Cell Biology

Enteropathogenic E. coli-mediated Fast and Coordinated Ca²⁺ responses regulate NF-κB activation

1. Fangrui Guo
2. Roberto Ornelas Guevara
3. Linda Oussaedine
4. Geneviève Dupont
5. Laurent Combettes
6. Guy Tran Van Nhieu

• Curated by eLife

  eLife Assessment

  This study reports important advances in our understanding of how enteropathogenic E. coli (EPEC) interacts at the intestinal interface. Solid data describe a novel model of spatially coordinated calcium signaling to modulate NF-kB activation; additional data and clarification of methods would improve the strength of these conclusions. These findings, which integrate imaging, genetics, and computational modeling, provide a new way to consider host-pathogen interactions in EPEC infections that may lead to improved therapies.

Reviewed by eLife

A retrograde transit filter mediated by optineurin controls mitostasis in distal axons

1. Natalia A. Marahori
2. Barbara Gailer
3. Martina Schifferer
4. Tatjana Kleele
5. Anna Iatroudi
6. Shabab B. Hannan
7. Petros Avramopoulos
8. Stefan Engelhardt
9. Melike Lakadamyali
10. Monika S. Brill
11. Thomas Misgeld

Reviewed by PREreview

mTORC1 signaling modulate microtubule tyrosination/detyrosination status to regulate lysosome dynamics

1. Jeganath Ammavasai
2. Nitin Mohan

Reviewed by PREreview

Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of osteoarthritis

1. Nedaa Al-Jezani
2. Asmaa Affan
3. Catherine Leonard
4. Nabangshu Das
5. Luiz Gustavo Almeida
6. Daniel Young
7. Anand O Masson
8. Antoine Dufour
9. Paul Salo
10. Pam Railton
11. James N Powell
12. Roman J Krawetz

• Curated by eLife

  eLife Assessment

  This important study characterized and identified clonal MSC populations from human synovium. The authors provide convincing evidence that clonal MSC populations can be isolated and expanded from both normal and osteoarthritic synovium and that CD47 represents a potential marker for improved chondrogenic potential of MSC sub-populations. These findings could provide new avenues for osteoarthritis treatment in the future and deeper mechanistic understanding of the factors involved in the repair.

Reviewed by eLife

GMCL1 controls 53BP1 stability and modulates taxane sensitivity

1. Yuki Kito
2. Tania J González-Robles
3. Sharon Kaisari
4. Juhee Pae
5. Sheena Faye Garcia
6. Juliana Ortiz-Pacheco
7. Beatrix Ueberheide
8. Antonio Marzio
9. Gergely Róna
10. Michele Pagano

• Curated by eLife

  eLife Assessment

  This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study proposes a novel mechanism by which cancer cells evade the mitotic surveillance pathway through GMCL1-mediated degradation of 53BP1, leading to reduced p53 activation and paclitaxel resistance. These data are the most useful aspect of the study, but the data supporting the authors' conclusions as to the clinical relevance of the study are inadequate. The authors have not taken relevant data about the clinical mechanism of taxanes into account.

Reviewed by eLife

Cell type specific allometry controls sex-differences in Drosophila body size

1. Soumitra Pal
2. Jerome Avellaneda
3. Celena M. Cherian
4. Puja Biswas
5. Georg Vogler
6. Elizabeth J. Rideout
7. Frank Schnorrer
8. Teresa M. Przytycka
9. Brian Oliver

Reviewed by Review Commons

CROP2, a Retriever-PROPPIN Complex Mediating Protein Export from Endosomes to the Plasma Membrane

1. Maria Giovanna De Leo
2. Andreas Mayer

• Curated by eLife

  eLife Assessment

  The authors present evidence for a WIPI2-Retriever complex (termed CROP2) that couples cargo selection to carrier fission at endosomes. CROP2 appears to function analogously to the previously described CROP1 complex, formed by WIPI1 and Retromer, with which it shares structural similarities. They provide convincing evidence that CROP1 and CROP2 regulate the trafficking of distinct subsets of cargoes; however, the cellular evidence for the existence of these distinct complexes remains incomplete. Overall, the findings are important and expand our understanding of how cargo selection by Retriever and Retromer is orchestrated at endosomes.

Reviewed by eLife

Disruption of Iron Metabolism Resulting from Dmt1/Slc11A2 Deficiency Compromises Notch Protein Degradation and Transcriptional Activation

1. Rui Zhang
2. Somaieh Ahmadian
3. Jolanda Piepers
4. Florian Bock
5. Tom Keulers
6. Marc A. Vooijs

Reviewed by PREreview

Loss of MGST1 during fibroblast differentiation enhances vulnerability to oxidative stress in human heart failure

1. Mohamad Youness
2. Onne A.H.O. Ronda
3. Ankit Pradhan
4. Filip Rega
5. Karin R. Sipido
6. H. Llewelyn Roderick

Reviewed by preLights

The Rho effector ARHGAP18 coordinates a Hippo pathway feedback loop through YAP and Merlin to regulate the cytoskeleton and epithelial cell polarity

1. Emma C. Murray
2. Gillian M. Hodge
3. Khanh Pham
4. Leighton S. Lee
5. Cameron A.R. Mitchell
6. Yongho Bae
7. Andrew T. Lombardo

Reviewed by Review Commons