Cell Biology

The G ₂ phase controls binary division of Toxoplasma gondii

1. Lauren M. Hawkins
2. Chengqi Wang
3. Dale Chaput
4. Mrinalini Batra
5. Clem Marsilia
6. Danya Awshah
7. Elena S. Suvorova

Reviewed by Review Commons

Plakins are involved in the maintenance of epithelial polarity

1. Juliana Geay
2. Yoran Margaron
3. David Gentien
4. Fabien Reyal
5. Alain Puisieux
6. Laurent Blanchoin
7. Laurent Guyon
8. Manuel Théry

Reviewed by Review Commons

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex

1. Marisa Bedir
2. Emily Outwin
3. Rita Colnaghi
4. Lydia Bassett
5. Iga Abramowicz
6. Mark O’Driscoll

Reviewed by Review Commons

Proteasome gene expression is controlled by the coordinated functions of multiple transcription factors

1. Jennifer E. Gilda
2. Asrafun Nahar
3. Dharanibalan Kasiviswanathan
4. Nadav Tropp
5. Tamar Gilinski
6. Tamar Lahav
7. Yael Mandel-Gutfreund
8. Soyeon Park
9. Shenhav Cohen

Reviewed by Review Commons

Dynamin 1xA interacts with Endophilin A1 via its spliced long C-terminus for ultrafast endocytosis

1. Yuuta Imoto
2. Jing Xue
3. Lin Luo
4. Sumana Raychaudhuri
5. Kie Itoh
6. Ye Ma
7. George E. Craft
8. Ann H. Kwan
9. Joel P. Mackay
10. Taekjip Ha
11. Shigeki Watanabe
12. Phillip J. Robinson

Reviewed by Review Commons

Circadian regulation of macromolecular complex turnover and proteome renewal

1. Estere Seinkmane
2. Anna Edmondson
3. Sew Y Peak-Chew
4. Aiwei Zeng
5. Nina M Rzechorzek
6. Nathan R James
7. James West
8. Jack Munns
9. David CS Wong
10. Andrew D Beale
11. John S O’Neill

Reviewed by Review Commons

Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

1. Yi Zeng
2. Jonathan P. Staley

• Curated by eLife

  eLife assessment

  This is an important study that demonstrates that RNA intermediates arising from improper splicing are exported out of the nucleus via the canonical mRNA export machinery and the nuclear pore basket. The authors provide convincing evidence that the role of the nuclear basket rather than retaining the transcripts is stimulating their export, putting into question the current model of the role of the basket. The conclusions are in line with recent studies in mammalian cells that suggest that the basket's role in mRNA export and quality control has to be revised.

Reviewed by eLife

Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

1. Ryosuke Isotani
2. Masaki Igarashi
3. Masaomi Miura
4. Kyoko Naruse
5. Satoshi Kuranami
6. Manami Katoh
7. Seitaro Nomura
8. Toshimasa Yamauchi

• Curated by eLife

  eLife assessment

  This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. However, the evidence supporting the authors' claims remains incomplete. Additional analysis on how stem cells uniquely respond to nicotine could provide more definitive evidence and strengthen the study. This research will be of interest to medical biologists specializing in intestinal tumors.

Reviewed by eLife

Heterotypic interaction promotes asymmetric division of human hematopoietic stem and progenitor cells

1. Adrian Candelas
2. Benoit Vianay
3. Matthieu Gelin
4. Lionel Faivre
5. Jerome Larghero
6. Laurent Blanchoin
7. Manuel Théry
8. Stephane Brunet

Reviewed by Review Commons

A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function

1. Denny Yang
2. Austin Lai
3. Amelie Davies
4. Anne FJ Janssen
5. Delphine Larrieu

Reviewed by Review Commons