Cell Biology

  1. Single-molecule lipid biosensors mitigate inhibition of endogenous effector proteins

    1. Victoria L. Holmes
    2. Morgan M.C. Ricci
    3. Claire C. Weckerly
    4. Michael Worcester
    5. Gerald R.V. Hammond

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  2. Cytoplasmic ribosomes hitchhike on mitochondria to dendrites

    1. Corbin J Renken
    2. Susie Kim
    3. Youjun Wu
    4. Marc Hammarlund
    5. Shaul Yogev

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  3. A novel human pluripotent stem cell gene activation system identifies IGFBP2 as a mediator in the production of haematopoietic progenitors in vitro

    1. Paolo Petazzi
    2. Telma Ventura
    3. Francesca Paola Luongo
    4. Heather McClafferty
    5. Alisha May
    6. Helen Alice Taylor
    7. Michael J Shipston
    8. Nicola Romanò
    9. Lesley M Forrester
    10. Pablo Menendez
    11. Antonella Fidanza

    • Curated by eLife

      eLife Assessment

      This study presents useful findings to inform and improve the in vitro differentiation of hematopoietic progenitor cells from human induced pluripotent stem cells. Relying on a well-characterised technical approach, the data analysis is overall solid and reasonably supports the main conclusions.

    Reviewed by eLife

    7 evaluationsAppears in 1 listLatest version Latest activity

  4. Unbiased identification of cell identity in dense mixed neural cultures

    1. Sarah De Beuckeleer
    2. Tim Van De Looverbosch
    3. Johanna Van Den Daele
    4. Peter Ponsaerts
    5. Winnok H De Vos

    • Curated by eLife

      eLife Assessment

      This study presents an important application of high-content image-based morphological profiling to quantitatively and systematically characterize induced pluripotent stem cell-derived mixed neural cultures cell type compositions. Exceptional evidence through rigorous experimental and computational validations support new potential applications of this cheap and simple assay.

    Reviewed by eLife

    10 evaluationsAppears in 1 listLatest version Latest activity

  5. The dependence of shugoshin on Bub1-kinase activity is dispensable for the maintenance of spindle assembly checkpoint response in Cryptococcus neoformans

    1. Satya Dev Polisetty
    2. Krishna Bhat
    3. Kuladeep Das
    4. Ivan Clark
    5. Kevin G. Hardwick
    6. Kaustuv Sanyal

    Reviewed by Review Commons

    5 evaluationsAppears in 1 listLatest version Latest activity

  6. Immunosuppression Drugs Exhibit Differential Effects on Endothelial Cell Function

    1. Aly Elezaby
    2. Ryan Dexheimer
    3. David Wu
    4. Sze Yu Chan
    5. Ian Y. Chen
    6. Nazish Sayed
    7. Karim Sallam

    Reviewed by PREreview

    1 evaluationAppears in 1 listLatest version Latest activity

  7. Nicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway

    1. Ryosuke Isotani
    2. Masaki Igarashi
    3. Masaomi Miura
    4. Kyoko Naruse
    5. Satoshi Kuranami
    6. Manami Katoh
    7. Seitaro Nomura
    8. Toshimasa Yamauchi

    • Curated by eLife

      eLife Assessment

      This study presents a valuable finding on a potential signaling pathway responsible for the direct effects of nicotine on intestinal stem cell growth and tumorigenesis. The evidence supporting the claims of the authors is solid. This research will be of interest to medical biologists specializing in intestinal tumors.

    Reviewed by eLife

    11 evaluationsAppears in 1 listLatest version Latest activity

  8. RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress

    1. Gayatri Mohanan
    2. Raju Roy
    3. Hélène Malka-Mahieu
    4. Swati Lamba
    5. Lucilla Fabbri
    6. Anusmita Biswas
    7. Sylvain Martineau
    8. Céline M. Labbé
    9. Stéphan Vagner
    10. Purusharth I Rajyaguru

    Reviewed by Review Commons

    4 evaluationsAppears in 1 listLatest version Latest activity

  9. Pin4 Links Post-transcriptional and Transcriptional Responses to Glucose Starvation in Yeast

    1. Michaela Ristová
    2. Katherine Bexley
    3. Vadim Shchepachev
    4. Atlanta G. Cook
    5. David Tollervey

    Reviewed by Arcadia Science

    3 evaluationsAppears in 1 listLatest version Latest activity

  10. Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    1. Breanna Lam
    2. Kathrin M Kajderowicz
    3. Heather R Keys
    4. Julian M Roessler
    5. Evgeni M Frenkel
    6. Adina Kirkland
    7. Punam Bisht
    8. Mohamed A El-Brolosy
    9. Rudolf Jaenisch
    10. George W Bell
    11. Jonathan S Weissman
    12. Eric C Griffith
    13. Sinisa Hrvatin

    • Curated by eLife

      eLife Assessment

      This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The evidence supporting these conclusions is compelling, combining multi-species CRISPR screening with rigorous pharmacological assays. This work will be of significant interest to biologists studying hibernation physiology and medical researchers interested in cold tolerance.

    Reviewed by eLife

    5 evaluationsAppears in 1 listLatest version Latest activity
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