Cell Biology

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

1. Xiaoning Gao
2. Wuyan Guo
3. Peiyuan Liu
4. Mingyue Yuwen
5. Hongyu Ren
6. Shengtao Hu
7. Zixiang Liu
8. Ruyang Tan
9. Kairui Liu
10. Zhiru Yang
11. Junli Ba
12. Xue Bai
13. Shiti Shama
14. Cong Tang
15. Kai Miao
16. Haozhi Pei
17. Liren Liu
18. Cheng Zhu
19. Tao Wang
20. Bo Zhang
21. Jun Kang

• Curated by eLife

  eLife Assessment

  This valuable study suggests that capsaicin nanoparticle administration in rats activates the transcription factor Nrf2 by directly binding to its repressor, KEAP1, leading to the induction of cytoprotective genes and preventing alcohol-induced gastric damage, offering a potential avenue for treating alcoholism-related gastric disorders. The authors provide solid evidence through a wealth of biochemical experiments in vitro, in cultured cells as well as in a rat model. The work will be of great interest to researchers studying oxidative damage in a variety of different diseases and the exploitation of molecules for therapeutic approaches.

Reviewed by eLife

Multi-omics studies reveal how ambient temperature changes govern cellular responses of Chlamydomonas

1. Prateek Shetty
2. Trang Vuong
3. Chulin Li
4. Volker Wagner
5. Dinara Myrzakhmetova
6. Chia-Chi Peng
7. Wenshuang Li
8. Joel Ching
9. Ariane Zander
10. Sophie Weiser
11. Miriam A Rosenbaum
12. Rosalind J Allen
13. Markus Lakemeyer
14. Maria Mittag

Reviewed by Arcadia Science

Chlamydomonas γ-tubulin mutations reveal a critical role for γ-TuRC in maintaining the stability of centriolar microtubules

1. Yuki Nakazawa
2. Naoto Kubota
3. Mao Horii
4. Akira Noga
5. Yoshikazu Koike
6. Hiroko Kawai-Toyooka
7. Hideo Dohra
8. Katsushi Yamaguchi
9. Shuji Shigenobu
10. Ken-ichi Wakabayashi
11. Masafumi Hirono

Reviewed by Arcadia Science

The tetraspanin disc proteins, peripherin-2 and ROM1, facilitate CNG channel localization to the rod outer segment

1. Molly T. Thorson
2. Stephanie E. Wei
3. Junseo Park
4. Jorge Y. Martínez-Márquez
5. David G. Ball
6. Jason R. Willer
7. William J. Spencer
8. Jillian N. Pearring

Reviewed by Review Commons

Branched chain fatty acid-rich diet promotes lipid droplet enlargement and impacts organismal health in Caenorhabditis elegans

1. Kam Ue Roy Li
2. Wing Ka Lo
3. Meigui Yang
4. Chenyin Wang
5. Lau Chun Yin
6. Jetty Chung-Yung Lee
7. Chaogu Zheng

Reviewed by Arcadia Science

MIRO1 controls energy production and proliferation of vascular smooth muscle cells

1. Lan Qian
2. Olha M Koval
3. Benney T Endoni
4. Denise Juhr
5. Colleen S Stein
6. Chantal Allamargot
7. Li-Hsien Lin
8. Deng-Fu Guo
9. Kamal Rahmouni
10. Antentor O Hinton
11. E Dale Abel
12. Ryan L Boudreau
13. Jennifer Streeter
14. William H Thiel
15. Isabella M Grumbach

• Curated by eLife

  eLife Assessment

  This important study highlights the role of MIRO1 in regulating mitochondrial oxidative phosphorylation in smooth muscle cells, a process that appears necessary to sustain their proliferation. Overall, the work provides convincing evidence that mitochondrial positioning and function influence vascular disease, although several bioenergetic and mechanistic aspects would benefit from deeper investigation.

Reviewed by eLife

Membrane rupture and independent extension of sister membranes drive cytokinesis in C. elegans embryos

1. Jingjing Liang
2. Tingrui Huang
3. Xun Huang
4. Mei Ding

• Curated by eLife

  eLife Assessment

  In this manuscript, based on electron microscopy observations of C. elegans embryos, the authors make the bold claim that the plasma membrane ruptures during cell division and that closure of this opening by membrane extension contributes to cytokinesis. Although the findings are potentially valuable, the evidence in support of the authors' claims is inadequate.

Reviewed by eLife

Fluorescence Lifetime Unmixing: A New Workflow for FLIM Live-Cell Imaging

1. Cornelia Wetzker
2. Marcelo Leomil Zoccoler
3. Svetlana Iarovenko
4. Chukwuebuka William Okafornta
5. Anja Nobst
6. Hella Hartmann
7. Thomas Müller-Reichert
8. Robert Haase
9. Gunar Fabig

Reviewed by Arcadia Science

Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell

1. David Jones
2. Hugo Belda
3. Malgorzata Broncel
4. Gwendolin Fuchs
5. David Anaguano
6. Stephanie D Nofal
7. Moritz Treeck

• Curated by eLife

  eLife Assessment

  This important study provides compelling evidence that fever-like temperatures enhance the export of Plasmodium falciparum transmembrane proteins, including the cytoadherence protein PfEMP1 and the nutrient channel PSAC, to the red blood cell surface, thereby increasing cytoadhesion. Using rigorous and well-controlled experiments, the authors convincingly demonstrate that this effect results from accelerated protein trafficking rather than changes in protein production or parasite development. These findings significantly advance our understanding of parasite virulence mechanisms and offer insights into how febrile episodes may exacerbate malaria severity.

Reviewed by eLife

The multifaceted role of EXOC6A in ciliogenesis

1. Te-Lin Lin
2. Chien-Ting Wu
3. Tang K Tang

• Curated by eLife

  eLife Assessment

  This important study elucidates the role of the exocyst component EXOC6A at distinct stages of ciliogenesis, which advances our understanding of ciliary membrane remodeling and cilium formation. The authors provide compelling evidence through high quality light and electron microscopic imaging, and careful analysis of knockout cell lines, that EXOC6A interacts with myosin-Va and is dynamically recruited via dynein-, microtubule-, and actin-dependent mechanisms, to support proper formation of the ciliary membrane. The study will be of interest to cell biologists and other researchers interested in vesicular trafficking, organellar membrane dynamics, and ciliogenesis.

Reviewed by eLife