Cell Biology

JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease

1. Yunpo Zhao
2. Jianli Duan
3. Hannah Seah
4. Joyce van de Leemput
5. Zhe Han

• Curated by eLife

  eLife Assessment

  This study presents important new insights linking obesity to kidney disease using a Drosophila model. A series of compelling experiments demonstrate that a high-fat diet induces excretion of a leptin-like JAK-STAT ligand from fat body, driving the adipose-nephrocyte axis through activated JAK-STAT signaling and subsequently causing a functional defect in nephrocytes. The approach using combination of genetic tools and pharmacological intervention is solid and confirms the mechanistic link, together with phenotypic analysis that further supports the authors conclusions.

Reviewed by eLife

Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins

1. Carole Luthold
2. Marie Didion
3. Vanessa Samira Rácz
4. Emilio Benedum
5. Ann-Kathrin Burkhart
6. Nina Demmerle
7. Evelyn Wirth
8. Gubesh Gunaratnam
9. Sudharshini Thangamurugan
10. Volkhard Helms
11. Markus Bischoff
12. Annika Ridzal
13. Sandra Iden

Reviewed by Review Commons

Sphingolipid imbalance aggravates tau pathology by endomembrane rigidification and rupture

1. Jessica Tittelmeier
2. Carl Alexander Sandhof
3. Nicole Martin
4. Deike El-Kabarity
5. Soki-Bradel Ngonza-Nito
6. Ronald Melki
7. Carmen Nussbaum-Krammer

• Curated by eLife

  eLife Assessment

  This valuable study addresses the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau pathology in Caenorhabditis elegans and human cell culture models. The methods are solid and the proposed mechanisms are conceivable. However, the current evidence is incomplete and could be strengthened, due to reliance on imaging data and insufficient biochemical validation. The work will be of broad interest to cell biologists and biologists working on Alzheimer's disease and related proteinopathies.

Reviewed by eLife

Intra-manchette transport employs both microtubule and actin tracks

1. Jo H. Judernatz
2. Laura Pérez Pañeda
3. Tereza Kadavá
4. Albert J. R. Heck
5. Tzviya Zeev-Ben-Mordehai

Reviewed by Review Commons

Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase

1. Madeleine L. Hart
2. David Sokolov
3. Serwah Danquah
4. Eric Zheng
5. Alex D. Doan
6. Kristian Davidsen
7. David MacPherson
8. Lucas B. Sullivan

Reviewed by preLights

Intestinal stem cell renewal controlled by capillary morphogenesis gene 2 following injury

1. Lucie Bracq
2. Audrey Chuat
3. Béatrice Kunz
4. Olivier Burri
5. Romain Guiet
6. F. Gisou van der Goot

Reviewed by Review Commons

The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

1. Fan Zhang
2. Yuan Wang
3. Luyang Zhang
4. Chunjie Wang
5. Deping Chen
6. Haibo Liu
7. Ren Xu
8. Cole M Haynes
9. Jae-Hyuck Shim
10. Xianpeng Ge

• Curated by eLife

  eLife Assessment

  This important work advances our understanding of CHMP5's role in regulating osteogenesis through its impact on cellular senescence. The evidence supporting the conclusion is convincing and the revised manuscript is largely improved. This paper holds potential interest for skeletal biologists who study the pathogenesis of age-associated skeletal disorders.

Reviewed by eLife

Clearance of protein aggregates during cell division

1. Shoukang Du
2. Yuhan Wang
3. Bowen Chen
4. Shuangshuang Xie
5. Kuan Yoow Chan
6. David C Hay
7. Ting Gang Chew

• Curated by eLife

  eLife Assessment

  How misfolded proteins are segregated and cleared is a significant question in cell biology, since clearance of these aggregates can protect against pathologies that may otherwise arise. The authors discover a cell cycle stage-dependent clearing mechanism that involves the ER chaperone BiP, the proteosome, and CDK inactivation, but is curiously independent of the anaphase promoting complex (APC). These are valuable and interesting new observations, and the evidence supporting these claims is solid.

Reviewed by eLife

Profiling the physiological impact of aberrant folded-state protein filamentation in cells

1. Tal Levin
2. Hector Garcia-Seisdedos
3. Arseniy Lobov
4. Matthias Wojtynek
5. Alexander Alexandrov
6. Ghil Jona
7. Dikla Levi
8. Ohad Medalia
9. D. Emmanuel Levy

Reviewed by Review Commons

N-cadherin mechanosensing in ovarian follicles controls oocyte maturation and ovulation

1. Alaknanda Emery
2. Orest W Blaschuk
3. Doan T Dinh
4. Tim McPhee
5. Rouven Becker
6. Andrew D Abell
7. Krzysztof M Mrozik
8. Andrew CW Zannettino
9. Rebecca L Robker
10. Darryl L Russell

• Curated by eLife

  eLife assessment

  The manuscript describes important findings regarding the significance of CHD2 in ovarian folliculogenesis. Overall, the results lead to convincing conclusions, with minimal concerns raised by the reviewers. Both the results and conclusions are well discussed. This work will be of interest to ovarian biologists and physicians working on female fertility.

Reviewed by eLife