1. Fertilization triggers cytosolic functions and P-body recruitment of the RNA-binding protein Mei2 to drive fission yeast zygotic development

    This article has 3 authors:
    1. Ayokunle Araoyinbo
    2. Clàudia Salat-Canela
    3. Aleksandar Vještica

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Optogenetic control of mechanotransduction based on light-induced homodimerization of talin

    This article has 6 authors:
    1. Ryosuke Nishimura
    2. Samuel F. H. Barnett
    3. Kashish Jain
    4. Zengxin Huang
    5. Benjamin T. Goult
    6. Pakorn Kanchanawong

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Transcriptional dynamics uncover the role of BNIP3 in mitophagy during muscle remodeling in Drosophila

    This article has 12 authors:
    1. Hiroki Taoka
    2. Tadayoshi Murakawa
    3. Kohei Kawaguchi
    4. Michiko Koizumi
    5. Tatsuya Kaminishi
    6. Yuriko Sakamaki
    7. Kaori Tanaka
    8. Akihito Harada
    9. Keiichi Inoue
    10. Tomotake Kanki
    11. Yasuyuki Ohkawa
    12. Naonobu Fujita
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This paper presents the important finding that BNIP3/NIX, a mitophagy receptor, and its binding to ATG18 are required for mitophagy during muscle cell reorganization in Drosophila. Although the involvement of the BNIP3-ATG18/WIPI axis in mitophagy induction has been reported in mammalian cell culture systems, this study provides the first compelling evidence for this pathway in vivo in animals. The physiological significance of this BNIP3-dependent mitophagy will require further investigation.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  4. ATG2A engages RAB1A and ARFGAP1 positive membranes during autophagosome biogenesis

    This article has 11 authors:
    1. Devin M Fuller
    2. Yumei Wu
    3. Florian Schueder
    4. Burha Rasool
    5. Shanta Nag
    6. Justin L Korfhage
    7. Rolando Garcia-Milian
    8. Katerina D Melnyk
    9. Joerg Bewersdorf
    10. Pietro De Camilli
    11. Thomas J Melia
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into the crosstalk between ATG2A with components of the early secretory pathway, namely RAB1A and ARFGAP1. The evidence supporting the claims is convincing. However, the manuscript would benefit from a more in-depth exploration of the details of the role of RAB1A in autophagy and the functional implications of its interaction with ATG2A. In addition, the molecular details of the role of ARFGAP1 in this complex need further clarification

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  5. Live-cell imaging reveals nutrient-dependent dynamics of ER-mitochondria contact formation via PDZD8

    This article has 4 authors:
    1. Saeko Aoyama-Ishiwatari
    2. Koki Nakamura
    3. Takahiro Nagao
    4. Yusuke Hirabayashi

    Reviewed by Review Commons

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  6. G1 and G2 ApolipoproteinL1 modulate macrophage inflammation and lipid accumulation through the polyamine pathway

    This article has 12 authors:
    1. Esther Liu
    2. Matthew Wright
    3. Andrew O Kearney
    4. Tiffany Caza
    5. Johnson Y Yang
    6. Valerie Garcia
    7. Amal O Dadi
    8. Shuta Ishibe
    9. Navdeep S Chandel
    10. Hanrui Zhang
    11. Edward B Thorp
    12. Jennie Lin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The authors study how apolipoprotein L1 variants impact inflammation and lipid accumulation in macrophages. The findings will be useful for researchers investigating macrophage metabolism and inflammation. The discovery that the polyamine spermidine in part mediates such effects is interesting, but the supporting evidence for a physiologically relevant role is currently incomplete due to the lack of relevant in vivo studies.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  7. Impact of Maximal Overexpression of a Non-toxic Protein on Yeast Cell Physiology

    This article has 4 authors:
    1. Yuri Fujita
    2. Shotaro Namba
    3. Yoshiaki Kamada
    4. Hisao Moriya
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This convincing study advances our understanding of the physiological consequences of the strong overexpression of non-toxic proteins in baker's yeast. The findings suggest that a massive protein burden results in nitrogen starvation and a shift in metabolism likely regulated via the TORC1 pathway, as well as defects in ribosome biogenesis in the nucleolus. The study presents findings and tools that are important for the cell biology and protein homeostasis fields.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. C-terminal tagging, transmembrane domain hydrophobicity, and an ER retention motif influence the secretory trafficking of the inner nuclear membrane protein emerin

    This article has 4 authors:
    1. Jessica Mella
    2. Regan F Volk
    3. Balyn W Zaro
    4. Abigail Buchwalter
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on the delivery of a nuclear envelop protein to lysosomes and the impact of C-terminal tagging on its traffic. The authors provide solid evidence for the potential artifacts introduced by large terminal tags, particularly in the context of membrane protein localization and stability.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  9. Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

    This article has 11 authors:
    1. Gabriel M Kline
    2. Lisa Boinon
    3. Adrian Guerrero
    4. Sergei Kutseikin
    5. Gabrielle Cruz
    6. Marnie P Williams
    7. Ryan J Paxman
    8. William E Balch
    9. Jeffery W Kelly
    10. Tingwei Mu
    11. R Luke Wiseman
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  10. Novel Fatigue Profiling Approach Highlights Temporal Dynamics of Human Sperm Motility

    This article has 3 authors:
    1. Athanasia Sergounioti
    2. Efstathios Alonaris
    3. Dimitrios Rigas

    Reviewed by PREreview

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
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