Cell Biology

Polarity reversal of stable microtubules during neuronal development

1. Malina K. Iwanski
2. Albert K. Serweta
3. H. Noor Verwei
4. Bronte C. Donders
5. Lukas C. Kapitein

Reviewed by Review Commons

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

1. Zongwang Zhang
2. Lixia Zheng
3. Yang Chen
4. Yuanyuan Chen
5. Junjie Hou
6. Chenglu Xiao
7. Xiaojun Zhu
8. Shi-Min Zhao
9. Jing-Wei Xiong

• Curated by eLife

  eLife Assessment

  This important study highlights the essential role of AARS2 in safeguarding cardiomyocytes against ischemic stress by modulating energy metabolism towards glycolysis via PKM2. This mechanism unveils a promising new therapeutic target for treating myocardial infarction. Convincing findings are underpinned by a comprehensive dataset, including cardiomyocyte-specific genetic modifications, functional assays, and ribosome profiling, all collectively providing strong evidence for the critical involvement of the AARS2-PKM2 signalling pathway in cardiac protection.

Reviewed by eLife

CellPhePy: A python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time‐lapse videos

1. Laura Wiggins
2. Stuart Lacy
3. Graeme Park
4. Joanne Marrison
5. Ben Powell
6. Beth Cimini
7. Peter O'Toole
8. Julie Wilson
9. William J. Brackenbury

Reviewed by Arcadia Science

Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion

1. Jessica Wagner
2. Konstantina Feller
3. Nicole Schrenke
4. Nina Schulze
5. Annette Paschen
6. Leif Dehmelt
7. Perihan Nalbant

Reviewed by preLights

Microtubule-dependent cell polarity regulates skin-resident macrophage phagocytosis and directed cell migration

1. Eric Peterman
2. Andrew Murphy
3. Ian A. Swinburne
4. Sean G. Megason
5. Jeffrey P. Rasmussen

Reviewed by PREreview

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

1. Andreas Fellas
2. Alison L. Pidoux
3. Pin Tong
4. Harriet H. Hewes
5. Emma C. Wallace
6. Robin C. Allshire

Reviewed by Review Commons

Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

1. San Pin Steve Wu
2. Elvis Quiroz
3. Tianyuan Wang
4. Skylar G Montague Redecke
5. Xin Xu
6. Lin Lin
7. Matthew L Anderson
8. Francesco J DeMayo

• Curated by eLife

  eLife Assessment

  This valuable study employed a multi-omics approach to elucidate the regulatory mechanism underlying parturition and myometrial quiescence. The data presented to support the main conclusion are solid. This work will be of interest to both basic researchers who work on reproductive biology and clinicians who practice reproductive medicine.

Reviewed by eLife

Cell cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes

1. James P. Kemp
2. Mark S. Geisler
3. Mia Hoover
4. Chun-Yi Cho
5. Patrick H. O’Farrell
6. William F. Marzluff
7. Robert J. Duronio

Reviewed by Review Commons

Emergence of Dip2-mediated specific DAG-based PKC signalling axis in eukaryotes

1. Sakshi Shambhavi
2. Sudipta Mondal
3. Arnab Chakraborty
4. Nikita Shukla
5. Bapin Kumar Panda
6. Santhosh Kumar
7. Priyadarshan Kinatukara
8. Biswajit Pal
9. Siddhesh S Kamat
10. Rajan Sankaranarayanan

• Curated by eLife

  eLife Assessment

  This is an interesting study that adds useful new data addressing how different DAG pools influence cellular signaling. The study dissects how the enzyme Dip2 modulates the minor lipid signaling DAG pool, which is distinct from the lipid metabolism DAG pool utilized in membrane production. Overall the analysis is solid and broadly supports the claims.

Reviewed by eLife

Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway in budding yeast

1. Prakhar Agarwal
2. Anushka Alekar
3. Shubhomita Mallick
4. Kannan Harini
5. Santanu K Ghosh

Reviewed by Review Commons