Cell Biology

C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

1. Jessica Mella
2. Regan F Volk
3. Balyn W Zaro
4. Abigail Buchwalter

• Curated by eLife

  eLife Assessment

  This study presents a valuable finding on the delivery of a nuclear envelop protein to lysosomes and the impact of C-terminal tagging on its traffic. The authors provide solid evidence for the potential artifacts introduced by large terminal tags, particularly in the context of membrane protein localization and stability.

Reviewed by eLife

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

1. Gabriel M Kline
2. Lisa Boinon
3. Adrian Guerrero
4. Sergei Kutseikin
5. Gabrielle Cruz
6. Marnie P Williams
7. Ryan J Paxman
8. William E Balch
9. Jeffery W Kelly
10. Tingwei Mu
11. R Luke Wiseman

• Curated by eLife

  eLife Assessment

  This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

Reviewed by eLife

Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

1. Athanasia Sergounioti
2. Efstathios Alonaris
3. Dimitrios Rigas

Reviewed by PREreview

Tmbim5 and Slc8b1 cooperate in tissue-specific mitochondrial calcium regulation in zebrafish

1. Iga Wasilewska
2. Łukasz Majewski
3. Dobrochna Adamek-Urbańska
4. Sofiia Baranykova
5. Matylda Macias
6. Aleksandra Szybińska
7. Axel Methner

Reviewed by Review Commons

Key roles of the zona pellucida and perivitelline space in promoting gamete fusion and fast block to polyspermy inferred from the choreography of spermatozoa in mice oocytes

1. Yaëlle Dubois
2. Sophie Favier
3. Nathan Martin-Fornier
4. Mohyeddine Omrane
5. David Stroebel
6. Eric Perez
7. Sandrine Barbaux
8. Ahmed Ziyyat
9. Nicolas Rodriguez
10. Christine Gourier

Reviewed by Review Commons

CellBinDB: A Large-Scale Multimodal Annotated Dataset for Cell Segmentation with Benchmarking of Universal Models

1. Can Shi
2. Jinghong Fan
3. Zhonghan Deng
4. Huanlin Liu
5. Qiang Kang
6. Yumei Li
7. Jing Guo
8. Jingwen Wang
9. Jinjiang Gong
10. Sha Liao
11. Ao Chen
12. Ying Zhang
13. Mei Li

Reviewed by GigaScience

Lipid packing contributes to the confinement of caveolae to the plasma membrane

1. E. Larsson
2. A. Kabedev
3. H. Pace
4. J. Lindwall
5. F. Bano
6. R.G. Parton
7. C.A.S. Bergström
8. I. Parmryd
9. M. Bally
10. R. Lundmark

Reviewed by Review Commons

TORC2-regulated sterol redistribution mediates recovery from membrane perturbation by small amphipathic molecules.

1. Maria G. Tettamanti
2. Paulina Nowak
3. Beata Kusmider
4. Jennifer M Kefauver
5. Vincent Mercier
6. Aurelien Roux
7. Robbie Loewith

Reviewed by Review Commons

Mycobacterium tuberculosis -infected macrophages accumulate more nanoparticles

1. Amine Pochet
2. Tom Bourguignon
3. Axelle Grandé
4. Jesus Alfredo Godinez-Leon
5. Joan Fine
6. Priscille Brodin
7. Arnaud Machelart
8. Ruxandra Gref

Reviewed by Rapid Reviews Infectious Diseases

The microcephaly protein WDR62 regulates cellular purine metabolism through the HSP70/HSP90 chaperone machinery

1. Matthew J. Morris
2. Yvonne Y. Yeap
3. Chi Chen
4. S. Sean Millard
5. Julia K. Pagan
6. Dominic C. H. Ng

Reviewed by Review Commons