Cell Biology

Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

1. Samarpan Maiti
2. Kaushik Bhattacharya
3. Diana Wider
4. Dina Hany
5. Olesya Panasenko
6. Lilia Bernasconi
7. Nicolas Hulo
8. Didier Picard

• Curated by eLife

  eLife assessment

  This important study describes the coordinated regulation of cellular size and protein translation in response to chronic stress as an adaptive mechanism, termed the 'rewiring stress response' regulated by the heat shock response. The evidence supporting this conclusion is solid, utilizing diverse methods to monitor and manipulate cell size and evaluate stress resistance. The study could be strengthened by the inclusion of more experiments focused on defining the mechanistic basis of this coordination and broadening the scope of the specific role of the 'rewiring stress response' across different chronic cellular stresses. This work will be of broad interest to researchers interested in diverse fields including cellular proteostasis, stress-responsive signaling, and aging and senescence.

Reviewed by eLife

Active compensation for changes in TDH3 expression mediated by direct regulators of TDH3 in Saccharomyces cerevisiae

1. Pétra Vande Zande
2. Mohammad A. Siddiq
3. Andrea Hodgins-Davis
4. Lisa Kim
5. Patricia J. Wittkopp

Reviewed by Review Commons

Asymmetric tethering by exocyst in vitro requires a Rab GTPase, an R-SNARE and a Sac1-sensitive phosphoinositide lipid

1. Guendalina Rossi
2. Gabrielle C. Puller
3. Patrick Brennwald

Reviewed by PREreview

Optineurin provides a mitophagy contact site for TBK1 activation

1. Koji Yamano
2. Momoha Sawada
3. Reika Kikuchi
4. Kafu Nagataki
5. Waka Kojima
6. Ryu Endo
7. Hiroki Kinefuchi
8. Atsushi Sugihara
9. Tomoshige Fujino
10. Aiko Watanabe
11. Keiji Tanaka
12. Gosuke Hayashi
13. Hiroshi Murakami
14. Noriyuki Matsuda

Reviewed by Review Commons

Cross-regulations of two connected domains form a mechanical circuit for steady force transmission during clathrin-mediated endocytosis

1. Yuan Ren
2. Jie Yang
3. Barbara Fujita
4. Yongli Zhang
5. Julien Berro

Reviewed by Arcadia Science

cellPLATO – an unsupervised method for identifying cell behaviour in heterogeneous cell trajectory data

1. Michael J. Shannon
2. Shira E. Eisman
3. Alan R. Lowe
4. Tyler F. W. Sloan
5. Emily M. Mace

Reviewed by Arcadia Science

ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims

1. Tylor R Lewis
2. Mustafa S Makia
3. Carson M Castillo
4. Ying Hao
5. Muayyad R Al-Ubaidi
6. Nikolai P Skiba
7. Shannon M Conley
8. Vadim Y Arshavsky
9. Muna I Naash

• Curated by eLife

  eLife assessment

  This valuable study is focused on the requirement of the photoreceptor-specific tetraspanins, ROM1 and PRPH2, for the formation of light-sensitive membrane discs. The evidence supporting the claim that deficiency in one of the proteins can be compensated by the other is convincing, with both established and advanced techniques yielding results that will be of interest to those studying photoreceptor development and membrane curvature.

Reviewed by eLife

GLUD1 dictates muscle stem cell differentiation by controlling mitochondrial glutamate levels

1. Inés Soro-Arnáiz
2. Sarah Cherkaoui
3. Gillian Fitzgerald
4. Jing Zhang
5. Paola Gilardoni
6. Adhideb Ghosh
7. Ori Bar-Nur
8. Evi Masschelein
9. Pierre Maechler
10. Nicola Zamboni
11. Martin Poms
12. Alessio Cremonesi
13. Juan Carlos García Cañaveras
14. Katrien De Bock
15. Raphael J. Morscher

Reviewed by PREreview

Microtubule reorganization during mitotic cell division in the dinoflagellate Ostreospis cf. ovata

1. David Velasquez-Carvajal
2. Flavie Garampon
3. Rodolphe Lemée
4. Sebastian Schaub
5. Stefania Castagnetti

Reviewed by Arcadia Science

Distinct states of nucleolar stress induced by anticancer drugs

1. Tamara A Potapova
2. Jay R Unruh
3. Juliana Conkright-Fincham
4. Charles AS Banks
5. Laurence Florens
6. David Alan Schneider
7. Jennifer L Gerton

• Curated by eLife

  eLife assessment

  This study and associated data is compelling, novel, important, and well-carried out. The study demonstrates a novel finding that different chemotherapeutic agents can induce nucleolar stress, which manifests with varying cellular and molecular characteristics. The study also proposes a mechanism for how a novel type of nucleolar stress driven by CDK inhibitors may be regulated. The study sheds light on the importance of nucleolar stress in defining the on-target and off-target effects of chemotherapy in normal and cancer cells.

Reviewed by eLife