1. Single-nucleus transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

    This article has 10 authors:
    1. Simon Perrin
    2. Maria Ethel
    3. Vincent Bretegnier
    4. Cassandre Goachet
    5. Cécile-Aurore Wotawa
    6. Marine Luka
    7. Fanny Coulpier
    8. Cécile Masson
    9. Mickael Ménager
    10. Céline Colnot
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This fundamental study generated a single cell atlas of mouse periosteal cells under both steady-state and fracture healing conditions to address the knowledge gap regarding cellular composition of the periosteum and their responses to injury. Based on convincing transcriptome analyses and experimental validation, the authors identified the injury induced fibrogenic cell (IIFC) as a characteristic cell type appearing in the bone regeneration process and proposed that the IIFC is a progenitor undergoing osteochondrogenic differentiation. This study will provide a significant publicly accessible dataset to reexamine the expression of the reported periosteal stem and progenitor cell markers.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Long range mutual activation establishes Rho and Rac polarity during cell migration

    This article has 9 authors:
    1. Henry De Belly
    2. Andreu Fernandez Gallen
    3. Evelyn Strickland
    4. Dorothy C. Estrada
    5. Patrick J. Zager
    6. Tamas L. Nagy
    7. Janis K Burkhardt
    8. Hervé Turlier
    9. Orion D. Weiner

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  3. Membrane potential modulates ERK activity and cell proliferation

    This article has 4 authors:
    1. Mari Sasaki
    2. Masanobu Nakahara
    3. Takuya Hashiguchi
    4. Fumihito Ono
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper employs multiple experimental approaches and presents evidence that changes in membrane voltage directly affect ERK signaling to regulate cell division. This result is relevant because it supports an ion channel-independent pathway by which changes in membrane voltage can affect cell growth. The reviewers point out that some experimental results and interpretations are compelling, but the strength of evidence is incomplete and additional experiments are needed to rule out other possible interpretations of the data.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Intracellular diffusion in the cytoplasm increases with cell size in fission yeast

    This article has 5 authors:
    1. Catherine Tan
    2. Michael C. Lanz
    3. Matthew Swaffer
    4. Jan Skotheim
    5. Fred Chang

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  5. PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

    This article has 3 authors:
    1. Weihong Xiong
    2. Maozhen Qin
    3. Haining Zhong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important paper demonstrates that different PKA subtypes exhibit distinct subcellular localization at rest in CA1 neurons. The authors provide compelling evidence that when all tested PKA subtypes are activated by norepinephrine, catalytic subunits translocate to dendritic spines but regulatory subunits remain unmoved. Furthermore, PKA-dependent regulation of synaptic plasticity and transmission can be supported only by wildtype, dissociable PKA, but not by inseparable PKA.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  6. Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

    This article has 10 authors:
    1. Yue Miao
    2. Yongtao Du
    3. Baolei Wang
    4. Jingjing Liang
    5. Yu Liang
    6. Song Dang
    7. Jiahao Liu
    8. Dong Li
    9. Kangmin He
    10. Mei Ding
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The manuscript presents an important model for the field of endosome maturation, providing perspective on the role of the deubiquitinating enzyme UPS-50/USP8 in the process. The evidence presented in the paper is clear, incorporating well-designed experiments that suggest the dual actions of UPS-50 and USP8 in the conversion of early endosomes into late endosomes. Overall, the work is convincing and centers on an intriguing subject.

    Reviewed by eLife

    This article has 15 evaluationsAppears in 1 listLatest version Latest activity
  7. Non-disruptive inducible labeling of ER-membrane contact sites using the Lamin B Receptor

    This article has 4 authors:
    1. Laura Downie
    2. Nuria Ferrandiz
    3. Megan Jones
    4. Stephen J. Royle

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  8. Golgi compaction facilitates microtubule nucleation to drive adult vertebrate peripheral neuron regeneration

    This article has 3 authors:
    1. Alice E Mortimer
    2. Adam J Reid
    3. Raman M Das

    Reviewed by preLights

    This article has 1 evaluationAppears in 1 listLatest version Latest activity
  9. LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

    This article has 12 authors:
    1. Kai Xu
    2. Xiaoyue Pan
    3. Hui Lian
    4. Yaxuan Wang
    5. Ruyan Wan
    6. Zhongzheng Li
    7. Xin Pan
    8. Yajun Li
    9. Juntang Yang
    10. Ivan Rosas
    11. Lan Wang
    12. Guoying Yu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable manuscript, the authors propose that the lysosomal protein LAPTM4B plays a role in suppressing the TGF-β/SMAD signaling pathway and suggest that enhancing LAPTM4B function could be a potential therapeutic strategy for alleviating bleomycin-induced lung fibrosis. The findings will be of interest to the lung disease field, and the data presented to support the authors' conclusions is solid. However, it remains unclear whether the suppressive effect of LAPTM4b on idiopathic pulmonary fibrosis is mediated by Nedd4l.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  10. Cigarette smoke impairs the endocytotic process in Saccharomyces cerevisiae

    This article has 3 authors:
    1. Aditya Shukla
    2. Srimonti Sarkar
    3. Alok Kumar Sil

    Reviewed by Arcadia Science

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
Previous Page 23 of 154 Next