Cell Biology

Chromatin organization controls nuclear stiffness

1. Hector Romero
2. Anahid Amiri
3. Maruthi K. Pabba
4. Hui Zhang
5. Veronika Berg
6. Maria Arroyo
7. Paulina Prorok
8. Nina Trautwein
9. Bodo Laube
10. Christian Dietz
11. Robert W. Stark
12. M. Cristina Cardoso

Reviewed by Life Science Editors Foundation

SUMOylation regulates protein cargo in Astrocyte-derived small extracellular vesicles

1. Anllely Fernández
2. Maxs Méndez
3. Octavia Santis
4. Katherine Corvalan
5. Maria-Teresa Gomez
6. Peter Landgraf
7. Thilo Kahne
8. Alejandro Rojas-Fernandez
9. Ursula Wyneken

Reviewed by PREreview

Interferon-Induced PARP14-Mediated ADP-Ribosylation in p62 Bodies Requires an Active Ubiquitin-Proteasome System

1. Rameez Raja
2. Banhi Biswas
3. Rachy Abraham
4. Hongrui Liu
5. Che-Yuan Chang
6. Hien Vu
7. Anthony K. L. Leung

Reviewed by PREreview, Review Commons

Clearance of protein aggregates during cell division

1. Shoukang Du
2. Yuhan Wang
3. Bowen Chen
4. Shuangshuang Xie
5. Kuan Yoow Chan
6. David C. Hay
7. Ting Gang Chew

• Curated by eLife

  eLife Assessment

  How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC). These are valuable and interesting new observations, but the evidence supporting these claims is partially incomplete. New experiments and/or toning down the conclusions and highlighting what has not been learned may be appropriate and can then spur more work in the field.

Reviewed by eLife

Chromokinesin Klp-19 regulates microtubule overlap and dynamics during anaphase in C. elegans

1. Vitaly Zimyanin
2. Magdalena Magaj
3. Nadia Ingabire Manzi
4. Che-Hang Yu
5. Theresa Gibney
6. Yu-Zen Chen
7. Mustafa Basaran
8. Xavier Horton
9. Karsten Siller
10. Ariel Pani
11. Daniel Needleman
12. Daniel J. Dickinson
13. Stefanie Redemann

Reviewed by Review Commons

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

1. Mengjia Li
2. Hengchao Zhang
3. Xiuyun Wu
4. Mengqi Yu
5. Qianqian Yang
6. Lei Sun
7. Wei Li
8. Zhongxing Jiang
9. Fumin Xue
10. Ting Wang
11. Xiuli An
12. Lixiang Chen

• Curated by eLife

  eLife Assessment

  This study by Li et al. presents important findings on the metabolism-independent role of nuclear IDH1 in chromatin regulation during erythropoiesis. The authors provide convincing evidence that IDH1 deficiency disrupts H3K79 methylation and nuclear architecture, contributing to dyserythropoiesis. Their findings offer invaluable mechanistic insights with potential therapeutic implications for erythroid disorders and hematologic malignancies.

Reviewed by eLife

MARK2 regulates Golgi apparatus reorientation by phosphorylation of CAMSAP2 in directional cell migration

1. Peipei Xu
2. Rui Zhang
3. Zhengrong Zhou
4. Honglin Xu
5. Yuejia Li
6. Mengge Yang
7. Ruifan Lin
8. Yingchun Wang
9. Xiahe Huang
10. Qi Xie
11. Wenxiang Meng

• Curated by eLife

  eLife Assessment

  The authors propose that the kinase MARK2 regulates the Golgi's reorientation towards the cell's leading edge through the regulation of microtubule binding protein CAMSAP2 and its binding to USO1. While the model is interesting and the study is useful, the quantification of an insufficient number of cells and insufficient description of the methods and biological replicates mean the results are inadequate to support the model.

  [Editors' note: this paper was reviewed by Review Commons.]

Reviewed by eLife

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

1. Tony Marchand
2. Kemi E Akinnola
3. Shoichiro Takeishi
4. Maria Maryanovich
5. Sandra Pinho
6. Julien Saint-Vanne
7. Alexander Birbrair
8. Thierry Lamy
9. Karin Tarte
10. Paul S Frenette
11. Kira Gritsman

• Curated by eLife

  eLife Assessment

  The study presents valuable insights into the role of periosteal stem cells in bone marrow regeneration. The evidence is convincing. The data broadly support their claims and in line with state-of-art methodology. Future study on their model will help to strengthen their discovery further.

Reviewed by eLife

Tmbim5 loss causes muscle atrophy in zebrafish without exacerbating mcu or slc8b1 knockout phenotypes

1. Iga Wasilewska
2. Łukasz Majewski
3. Dobrochna Adamek-Urbańska
4. Sofiia Baranykova
5. Matylda Macias
6. Aleksandra Szybińska
7. Axel Methner

Reviewed by Review Commons

Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

1. Jessica Jocher
2. Philipp Janssen
3. Beate Vieth
4. Fiona C Edenhofer
5. Tamina Dietl
6. Anita Térmeg
7. Paulina Spurk
8. Johanna Geuder
9. Wolfgang Enard
10. Ines Hellmann

• Curated by eLife

  eLife Assessment

  The authors have generated important resources such as a reference dataset of early primate development by utilizing single-cell transcriptomic technology together with induced pluripotent stem cells (iPSCs) from four primate species: humans, orangutans, cynomolgus macaques, and rhesus macaques. By analyzing marker gene expression and cell types across species during undirected differentiation of iPSCs, the authors provide solid evidence that the transferability of marker genes decreases as the evolutionary distance between species increases. This work demonstrates the extended usage of iPSCs for broader fields, which will benefit several scientific communities including anthropology, comparative biology, and evolutionary biology.

Reviewed by eLife