Cell Biology

Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity

1. Alexandra C. Belfi
2. Sage G. Aviles
3. Rachel Forman-Rubinsky
4. Hasreet K. Gill
5. Jennifer D. Cohen
6. Aleksandra Nawrocka
7. Axelle Bourez
8. Pierre van Antwerpen
9. Patrick Laurent
10. Meera V. Sundaram

Reviewed by Review Commons

TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling

1. Janik Engelmann
2. Jennifer Zarrer
3. Max Schmerder
4. Christian Mess
5. Deniz Ragipoglu
6. Kristoffer Riecken
7. Tal Burstyn-Cohen
8. Emily J. Alberto
9. Sourav Ghosh
10. Carla Rothlin
11. Klaus Pantel
12. Carsten Bokemeyer
13. Eric Hesse
14. Hanna Taipaleenmäki
15. Sonja Loges
16. Isabel Ben-Batalla

Reviewed by preLights

Co-option of lysosomal machinery shapes the symbiosis supporting coral reefs

1. Shumpei Maruyama
2. Catherine F Henderson
3. Natalie Swinhoe
4. Griffin P Kowalewski
5. Emily K Meier
6. Ty R Engelke
7. Phillip A Cleves

Reviewed by Arcadia Science

Organelle membrane-associated proteins recruit cGAS via phase separation to facilitate its membrane localization

1. Chengrui Shi
2. Chaofei Su
3. Kaixiang Zhang
4. Hang Yin

• Curated by eLife

  eLife Assessment

  This useful study investigates how intrinsically disordered domains can interact to dictate the sub-cellular localization of a major innate immune sensor termed cGAS. The data from various cellular and biochemical assays are mostly solid, but the main conclusions from these experiments need to be validated further. This paper is relevant to immunologists, especially those interested in cytosolic DNA-sensing pathways.

Reviewed by eLife

JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux

1. Layla M. Nassar
2. Xiaojian Shi
3. Agnes Roczniak-Ferguson
4. Hongying Shen
5. Shawn M. Ferguson

Reviewed by Arcadia Science

Stress response of membrane-based cell organelles in budding yeast

1. Sheng Peng
2. Bai Li-zhe
3. Cao Hong
4. Li Dan

Reviewed by Arcadia Science

Tracking maternal proteins uncovers a central role for the residual body in organelle recycling during Toxoplasma gondii replication

1. Julia von Knoerzer-Suckow
2. Parnian Sazegar
3. Javier Periz
4. Simon Gras
5. Markus Meissner

• Curated by eLife

  eLife Assessment

  This important study provides new insights into the patterns of organelle inheritance in the protozoan parasite Toxoplasma gondii. The authors introduce an innovative dual-labeling approach to distinguish maternally inherited from de novo synthesized organelles, representing convincing evidence that different organelles follow distinct inheritance fates during parasite replication. Future studies will be needed to determine whether the residual body functions as a central recycling hub, as the current data are also consistent with alternative models.

Reviewed by eLife