Cell Biology

Stress granules and protein aggregates reveal intracellular resource competition

1. Hannah E. Buchholz
2. Sean A. Martin
3. Jane E. Dorweiler
4. Derek C. Prosser
5. Emily M. Sontag
6. Anita L. Manogaran

Reviewed by Arcadia Science

Division Asymmetry Drives Cell Size Variability in Budding Yeast

1. Félix Proulx-Giraldeau
2. Xin Gao
3. Yagya Chadha
4. Jordan Xiao
5. Kurt M. Schmoller
6. Jan M. Skotheim
7. Paul Francois

Reviewed by Arcadia Science

Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance

1. Atsushi Matsumoto
2. Akihito Inoko
3. Takuya Tanaka
4. Gen-Ichi Konishi
5. Waki Hosoda
6. Takahiro Kojima
7. Koji Ohnishi
8. Junichi Ikenouchi

• Curated by eLife

  eLife Assessment

  This paper presents the fundamental discovery that lipid metabolic imbalance induced by Snail, an EMT-related transcription factor, contributes to the acquisition of chemoresistance in cancer cells. The evidence, supported by a wide range of methods and adequate quantification, provides a convincing mechanistic explanation of how Snail drives ectopic expression of the cholesterol- and drug-efflux transporter ABCA1. This work, which introduces a novel therapeutic concept targeting invasive cancer, will be of broad interest to researchers in cancer biology, lipid metabolism, and cell biology.

Reviewed by eLife

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity

1. Gabriel M Kline
2. Lisa Boinon
3. Adrian Guerrero
4. Sergei Kutseikin
5. Gabrielle Cruz
6. Marnie P Williams
7. Ryan J Paxman
8. William E Balch
9. Jeffery W Kelly
10. Tingwei Mu
11. R Luke Wiseman

• Curated by eLife

  eLife Assessment

  This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis remodeling. The evidence supporting the conclusions is convincing, with rigorous assays used to benchmark the changes in potency and efficacy of the AA263 analogs as well as AA263 targets. The ability of AA263 analogs to restore the loss of function associated with disease-associated proteins prone to misfolding will be of interest to pharmacologists, chemical biologists, and cell biologists, as well as those working on protein misfolding disorders.

Reviewed by eLife

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

1. Daniel A. Reed
2. Anna E. Howell
3. Nadia Kuepper
4. Alice M. H. Tran
5. Astrid Magenau
6. Deborah S. Barkauskas
7. Max Nobis
8. Cecilia R. Chambers
9. Victoria Lee
10. Lily M. Channon
11. Jessie Zhu
12. Shona Ritchie
13. Janett Stoehr
14. Kaitlin Wylie
15. Julia Chen
16. Denise Attwater
17. Kate Harvey
18. Sunny Z. Wu
19. Kate Saw
20. Ruth J. Lyons
21. Anaiis Zaratzian
22. Michael Tayao
23. Andrew Da Silva
24. David Gallego-Ortega
25. Anthony J. Gill
26. Thomas R. Cox
27. Brooke A. Pereira
28. Kendelle J. Murphy
29. Jennifer P. Morton
30. Elgene Lim
31. Alexander Swarbrick
32. Sandra O’Toole
33. Michael S. Samuel
34. C. Elizabeth Caldon
35. Alexandra Zanin-Zhorov
36. Paul Timpson
37. David Herrmann

Reviewed by preLights

Specialisation of meiotic kinetochores revealed through a synthetic SAC strategy

1. Lori B Koch
2. Christos Spanos
3. Adele L Marston

Reviewed by Review Commons

Ceramide transfer protein regulates G-protein coupled phospholipase signalling in Drosophila photoreceptors

1. Shirish Mishra
2. Ali Khan
3. Vaisaly R Nath
4. Tejaswini Manoj
5. BG Thejaswini
6. Amruta Naik
7. Ujjaini Dasgupta
8. Padinjat Raghu

Reviewed by Review Commons

Sterols regulate ciliary membrane dynamics and hedgehog signaling in health and disease

1. Antonin Lamazière
2. Lucie Kozlowski
3. Jesus Ayala-Sanmartin
4. Manal Farhat
5. Nabil Belaid
6. Alexandre Certain
7. Bertrand Isidor
8. Thomas Besnard
9. Germain Trugnan
10. Gregory J Pazour
11. Gaëtan Després
12. Céline Deseille
13. Sarah Moreno
14. Thibaut Eguether

Reviewed by Review Commons

Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation

1. Rudolf Pisa
2. Tom A. Rapoport

Reviewed by preLights

Human dynein-dynactin is a fast processive motor in living cells

1. Vikash Verma
2. Patricia Wadsworth
3. Thomas J Maresca

• Curated by eLife

  eLife Assessment

  In this valuable technical report, Verma et al. provide convincing evidence that endogenously tagged dynein and dynactin form processive motor complexes that move along microtubules in living cells. Using quantitative fluorescence microscopy, they directly compare the stoichiometry and motility of these complexes to kinesin-1, revealing distinct transport behaviors and regulatory properties. This study offers key methodological and conceptual advance for understanding the dynamics of native motor proteins within the cellular environment and will be of interest to the cell biology community.

Reviewed by eLife