Cell Biology

Compromised DNA replication in gut cells underlies tardigrade sensitivity to genotoxic stress

1. Gonzalo Quiroga-Artigas
2. Pauline Fontanié
3. Benjamin Lacroix
4. Maria Dolores Molina
5. María Moriel-Carretero

Reviewed by Review Commons

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation Change

1. Haihui Zhang
2. Zhengyang Lei
3. Fatemeh Momen-Heravi
4. Peiwu Qin

• Curated by eLife

  eLife Assessment

  This study provides valuable information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis, as well as on telomere dynamics through live cell imaging. However, the conclusions remain inadequately supported by the current data, and several of the major technical concerns raised in the first round have not yet been fully resolved.

Reviewed by eLife

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

1. Alexandra C. Belfi
2. Sage G. Aviles
3. Rachel Forman-Rubinsky
4. Hasreet K. Gill
5. Jennifer D. Cohen
6. Aleksandra Nawrocka
7. Axelle Bourez
8. Pierre van Antwerpen
9. Patrick Laurent
10. Meera V. Sundaram

Reviewed by Review Commons

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

1. Chengrui Shi
2. Chaofei Su
3. Kaixiang Zhang
4. Hang Yin

• Curated by eLife

  eLife Assessment

  This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

Reviewed by eLife