1. Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

    This article has 25 authors:
    1. Maria Llamazares Prada
    2. Uwe Schwartz
    3. Darius F. Pease
    4. Stephanie T. Pohl
    5. Deborah Ackesson
    6. Renjiao Li
    7. Annika Behrendt
    8. Raluca Tamas
    9. Mandy Richter
    10. Thomas Muley
    11. Joschka Hey
    12. Elisa Espinet
    13. Claus P. Heußel
    14. Arne Warth
    15. Mark Schneider
    16. Hauke Winter
    17. Felix Herth
    18. Charles D Imbusch
    19. Benedikt Brors
    20. Vladimir Benes
    21. David Wyatt
    22. Tomasz P. Jurkowski
    23. Heiko F. Stahl
    24. Christoph Plass
    25. Renata Z. Jurkowska

    Reviewed by Review Commons

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. CCDC32 stabilizes clathrin-coated pits and drives their invagination

    This article has 12 authors:
    1. Ziyan Yang
    2. Changsong Yang
    3. Zheng Huang
    4. Peiliu Xu
    5. Yueping Li
    6. Lu Han
    7. Linyuan Peng
    8. Xiangying Wei
    9. John Pak
    10. Tatyana Svitkina
    11. Sandra L Schmid
    12. Zhiming Chen
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript presents a valuable finding that CCDC32, beyond its reported role in AP2 assembly, follows AP2 to the plasma membrane and regulates clathrin-coated pit assembly and dynamics. The authors further identify an alpha-helical region within CCDC32 that is essential for its interaction with AP2 and its cellular function. While live-cell and ultrastructural imaging data are solid, future biochemical studies will be needed to confirm the proposed CCDC32-AP2 interaction.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 14 evaluationsAppears in 2 listsLatest version Latest activity
  3. Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

    This article has 7 authors:
    1. Dong Luo
    2. Jing Zheng
    3. Shuning Lv
    4. Ren Sheng
    5. Maorong Chen
    6. Xi He
    7. Xinjun Zhang
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents important findings demonstrating that the internalization and degradation of FZD5 and FZD8, two of the ten Frizzled proteins, are WNT dependent and do not involve DVL. The evidence supporting the claims of the authors is convincing. This research will be of interest to biologists specializing in Wnt signaling, cancer, and regenerative medicine.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  4. Specific GPCRs Elicit Unique Extracellular Vesicle MiRNA Array Signatures: An Exploratory Study

    This article has 6 authors:
    1. Xiao Shi
    2. Michelle C Palumbo
    3. Sheila Benware
    4. Jack Wiedrick
    5. Sheila Markwardt
    6. Aaron Janowsky
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents valuable findings by demonstrating that specific GPCR subtypes induce distinct extracellular vesicle miRNA signatures, highlighting a potential novel mechanism for intercellular communication with implications for receptor pharmacology within the field. The data is compelling, however, more evidence is needed to determine whether the distinct extracellular vesicle miRNA signatures result from GPCR-dependent miRNA expression or GPCR-dependent incorporation of miRNAs into extracellular vesicles.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. RNA triggers chronic stress during neuronal aging

    This article has 12 authors:
    1. Kevin Rhine
    2. Elle Epstein
    3. Natasha M. Carlson
    4. Xuezhen Ge
    5. Orel Mizrahi
    6. Anika Kamat
    7. Anita Hermann
    8. William R. Brothers
    9. John Ravits
    10. Eric J. Bennett
    11. Gülçin Pekkurnaz
    12. Gene W. Yeo

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  6. Microscopy Nodes: versatile 3D microscopy visualization with Blender

    This article has 6 authors:
    1. Oane Gros
    2. Chandni Bhickta
    3. Granita Lokaj
    4. Yannick Schwab
    5. Simone Köhler
    6. Niccolò Banterle

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes

    This article has 11 authors:
    1. Wencong Lyu
    2. Haochen Wang
    3. Zhehao Du
    4. Ran Wei
    5. Jianuo He
    6. Fanju Meng
    7. Jinlong Bi
    8. Lijun Zhang
    9. Chao Zhang
    10. Yiting Guan
    11. Wei Tao
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into the anti-senescence effects of enalapril, identifying pSmad1/5/9 signaling and associated antioxidant pathways as key mediators of its physiological benefits in aged mice. The authors present solid experimental evidence across both in vitro and in vivo systems, demonstrating improved organ function and reduced senescence markers following treatment. Overall, the work supports the repurposing potential of enalapril in aging research and expands understanding of its molecular targets.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  8. Testosterone-Induced Metabolic Changes in Seminal Vesicle Epithelium Modify Seminal Plasma Components with Potential to Improve Sperm Motility

    This article has 6 authors:
    1. Takahiro Yamanaka
    2. Zimo Xiao
    3. Natsumi Tsujita
    4. Mahmoud Awad
    5. Takashi Umehara
    6. Masayuki Shimada
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important work elucidates the biological processes and detailed mechanisms by which testosterone influences seminal plasma metabolites in mice. The evidence supporting the upregulation of metabolic enzymes and the role of ACLY is solid, highlighting the potential contributions of fatty acids to sperm motility.

    Reviewed by eLife

    This article has 16 evaluationsAppears in 2 listsLatest version Latest activity
  9. Organization of the Yeast Seipin Complex Reveals Differential Recruitment of Regulatory Proteins

    This article has 2 authors:
    1. Yoel A. Klug
    2. Pedro Carvalho

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Efficiency and localisation of AURKA degradation by PROTACs is modulated by deubiquitinases UCHL5 and target-selective OTUD6A

    This article has 3 authors:
    1. Annabel Cardno
    2. Karen Roberts
    3. Catherine Lindon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study describes a genetic screen to identify deubiquitinases (DUBs) that counteract the activity of small-molecule degraders (PROTACs). The presented data are valuable, identifying OTUD6A and UCHL5 as DUBs that impact the efficacy and potency of PROTACs. While the conclusions are broadly supported and the methods employed are solid, the mechanistic depth and validation are incomplete. Overall, these findings merit further evaluation by the targeted protein degradation community when developing and optimizing PROTACs.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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