Cell Biology

Dual regulation of the unfolded protein response by IGF2BP3 during ER stress

1. Aleksandra S Anisimova
2. Harald Hornegger
3. Irmgard Fischer
4. Gijs A Versteeg
5. Stefan L Ameres
6. G Elif Karagöz

Reviewed by PREreview

Random UV Mutagenesis for the production of Chlorella vulgaris mutants with low chlorophyll content for the food industry

1. Ivan N. Ivanov
2. Jiří Kopecký
3. Karolína Štěrbová
4. Pavel Hrouzek
5. Martin Lukeš
6. Kateřina Bišová
7. Setyo Budi Kurniawan

Reviewed by Arcadia Science

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

1. Zhengming Tian
2. Yuning Li
3. Feiyang Jin
4. Zirui Xu
5. Yakun Gu
6. Mengyuan Guo
7. Qianqian Shao
8. Yingxia Liu
9. Hanjiang Luo
10. Yue Wang
11. Suyu Zhang
12. Chenlu Yang
13. Xin Liu
14. Xunming Ji
15. Jia Liu

• Curated by eLife

  eLife Assessment

  This valuable paper analyses the role of endogenous CNS hemoglobin in protecting mitochondrial homeostasis in hypoxic conditions. The work is solid and opens the doors to future work in this field. However, it leaves many questions open regarding CNS-specific ischemia/hypoxia that should be considered in future work. In particular, a whole-body hypoxia model may liberate exosomes from other hypoxic organs, which may contribute to the protective effect. Overall, this work has the potential to be of broad interest to the neuroscience and hypoxia communities.

Reviewed by eLife

Polarity reversal of stable microtubules during neuronal development

1. Malina K. Iwanski
2. Albert K. Serweta
3. H. Noor Verwei
4. Bronte C. Donders
5. Lukas C. Kapitein

Reviewed by Review Commons

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

1. Zongwang Zhang
2. Lixia Zheng
3. Yang Chen
4. Yuanyuan Chen
5. Junjie Hou
6. Chenglu Xiao
7. Xiaojun Zhu
8. Shi-Min Zhao
9. Jing-Wei Xiong

• Curated by eLife

  eLife Assessment

  This important study highlights the essential role of AARS2 in safeguarding cardiomyocytes against ischemic stress by modulating energy metabolism towards glycolysis via PKM2. This mechanism unveils a promising new therapeutic target for treating myocardial infarction. Convincing findings are underpinned by a comprehensive dataset, including cardiomyocyte-specific genetic modifications, functional assays, and ribosome profiling, all collectively providing strong evidence for the critical involvement of the AARS2-PKM2 signalling pathway in cardiac protection.

Reviewed by eLife

CellPhePy: A python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time‐lapse videos

1. Laura Wiggins
2. Stuart Lacy
3. Graeme Park
4. Joanne Marrison
5. Ben Powell
6. Beth Cimini
7. Peter O'Toole
8. Julie Wilson
9. William J. Brackenbury

Reviewed by Arcadia Science

Optogenetic stimulation of Lbc GEF-mediated Rho activity dynamics promotes cell invasion

1. Jessica Wagner
2. Konstantina Feller
3. Nicole Schrenke
4. Nina Schulze
5. Annette Paschen
6. Leif Dehmelt
7. Perihan Nalbant

Reviewed by preLights

Microtubule-dependent cell polarity regulates skin-resident macrophage phagocytosis and directed cell migration

1. Eric Peterman
2. Andrew Murphy
3. Ian A. Swinburne
4. Sean G. Megason
5. Jeffrey P. Rasmussen

Reviewed by PREreview

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

1. Andreas Fellas
2. Alison L. Pidoux
3. Pin Tong
4. Harriet H. Hewes
5. Emma C. Wallace
6. Robin C. Allshire

Reviewed by Review Commons

Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy

1. San Pin Steve Wu
2. Elvis Quiroz
3. Tianyuan Wang
4. Skylar G Montague Redecke
5. Xin Xu
6. Lin Lin
7. Matthew L Anderson
8. Francesco J DeMayo

• Curated by eLife

  eLife Assessment

  This valuable study employed a multi-omics approach to elucidate the regulatory mechanism underlying parturition and myometrial quiescence. The data presented to support the main conclusion are solid. This work will be of interest to both basic researchers who work on reproductive biology and clinicians who practice reproductive medicine.

Reviewed by eLife