-Hyeon Lee

Reviewed by ScreenIT

Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

1. Claudia Pommerenke
2. Ulfert Rand
3. Cord C. Uphoff
4. Stefan Nagel
5. Margarete Zaborski
6. Vivien Hauer
7. Maren Kaufmann
8. Corinna Meyer
9. Sabine A. Denkmann
10. Peggy Riese
11. Kathrin Eschke
12. Yeonsu Kim
13. Zeljka Macak Safranko
14. Ivan-Christian Kurolt
15. Alemka Markotic
16. Luka Cicin-Sain
17. Laura Steenpass

Reviewed by ScreenIT

Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

1. Emma L. Robinson
2. Kanar Alkass
3. Olaf Bergmann
4. Janet J. Maguire
5. H. Llewelyn Roderick
6. Anthony P. Davenport

Reviewed by ScreenIT