Cell Biology

Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

1. Qi Zhang
2. Yunfeng Wang
3. Xueli Fu
4. Ziguang Wang
5. Yang Zhang
6. Lizhong Yan
7. Yuejia Wang
8. Muhan Yang
9. Dongze Song
10. Ruixing Zhang
11. Hongru Zhang
12. Shian Wu
13. Shaowei Zhao

• Curated by eLife

  eLife Assessment

  This valuable study examines the role of E2 ubiquitin enzyme, Uev1a in tissue resistance to oncogenic RasV12 in Drosophila melanogaster polyploid germline cells and human cancer cell lines. The solid evidence suggests that Uev1a works with the E3 ligase APC/C to degrade Cyclin A. This work would be of interest to researchers in germline biology and cancer.

Reviewed by eLife

Abnormal shear stress induces ferroptosis in endothelial cells via KLF6 downregulation

1. Jingang Cui
2. Zhiyu Fan
3. Suoqi Ding
4. Jiazhen Zhang
5. Huihong Shen
6. Syeda Armana Zaidi
7. Yongsheng Ding

• Curated by eLife

  eLife Assessment

  This study presents valuable findings on the role of KLF6 in in vitro endothelial cells exposed to altered (high or low) shear stress with a customized microfluidic device to investigate mechanisms of atherosclerosis. The finding that altered shear stress results in endothelial cell ferroptosis through reduced expression of KLF6 is compelling and adds a new layer of complexity to the pathogenesis of atherosclerotic plaques. However, more detailed characterization of ferroptosis is needed.

Reviewed by eLife

LRRK2G2019S acts as a dominant interfering mutant in the context of iron overload

1. Andres Goldman
2. Mai Nguyen
3. Joel Lanoix
4. Ahmed Fahmy
5. Yong Zhong Xu
6. Erwin Schurr
7. Pierre Thibault
8. Michel Desjardins
9. Heidi McBride

Reviewed by Review Commons

Human receptive endometrial assembloid for deciphering the implantation window

1. Yu Zhang
2. Rusong Zhao
3. Chaoyan Yang
4. Jinzhu Song
5. Peishu Liu
6. Yan Li
7. Boyang Liu
8. Tao Li
9. Changjian Yin
10. Minghui Lu
11. Zhenzhen Hou
12. Chuanxin Zhang
13. Zi-Jiang Chen
14. Keliang Wu
15. Han Zhao

• Curated by eLife

  eLife Assessment

  This important study reports an endometrial organoid culture system mimicking the window of implantation. The evidence supporting the conclusion drawn is convincing. The data will be of interest to embryologists and investigators working on reproductive biology and medicine.

Reviewed by eLife

A bipartite, mutation-tolerant NLS regulates interaction of ΔNp63α with importin alpha, nuclear transport and transcriptional activity

1. Anna Demarinis
2. Sara Esmaeili
3. Crystall M. D. Swarbrick
4. Simone Ranno
5. Silvia Pavan
6. Jade K. Forwood
7. Brian P. McSharry
8. Martin Pal
9. Enzo Di Iorio
10. Gualtiero Alvisi

Reviewed by Review Commons

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

1. Stefano Sellitto
2. Davide Caredio
3. Matteo Bimbati
4. Giovanni Mariutti
5. Martina Cerisoli
6. Lukas Frick
7. Vangelis Bouris
8. Carlos Omar Oueslati Morales
9. Dalila Laura Vena
10. Sandesh Neupane
11. Federico Baroni
12. Kathi Ging
13. Jiang-An Yin
14. Elena De Cecco
15. Andrea Armani
16. Adriano Aguzzi

Reviewed by Review Commons

Unremodeled plasma membrane GPI-anchored proteins trigger aberrant clathrin-mediated endocytosis

1. Li Chen
2. David K. Banfield

Reviewed by PREreview

Probing metazoan polyphosphate biology using Drosophila reveals novel and conserved polyP functions

1. Sunayana Sarkar
2. Harsha Sharma
3. SK Yasir Hosen
4. Jayashree S Ladke
5. Sandra Moser
6. Deepa Balasubramanian
7. Sreejith Raran-Kurussi
8. Henning J Jessen
9. Rashna Bhandari
10. Manish Jaiswal

• Curated by eLife

  eLife Assessment

  Studying the biological roles of polyphosphates in metazoans has been a longstanding challenge to the field given that the polyP synthase has yet to be discovered in metazoans. This important study capitalizes on the sophisticated genetics available in the Drosophila system and uses a combination of methodologies to start to tease apart how polyphosphate participates in Drosophila development and in the clotting of Drosophila hemolymph. The data validating one of these tools (cyto-FLYX ) are solid and well-documented and they will open up a field of research into the functional roles of polyP in a metazoan model. The other tools for tissue specific knockdown of polyP (Mito-FLYX, ER-FLYX, and Nuc-FLYX) have not yet been validated but will be invaluable to the field when they are.

Reviewed by eLife

PHD1-dependent hydroxylation of RepoMan (CDCA2) on P604 modulates the control of mitotic progression

1. Jimena Druker
2. Hao Jiang
3. Dilem Shakir
4. Fraser Child
5. Vanesa Alvarez
6. Melpomeni Platani
7. Andrea Corno
8. Constance Alabert
9. Adrian T Saurin
10. Jason R Swedlow
11. Sonia Rocha
12. Angus I Lamond

• Curated by eLife

  eLife Assessment

  This compelling work describes how the cell cycle-regulating phosphatase subunit, RepoMan, is regulated by the oxygen-dependent, metabolite-sensing hydroxylase PHD1. The characterisation of how proline hydroxylation alters signalling at the molecular and cellular level provides important evidence to enhance our understanding of how 2-oxoglutarate-dependent dioxygenases influence the cell cycle and mitosis.

Reviewed by eLife

Metabolite import via SLC33A1 enables ATF6 activation by endoplasmic reticulum stress

1. Ginto George
2. Heather P. Harding
3. Richard Kay
4. David Ron
5. Adriana Ordóñez

Reviewed by Review Commons