Cell Biology

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

1. Yoichi Miyamoto
2. Reo Kisanuki
3. Rieko Oshima
4. Shige H Yoshimura
5. Mutsumi Yokota
6. Kazumitsu Maehara
7. Chiaki Hata
8. Taro Tachibana
9. Hiroshi Kimura
10. Masato Koike
11. Yasuyuki Ohkawa
12. Toyomasa Katagiri
13. Yoshihiro Yoneda
14. Masahiro Oka
15. Hisato Saitoh

Reviewed by Review Commons

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

1. Haihui Zhang
2. Zhengyang Lei
3. Fatemeh Momen-Heravi
4. Peiwu Qin

• Curated by eLife

  eLife Assessment

  This study provides valuable information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis, as well as on telomere dynamics through live cell imaging. However, the conclusions remain inadequately supported by the current data, and several of the major technical concerns raised in the first round have not yet been fully resolved.

Reviewed by eLife

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

1. Alexandra C. Belfi
2. Sage G. Aviles
3. Rachel Forman-Rubinsky
4. Hasreet K. Gill
5. Jennifer D. Cohen
6. Aleksandra Nawrocka
7. Axelle Bourez
8. Pierre van Antwerpen
9. Patrick Laurent
10. Meera V. Sundaram

Reviewed by Review Commons

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

1. Janik Engelmann
2. Jennifer Zarrer
3. Max Schmerder
4. Christian Mess
5. Deniz Ragipoglu
6. Kristoffer Riecken
7. Tal Burstyn-Cohen
8. Emily J. Alberto
9. Sourav Ghosh
10. Carla Rothlin
11. Klaus Pantel
12. Carsten Bokemeyer
13. Eric Hesse
14. Hanna Taipaleenmäki
15. Sonja Loges
16. Isabel Ben-Batalla

Reviewed by preLights

Membrane potential modulates ERK activity and cell proliferation in human cells

1. Mari Sasaki
2. Masanobu Nakahara
3. Takuya Hashiguchi
4. Fumihito Ono

• Curated by eLife

  eLife Assessment

  This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The evidence now presented is solid and the data support the conclusions. This paper should be of interest to a broad readershp in the areas of cell and developemental biology and electrophysiology.

Reviewed by eLife

Co-option of lysosomal machinery shapes the symbiosis supporting coral reefs

1. Shumpei Maruyama
2. Catherine F Henderson
3. Natalie Swinhoe
4. Griffin P Kowalewski
5. Emily K Meier
6. Ty R Engelke
7. Phillip A Cleves

Reviewed by Arcadia Science

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

1. Chengrui Shi
2. Chaofei Su
3. Kaixiang Zhang
4. Hang Yin

• Curated by eLife

  eLife Assessment

  This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

Reviewed by eLife

Explainable machine learning-assisted exploration of chromatin dynamics reveals chromosome-specific response to serum starvation

1. Taras Redchuk
2. Antti Pennanen
3. Harri Jäälinoja
4. Olli Natri
5. Lassi Paavolainen
6. Maria K Vartiainen

• Curated by eLife

  eLife Assessment

  This interesting study adapts machine learning tools to analyze movements of a chromatin locus in living cells in response to serum starvation. The machine learning approach developed is useful, the experiments are well controlled, and the data are solid. The study would be greatly strengthened by testing key predictions made using perturbation experiments. This work will be of interest to those studying chromosome biology and gene expression patterns.

Reviewed by eLife

Overexpression of Ssd1 and calorie restriction extend yeast replicative lifespan by preventing deleterious age-dependent iron uptake

1. J Ignacio Gutierrez
2. Claudia Edgar
3. Jessica K Tyler

• Curated by eLife

  eLife Assessment

  This important study uses innovative microfluidics-based single-cell imaging to monitor replicative lifespan, protein localization, and intracellular iron levels in aging yeast cells. The evidence for the proposed role of Ssd1 and reduced nutrients for lifespan through limiting iron uptake is convincing, even though some mechanistic details remain unclear. This work will be of interest to cell biologists working on aging and iron metabolism.

Reviewed by eLife

A conserved Hsp70 phosphorylation regulates cell cycle progression after DNA damage

1. Thomas Moss
2. Alexandra Wooldredge
3. Koustav Bhakta
4. Matthew Cronin
5. Jason E. Gestwicki
6. Shaeri Mukherjee

Reviewed by preLights